{"id":"https://openalex.org/W2964800100","doi":"https://doi.org/10.2174/1389200220666190729130020","title":"Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide","display_name":"Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide","publication_year":2019,"publication_date":"2019-07-30","ids":{"openalex":"https://openalex.org/W2964800100","doi":"https://doi.org/10.2174/1389200220666190729130020","mag":"2964800100","pmid":"https://pubmed.ncbi.nlm.nih.gov/31362668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7062010"},"language":"en","primary_location":{"id":"doi:10.2174/1389200220666190729130020","doi":"https://doi.org/10.2174/1389200220666190729130020","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1389200220666190729130020","pdf_url":"http://www.eurekaselect.com/article/100009","source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.eurekaselect.com/article/100009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040751228","display_name":"Suping Xiong","orcid":"https://orcid.org/0000-0003-2453-0324","observed_orcids":["https://orcid.org/0000-0003-2453-0324"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suping Xiong","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0003-2453-0324","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100720245","display_name":"Yanting Li","orcid":"https://orcid.org/0000-0003-2973-3016","observed_orcids":["https://orcid.org/0000-0003-2973-3016","https://orcid.org/0009-0002-3147-1406"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanting Li","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023076380","display_name":"Xiang Dong Yang","orcid":"https://orcid.org/0000-0002-1261-8006","observed_orcids":["https://orcid.org/0000-0002-1261-8006"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Xiang","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0002-1261-8006","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Na Peng","orcid":"https://orcid.org/0000-0001-9100-8590","observed_orcids":["https://orcid.org/0000-0001-9100-8590"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Peng","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0001-9100-8590","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chunmiao Shen","orcid":"https://orcid.org/0000-0002-7290-3271","observed_orcids":["https://orcid.org/0000-0002-7290-3271"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunmiao Shen","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0002-7290-3271","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101237908","display_name":"Yanqiu Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanqiu Cai","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102764623","display_name":"Dandan Song","orcid":"https://orcid.org/0000-0003-3766-9237","observed_orcids":["https://orcid.org/0000-0003-3766-9237"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Song","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0003-3766-9237","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364035","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0003-3981-5162","observed_orcids":["https://orcid.org/0000-0003-3981-5162","https://orcid.org/0000-0001-7493-4330"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0001-7493-4330","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424269","display_name":"Xiaolong Wang","orcid":"https://orcid.org/0000-0002-9681-111X","observed_orcids":["https://orcid.org/0000-0002-9681-111X"]},"institutions":[{"id":"https://openalex.org/I4210143313","display_name":"Jilin Maternity and Child Health Care Hospital","ror":"https://ror.org/0516vxk09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143313"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolong Wang","raw_affiliation_strings":["Traditional Chinese Medicine Department, Jilin Women and Children Health Hospital, Changchun, China"],"raw_orcid":"https://orcid.org/0000-0002-9681-111X","affiliations":[{"raw_affiliation_string":"Traditional Chinese Medicine Department, Jilin Women and Children Health Hospital, Changchun, China","institution_ids":["https://openalex.org/I4210143313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112458376","display_name":"Xuihui Zeng","orcid":"https://orcid.org/0000-0002-5936-4699","observed_orcids":["https://orcid.org/0000-0002-5936-4699"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuihui Zeng","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0002-5936-4699","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101506180","display_name":"Xiaoning Zhang","orcid":"https://orcid.org/0000-0003-1227-866X","observed_orcids":["https://orcid.org/0000-0003-1227-866X"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoning Zhang","raw_affiliation_strings":["Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0003-1227-866X","affiliations":[{"raw_affiliation_string":"Institute of Life Science and School of Life Science, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101506180"],"corresponding_institution_ids":["https://openalex.org/I141649914"],"apc_list":null,"apc_paid":null,"fwci":1.8952,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.82530659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"20","issue":"8","first_page":"665","last_page":"673"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.22750000655651093,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triptolide","display_name":"triptolide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/male-reproductive-toxicity","display_name":"male reproductive toxicity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.7559999823570251},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.6980000138282776},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.9670000076293945},{"id":"https://openalex.org/keywords/testis-transcriptome","display_name":"testis transcriptome","score":0.7260000109672546},{"id":"https://openalex.org/keywords/sperm-morphology","display_name":"sperm morphology","score":0.6359999775886536},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.8090000152587891},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2781164371","wikidata":"https://www.wikidata.org/wiki/Q906351","display_name":"Triptolide","level":3,"score":0.8683667778968811},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3718910813331604},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3713605999946594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3201741576194763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12636461853981018},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06465795636177063}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000988","descriptor_name":"Antispermatogenic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2174/1389200220666190729130020","doi":"https://doi.org/10.2174/1389200220666190729130020","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1389200220666190729130020","pdf_url":"http://www.eurekaselect.com/article/100009","source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},{"id":"pmid:31362668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31362668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7062010","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7062010/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Drug