{"id":"https://openalex.org/W2964657659","doi":"https://doi.org/10.2147/rmi.s194083","title":"Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy","display_name":"Neurite orientation and dispersion density imaging: clinical utility, efficacy, and role in therapy","publication_year":2019,"publication_date":"2019-08-01","ids":{"openalex":"https://openalex.org/W2964657659","doi":"https://doi.org/10.2147/rmi.s194083","mag":"2964657659"},"language":"en","primary_location":{"id":"doi:10.2147/rmi.s194083","doi":"https://doi.org/10.2147/rmi.s194083","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rmi.s194083","pdf_url":"https://www.dovepress.com/getfile.php?fileID=51774","source":{"id":"https://openalex.org/S4210192167","display_name":"Reports in Medical Imaging","issn_l":"1179-1586","issn":["1179-1586"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reports in Medical Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=51774","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061347126","display_name":"Daichi Sone","orcid":"https://orcid.org/0000-0001-9617-706X","observed_orcids":["https://orcid.org/0000-0001-9617-706X"]},"institutions":[{"id":"https://openalex.org/I4210103779","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210103779"]},{"id":"https://openalex.org/I4405287631","display_name":"Integrative Brain Imaging Center","ror":"https://ror.org/05q6adx90","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4405287631"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Daichi Sone","raw_affiliation_strings":["Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9617-706X","affiliations":[{"raw_affiliation_string":"Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan","institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4405287631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061347126"],"corresponding_institution_ids":["https://openalex.org/I4210103779","https://openalex.org/I4405287631"],"apc_list":{"value":1806,"currency":"USD","value_usd":1806},"apc_paid":{"value":1806,"currency":"USD","value_usd":1806},"fwci":1.1406,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76268554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"Volume 12","issue":null,"first_page":"17","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noddi","display_name":"NODDI","score":0.972000002861023},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"diffusion MRI","score":0.925000011920929},{"id":"https://openalex.org/keywords/brain-microstructure","display_name":"brain microstructure","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neurite-density","display_name":"neurite density","score":0.890999972820282},{"id":"https://openalex.org/keywords/neurite-orientation-dispersion","display_name":"neurite orientation dispersion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/axons","display_name":"axons","score":0.46299999952316284},{"id":"https://openalex.org/keywords/dendrites","display_name":"dendrites","score":0.9679999947547913},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.9789999723434448},{"id":"https://openalex.org/keywords/clinical-utility","display_name":"clinical utility","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.8370230197906494},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7824381589889526},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.6595970392227173},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.6369079351425171},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.62027508020401},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.573539137840271},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5660895109176636},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.555819034576416},{"id":"https://openalex.org/C2992283565","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion imaging","level":4,"score":0.5224981904029846},{"id":"https://openalex.org/C177562468","wikidata":"https://www.wikidata.org/wiki/Q182893","display_name":"Dispersion (optics)","level":2,"score":0.4165632128715515},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4087079167366028},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4059194326400757},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2879824936389923},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1601337194442749},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14146196842193604},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13248789310455322},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.09467628598213196},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2147/rmi.s194083","doi":"https://doi.org/10.2147/rmi.s194083","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rmi.s194083","pdf_url":"https://www.dovepress.com/getfile.php?fileID=51774","source":{"id":"https://openalex.org/S4210192167","display_name":"Reports in Medical Imaging","issn_l":"1179-1586","issn":["1179-1586"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reports in Medical Imaging","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:890ad205ff59468ab616fe18f8c8825d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/890ad205ff59468ab616fe18f8c8825d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reports in Medical Imaging, Vol Volume 12, Pp 17-29 (2019)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/47640","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/neurite-orientation-and-dispersion-density-imaging-clinical-utility-ef-peer-reviewed-article-RMI","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/rmi.s194083","doi":"https://doi.org/10.2147/rmi.s194083","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rmi.s194083","pdf_url":"https://www.dovepress.com/getfile.php?fileID=51774","source":{"id":"https://openalex.org/S4210192167","display_name":"Reports in Medical Imaging","issn_l":"1179-1586","issn":["1179-1586"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reports in Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325772","display_name":"National Center of Neurology and Psychiatry","ror":"https://ror.org/0254bmq54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964657659.pdf","grobid_xml":"https://content.openalex.org/works/W2964657659.