{"id":"https://openalex.org/W2964584752","doi":"https://doi.org/10.3390/cells8080795","title":"Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases","display_name":"Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases","publication_year":2019,"publication_date":"2019-07-30","ids":{"openalex":"https://openalex.org/W2964584752","doi":"https://doi.org/10.3390/cells8080795","mag":"2964584752","pmid":"https://pubmed.ncbi.nlm.nih.gov/31366145","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6721602"},"language":"en","primary_location":{"id":"doi:10.3390/cells8080795","doi":"https://doi.org/10.3390/cells8080795","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells8080795","pdf_url":"https://www.mdpi.com/2073-4409/8/8/795/pdf?version=1565314098","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/8/8/795/pdf?version=1565314098","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015107900","display_name":"St\u00e9phane Demine","orcid":"https://orcid.org/0000-0002-7254-2269","observed_orcids":["https://orcid.org/0000-0002-7254-2269"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Demine","raw_affiliation_strings":["ULB Center for Diabetes Research, University of Brussels (ULB), 1070 Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-7254-2269","affiliations":[{"raw_affiliation_string":"ULB Center for Diabetes Research, University of Brussels (ULB), 1070 Brussels, Belgium","institution_ids":["https://openalex.org/I132053463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034814853","display_name":"Patricia Renard","orcid":"https://orcid.org/0000-0003-4144-3353","observed_orcids":["https://orcid.org/0000-0003-4144-3353"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Patricia Renard","raw_affiliation_strings":["Laboratory of Biochemistry and Cell Biology (URBC), NARILIS (Namur Research Institute for Life Sciences), University of Namur (UNamur), 5000 Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4144-3353","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Cell Biology (URBC), NARILIS (Namur Research Institute for Life Sciences), University of Namur (UNamur), 5000 Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085315778","display_name":"Thierry Arnould","orcid":"https://orcid.org/0000-0003-2101-2660","observed_orcids":["https://orcid.org/0000-0003-2101-2660"]},"institutions":[{"id":"https://openalex.org/I149768937","display_name":"University of Namur","ror":"https://ror.org/03d1maw17","country_code":"BE","type":"education","lineage":["https://openalex.org/I149768937"]},{"id":"https://openalex.org/I4391767857","display_name":"Namur Research Institute for Life Sciences","ror":"https://ror.org/038bmak92","country_code":"BE","type":"facility","lineage":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Thierry Arnould","raw_affiliation_strings":["Laboratory of Biochemistry and Cell Biology (URBC), NARILIS (Namur Research Institute for Life Sciences), University of Namur (UNamur), 5000 Namur, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-2101-2660","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry and Cell Biology (URBC), NARILIS (Namur Research Institute for Life Sciences), University of Namur (UNamur), 5000 Namur, Belgium","institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085315778"],"corresponding_institution_ids":["https://openalex.org/I149768937","https://openalex.org/I4391767857"],"apc_list":{"value":1800,"currency":"CHF","value_usd":1824},"apc_paid":{"value":1800,"currency":"CHF","value_usd":1824},"fwci":4.0902,"has_fulltext":true,"cited_by_count":494,"citation_normalized_percentile":{"value":0.9665979,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"8","issue":"8","first_page":"795","last_page":"795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-uncoupling","display_name":"mitochondrial uncoupling","score":1.0},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/uncoupling-proteins","display_name":"uncoupling proteins","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9710000157356262},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.8849999904632568},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9900000095367432},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.9430000185966492},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/adipose-tissue-metabolism","display_name":"adipose