Metab","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2174/1389200220666190729130020","doi":"https://doi.org/10.2174/1389200220666190729130020","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1389200220666190729130020","pdf_url":"http://www.eurekaselect.com/article/100009","source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7409992211","display_name":"\u5f31\u7cbe\u75c7\u76f8\u5173lncRNA ASAL1\u5728\u4eba\u6210\u719f\u7cbe\u5b50\u4e2d\u7684\u529f\u80fd\u4e0e\u673a\u5236\u7814\u7a76","funder_award_id":"81760283","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8153262474","display_name":null,"funder_award_id":"31801238","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964800100.pdf","grobid_xml":"https://content.openalex.org/works/W2964800100.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W242621753","https://openalex.org/W1483481795","https://openalex.org/W1604920482","https://openalex.org/W1942667155","https://openalex.org/W1942701872","https://openalex.org/W1969670847","https://openalex.org/W1984236721","https://openalex.org/W1993481243","https://openalex.org/W1996164445","https://openalex.org/W1998526450","https://openalex.org/W2003774554","https://openalex.org/W2012139589","https://openalex.org/W2017919052","https://openalex.org/W2025304475","https://openalex.org/W2031860536","https://openalex.org/W2043777033","https://openalex.org/W2070887218","https://openalex.org/W2076973395","https://openalex.org/W2088069070","https://openalex.org/W2088999851","https://openalex.org/W2095736672","https://openalex.org/W2103920425","https://openalex.org/W2106398818","https://openalex.org/W2117144912","https://openalex.org/W2139444346","https://openalex.org/W2139686199","https://openalex.org/W2150143752","https://openalex.org/W2162109652","https://openalex.org/W2170659029","https://openalex.org/W2332416611","https://openalex.org/W2419516302","https://openalex.org/W2463915366","https://openalex.org/W2514088426","https://openalex.org/W2514121587","https://openalex.org/W2515994634","https://openalex.org/W2567175297","https://openalex.org/W2579464301","https://openalex.org/W2592303453","https://openalex.org/W2595616599","https://openalex.org/W2605479380","https://openalex.org/W2769350205","https://openalex.org/W2789536459","https://openalex.org/W2794143667","https://openalex.org/W2809797424","https://openalex.org/W2883303543","https://openalex.org/W2883432021","https://openalex.org/W2888370728","https://openalex.org/W2898334176","https://openalex.org/W2901422983","https://openalex.org/W2906112510"],"related_works":["https://openalex.org/W3092190549","https://openalex.org/W4405236099","https://openalex.org/W4365505101","https://openalex.org/W1848407029","https://openalex.org/W2471437516","https://openalex.org/W2571900425","https://openalex.org/W2334833108","https://openalex.org/W4363674420","https://openalex.org/W2147759279","https://openalex.org/W3134382109"],"abstract_inverted_index":{"BACKGROUND:":[0],"Triptolide":[1,109],"has":[2],"been":[3],"shown":[4],"to":[5,80,87,100,174],"exert":[6],"various":[7],"pharmacological":[8],"effects":[9],"on":[10,226],"systemic":[11],"autoimmune":[12],"diseases":[13],"and":[14,37,56,116,119,123,130,153,169,220,233],"cancers.":[15],"However,":[16,63],"its":[17,24,235],"severe":[18],"toxicity,":[19,22],"especially":[20],"reproductive":[21,70,200,216],"prevents":[23],"widespread":[25],"clinical":[26],"use":[27],"for":[28,54,197,224],"people":[29],"with":[30],"fertility":[31],"needs.":[32],"Noncoding":[33],"RNAs":[34,84],"including":[35],"lncRNAs":[36],"circRNAs":[38],"are":[39,52,66],"novel":[40],"regulatory":[41],"molecules":[42],"that":[43,157],"mediate":[44],"a":[45,206],"wide":[46],"variety":[47],"of":[48,78,149,160,209,214,218,231],"physiological":[49],"activities;":[50],"they":[51,65],"crucial":[53],"spermatogenesis":[55],"their":[57,191],"dysregulation":[58],"might":[59],"cause":[60],"male":[61,199],"infertility.":[62],"whether":[64],"involved":[67,177],"in":[68,105,127,135,178],"triptolide-induced":[69,106,198,210],"toxicity":[71,217],"is":[72],"completely":[73],"unknown.":[74],"METHODS:":[75],"After":[76],"exposure":[77],"mice":[79,144],"triptolide,":[81,219],"the":[82,97,139,142,158,161,215,222,228],"total":[83],"were":[85,132,171,184],"used":[86],"investigate":[88],"lncRNA/circRNA/mRNA":[89],"expression":[90,147],"profiles":[91,148],"by":[92],"strand-specific":[93],"RNA":[94],"sequencing":[95],"at":[96],"transcriptome":[98,140],"level":[99],"help":[101],"uncover":[102],"RNA-related":[103],"mechanisms":[104],"toxicity.":[107,201,236],"RESULTS:":[108],"significantly":[110],"decreased":[111],"testicular":[112],"weight,":[113],"damaged":[114],"testis":[115],"sperm":[117,121,128],"morphology,":[118],"reduced":[120],"motility":[122],"density.":[124],"Remarkable":[125],"deformities":[126],"head":[129],"tail":[131],"also":[133],"found":[134],"triptolide-exposed":[136],"mice.":[137],"At":[138],"level,":[141],"triptolide-treated":[143],"exhibited":[145],"aberrant":[146],"lncRNAs/circRNAs/mRNAs.":[150],"Gene":[151],"Ontology":[152],"pathway":[154],"analyses":[155],"revealed":[156],"functions":[159],"differentially":[162],"expressed":[163],"lncRNA":[164],"targets,":[165],"circRNA":[166],"cognate":[167],"genes,":[168],"mRNAs":[170],"closely":[172],"linked":[173],"many":[175],"processes":[176],"spermatogenesis.":[179],"In":[180],"addition,":[181],"some":[182],"lncRNAs/circRNAs":[183],"greatly":[185],"upregulated":[186],"or":[187],"inducibly":[188],"expressed,":[189],"implying":[190],"potential":[192],"value":[193],"as":[194],"candidate":[195],"markers":[196],"CONCLUSION:":[202],"This":[203],"study":[204],"provides":[205],"preliminary":[207],"database":[208],"transcriptome,":[211],"promotes":[212],"understanding":[213],"highlights":[221],"need":[223],"research":[225],"increasing":[227],"medical":[229],"efficacy":[230],"triptolide":[232],"decreasing":[234]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-08-13T00:00:00"}