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W1479935944","https://openalex.org/W1850550907","https://openalex.org/W1899759537","https://openalex.org/W1969933202","https://openalex.org/W1970713332","https://openalex.org/W1977143881","https://openalex.org/W1979849031","https://openalex.org/W2005552408","https://openalex.org/W2006690959","https://openalex.org/W2012931001","https://openalex.org/W2014835131","https://openalex.org/W2032254014","https://openalex.org/W2036969062","https://openalex.org/W2071472203","https://openalex.org/W2094093075","https://openalex.org/W2101960039","https://openalex.org/W2110147062","https://openalex.org/W2116823839","https://openalex.org/W2128675823","https://openalex.org/W2155477484","https://openalex.org/W2177835590","https://openalex.org/W2262435596","https://openalex.org/W2277503321","https://openalex.org/W2333323607","https://openalex.org/W2397498493","https://openalex.org/W2409770038","https://openalex.org/W2413955537","https://openalex.org/W2500850421","https://openalex.org/W2529983878","https://openalex.org/W2543160049","https://openalex.org/W2547535934","https://openalex.org/W2553827870","https://openalex.org/W2559779481","https://openalex.org/W2588031085","https://openalex.org/W2594600702","https://openalex.org/W2610340727","https://openalex.org/W2610402968","https://openalex.org/W2614895229","https://openalex.org/W2620311529","https://openalex.org/W2734805370","https://openalex.org/W2734984108","https://openalex.org/W2735788991","https://openalex.org/W2736493146","https://openalex.org/W2745760221","https://openalex.org/W2747366609","https://openalex.org/W2760933032","https://openalex.org/W2765999949","https://openalex.org/W2767355593","https://openalex.org/W2772104023","https://openalex.org/W2772781840","https://openalex.org/W2773876012","https://openalex.org/W2778087480","https://openalex.org/W2778286472","https://openalex.org/W2778572316","https://openalex.org/W2779380468","https://openalex.org/W2781617553","https://openalex.org/W2789415663","https://openalex.org/W2792229831","https://openalex.org/W2792535737","https://openalex.org/W2793270441","https://openalex.org/W2794756885","https://openalex.org/W2796332068","https://openalex.org/W2796514375","https://openalex.org/W2799532860","https://openalex.org/W2799556124","https://openalex.org/W2799992439","https://openalex.org/W2802608235","https://openalex.org/W2804912072","https://openalex.org/W2807359563","https://openalex.org/W2810993035","https://openalex.org/W2860007030","https://openalex.org/W2883136143","https://openalex.org/W2887241590","https://openalex.org/W2889356006","https://openalex.org/W2890407876","https://openalex.org/W2892516306","https://openalex.org/W2892666713","https://openalex.org/W2892967124","https://openalex.org/W2894044595","https://openalex.org/W2896455370","https://openalex.org/W2898209364","https://openalex.org/W2898268106","https://openalex.org/W2899247639","https://openalex.org/W2900509557","https://openalex.org/W2900757815","https://openalex.org/W2901466843","https://openalex.org/W2905657554","https://openalex.org/W2905880506","https://openalex.org/W2913905121","https://openalex.org/W2917050866","https://openalex.org/W2917581885","https://openalex.org/W2927160693","https://openalex.org/W2940032434","https://openalex.org/W2944454351","https://openalex.org/W2945792041","https://openalex.org/W2947667654","https://openalex.org/W2955847041","https://openalex.org/W2956846297","https://openalex.org/W2961338082","https://openalex.org/W6959406008"],"related_works":["https://openalex.org/W2032254014","https://openalex.org/W3049304068","https://openalex.org/W2937898654","https://openalex.org/W2594575015","https://openalex.org/W2971588409","https://openalex.org/W3118452608","https://openalex.org/W2942862165","https://openalex.org/W2605518610","https://openalex.org/W2494406891","https://openalex.org/W2671247710"],"abstract_inverted_index":{"Abstract:":[0],"In":[1],"the":[2,67,91,106,144],"field":[3],"of":[4,45,66,74,94,108,117,147],"diffusion":[5,20,33,46,60,86,156],"magnetic":[6,157],"resonance":[7,158],"imaging":[8,22,53],"(MRI)":[9],"for":[10,139],"neuroimaging,":[11],"white":[12],"matter":[13],"tracts":[14],"have":[15,35],"traditionally":[16],"been":[17],"analyzed":[18],"using":[19,42,120],"tensor":[21],"(DTI)":[23],"measures,":[24],"such":[25,57],"as":[26,80],"fractional":[27],"anisotropy.":[28],"However,":[29],"recent":[30,103],"advances":[31],"in":[32,110],"MRI":[34,61,87],"provided":[36],"further":[37],"information":[38],"on":[39,102,105],"brain":[40,75,160],"microstructures":[41],"multi-shell":[43],"protocols":[44],"MRI.":[47],"Neurite":[48],"orientation":[49,72,151],"dispersion":[50,73,152],"and":[51,70,83,96,125,153],"density":[52,69,154],"(NODDI)":[54],"is":[55],"one":[56],"emerging":[58],"advanced":[59],"method":[62],"that":[63],"enables":[64],"investigation":[65],"neurite":[68,71,150],"microstructures.":[76],"NODDI":[77,109,121],"was":[78],"developed":[79],"a":[81,114],"practical":[82],"clinically":[84],"feasible":[85],"technique":[88],"to":[89,122,141],"evaluate":[90],"microstructural":[92],"complexity":[93],"dendrites":[95],"axons.":[97],"This":[98],"review":[99],"shed":[100],"light":[101],"studies":[104,118],"use":[107,146],"human":[111],"brain.":[112],"Indeed,":[113],"growing":[115],"number":[116],"are":[119],"examine":[123],"neurological":[124,162],"psychiatric":[126,164],"disorders,":[127],"with":[128],"most":[129],"reporting":[130],"its":[131],"clinical":[132,145],"utility.":[133],"The":[134],"time":[135],"has":[136],"thus":[137],"come,":[138],"us":[140],"seriously":[142],"consider":[143],"NODDI.":[148],"Keywords:":[149],"imaging,":[155,159],"image,":[161],"diseases,":[163],"disorders":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-13T00:00:00"}