{"id":"https://openalex.org/W2964533563","doi":"https://doi.org/10.1128/jvi.00649-19","title":"TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes","display_name":"TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes","publication_year":2019,"publication_date":"2019-08-06","ids":{"openalex":"https://openalex.org/W2964533563","doi":"https://doi.org/10.1128/jvi.00649-19","mag":"2964533563","pmid":"https://pubmed.ncbi.nlm.nih.gov/31391268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803253"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00649-19","doi":"https://doi.org/10.1128/jvi.00649-19","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00649-19","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803253","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018099170","display_name":"Hannah Limburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannah Limburg","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051704002","display_name":"Anne Harbig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Harbig","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044308736","display_name":"Dorothea Bestle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dorothea Bestle","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049658579","display_name":"David A. Stein","orcid":"https://orcid.org/0000-0002-5446-5167","observed_orcids":["https://orcid.org/0000-0002-5446-5167"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Stein","raw_affiliation_strings":["Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086447462","display_name":"Hong M. Moulton","orcid":"https://orcid.org/0000-0002-8095-1513","observed_orcids":["https://orcid.org/0000-0002-8095-1513"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong M. Moulton","raw_affiliation_strings":["Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110629926","display_name":"Julia Jaeger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Jaeger","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057002790","display_name":"Harshavardhan Janga","orcid":"https://orcid.org/0000-0002-3142-2850","observed_orcids":["https://orcid.org/0000-0002-3142-2850"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Harshavardhan Janga","raw_affiliation_strings":["Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080215543","display_name":"Kornelia Hardes","orcid":"https://orcid.org/0009-0000-1670-7383","observed_orcids":["https://orcid.org/0009-0000-1670-7383"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kornelia Hardes","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108925132","display_name":"Janine Koepke","orcid":"https://orcid.org/0009-0009-0833-1465","observed_orcids":["https://orcid.org/0009-0009-0833-1465"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janine Koepke","raw_affiliation_strings":["Department of Pulmonary Rehabilitation, Philipps University of Marburg, German Center for Lung Research (DZL), Marburg, Germany","Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Rehabilitation, Philipps University of Marburg, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008059467","display_name":"Leon N. Schulte","orcid":"https://orcid.org/0000-0001-6814-9344","observed_orcids":["https://orcid.org/0000-0001-6814-9344"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leon Schulte","raw_affiliation_strings":["Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005751035","display_name":"Andreas Rembert Koczulla","orcid":"https://orcid.org/0000-0002-5884-3006","observed_orcids":["https://orcid.org/0000-0002-5884-3006"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Rembert Koczulla","raw_affiliation_strings":["Department of Pulmonary Rehabilitation, Philipps University of Marburg, German Center for Lung Research (DZL), Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Rehabilitation, Philipps University of Marburg, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070409333","display_name":"Bernd Schmeck","orcid":"https://orcid.org/0000-0002-2767-3606","observed_orcids":["https://orcid.org/0000-0002-2767-3606"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Schmeck","raw_affiliation_strings":["Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University, German Center for Lung Research (DZL), Marburg, Germany","Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps University, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I268975460","https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Institute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps University Marburg, German Center for Lung Research (DZL), Marburg, Germany","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113991781","display_name":"Hans\u2010Dieter Klenk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Dieter Klenk","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028520054","display_name":"Eva B\u00f6ttcher\u2010Friebertsh\u00e4user","orcid":"https://orcid.org/0000-0002-0007-8110","observed_orcids":["https://orcid.org/0000-0002-0007-8110"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eva B\u00f6ttcher-Friebertsh\u00e4user","raw_affiliation_strings":["Institute of Virology, Philipps University, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Virology, Philipps University, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":15.8645,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":0.99581184,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"93","issue":"21","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tmprss2","display_name":"TMPRSS2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.949999988079071},{"id":"https://openalex.org/keywords/influenza-b","display_name":"influenza B","score":1.0},{"id":"https://openalex.org/keywords/hemagglutinin-cleavage","display_name":"hemagglutinin cleavage","score":0.9649999737739563},{"id":"https://openalex.org/keywords/host-proteases","display_name":"host proteases","score":0.7720000147819519},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7099999785423279},{"id":"https://openalex.org/keywords/influenza-treatment","display_name":"influenza treatment","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8750215172767639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7837656736373901},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7545908689498901},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7444528341293335},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6261706352233887},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.6062086820602417},{"id":"https://openalex.org/C134164806","wikidata":"https://www.wikidata.org/wiki/Q409485","display_name":"Neuraminidase","level":3,"score":0.5440704822540283},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.5301785469055176},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5294753313064575},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.5190892219543457},{"id":"https://openalex.org/C83100098","wikidata":"https://www.wikidata.org/wiki/Q106297070","display_name":"NS2-3 