{"id":"https://openalex.org/W2964596901","doi":"https://doi.org/10.1093/humrep/dez124","title":"Uterine spiral artery muscle dedifferentiation","display_name":"Uterine spiral artery muscle dedifferentiation","publication_year":2019,"publication_date":"2019-07-18","ids":{"openalex":"https://openalex.org/W2964596901","doi":"https://doi.org/10.1093/humrep/dez124","mag":"2964596901","pmid":"https://pubmed.ncbi.nlm.nih.gov/31348822"},"language":"en","primary_location":{"id":"doi:10.1093/humrep/dez124","doi":"https://doi.org/10.1093/humrep/dez124","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/dez124","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063660785","display_name":"Andrew Robson","orcid":"https://orcid.org/0000-0002-0638-6368","observed_orcids":["https://orcid.org/0000-0002-0638-6368"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Robson","raw_affiliation_strings":["Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK","Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029147678","display_name":"Gendie E. Lash","orcid":"https://orcid.org/0000-0002-3606-1361","observed_orcids":["https://orcid.org/0000-0002-3606-1361"]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","GB"],"is_corresponding":false,"raw_author_name":"G E Lash","raw_affiliation_strings":["Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China","Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030830454","display_name":"Barbara A. Innes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B A Innes","raw_affiliation_strings":["Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084806220","display_name":"J Y Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Y Zhang","raw_affiliation_strings":["Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050509889","display_name":"Stephen Courtenay Robson","orcid":"https://orcid.org/0000-0001-7897-7987","observed_orcids":["https://orcid.org/0000-0001-7897-7987"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S C Robson","raw_affiliation_strings":["Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058998346","display_name":"Judith Nicola Bulmer","orcid":"https://orcid.org/0000-0002-0001-1004","observed_orcids":["https://orcid.org/0000-0002-0001-1004"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J N Bulmer","raw_affiliation_strings":["Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive and Vascular Biology Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058998346"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":4097,"currency":"EUR","value_usd":4630},"apc_paid":null,"fwci":9.3,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.98479138,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"34","issue":"8","first_page":"1428","last_page":"1438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.026799999177455902,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cell-dedifferentiation","display_name":"vascular smooth muscle cell dedifferentiation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/uterine-natural-killer-cells","display_name":"uterine natural killer cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/extravillous-trophoblast","display_name":"extravillous trophoblast","score":0.9340000152587891},{"id":"https://openalex.org/keywords/angiogenic-factors","display_name":"angiogenic factors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tgf-beta-receptor","display_name":"TGF-beta receptor","score":0.8069999814033508},{"id":"https://openalex.org/keywords/interferon-gamma-receptor","display_name":"interferon-gamma receptor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tie2","display_name":"Tie2","score":0.8500000238418579},{"id":"https://openalex.org/keywords/early-pregnancy","display_name":"early pregnancy","score":0.4909999966621399},{"id":"https://openalex.org/keywords/placental-bed","display_name":"placental bed","score":0.7559999823570251},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.5960000157356262},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C99322962","wikidata":"https://www.wikidata.org/wiki/Q17165464","display_name":"Vascular remodelling in the embryo","level":2,"score":0.7544214725494385},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.6369004249572754},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6072467565536499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5643627643585205},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4794405996799469},{"id":"https://openalex.org/C2780771523","wikidata":"https://www.wikidata.org/wiki/Q7577753","display_name":"Spiral