tissue metabolism","score":0.9240000247955322},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.949999988079071},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neurological-disorders","display_name":"neurological disorders","score":0.875},{"id":"https://openalex.org/keywords/disease-therapy","display_name":"disease therapy","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C2779406938","wikidata":"https://www.wikidata.org/wiki/Q24720289","display_name":"Uncoupling protein","level":4,"score":0.8883163928985596},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7432225942611694},{"id":"https://openalex.org/C81979416","wikidata":"https://www.wikidata.org/wiki/Q419493","display_name":"Thermogenin","level":4,"score":0.6463858485221863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6101354360580444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5761567950248718},{"id":"https://openalex.org/C2910689142","wikidata":"https://www.wikidata.org/wiki/Q65089491","display_name":"Uncoupling Agents","level":3,"score":0.5431907773017883},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.469310998916626},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.4656354486942291},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.421671599149704},{"id":"https://openalex.org/C111491248","wikidata":"https://www.wikidata.org/wiki/Q18033821","display_name":"DNAJA3","level":5,"score":0.41137388348579407},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.3139994144439697},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.29580414295196533},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2853608727455139},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.2849833369255066},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.20772498846054077},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11043804883956909},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06597092747688293}],"mesh":[{"descriptor_ui":"D000071245","descriptor_name":"Mitochondrial Uncoupling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014475","descriptor_name":"Uncoupling Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/cells8080795","doi":"https://doi.org/10.3390/cells8080795","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells8080795","pdf_url":"https://www.mdpi.com/2073-4409/8/8/795/pdf?version=1565314098","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmid:31366145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31366145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6721602","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6721602/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmh:oai:pure.unamur.be:openaire/79c63f3c-ea82-419d-9dac-da24e6ca0956","doi":null,"is_oa":true,"landing_page_url":"https://researchportal.unamur.be/en/publications/79c63f3c-ea82-419d-9dac-da24e6ca0956","pdf_url":null,"source":{"id":"https://openalex.org/S4406922457","display_name":"Repository of the University of Namur","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dermine, S, Renard, P & Arnould, T 2019, 'Mitochondrial Uncoupling : A Key Controller of Biological Processes in Physiology and Diseases', Cells, vol. 8, no. 8, 795, pp. 795-838. https://doi.org/10.3390/cells8080795","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/312429","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312429","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, 8 (8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ff035ed50a5940628005f3a0aaa63270","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ff035ed50a5940628005f3a0aaa63270","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 8, Iss 8, p 795 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells8080795","doi":"https://doi.org/10.3390/cells8080795","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/cells8080795","pdf_url":"https://www.mdpi.com/2073-4409/8/8/795/pdf?version=1565314098","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7100383984","display_name":null,"funder_award_id":"Cr\u00e9dit de Recherche J.0034.18","funder_id":"https://openalex.org/F4320321390","funder_display_name":"Fonds De La Recherche Scientifique - FNRS"}],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964584752.pdf","grobid_xml":"https://content.openalex.org/works/W2964584752.grobid-xml"},"referenced_works_count":301,"referenced_works":["https://openalex.org/W28665888","https://openalex.org/W56822087","https://openalex.org/W562354568","https://openalex.org/W749147421","https://openalex.org/W833232761","https://openalex.org/W918084489","https://openalex.org/W993193191","https://openalex.org/W1146046970","https://openalex.org/W1494515526","https://openalex.org/W1501975414","https://openalex.org/W1513078811","https://openalex.org/W1532917355","https://openalex.org/W1580274065","https://openalex.org/W1607149064","https://openalex.org/W1675974676","https://openalex.org/W1849369000","https://openalex.org/W1853148353","https://openalex.org/W1853519360","https://openalex.org/W1891170558","https://openalex.org/W1894605635","https://openalex.org/W1923336662","https://openalex.org/W1925799544","https://openalex.org/W1931041435","https://openalex.org/W1941860036","https://openalex.org/W1954270231","https://openalex.org/W1957826674","https://openalex.org/W1966012125","https://openalex.org/W1967880167","https://openalex.org/W1968217511","https://openalex.org/W1969195108","https://openalex.org/W1970040971","https://openalex.org/W1970735575","https://openalex.org/W1973134318","https://openalex.org/W1974050119","https://openalex.org/W1974677595","https://openalex.org/W1974682175","https://openalex.org/W1975927237","https://openalex.org/W1976676611","https://openalex.org/W1980455487","https://openalex.org/W1983755598","https://openalex.org/W1984677592","https://openalex.org/W1986509092","https://openalex.org/W1988791330","https://openalex.org/W1992919722","https://openalex.org/W1993152627","https://openalex.org/W1996324277","https://openalex.org/W1996652459","https://openalex.org/W1997160767","https://openalex.org/W1997225393","https://openalex.org/W1997757821","https://openalex.org/W1998564562","https://openalex.org/W2000038116","https://openalex.org/W2001648286","https://openalex.org/W2004499394","https://openalex.org/W2004642771","https://openalex.org/W2005970630","https://openalex.org/W2006732634","https://openalex.org/W2006922404","https://openalex.org/W2008012245","https://openalex.org/W2008675205","https://openalex.org/W2008984486","https://openalex.org/W2009128541","https://openalex.org/W2009255184","https://openalex.org/W2010457089","https://openalex.org/W2012050664","https://openalex.org/W2018289980","https://openalex.org/W2018720754","https://openalex.org/W2019019494","https://openalex.org/W2020061801","https://openalex.org/W2023674811","https://openalex.org/W2027048243","https://openalex.org/W2028159245","https://openalex.org/W2030885856","https://openalex.org/W2031165402","https://openalex.org/W2031225059","https://openalex.org/W2031933537","https://openalex.org/W2032301380","https://openalex.org/W2032557664","https://openalex.org/W2032662185","https://openalex.org/W2032910880","https://openalex.org/W2033445242","https://openalex.org/W2034223813","https://openalex.org/W2034679839","https://openalex.org/W2035028095","https://openalex.org/W2035127779","https://openalex.org/W2036871097","https://openalex.org/W2037587285","https://openalex.org/W2041007401","https://openalex.org/W2041149156","https://openalex.org/W2042446609","https://openalex.org/W2042856235","https://openalex.org/W2044473896","https://openalex.org/W2044621729","https://openalex.org/W2045081864","https://openalex.org/W2045092753","https://openalex.org/W2045325776","https://openalex.org/W2045387309","https://openalex.org/W2052375464","https://openalex.org/W2056400389","https://openalex.org/W2059355816","https://openalex.org/W2060474003","https://openalex.org/W2061027163","https://openalex.org/W2064694581","https://openalex.org/W2066348191","https://openalex.org/W2066403680","https://openalex.org/W2067827070","https://openalex.org/W2070663098","https://openalex.org/W2072444935","https://openalex.org/W2074802536","https://openalex.org/W2075282827","https://openalex.org/W2076647847","https://openalex.org/W2079100436","https://openalex.org/W2080343366","https://openalex.org/W2081808451","https://openalex.org/W2085377666","https://openalex.org/W2085397620","https://openalex.org/W2086198406","https://openalex.org/W2086327820","https://openalex.org/W2088940658","https://openalex.org/W2092230232","https://openalex.org/W2092479957","https://openalex.org/W2092566326","https://