protease","level":4,"score":0.4678047001361847},{"id":"https://openalex.org/C2778692840","wikidata":"https://www.wikidata.org/wiki/Q9136673","display_name":"Hemagglutinin (influenza)","level":3,"score":0.41011959314346313},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2175205647945404},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.17556995153427124},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11168992519378662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06497764587402344},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.05679136514663696},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009976","descriptor_name":"Orthomyxoviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D009980","descriptor_name":"Influenza A virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009981","descriptor_name":"Influenza B virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00649-19","doi":"https://doi.org/10.1128/jvi.00649-19","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00649-19","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:6103452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31391268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31391268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6803253","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6803253/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:6103452","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6803253","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1080162133","display_name":null,"funder_award_id":"SFB1021 TP B07","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3673810263","display_name":null,"funder_award_id":"SFB/TR84 TP C01","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5896109385","display_name":null,"funder_award_id":"63-0005","funder_id":"https://openalex.org/F4320311021","funder_display_name":"Von-Behring-R\u00f6ntgen-Stiftung"},{"id":"https://openalex.org/G6524590466","display_name":null,"funder_award_id":"SFB/TR-84 TP C10","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G993534505","display_name":null,"funder_award_id":"FKZ 66-LV07","funder_id":"https://openalex.org/F4320311021","funder_display_name":"Von-Behring-R\u00f6ntgen-Stiftung"}],"funders":[{"id":"https://openalex.org/F4320311021","display_name":"Von-Behring-R\u00f6ntgen-Stiftung","ror":"https://ror.org/05m7g4v96"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1945881575","https://openalex.org/W1964085020","https://openalex.org/W1965400930","https://openalex.org/W1970430555","https://openalex.org/W1972032770","https://openalex.org/W1972740819","https://openalex.org/W1974355337","https://openalex.org/W1976400886","https://openalex.org/W1977461039","https://openalex.org/W1993337771","https://openalex.org/W1997414761","https://openalex.org/W2002581355","https://openalex.org/W2006079378","https://openalex.org/W2033952224","https://openalex.org/W2036952631","https://openalex.org/W2046378278","https://openalex.org/W2048010092","https://openalex.org/W2049770171","https://openalex.org/W2049949004","https://openalex.org/W2055785303","https://openalex.org/W2056827251","https://openalex.org/W2060445509","https://openalex.org/W2062919894","https://openalex.org/W2067284235","https://openalex.org/W2068353535","https://openalex.org/W2078334493","https://openalex.org/W2084981497","https://openalex.org/W2087269855","https://openalex.org/W2087714421","https://openalex.org/W2090480076","https://openalex.org/W2091527885","https://openalex.org/W2097419379","https://openalex.org/W2099549544","https://openalex.org/W2102637313","https://openalex.org/W2115892399","https://openalex.org/W2118586651","https://openalex.org/W2126665429","https://openalex.org/W2132228958","https://openalex.org/W2142861733","https://openalex.org/W2143088475","https://openalex.org/W2149059384","https://openalex.org/W2150066073","https://openalex.org/W2155628535","https://openalex.org/W2156848440","https://openalex.org/W2157661702","https://openalex.org/W2157764725","https://openalex.org/W2158041351","https://openalex.org/W2170463984","https://openalex.org/W2191641478","https://openalex.org/W2208376875","https://openalex.org/W2287495486","https://openalex.org/W2325018865","https://openalex.org/W2469500234","https://openalex.org/W2593581914","https://openalex.org/W2602208147","https://openalex.org/W2602810763","https://openalex.org/W2613674576","https://openalex.org/W2804090497","https://openalex.org/W2804771656","https://openalex.org/W2809046636","https://openalex.org/W2887166156","https://openalex.org/W2909787042","https://openalex.org/W3033379609","https://openalex.org/W3168314838"],"related_works":["https://openalex.org/W3185878796","https://openalex.org/W3017272480","https://openalex.org/W2071219890","https://openalex.org/W2099549544","https://openalex.org/W7097002591","https://openalex.org/W2056827251","https://openalex.org/W1964732021","https://openalex.org/W643879909","https://openalex.org/W2920147347","https://openalex.org/W2469500234"],"abstract_inverted_index":{"Influenza":[0],"A":[1],"viruses":[2,7,60],"(IAV)":[3],"and":[4,12,34,68,102,106,119,139],"influenza":[5,59,147],"B":[6],"(IBV)":[8],"cause":[9],"significant":[10],"morbidity":[11],"mortality":[13],"during":[14],"seasonal":[15],"outbreaks.":[16],"Cleavage":[17],"of":[18,40,53,57,71,95,103,137],"the":[19,51,86,91,135],"viral":[20],"surface":[21],"glycoprotein":[22],"hemagglutinin":[23],"(HA)":[24],"by":[25],"host":[26],"proteases":[27,42,72],"is":[28,61,90],"a":[29,44,64,69],"prerequisite":[30],"for":[31,36,146],"membrane":[32],"fusion":[33],"essential":[35],"virus":[37],"infectivity.":[38],"Inhibition":[39],"relevant":[41],"provides":[43],"promising":[45],"therapeutic":[46],"approach":[47],"that":[48,85,117],"may":[49],"avoid":[50],"development":[52,136],"drug":[54],"resistance.":[55],"HA":[56,78],"most":[58],"cleaved":[62],"at":[63],"monobasic":[65],"cleavage":[66],"site,":[67],"number":[70],"have":[73],"been":[74],"shown":[75],"to":[76],"cleave":[77],"in":[79,97,108,125],"vitro":[80],".":[81],"This":[82],"study":[83],"demonstrates":[84],"transmembrane":[87],"protease":[88,94,128,141],"TMPRSS2":[89],"major":[92],"HA-activating":[93],"IAV":[96,105],"primary":[98,109],"human":[99,110,118],"bronchial":[100],"cells":[101,122],"both":[104],"IBV":[107],"type":[111],"II":[112],"pneumocytes.":[113],"It":[114],"further":[115],"reveals":[116],"murine":[120],"airway":[121],"can":[123],"differ":[124],"their":[126],"HA-cleaving":[127],"repertoires.":[129],"Our":[130],"data":[131],"will":[132],"help":[133],"drive":[134],"potent":[138],"selective":[140],"inhibitors":[142],"as":[143],"novel":[144],"drugs":[145],"treatment.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":41},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-08-13T00:00:00"}
