{"id":"https://openalex.org/W2964734646","doi":"https://doi.org/10.9734/jammr/2019/v30i530194","title":"Effects of Diabetogenic Agent Streptozotocin on Hematological Parameters of Wistar Albino Rats \u201cAn Experimental Study\u201d","display_name":"Effects of Diabetogenic Agent Streptozotocin on Hematological Parameters of Wistar Albino Rats \u201cAn Experimental Study\u201d","publication_year":2019,"publication_date":"2019-08-06","ids":{"openalex":"https://openalex.org/W2964734646","doi":"https://doi.org/10.9734/jammr/2019/v30i530194","mag":"2964734646"},"language":"en","primary_location":{"id":"doi:10.9734/jammr/2019/v30i530194","doi":"https://doi.org/10.9734/jammr/2019/v30i530194","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jammr/2019/v30i530194","pdf_url":null,"source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advances in Medicine and Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.9734/jammr/2019/v30i530194","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104045889","display_name":"Akhtar Ali","orcid":"https://orcid.org/0009-0009-3415-3586","observed_orcids":["https://orcid.org/0009-0009-3415-3586","https://orcid.org/0000-0002-2078-7678"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Akhtar Ali","raw_affiliation_strings":["Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112568569","display_name":"Shehla Shaheen","orcid":"https://orcid.org/0000-0002-1822-4139","observed_orcids":["https://orcid.org/0000-0002-1822-4139"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Shehla Shaheen","raw_affiliation_strings":["Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521071","display_name":"Zahida Memon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zahida Memon","raw_affiliation_strings":["Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016051722","display_name":"Faiza Agha","orcid":"https://orcid.org/0009-0007-2683-239X","observed_orcids":["https://orcid.org/0009-0007-2683-239X"]},"institutions":[{"id":"https://openalex.org/I2799309473","display_name":"Liaquat National Hospital","ror":"https://ror.org/01xytvd82","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2799309473"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Faiza Agha","raw_affiliation_strings":["Department of Biochemistry, Liaqat National Medical College Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Liaqat National Medical College Karachi, Pakistan","institution_ids":["https://openalex.org/I2799309473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103884171","display_name":"Moazzam Ali Shahid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Moazzam Ali Shahid","raw_affiliation_strings":["Department of Research, Ziauddin Medical College, Ziauddin University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Ziauddin Medical College, Ziauddin University, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059645645","display_name":"Nisha Zahid","orcid":"https://orcid.org/0000-0001-9656-7906","observed_orcids":["https://orcid.org/0000-0001-9656-7906"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nisha Zahid","raw_affiliation_strings":["Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Pakistan","institution_ids":["https://openalex.org/I923305593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1939,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.43972332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"30","issue":"5","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.03929999843239784,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptozotocin","display_name":"streptozotocin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6449999809265137},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6259999871253967},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.9890000224113464},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.847000002861023},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.9959999918937683},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hematopoietic-toxicity","display_name":"hematopoietic toxicity","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.8607916831970215},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6832506656646729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6382779479026794},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6140530109405518},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.556036114692688},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4767216742038727},{"id":"https://openalex.org/C3020000481","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Experimental animal","level":2,"score":0.4549339711666107},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.44063568115234375},{"id":"https://openalex.org/C3018233652","wikidata":"https://www.wikidata.org/wiki/Q101965","display_name":"Experimental research","level":2,"score":0.43983641266822815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36002200841903687},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23607909679412842},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.20576369762420654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15607285499572754},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.09460890293121338},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.9734/jammr/2019/v30i530194","doi":"https://doi.org/10.9734/jammr/2019/v30i530194","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jammr/2019/v30i530194","pdf_url":null,"source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advances