{"id":"https://openalex.org/W2964765150","doi":"https://doi.org/10.3390/molecules24152724","title":"Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors","display_name":"Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors","publication_year":2019,"publication_date":"2019-07-26","ids":{"openalex":"https://openalex.org/W2964765150","doi":"https://doi.org/10.3390/molecules24152724","mag":"2964765150","pmid":"https://pubmed.ncbi.nlm.nih.gov/31357491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6695594"},"language":"en","primary_location":{"id":"doi:10.3390/molecules24152724","doi":"https://doi.org/10.3390/molecules24152724","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules24152724","pdf_url":"https://www.mdpi.com/1420-3049/24/15/2724/pdf?version=1564144355","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/24/15/2724/pdf?version=1564144355","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101746230","display_name":"Lijiao Wang","orcid":"https://orcid.org/0000-0002-7708-2062","observed_orcids":["https://orcid.org/0000-0002-7708-2062"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijiao Wang","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100323254","display_name":"Chao Li","orcid":"https://orcid.org/0000-0003-1568-9704","observed_orcids":["https://orcid.org/0000-0003-1568-9704"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Li","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344582","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0003-3720-718X","observed_orcids":["https://orcid.org/0000-0003-3720-718X","https://orcid.org/0009-0003-6498-0829"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100727994","display_name":"Chen Song","orcid":"https://orcid.org/0000-0001-9730-3216","observed_orcids":["https://orcid.org/0000-0001-9730-3216"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Song","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399164","display_name":"Xing Zhang","orcid":"https://orcid.org/0009-0004-8215-8000","observed_orcids":["https://orcid.org/0009-0004-8215-8000"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Zhang","raw_affiliation_strings":["College of Science, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712121","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-5884-3751","observed_orcids":["https://orcid.org/0000-0002-5884-3751"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337496","display_name":"Chen Wang","orcid":"https://orcid.org/0000-0001-7571-847X","observed_orcids":["https://orcid.org/0000-0001-7571-847X"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320675","display_name":"Yuanyuan Zhang","orcid":"https://orcid.org/0000-0002-9263-6262","observed_orcids":["https://orcid.org/0000-0002-9263-6262","https://orcid.org/0009-0000-8464-3975"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhang","raw_affiliation_strings":["College of Science, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014902770","display_name":"Shan Qian","orcid":"https://orcid.org/0000-0002-9550-6885","observed_orcids":["https://orcid.org/0000-0002-9550-6885"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Qian","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025942009","display_name":"Zhouyu Wang","orcid":"https://orcid.org/0000-0002-0704-2532","observed_orcids":["https://orcid.org/0000-0002-0704-2532"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhouyu Wang","raw_affiliation_strings":["College of Science, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Science, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033599023","display_name":"Lingling Yang","orcid":"https://orcid.org/0000-0001-8397-8079","observed_orcids":["https://orcid.org/0000-0001-8397-8079"]},"institutions":[{"id":"https://openalex.org/I102345215","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26","country_code":"CN","type":"education","lineage":["https://openalex.org/I102345215"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingling Yang","raw_affiliation_strings":["College of Food and Bioengineering, Xihua University, Sichuan 610039, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Bioengineering, Xihua University, Sichuan 610039, China","institution_ids":["https://openalex.org/I102345215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025942009","https://openalex.org/A5033599023"],"corresponding_institution_ids":["https://openalex.org/I102345215"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":0.6957,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.69081321,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"15","first_page":"2724","last_page":"2724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt2","display_name":"SIRT2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/sirt2-inhibitors","display_name":"SIRT2 inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7940000295639038},{"id":"https://openalex.org/keywords/water-solubility","display_name":"water solubility","score":0.6869999766349792},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8080000281333923},{"id":"https://openalex.org/keywords/anticancer-drug-targets","display_name":"anticancer drug targets","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C199848840","wikidata":"https://www.wikidata.org/wiki/Q18036605","display_name":"SIRT2","level":5,"score":0.9323068857192993},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.8117576241493225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5871721506118774},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5162963271141052},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.45932385325431824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4577147364616394},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.42211657762527466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3954107165336609},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35858598351478577},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3555852174758911},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25808870792388916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22788184881210327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1828027367591858},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15537512302398682},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.07375973463058472},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules24152724","doi":"https://doi.org/10.3390/molecules24152724","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules24152724","pdf_url":"https://www.mdpi.com/1420-3049/24/15/2724/pdf?version=1564144355","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:31357491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31357491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6695594","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6695594/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4e96a5f531b44404a5db66b3b2a223ed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4e96a5f531b44404a5db66b3b2a223ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 