{"id":"https://openalex.org/W2964925642","doi":"https://doi.org/10.1016/j.cyto.2019.154782","title":"Activin A-mediated epithelial de-differentiation contributes to injury repair in an in vitro gastrointestinal reflux model","display_name":"Activin A-mediated epithelial de-differentiation contributes to injury repair in an in vitro gastrointestinal reflux model","publication_year":2019,"publication_date":"2019-07-29","ids":{"openalex":"https://openalex.org/W2964925642","doi":"https://doi.org/10.1016/j.cyto.2019.154782","mag":"2964925642","pmid":"https://pubmed.ncbi.nlm.nih.gov/31369967","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6739184"},"language":"en","primary_location":{"id":"doi:10.1016/j.cyto.2019.154782","doi":"https://doi.org/10.1016/j.cyto.2019.154782","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2019.154782","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6739184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053296766","display_name":"Cedric Roudebush","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cedric Roudebush","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018046057","display_name":"Alma Catala-Valentin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alma Catala-Valentin","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013343878","display_name":"Thomas Andl","orcid":"https://orcid.org/0009-0006-7163-3624","observed_orcids":["https://orcid.org/0009-0006-7163-3624","https://orcid.org/0000-0002-5555-468X"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Andl","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086892130","display_name":"Gr\u00e9goire F. Le Bras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregoire F. Le Bras","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020588666","display_name":"Claudia D. Andl","orcid":"https://orcid.org/0000-0001-7358-9520","observed_orcids":["https://orcid.org/0000-0001-7358-9520"]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claudia D. Andl","raw_affiliation_strings":["Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States. Electronic address: Claudia.andl@ucf.edu","Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States. Electronic address: Claudia.andl@ucf.edu","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Burnett School of Biomedical Sciences, University of Central Florida, 4110 Libra Dr., BMS, Building 20, rm 223, Orlando, FL 32816, United States","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020588666"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":1.4314,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.81188257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"123","issue":null,"first_page":"154782","last_page":"154782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.423799991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.423799991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.20749999582767487,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/activin-a","display_name":"activin A","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gastroesophageal-reflux","display_name":"gastroesophageal reflux","score":0.7850000262260437},{"id":"https://openalex.org/keywords/reflux-esophagitis","display_name":"reflux esophagitis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/barrett-s-metaplasia","display_name":"Barrett's metaplasia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.722000002861023},{"id":"https://openalex.org/keywords/acid-exposure","display_name":"acid exposure","score":0.6970000267028809},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.796999990940094},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8370000123977661},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sox9","display_name":"SOX9","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lgr5","display_name":"Lgr5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dclk1","display_name":"DCLK1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9940000176429749},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/keratin-17","display_name":"keratin 17","score":0.9520000219345093},{"id":"https://openalex.org/keywords/esophageal-adenocarcinoma","display_name":"esophageal adenocarcinoma","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2780806702","wikidata":"https://www.wikidata.org/wiki/Q14866198","display_name":"Amphiregulin","level":4,"score":0.5839192867279053},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.5105898976325989},{"id":"https://openalex.org/C2909576783","wikidata":"https://www.wikidata.org/wiki/Q298230","display_name":"Reflux esophagitis","level":4,"score":0.4937065541744232},{"id":"https://openalex.org/C2778589982","wikidata":"https://www.wikidata.org/wiki/Q808892","display_name":"Barrett's esophagus","level":4,"score":0.489156037569046},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.4751177430152893},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4738224744796753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45370668172836304},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.41885846853256226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4175333082675934},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.414632648229599},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36274322867393494},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.2785685360431671},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.2706356644630432},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22971758246421814},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12496668100357056},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.07361966371536255},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cyto.2019.154782","doi":"https://doi.org/10.1016/j.cyto.2019.154782","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2019.154782","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},{"id":"pmid:31369967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31369967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6739184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6739184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cytokine","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6739184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6739184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cytokine","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G824091990","display_name":"The role of Activin A signaling in esophageal cell invasion","funder_award_id":"R01DK094900","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1528154790","https://openalex.org/W1967120118","https://openalex.org/W1969989929","https://openalex.org/W1982871919","https://openalex.org/W1983871625","https://openalex.org/W1985576731","https://openalex.org/W1995160678","https://openalex.org/W1999318918","https://openalex.org/W2000881730","https://openalex.org/W2022904912","https://openalex.org/W2025727818","https://openalex.org/W2026088179","https://openalex.org/W2026108627","https://openalex.org/W2042047157","https://openalex.org/W2046663756","https://openalex.org/W2052904826","https://openalex.org/W2053426793","https://openalex.org/W2054451629","https://openalex.org/W2055733334","https://openalex.org/W2055823059","https://openalex.org/W2058503472","https://openalex.org/W2063307907","https://openalex.org/W2070314951","https://openalex.org/W2070881335","https://openalex.org/W2070999405","https://openalex.org/W2075890816","https://openalex.org/W2077973474","https://openalex.org/W2081716261","https://openalex.org/W2082019843","https://openalex.org/W2085293124","https://openalex.org/W2090423996","https://openalex.org/W2094313689","https://openalex.org/W2097968887","https://openalex.org/W2098837984","https://openalex.org/W2100837310","https://openalex.org/W2102944297","https://openalex.org/W2106562993","https://openalex.org/W2107511253","https://openalex.org/W2112789125","https://openalex.org/W2117841435","https://openalex.org/W2122483745","https://openalex.org/W2128292315","https://openalex.org/W2130699826","https://openalex.org/W2141725935","https://openalex.org/W2147224721","https://openalex.org/W2148020282","https://openalex.org/W2151899062","https://openalex.org/W2156571438","https://openalex.org/W2158203062","https://openalex.org/W2158544588","https://openalex.org/W2158690779","https://openalex.org/W2159267239","https://openalex.org/W2167312662","https://openalex.org/W2168544170","https://openalex.org/W2170202550","https://openalex.org/W2174026431","https://openalex.org/W2313441807","https://openalex.org/W2395526836","https://openalex.org/W2405241483","https://openalex.org/W2483248188","https://openalex.org/W2491162902","https://openalex.org/W2560186680","https://openalex.org/W2567946031","https://openalex.org/W2603342209","https://openalex.org/W2606870500","https://openalex.org/W2735265983","https://openalex.org/W2758484077","https://openalex.org/W2762148478","https://openalex.org/W2773293509","https://openalex.org/W2788976067","https://openalex.org/W2790254198","https://openalex.org/W2791631258","https://openalex.org/W2801982673","https://openalex.org/W2805193692","https://openalex.org/W2811446453","https://openalex.org/W2811446995","https://openalex.org/W2889118555","https://openalex.org/W2893734330","https://openalex.org/W4247399018","https://openalex.org/W6681746546"],"related_works":["https://openalex.org/W3110378290","https://openalex.org/W2049396261","https://openalex.org/W1983293493","https://openalex.org/W2039918372","https://openalex.org/W2020536945","https://openalex.org/W2153804605","https://openalex.org/W2130699826","https://openalex.org/W3085887712","https://openalex.org/W4388646430","https://openalex.org/W1986072501"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-13T00:00:00"}