{"id":"https://openalex.org/W2964598573","doi":"https://doi.org/10.1016/j.tox.2019.152267","title":"Ghrelin ameliorates A549 cell apoptosis caused by paraquat via p38-MAPK regulated mitochondrial apoptotic pathway","display_name":"Ghrelin ameliorates A549 cell apoptosis caused by paraquat via p38-MAPK regulated mitochondrial apoptotic pathway","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2964598573","doi":"https://doi.org/10.1016/j.tox.2019.152267","mag":"2964598573","pmid":"https://pubmed.ncbi.nlm.nih.gov/31381934"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2019.152267","doi":"https://doi.org/10.1016/j.tox.2019.152267","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2019.152267","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049357248","display_name":"Shuqing Cui","orcid":"https://orcid.org/0000-0001-5019-8842","observed_orcids":["https://orcid.org/0000-0001-5019-8842"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqing Cui","raw_affiliation_strings":["Standardized Residency Training Center, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Standardized Residency Training Center, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014315145","display_name":"Qing Nian","orcid":"https://orcid.org/0000-0001-7986-866X","observed_orcids":["https://orcid.org/0000-0001-7986-866X"]},"institutions":[{"id":"https://openalex.org/I4210159428","display_name":"Children's Hospital of Chongqing Medical University","ror":"https://ror.org/05pz4ws32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Nian","raw_affiliation_strings":["Department of Emergency, Children's Hospital of Chongqing Medical University, Chongqing 400014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Children's Hospital of Chongqing Medical University, Chongqing 400014, China","institution_ids":["https://openalex.org/I4210159428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389213","display_name":"Gang Chen","orcid":"https://orcid.org/0000-0001-5280-0198","observed_orcids":["https://orcid.org/0000-0001-5280-0198"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Chen","raw_affiliation_strings":["Department of Vascular Intervention, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Intervention, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059689669","display_name":"Xingyong Wang","orcid":"https://orcid.org/0000-0001-9597-8383","observed_orcids":["https://orcid.org/0000-0001-9597-8383"]},"institutions":[{"id":"https://openalex.org/I4210159428","display_name":"Children's Hospital of Chongqing Medical University","ror":"https://ror.org/05pz4ws32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyong Wang","raw_affiliation_strings":["Department of Emergency, Children's Hospital of Chongqing Medical University, Chongqing 400014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Children's Hospital of Chongqing Medical University, Chongqing 400014, China","institution_ids":["https://openalex.org/I4210159428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100635487","display_name":"Jinying Zhang","orcid":"https://orcid.org/0000-0002-2525-6171","observed_orcids":["https://orcid.org/0000-0002-2525-6171"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinying Zhang","raw_affiliation_strings":["Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110687226","display_name":"Jian-qing Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianqing Qiu","raw_affiliation_strings":["Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China. Electronic address: bbyyzzq@163.com","Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China. Electronic address: bbyyzzq@163.com","institution_ids":["https://openalex.org/I134841294"]},{"raw_affiliation_string":"Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100346718","display_name":"Zhiqiang Zhang","orcid":"https://orcid.org/0000-0002-7779-2937","observed_orcids":["https://orcid.org/0000-0002-7779-2937"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiqiang Zhang","raw_affiliation_strings":["Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China. Electronic address: ZhangZQ678@gmail.com","Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China. Electronic address: ZhangZQ678@gmail.com","institution_ids":["https://openalex.org/I134841294"]},{"raw_affiliation_string":"Department of Emergency, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100346718","https://openalex.org/A5110687226"],"corresponding_institution_ids":["https://openalex.org/I134841294"],"apc_list":{"value":3200,"currency":"USD","value_usd":3200},"apc_paid":null,"fwci":5.4871,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.96639766,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"426","issue":null,"first_page":"152267","last_page":"152267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13639","display_name":"Paraquat toxicity studies and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/paraquat","display_name":"paraquat","score":0.9919999837875366},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.7250000238418579},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.777999997138977},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8619999885559082},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.8610000014305115},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.8069999814033508},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8190000057220459},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.7953465580940247},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7131624221801758},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6813336610794067},{"id":"https://openalex.org/C2776527163","wikidata":"https://www.wikidata.org/wiki/Q409669","display_name":"Paraquat","level":2,"score":0.65569007396698},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.638776957988739},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.6196373701095581},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5574811100959778},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5005271434783936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4558876156806946},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.42681193351745605},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.42007723450660706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35172349214553833},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3256629705429077},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.32154759764671326},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2052953839302063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05902561545372009}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006540","descriptor_name":"Herbicides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010269","descriptor_name":"Paraquat","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010269","descriptor_name":"Paraquat","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2019.152267","doi":"https://doi.org/10.1016/j.tox.2019.152267","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2019.152267","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:31381934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31381934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4773971847","display_name":null,"funder_award_id":"ZR2019MH068","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320324321","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37"},{"id":"https://openalex.org/F4320325296","display_name":"Binzhou University","ror":"https://ror.org/05frpfj73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W133186721","https://openalex.org/W1638782943","https://openalex.org/W1862294800","https://openalex.org/W1970251244","https://openalex.org/W1976599392","https://openalex.org/W1976950210","https://openalex.org/W1977178308","https://openalex.org/W1985888351","https://openalex.org/W1986801116","https://openalex.org/W1994133951","https://openalex.org/W1995986855","https://openalex.org/W2012341562","https://openalex.org/W2012698286","https://openalex.org/W2019196493","https://openalex.org/W2027328852","https://openalex.org/W2037864697","https://openalex.org/W2042183116","https://openalex.org/W2074046054","https://openalex.org/W2077015396","https://openalex.org/W2084299658","https://openalex.org/W2093998004","https://openalex.org/W2123402012","https://openalex.org/W2143193867","https://openalex.org/W2146846089","https://openalex.org/W2165201727","https://openalex.org/W2166122010","https://openalex.org/W2342040495","https://openalex.org/W2469392715","https://openalex.org/W2475530759","https://openalex.org/W2561306779","https://openalex.org/W2566796873","https://openalex.org/W2604924786","https://openalex.org/W2606013689","https://openalex.org/W2607141808","https://openalex.org/W2610552567","https://openalex.org/W2753767497","https://openalex.org/W2762993139","https://openalex.org/W2807767061","https://openalex.org/W2858365419","https://openalex.org/W2887084844","https://openalex.org/W2892180546","https://openalex.org/W2896322748","https://openalex.org/W2896749565"],"related_works":["https://openalex.org/W4414675046","https://openalex.org/W2407241621","https://openalex.org/W3024009267","https://openalex.org/W3133079929","https://openalex.org/W4285258528","https://openalex.org/W2342040495","https://openalex.org/W3015160240","https://openalex.org/W2012341562","https://openalex.org/W4319265417","https://openalex.org/W2147397065"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-13T00:00:00"}