in Medicine and Medical Research","raw_type":"journal-article"},{"id":"pmh:oai:journaljammr.com:article/3413","doi":null,"is_oa":true,"landing_page_url":"https://www.journaljammr.com/index.php/JAMMR/article/view/3413","pdf_url":null,"source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2456-8899","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05335254v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05335254","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Advances in Medicine and Medical Research, 2019, 30 (5), pp.1-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1646353","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1646353","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.9734/jammr/2019/v30i530194","doi":"https://doi.org/10.9734/jammr/2019/v30i530194","is_oa":true,"landing_page_url":"https://doi.org/10.9734/jammr/2019/v30i530194","pdf_url":null,"source":{"id":"https://openalex.org/S4210232404","display_name":"Journal of Advances in Medicine and Medical Research","issn_l":"2231-0614","issn":["2231-0614","2456-8899"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["vabb-shw"],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Advances in Medicine and Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2993571918","https://openalex.org/W2810968436","https://openalex.org/W2334757127","https://openalex.org/W2494735969","https://openalex.org/W4393424615","https://openalex.org/W2374611560","https://openalex.org/W2471653562","https://openalex.org/W4376643885","https://openalex.org/W4205790807","https://openalex.org/W3179856144"],"abstract_inverted_index":{"Background:":[0],"Diabetes":[1,197],"mellitus":[2],"has":[3,56],"remained":[4],"the":[5,27,46,72,83,102,192,242,266,302],"major":[6],"concern":[7],"for":[8,35],"medical":[9],"sciences":[10],"researches":[11],"due":[12],"to":[13,30,44,100,261,286,331],"its":[14],"deleterious":[15],"effects":[16,67,103],"on":[17,106,200,223,232],"general,":[18],"physical":[19],"and":[20,29,121,127,140,173,177,210,212,248,283],"mental":[21],"health":[22],"of":[23,38,68,97,104,110,142,151,153,194,196,228,244,317,321],"patients.":[24],"To":[25,50],"understand":[26],"pathophysiology":[28],"explore":[31],"better":[32],"treatment":[33],"options":[34],"such":[36,112],"kind":[37],"metabolic":[39],"disorders":[40],"it":[41],"is":[42,310,323],"necessary":[43],"generate":[45],"experimental":[47],"animal":[48,53,74,149],"models.":[49],"create":[51],"diabetic":[52,73],"models,":[54,75],"streptozotocin":[55,80,105,183,289,322],"shown":[57],"predominance":[58],"in":[59,71,174,185,198,241,253,256,259,269,295,305,314],"selectivity":[60],"as":[61,113,304],"a":[62,77,239],"diabetogenic":[63],"agent.":[64],"While":[65,215],"studying":[66],"any":[69,131,336],"intervention":[70,337],"being":[76],"cytotoxic":[78],"drug":[79],"may":[81,328],"affect":[82],"study":[84,98,145],"results":[85],"by":[86],"inhibiting":[87],"highly":[88],"replicating":[89],"cells":[90],"especially":[91],"hematopoietic":[92],"cells.":[93],"Aims:":[94],"The":[95,144,325],"aim":[96],"was":[99,146,161,188,238,293],"analyze":[101],"various":[107,229],"cellular":[108],"components":[109],"blood":[111,203,216,274,326],"RBCs,":[114,279],"WBCs":[115,249],"(Lymphocytes,":[116],"Neutrophils,":[117],"Eosinophils),":[118],"Hb%,":[119],"HCT":[120],"Platelets,":[122],"at":[123,148,163],"baseline,":[124],"5th":[125,233],"day":[126,129,202,234],"15th":[128],"without":[130,335],"intervention.":[132],"Study":[133],"Design:":[134],"Animal":[135],"based":[136],"Experimental":[137],"study.":[138],"Place":[139],"duration":[141],"Study:":[143],"conducted":[147],"house":[150],"faculty":[152],"Pharmacy":[154],"Ziauddin":[155,165],"University":[156],"Karachi,":[157],"while":[158],"laboratory":[159],"work":[160],"performed":[162],"MDRL-1":[164],"University.":[166],"Methodology:":[167],"In":[168],"Group":[169,208,270],"A":[170,209,263],"normal":[171,186],"saline":[172,187],"group":[175,219,257,262,296,306],"B":[176,211,258],"C":[178,220,271],"60":[179],"mg":[180],"/":[181],"kg":[182],"diluted":[184],"administered":[189],"intraperitoneally.":[190],"After":[191],"confirmation":[193],"induction":[195],"rats,":[199],"fifth":[201],"samples":[204,217],"were":[205,213,221],"drawn":[206,222],"from":[207,218,288],"analyzed.":[214],"fifteenth":[224],"day.":[225],"Results:":[226],"Analysis":[227],"hematological":[230,315],"parameters":[231,316,327],"revealed":[235],"that":[236,292,312],"there":[237],"decrease":[240],"levels":[243],"Hb,":[245],"HCT,":[246,278],"RBCs":[247],"with":[250],"an":[251],"increase":[252],"platelet":[254],"count":[255],"comparison":[260],"(control).":[264],"On":[265],"other":[267],"hand,":[268],"(15th":[272],"day),":[273],"cell":[275],"counts":[276],"(Hb,":[277],"WBCs,":[280],"Lymphocytes,":[281],"Neutrophils":[282],"platelets)":[284],"seemed":[285],"recover":[287,329],"induced":[290],"decline":[291],"observed":[294],"B,":[297],"however":[298],"did":[299],"not":[300],"reach":[301],"baselines":[303],"A(control).":[307],"Conclusion:":[308],"It":[309],"concluded":[311],"change":[313],"rats":[318],"after":[319],"administration":[320],"reversible.":[324],"near":[330],"base":[332],"line":[333],"values":[334],"within":[338],"two":[339],"weeks.":[340]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2019-08-13T00:00:00"}