openalex.org/W2097260668","https://openalex.org/W2104304300","https://openalex.org/W2106674569","https://openalex.org/W2106970936","https://openalex.org/W2109773179","https://openalex.org/W2110318407","https://openalex.org/W2111889825","https://openalex.org/W2116389925","https://openalex.org/W2119649463","https://openalex.org/W2121491699","https://openalex.org/W2123472989","https://openalex.org/W2123973157","https://openalex.org/W2124906921","https://openalex.org/W2125445685","https://openalex.org/W2126153001","https://openalex.org/W2126160062","https://openalex.org/W2126272143","https://openalex.org/W2128342607","https://openalex.org/W2130979925","https://openalex.org/W2131138966","https://openalex.org/W2135592618","https://openalex.org/W2136689463","https://openalex.org/W2137168605","https://openalex.org/W2139200038","https://openalex.org/W2139930416","https://openalex.org/W2140808124","https://openalex.org/W2143472860","https://openalex.org/W2145142659","https://openalex.org/W2147128975","https://openalex.org/W2147785354","https://openalex.org/W2151672477","https://openalex.org/W2152637004","https://openalex.org/W2153096281","https://openalex.org/W2153723747","https://openalex.org/W2155015733","https://openalex.org/W2155843473","https://openalex.org/W2159226285","https://openalex.org/W2159748100","https://openalex.org/W2160787227","https://openalex.org/W2162186867","https://openalex.org/W2163912174","https://openalex.org/W2163915523","https://openalex.org/W2164180767","https://openalex.org/W2164944202","https://openalex.org/W2165503577","https://openalex.org/W2166122956","https://openalex.org/W2166706712","https://openalex.org/W2167435406","https://openalex.org/W2167601866","https://openalex.org/W2168851175","https://openalex.org/W2169091672","https://openalex.org/W2169368410","https://openalex.org/W2170761515","https://openalex.org/W2181471414","https://openalex.org/W2186023736","https://openalex.org/W2189933127","https://openalex.org/W2260247192","https://openalex.org/W2269129210","https://openalex.org/W2269587458","https://openalex.org/W2281763173","https://openalex.org/W2282815582","https://openalex.org/W2285110546","https://openalex.org/W2286067730","https://openalex.org/W2291197795","https://openalex.org/W2294018174","https://openalex.org/W2314798742","https://openalex.org/W2322556561","https://openalex.org/W2322869984","https://openalex.org/W2332777704","https://openalex.org/W2336756101","https://openalex.org/W2337916199","https://openalex.org/W2337936516","https://openalex.org/W2410861866","https://openalex.org/W2411689096","https://openalex.org/W2416184866","https://openalex.org/W2418897773","https://openalex.org/W2491264423","https://openalex.org/W2496267438","https://openalex.org/W2509486902","https://openalex.org/W2509808353","https://openalex.org/W2515205119","https://openalex.org/W2517341189","https://openalex.org/W2517759674","https://openalex.org/W2517909381","https://openalex.org/W2518640581","https://openalex.org/W2520622153","https://openalex.org/W2529194522","https://openalex.org/W2529255361","https://openalex.org/W2551005983","https://openalex.org/W2552459335","https://openalex.org/W2567320833","https://openalex.org/W2567547124","https://openalex.org/W2569960861","https://openalex.org/W2579519901","https://openalex.org/W2589260380","https://openalex.org/W2589759270","https://openalex.org/W2594459493","https://openalex.org/W2600136923","https://openalex.org/W2602809814","https://openalex.org/W2612692979","https://openalex.org/W2615078207","https://openalex.org/W2616359831","https://openalex.org/W2621728938","https://openalex.org/W2623539005","https://openalex.org/W2641602479","https://openalex.org/W2727527593","https://openalex.org/W2737430749","https://openalex.org/W2740802860","https://openalex.org/W2741202421","https://openalex.org/W2748339213","https://openalex.org/W2753963188","https://openalex.org/W2754716258","https://openalex.org/W2756208820","https://openalex.org/W2760102721","https://openalex.org/W2760494701","https://openalex.org/W2761538326","https://openalex.org/W2762129136","https://openalex.org/W2765770913","https://openalex.org/W2766183128","https://openalex.org/W2766214776","https://openalex.org/W2766638667","https://openalex.org/W2767100805","https://openalex.org/W2770053197","https://openalex.org/W2777749483","https://openalex.org/W2783209372","https://openalex.org/W2785019067","https://openalex.org/W2785050043","https://openalex.org/W2788644497","https://openalex.org/W2788702209","https://openalex.org/W2790152383","https://openalex.org/W2791814751","https://openalex.org/W2791957311","https://openalex.org/W2793550529","https://openalex.org/W2794117368","https://openalex.org/W2800496612","https://openalex.org/W2800603419","https://openalex.org/W2801649057","https://openalex.org/W2803820742","https://openalex.org/W2807007486","https://openalex.org/W2807479935","https://openalex.org/W2807640547","https://openalex.org/W2808819319","https://openalex.org/W2809666506","https://openalex.org/W2810660714","https://openalex.org/W2839619478","https://openalex.org/W2883542518","https://openalex.org/W2884995023","https://openalex.org/W2887296106","https://openalex.org/W2887362726","https://openalex.org/W2888403478","https://openalex.org/W2888741090","https://openalex.org/W2889062514","https://openalex.org/W2889413235","https://openalex.org/W2889919383","https://openalex.org/W2890910766","https://openalex.org/W2893495375","https://openalex.org/W2894391873","https://openalex.org/W2896323318","https://openalex.org/W2899375688","https://openalex.org/W2900549919","https://openalex.org/W2901070596","https://openalex.org/W2902234339","https://openalex.org/W2902322890","https://openalex.org/W2902765963","https://openalex.org/W2903319648","https://openalex.org/W2903804358","https://openalex.org/W2903848597","https://openalex.org/W2909644158","https://openalex.org/W2913376873","https://openalex.org/W2915015587","https://openalex.org/W2917027985","https://openalex.org/W2924938564","https://openalex.org/W2944627187","https://openalex.org/W2999488452","https://openalex.org/W4365601034","https://openalex.org/W6684572856","https://openalex.org/W6851279608","https://openalex.org/W6908549761","https://openalex.org/W7073915085"],"related_works":["https://openalex.org/W56406267","https://openalex.org/W2061606551","https://openalex.org/W2022483484","https://openalex.org/W2070728564","https://openalex.org/W2557334948","https://openalex.org/W166349519","https://openalex.org/W2045387309","https://openalex.org/W7100232658","https://openalex.org/W4321598459","https://openalex.org/W2796463805"],"abstract_inverted_index":{"Mitochondrial":[0],"uncoupling":[1,37,59,79,92,128],"can":[2],"be":[3,44,130],"defined":[4],"as":[5,33,73,75,100,138],"a":[6,26],"dissociation":[7],"between":[8],"mitochondrial":[9,27,58,71,91,127],"membrane":[10],"potential":[11],"generation":[12],"and":[13,66,93,102,120],"its":[14],"use":[15],"for":[16],"mitochondria-dependent":[17],"ATP":[18],"synthesis.":[19],"Although":[20],"this":[21,52],"process":[22,42],"was":[23],"originally":[24],"considered":[25],"dysfunction,":[28],"the":[29,41,57,86],"identification":[30],"of":[31,64],"UCP-1":[32],"an":[34],"endogenous":[35],"physiological":[36],"protein":[38,109],"suggests":[39],"that":[40],"could":[43,129],"involved":[45],"in":[46,62,117],"many":[47],"other":[48,94],"biological":[49,97],"processes.":[50],"In":[51],"review,":[53],"we":[54,84,124],"first":[55],"compare":[56],"agents":[60],"available":[61],"term":[63],"mechanistic":[65],"non-specific":[67],"effects.":[68],"Proteins":[69],"regulating":[70],"uncoupling,":[72],"well":[74],"chemical":[76],"compounds":[77],"with":[78],"properties":[80],"are":[81],"discussed.":[82],"Second,":[83],"summarize":[85],"most":[87],"recent":[88],"findings":[89],"linking":[90],"cellular":[95],"or":[96,142],"processes,":[98],"such":[99,137],"bulk":[101],"specific":[103],"autophagy,":[104],"reactive":[105],"oxygen":[106],"species":[107],"production,":[108],"secretion,":[110],"cell":[111,121],"death,":[112],"physical":[113],"exercise,":[114],"metabolic":[115],"adaptations":[116],"adipose":[118],"tissue,":[119],"signaling.":[122],"Finally,":[123],"show":[125],"how":[126],"used":[131],"to":[132],"treat":[133],"several":[134],"human":[135],"diseases,":[136,141],"obesity,":[139],"cardiovascular":[140],"neurological":[143],"disorders.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":51},{"year":2025,"cited_by_count":79},{"year":2024,"cited_by_count":83},{"year":2023,"cited_by_count":89},{"year":2022,"cited_by_count":72},{"year":2021,"cited_by_count":77},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-08-13T00:00:00"}