24, Iss 15, p 2724 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules24152724","doi":"https://doi.org/10.3390/molecules24152724","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/molecules24152724","pdf_url":"https://www.mdpi.com/1420-3049/24/15/2724/pdf?version=1564144355","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1191778136","display_name":null,"funder_award_id":"2016HH0075","funder_id":"https://openalex.org/F4320322922","funder_display_name":"Department of Science and Technology of Sichuan Province"},{"id":"https://openalex.org/G4730501523","display_name":null,"funder_award_id":"172507","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G6398527242","display_name":null,"funder_award_id":"No. 2016HH0075","funder_id":"https://openalex.org/F4320322922","funder_display_name":"Department of Science and Technology of Sichuan Province"}],"funders":[{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320322922","display_name":"Department of Science and Technology of Sichuan Province","ror":"https://ror.org/04323m874"},{"id":"https://openalex.org/F4320324858","display_name":"Xihua University","ror":"https://ror.org/04gwtvf26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964765150.pdf","grobid_xml":"https://content.openalex.org/works/W2964765150.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1601675369","https://openalex.org/W1606024367","https://openalex.org/W1848671119","https://openalex.org/W1900203882","https://openalex.org/W1968098522","https://openalex.org/W1970406609","https://openalex.org/W1977919654","https://openalex.org/W1981549228","https://openalex.org/W1991782854","https://openalex.org/W1998974491","https://openalex.org/W2001377421","https://openalex.org/W2012233199","https://openalex.org/W2018463433","https://openalex.org/W2022813351","https://openalex.org/W2037448827","https://openalex.org/W2038054564","https://openalex.org/W2040462263","https://openalex.org/W2052130151","https://openalex.org/W2064141488","https://openalex.org/W2069423751","https://openalex.org/W2070739037","https://openalex.org/W2084490228","https://openalex.org/W2097153041","https://openalex.org/W2098462847","https://openalex.org/W2102635586","https://openalex.org/W2104142860","https://openalex.org/W2110118637","https://openalex.org/W2117674849","https://openalex.org/W2120608933","https://openalex.org/W2123927456","https://openalex.org/W2140587516","https://openalex.org/W2165105249","https://openalex.org/W2165368743","https://openalex.org/W2168702014","https://openalex.org/W2281955860","https://openalex.org/W2319093261","https://openalex.org/W2554535625","https://openalex.org/W2596344481","https://openalex.org/W2605567181","https://openalex.org/W2740697399","https://openalex.org/W2746155344","https://openalex.org/W2793050307","https://openalex.org/W2808791482","https://openalex.org/W2896123713","https://openalex.org/W2905570543","https://openalex.org/W2940832643","https://openalex.org/W6638940676"],"related_works":["https://openalex.org/W2605567181","https://openalex.org/W2001568839","https://openalex.org/W2746155344","https://openalex.org/W2080626304","https://openalex.org/W2002934450","https://openalex.org/W1970406609","https://openalex.org/W7084060187","https://openalex.org/W2331761629","https://openalex.org/W2033307149","https://openalex.org/W2126599450"],"abstract_inverted_index":{"Human":[0],"sirtuin":[1,8],"2":[2],"(SIRT2),":[3],"a":[4,14,58,88,99],"member":[5],"of":[6,87,90,98,107,149],"the":[7,50,96,135,145],"family,":[9],"has":[10],"been":[11,32],"considered":[12],"as":[13],"promising":[15],"drug":[16],"target":[17],"in":[18,34],"cancer,":[19],"neurodegenerative":[20],"diseases,":[21],"type":[22],"II":[23],"diabetes,":[24],"and":[25,56,68,78,130],"bacterial":[26],"infections.":[27],"Thus,":[28],"SIRT2":[29,47,74],"inhibitors":[30],"have":[31],"involved":[33],"effective":[35],"treatment":[36],"strategies":[37],"for":[38,46],"related":[39],"diseases.":[40],"Using":[41],"previously":[42],"established":[43],"fluorescence-based":[44],"assays":[45],"activity":[48],"tests,":[49],"authors":[51],"screened":[52],"their":[53],"in-house":[54],"database":[55],"identified":[57],"compound,":[59],"4-(5-((3-(quinolin-5-yl)ureido)methyl)furan-2-yl)benzoic":[60],"acid":[61],"(20),":[62],"which":[63,110],"displayed":[64],"63":[65],"\u00b1":[66,70],"5%":[67],"35":[69],"3%":[71],"inhibition":[72],"against":[73],"at":[75],"100":[76],"\u03bcM":[77],"10":[79],"\u03bcM,":[80,109],"respectively.":[81],"The":[82],"structure-activity":[83],"relationship":[84],"(SAR)":[85],"analyses":[86,138],"series":[89],"synthesized":[91],"(5-phenylfuran-2-yl)methanamine":[92],"derivatives":[93],"led":[94],"to":[95],"identification":[97],"potent":[100,113],"compound":[101],"25":[102,121,141],"with":[103,144],"an":[104],"IC50":[105],"value":[106],"2.47":[108],"is":[111],"more":[112],"than":[114],"AGK2":[115],"(IC50":[116],"=":[117,128,132],"17.75":[118],"\u03bcM).":[119],"Meanwhile,":[120],"likely":[122],"possesses":[123],"better":[124],"water":[125],"solubility":[126],"(cLogP":[127],"1.63":[129],"cLogS":[131],"\u22123.63).":[133],"Finally,":[134],"molecular":[136],"docking":[137],"indicated":[139],"that":[140],"fitted":[142],"well":[143],"induced":[146],"hydrophobic":[147],"pocket":[148],"SIRT2.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-08-13T00:00:00"}
