{"id":"https://openalex.org/W2964523930","doi":"https://doi.org/10.1186/s12014-019-9253-1","title":"iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy","display_name":"iTRAQ plasma proteomics analysis for candidate biomarkers of type 2 incipient diabetic nephropathy","publication_year":2019,"publication_date":"2019-07-31","ids":{"openalex":"https://openalex.org/W2964523930","doi":"https://doi.org/10.1186/s12014-019-9253-1","mag":"2964523930","pmid":"https://pubmed.ncbi.nlm.nih.gov/31384238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668123"},"language":"en","primary_location":{"id":"doi:10.1186/s12014-019-9253-1","doi":"https://doi.org/10.1186/s12014-019-9253-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12014-019-9253-1","pdf_url":null,"source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12014-019-9253-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004690469","display_name":"Hongmei L\u00fc","orcid":"https://orcid.org/0000-0002-4686-4491","observed_orcids":["https://orcid.org/0000-0002-4686-4491","https://orcid.org/0000-0002-6240-2326"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongmei Lu","raw_affiliation_strings":["1The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808 China","The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808 China","institution_ids":["https://openalex.org/I176834541"]},{"raw_affiliation_string":"The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075667023","display_name":"Shaodong Deng","orcid":"https://orcid.org/0000-0001-8155-7369","observed_orcids":["https://orcid.org/0000-0001-8155-7369"]},"institutions":[{"id":"https://openalex.org/I176834541","display_name":"Guangdong Medical College","ror":"https://ror.org/04k5rxe29","country_code":"CN","type":"education","lineage":["https://openalex.org/I176834541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaodong Deng","raw_affiliation_strings":["1The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808 China","The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808 China","institution_ids":["https://openalex.org/I176834541"]},{"raw_affiliation_string":"The Second Clinical Medical College, Guangdong Medical University, Dongguan, 523808, China","institution_ids":["https://openalex.org/I176834541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100623076","display_name":"Minghui Zheng","orcid":"https://orcid.org/0000-0002-6570-1110","observed_orcids":["https://orcid.org/0000-0002-6570-1110"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Minghui Zheng","raw_affiliation_strings":["2Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120 China","Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120 China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058662448","display_name":"Kunhua Hu","orcid":"https://orcid.org/0000-0001-9422-7828","observed_orcids":["https://orcid.org/0000-0001-9422-7828"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kunhua Hu","raw_affiliation_strings":["3Proteomics Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080 China","Proteomics Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Proteomics Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080 China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Proteomics Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058662448","https://openalex.org/A5100623076"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.9657,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.75281664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetic-nephropathy","display_name":"type 2 diabetic nephropathy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.6959999799728394},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8410000205039978},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gelsolin","display_name":"gelsolin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/collectin-11","display_name":"collectin-11","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ptprj","display_name":"PTPRJ","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.8503760695457458},{"id":"https://openalex.org/C80722340","wikidata":"https://www.wikidata.org/wiki/Q18297560","display_name":"Gelsolin","level":3,"score":0.7880111932754517},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.7124045491218567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5035313963890076},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4531330466270447},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.42827868461608887},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4130845069885254},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40774834156036377},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3714587688446045},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30270057916641235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2831764817237854},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.25593146681785583},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