{"id":"https://openalex.org/W2964579537","doi":"https://doi.org/10.1136/jnnp-2019-anzan.84","title":"096 Assessment of the efficacy of erenumab during the open-label treatment (13\u201324 weeks) of subjects with episodic migraine who failed 2\u20134 prior preventive treatments: results of the LIBERTY study","display_name":"096 Assessment of the efficacy of erenumab during the open-label treatment (13\u201324 weeks) of subjects with episodic migraine who failed 2\u20134 prior preventive treatments: results of the LIBERTY study","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2964579537","doi":"https://doi.org/10.1136/jnnp-2019-anzan.84","mag":"2964579537"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2019-anzan.84","doi":"https://doi.org/10.1136/jnnp-2019-anzan.84","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp-2019-anzan.84","pdf_url":"https://jnnp.bmj.com/content/jnnp/90/e7/A31.1.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery & Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnnp.bmj.com/content/jnnp/90/e7/A31.1.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014304074","display_name":"Lauren Giles","orcid":"https://orcid.org/0000-0001-7492-0940","observed_orcids":["https://orcid.org/0000-0001-7492-0940"]},"institutions":[{"id":"https://openalex.org/I4210163497","display_name":"Austin Health","ror":"https://ror.org/05dbj6g52","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210163497"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lauren Giles","raw_affiliation_strings":["Austin Health, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Austin Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210163497"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051082265","display_name":"Uwe Reuter","orcid":"https://orcid.org/0000-0002-8527-0725","observed_orcids":["https://orcid.org/0000-0002-8527-0725"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Reuter","raw_affiliation_strings":["Department of Neurology, Charit\u00e9 Universit\u00e4ts Medizin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Charit\u00e9 Universit\u00e4ts Medizin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004525209","display_name":"Peter James Goadsby","orcid":"https://orcid.org/0000-0003-3260-5904","observed_orcids":["https://orcid.org/0000-0003-3260-5904"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Goadsby","raw_affiliation_strings":["University of California, San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017107612","display_name":"Michel Lant\u00e9ri\u2010Minet","orcid":"https://orcid.org/0000-0001-6717-9234","observed_orcids":["https://orcid.org/0000-0001-6717-9234"]},"institutions":[{"id":"https://openalex.org/I201841394","display_name":"Universit\u00e9 C\u00f4te d'Azur","ror":"https://ror.org/019tgvf94","country_code":"FR","type":"education","lineage":["https://openalex.org/I201841394"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Lanteri-Minet","raw_affiliation_strings":["Pain Department, Universit\u00e9 C\u00f4te d\u2019Azur, Nice, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Department, Universit\u00e9 C\u00f4te d\u2019Azur, Nice, France","institution_ids":["https://openalex.org/I201841394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075370558","display_name":"Peggy Hours-Zesiger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peggy Hours-Zesiger","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033456271","display_name":"Chrystel Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Chrystel Fernandes","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel Ferrari","raw_affiliation_strings":["Leiden University Hospital, Leiden, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Hospital, Leiden, Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103282311","display_name":"Jan Klatt","orcid":"https://orcid.org/0000-0002-2276-4701","observed_orcids":["https://orcid.org/0000-0002-2276-4701"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jan Klatt","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3996,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64494804,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"90","issue":"e7","first_page":"A31.1","last_page":"A31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erenumab","display_name":"erenumab","score":1.0},{"id":"https://openalex.org/keywords/episodic-migraine","display_name":"episodic migraine","score":0.996999979019165},{"id":"https://openalex.org/keywords/migraine-prevention","display_name":"migraine prophylaxis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/open-label-extension","display_name":"open-label extension","score":0.7020000219345093},{"id":"https://openalex.org/keywords/treatment-resistant-migraine","display_name":"treatment-resistant migraine","score":0.6579999923706055},{"id":"https://openalex.org/keywords/monthly-migraine-days","display_name":"monthly migraine