artery","level":5,"score":0.45913177728652954},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.43549680709838867},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43305426836013794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39919713139533997},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.3850187361240387},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35602259635925293},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3323969542980194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20600378513336182},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.16789522767066956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1673375368118286},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.14156538248062134},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040262","descriptor_name":"Receptors, Vascular Endothelial Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054337","descriptor_name":"Cell Dedifferentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/humrep/dez124","doi":"https://doi.org/10.1093/humrep/dez124","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humrep/dez124","pdf_url":null,"source":{"id":"https://openalex.org/S127900037","display_name":"Human Reproduction","issn_l":"0268-1161","issn":["0268-1161","1460-2350"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction","raw_type":"journal-article"},{"id":"pmid:31348822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31348822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G860405806","display_name":"Investigation of the role of uterine NK cells in initiation of spiral artery transformation in normal human pregnancy","funder_award_id":"BB/E016790/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W133774038","https://openalex.org/W172579969","https://openalex.org/W1486851320","https://openalex.org/W1523556909","https://openalex.org/W1535175417","https://openalex.org/W1596170938","https://openalex.org/W1912592877","https://openalex.org/W1918962518","https://openalex.org/W1970543597","https://openalex.org/W1975195151","https://openalex.org/W1980586568","https://openalex.org/W1988539054","https://openalex.org/W2003502536","https://openalex.org/W2020697426","https://openalex.org/W2024672801","https://openalex.org/W2028810337","https://openalex.org/W2034492080","https://openalex.org/W2036677302","https://openalex.org/W2037446005","https://openalex.org/W2039068212","https://openalex.org/W2041044779","https://openalex.org/W2046852090","https://openalex.org/W2053858672","https://openalex.org/W2077129920","https://openalex.org/W2080667675","https://openalex.org/W2081616047","https://openalex.org/W2083532140","https://openalex.org/W2093060517","https://openalex.org/W2113939866","https://openalex.org/W2121822802","https://openalex.org/W2128455103","https://openalex.org/W2130051277","https://openalex.org/W2137570167","https://openalex.org/W2139843241","https://openalex.org/W2140223314","https://openalex.org/W2141729646","https://openalex.org/W2143498816","https://openalex.org/W2143847855","https://openalex.org/W2153787928","https://openalex.org/W2165330108","https://openalex.org/W2166223726","https://openalex.org/W2325638361","https://openalex.org/W2409105605","https://openalex.org/W2589164015","https://openalex.org/W2770429142"],"related_works":["https://openalex.org/W3095768046","https://openalex.org/W2143498816","https://openalex.org/W2561102035","https://openalex.org/W7221533396","https://openalex.org/W2165330108","https://openalex.org/W2021970761","https://openalex.org/W3110858289","https://openalex.org/W4210922303","https://openalex.org/W3196170679","https://openalex.org/W4417427805"],"abstract_inverted_index":{"STUDY":[0,138,574],"QUESTION:":[1],"Is":[2],"vascular":[3,198],"smooth":[4],"muscle":[5,228],"cell":[6,182,381,482,489],"(VSMC)":[7],"dedifferentiation":[8,31,530],"a":[9,114,245,532,564,582],"feature":[10,533],"of":[11,24,32,66,78,159,166,180,251,264,270,307,324,349,439,448,470,487,508,534,551,558],"uterine":[12,26,41,88],"spiral":[13],"artery":[14,89],"(SpA)":[15],"remodelling":[16,82,123,168,516,537],"in":[17,38,61,80,85,93,116,124,163,275,282,288,312,339,373,465,480,502,514,517,546,571],"early":[18,535],"human":[19,25,125],"pregnancy?":[20],"SUMMARY":[21],"ANSWER:":[22],"Remodelling":[23],"SpAs":[27,56,342],"is":[28,83,107,127,500,531,556],"associated":[29,128],"with":[30,64,129,344],"VSMCs":[33,79,90,250],"and":[34,46,97,157,184,214,222,238,261,302,304,310,333,411,443,505,512,538,541,553,569,587],"can":[35],"be":[36],"induced":[37,436],"vitro":[39,164,276,374,503],"by":[40,72,133,249,257,284,549,581],"natural":[42],"killer":[43],"(uNK)":[44],"cells":[45,49,112,540],"extravillous":[47],"trophoblast":[48],"(EVTs).":[50],"WHAT":[51],"IS":[52],"KNOWN":[53],"ALREADY:":[54],"Uterine":[55],"undergo":[57],"profound":[58],"morphological":[59],"changes":[60],"normal":[62],"pregnancy":[63,126],"replacement":[65],"the":[67,94,103,178,252,271,372,466,485,506,559],"musculoelastic":[68],"arterial":[69,