days","score":0.6100000143051147},{"id":"https://openalex.org/keywords/hit-6","display_name":"HIT-6","score":0.8149999976158142},{"id":"https://openalex.org/keywords/sustained-efficacy","display_name":"sustained efficacy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide-receptor","display_name":"calcitonin gene-related peptide receptor","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8260841369628906},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8180937767028809},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7007624506950378},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49667006731033325},{"id":"https://openalex.org/C3019800554","wikidata":"https://www.wikidata.org/wiki/Q3813242","display_name":"Open label","level":3,"score":0.4154267907142639},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4103281795978546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35206517577171326},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.22185158729553223},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jnnp-2019-anzan.84","doi":"https://doi.org/10.1136/jnnp-2019-anzan.84","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp-2019-anzan.84","pdf_url":"https://jnnp.bmj.com/content/jnnp/90/e7/A31.1.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery & Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:jnnp:90/e7/A31-a","doi":null,"is_oa":false,"landing_page_url":"http://jnnp.bmj.com/cgi/content/short/90/e7/A31-a","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/jnnp-2019-anzan.84","doi":"https://doi.org/10.1136/jnnp-2019-anzan.84","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp-2019-anzan.84","pdf_url":"https://jnnp.bmj.com/content/jnnp/90/e7/A31.1.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery & Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964579537.pdf","grobid_xml":"https://content.openalex.org/works/W2964579537.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3006211681","https://openalex.org/W3215765922","https://openalex.org/W4395682178","https://openalex.org/W4389368800","https://openalex.org/W3119747395","https://openalex.org/W3159864859","https://openalex.org/W3093820723","https://openalex.org/W3138588219","https://openalex.org/W3181275729","https://openalex.org/W4389442213"],"abstract_inverted_index":{"Introduction":[0],"To":[1],"assess":[2],"efficacy":[3,179,230],"of":[4,11,19,69,123,175,209],"erenumab":[5,37,57,176,190,210,247],"in":[6,52,74,83,141,151,157,164,180,191,216,243],"the":[7,12,20,25,107,119,124,127,192,197],"first":[8,198],"three":[9],"months":[10],"open-label":[13],"extension":[14],"phase":[15,28,48],"(OLEP;":[16],"13\u201324":[17],"weeks)":[18],"LIBERTY":[21],"study.":[22],"Methods":[23],"In":[24,126],"double-blind":[26],"treatment":[27,227],"(DBTP),":[29],"246":[30],"patients":[31,45,117,137],"were":[32,50,67],"randomized":[33],"to":[34,54,64,189,219],"placebo":[35,188],"and":[36,100,135,155,159,162,167,239],"140":[38,58],"mg":[39],"for":[40],"12":[41],"weeks,":[42],"following":[43],"which,":[44],"completing":[46],"that":[47],"(N=240)":[49],"enrolled":[51],"OLEP,":[53],"receive":[55],"monthly":[56,62,75,85],"mg.":[59],"Outcomes":[60],"measured":[61,105],"throughout":[63,213],"week":[65,121],"24":[66,120,214,233],"achievement":[68],"at":[70,130,200],"least":[71],"50%/75%/100%":[72],"reduction":[73,140],"migraine":[76],"days":[77,89],"(MMD),":[78],"change":[79,147],"from":[80,148,187,196],"DBTP":[81,149],"baseline":[82,150],"MMD,":[84],"acute":[86],"migraine-specific":[87],"medication":[88],"(MSMD),":[90],"Headache":[91],"Impact":[92,111],"Test":[93],"(HIT-6TM)":[94],"total":[95],"score,":[96],"everyday":[97],"activities":[98],"(EA)":[99],"physical":[101],"impairment":[102],"(PI)":[103],"as":[104],"by":[106],"Migraine":[108],"Physical":[109],"Function":[110],"Diary":[112],"(MPFID).":[113],"Results":[114],"Overall,":[115,229],"228/240(95.0%)":[116],"completed":[118],"visit":[122],"OLEP.":[125],"overall":[128],"population":[129,222],"Week":[131,201],"24,":[132],"39.2%,":[133],"15.9%":[134],"7.0%":[136],"achieved":[138],"\u226550%/\u226575%/100%":[139],"MMD.":[142],"The":[143],"mean":[144],"(standard":[145],"deviation)":[146],"MMD":[152],"was":[153,211,241],"\u22122.7(4.4)":[154],"\u22121.4(3.0)":[156],"MSMD;":[158],"\u22127.6(8.0),":[160],"\u22122.5(9.2)":[161],"\u22124.0(9.0)":[163],"HIT-6TM,":[165],"MPFID-PI":[166],"MPFID-EA":[168],"scores":[169],"respectively.":[170],"Patients":[171,184],"with":[172,223,245],"continuous":[173],"use":[174],"showed":[177,194],"sustained":[178,212],"all":[181,204],"outcomes":[182,205],"assessed.":[183,206],"who":[185],"switched":[186],"OLEP":[193],"improvement":[195],"measurement":[199],"16":[202],"on":[203],"Conclusions":[207],"Efficacy":[208],"weeks":[215,234,237],"a":[217],"hard":[218],"treat":[220],"patient":[221],"multiple":[224],"prior":[225,246],"preventive":[226],"failures.":[228],"data":[231],"over":[232,236],"(assessed":[235],"13\u201316,17\u201320":[238],"21\u201324)":[240],"generally":[242],"line":[244],"trials.":[248]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2019-08-13T00:00:00"}