104],"wall":[70,96],"structure":[71],"fibrinoid":[73],"containing":[74],"EVTs.":[75],"The":[76,592],"fate":[77],"SpA":[81,117,122,167,321,515,536],"unknown;":[84],"guinea":[86],"pig":[87],"dedifferentiate,":[91],"remain":[92],"vessel":[95],"differentiate":[98],"after":[99,267,286,305],"parturition":[100],"to":[101,176,491,562,598],"restore":[102],"wall.":[105],"There":[106],"increasing":[108],"evidence":[109],"that":[110,121],"uNK":[111,134,289,294,380,412,481,488,509,539],"play":[113,543],"role":[115,507,566],"remodelling.":[118],"We":[119],"hypothesized":[120],"VSMC":[130,160,187,278,322,351,441,529,572],"dedifferentiation,":[131],"initiated":[132],"cell-derived":[135],"growth":[136,153,200,208],"factors.":[137],"DESIGN,":[139],"SIZE,":[140],"DURATION:":[141],"Formalin":[142],"fixed,":[143],"paraffin":[144],"embedded":[145],"placental":[146],"bed":[147,193],"biopsies":[148,194],"were":[149,195],"immunostained":[150,196],"for":[151,197,567],"angiogenic":[152],"factor":[154,201,209],"(AGF)":[155],"receptors":[156,202,212,220,254],"markers":[158,352,442],"differentiation.":[161,188],"An":[162],"model":[165],"using":[169,244],"chorionic":[170],"plate":[171],"arteries":[172],"(CPAs)":[173],"was":[174,242,255,280,353,579],"used":[175],"test":[177],"effect":[179],"different":[181],"types":[183],"AGFs":[185],"on":[186],"PARTICIPANTS/MATERIALS,":[189],"SETTING,":[190],"METHODS:":[191],"Placental":[192],"endothelial":[199],"1-3":[203],"(VEGF-R1,":[204],"VEGF-R2,":[205],"VEGF-R3),":[206],"transforming":[207],"beta":[210],"1":[211,221],"I":[213],"II":[215],"(TGF-\u03b2RI,":[216],"TGF-\u03b2RII),":[217],"interferon":[218],"gamma":[219],"2":[223],"(IFN-\u03b3R1,":[224],"IFN-\u03b3R2),":[225],"Tie2,":[226],"\u03b1-smooth":[227],"actin":[229],"(\u03b1-SMA),":[230],"H-caldesmon":[231],"(H-Cal),":[232],"myosin":[233],"heavy":[234],"chain":[235],"(MyHC),":[236],"osteopontin":[237,334,394,407,423,445],"smoothelin.":[239],"Staining":[240],"intensity":[241],"assessed":[243,281],"modified":[246],"quickscore.":[247],"Expression":[248],"AGF":[253],"confirmed":[256],"laser":[258,268],"capture":[259],"microdissection":[260],"real-time":[262],"RT-PCR":[263],"non-remodelled":[265,345],"SpAs,":[266,346],"removal":[269],"endothelium.":[272],"As":[273],"an":[274,501],"model,":[277,376],"differentiation":[279],"CPAs":[283],"immunohistochemistry":[285],"culture":[287],"cell-conditioned":[290],"medium":[291],"(CM),":[292],"EVT-CM,":[293],"cell/EVT":[295,413],"co-culture":[296],"CM,":[297],"Ang-1,":[298],"Ang-2,":[299],"IFN-\u03b3,":[300],"VEGF-A":[301],"VEGF-C,":[303],"blocking":[306],"both":[308],"Ang-1":[309,452,471,511,552,568],"Ang-2":[311,457,476,513,570],"uNK-CM.":[313],"MAIN":[314],"RESULTS":[315],"AND":[316],"THE":[317,527],"ROLE":[318],"OF":[319,526],"CHANCE:":[320],"expression":[323,348,438,464],"Tie-2":[325],"(P":[326,330,335,453,458,472,477],"=":[327,331,336,361,365,369,388,392,396,401,405,409,417,421,425,454,459,473,478],"0.0007),":[328],"VEGF-R2":[329],"0.005)":[332],"0.0001)":[337],"increased":[338,444],"partially":[340],"remodelled":[341],"compared":[343],"while":[347],"contractile":[350,440],"reduced":[354,437,462],"(\u03b1-SMA":[355],"P":[356,360,364,368,383,387,391,395,400,404,408,416,420,424],"<":[357,384],"0.0001,":[358,385],"H-Cal":[359,463,493],"0.03,":[362,366,389],"MyHC":[363,386,403,419],"smoothelin":[367],"0.0001).":[370],"In":[371],"CPA":[375,467],"supernatants":[377,483,490],"from":[378,584],"purified":[379],"(H-Cal":[382,399,415],"\u03b1-SMA":[390],"0.02,":[393,406],"0.03),":[397],"EVT":[398,542],"0.0006,":[402],"0.01)":[410],"co-cultures":[414],"0.001,":[418],"0.05,":[422],"0.02)":[426],"at":[427],"12-14":[428],"weeks,":[429,433],"but":[430],"not":[431,520],"8-10":[432],"gestational":[434],"age":[435],"expression.":[446,494],"Addition":[447],"exogenous":[449],"(10":[450],"ng/ml)":[451],"0.006)":[455],"or":[456,475],"0.009)":[460],"also":[461],"model.":[468],"Inhibition":[469],"0.0004)":[474],"0.004)":[479],"blocked":[484],"ability":[486],"reduce":[492],"LIMITATIONS,":[495],"REASONS":[496],"FOR":[497],"CAUTION:":[498],"This":[499,555,577],"study":[504],"cells,":[510],"vivo":[518],"has":[519],"yet":[521],"been":[522],"shown.":[523],"WIDER":[524],"IMPLICATIONS":[525],"FINDINGS:":[528],"key":[544],"roles":[545],"this":[547],"process":[548],"secretion":[550],"Ang-2.":[554],"one":[557],"first":[560],"studies":[561],"suggest":[563],"direct":[565],"biology.":[573],"FUNDING/COMPETING":[575],"INTEREST(S):":[576],"work":[578],"supported":[580],"grant":[583],"British":[585],"Biotechnology":[586],"Biosciences":[588],"Research":[589],"Council":[590],"(BB/E016790/1).":[591],"authors":[593],"have":[594],"no":[595],"competing":[596],"interests":[597],"declare.":[599]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-08-13T00:00:00"}