.20687010884284973},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16687563061714172},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12014-019-9253-1","doi":"https://doi.org/10.1186/s12014-019-9253-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12014-019-9253-1","pdf_url":null,"source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5627551","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668123","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6668123","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6668123","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Proteomics","raw_type":"Text"},{"id":"pmid:31384238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31384238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical proteomics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12014-019-9253-1","doi":"https://doi.org/10.1186/s12014-019-9253-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12014-019-9253-1","pdf_url":null,"source":{"id":"https://openalex.org/S103738789","display_name":"Clinical Proteomics","issn_l":"1542-6416","issn":["1542-6416","1559-0275"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3146247099","display_name":null,"funder_award_id":"81401689","funder_id":"https://openalex.org/F4320327557","funder_display_name":"National Office for Philosophy and Social Sciences"},{"id":"https://openalex.org/G8681251842","display_name":null,"funder_award_id":"B2013008","funder_id":"https://openalex.org/F4320322161","funder_display_name":"Guangdong Medical Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320322161","display_name":"Guangdong Medical Research Foundation","ror":null},{"id":"https://openalex.org/F4320327557","display_name":"National Office for Philosophy and Social Sciences","ror":"https://ror.org/04m0ms912"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1526927233","https://openalex.org/W1534729630","https://openalex.org/W1544976636","https://openalex.org/W1557343619","https://openalex.org/W1607900171","https://openalex.org/W1800577110","https://openalex.org/W1971859198","https://openalex.org/W1973834797","https://openalex.org/W1986116780","https://openalex.org/W1996608703","https://openalex.org/W2001820216","https://openalex.org/W2011897448","https://openalex.org/W2014803646","https://openalex.org/W2016332902","https://openalex.org/W2019482305","https://openalex.org/W2020267609","https://openalex.org/W2030385147","https://openalex.org/W2030564776","https://openalex.org/W2038906343","https://openalex.org/W2043317301","https://openalex.org/W2048583819","https://openalex.org/W2056345623","https://openalex.org/W2060451219","https://openalex.org/W2062993418","https://openalex.org/W2064648040","https://openalex.org/W2065309678","https://openalex.org/W2065919027","https://openalex.org/W2067339233","https://openalex.org/W2067611052","https://openalex.org/W2068891468","https://openalex.org/W2070550973","https://openalex.org/W2077096695","https://openalex.org/W2078281513","https://openalex.org/W2090700814","https://openalex.org/W2098120357","https://openalex.org/W2098267944","https://openalex.org/W2101761968","https://openalex.org/W2104009398","https://openalex.org/W2105487207","https://openalex.org/W2111890489","https://openalex.org/W2113191664","https://openalex.org/W2128563366","https://openalex.org/W2133418939","https://openalex.org/W2144838480","https://openalex.org/W2153189745","https://openalex.org/W2155201691","https://openalex.org/W2157098192","https://openalex.org/W2159425700","https://openalex.org/W2167660483","https://openalex.org/W2177131385","https://openalex.org/W2419459620","https://openalex.org/W2466126443","https://openalex.org/W2473376802","https://openalex.org/W2480445743","https://openalex.org/W2509368823","https://openalex.org/W2558591709","https://openalex.org/W2582219435","https://openalex.org/W2725539734","https://openalex.org/W2755757434","https://openalex.org/W2766102084","https://openalex.org/W2805886109","https://openalex.org/W2825893920","https://openalex.org/W2888732937","https://openalex.org/W2902329895","https://openalex.org/W2993996962"],"related_works":["https://openalex.org/W2023190338","https://openalex.org/W2017002388","https://openalex.org/W7214836827","https://openalex.org/W2068891468","https://openalex.org/W2151168574","https://openalex.org/W2006939427","https://openalex.org/W1998457852","https://openalex.org/W2045153875","https://openalex.org/W1966145904","https://openalex.org/W1982092732"],"abstract_inverted_index":{"BACKGROUND:":[0],"Diabetic":[1],"nephropathy":[2,18,50],"is":[3],"the":[4,24,72,102],"most":[5],"frequent":[6],"cause":[7],"of":[8,14,105],"end-stage":[9],"renal":[10],"disease":[11],"worldwide.":[12],"Identification":[13],"biomarkers":[15,86],"for":[16,19,87,101],"diabetic":[17,49,106],"early":[20,103],"diagnosis":[21],"may":[22],"be":[23],"key":[25],"to":[26,39],"avoiding":[27],"damage":[28],"from":[29],"this":[30],"condition.":[31],"METHODS:":[32],"Proteomic":[33],"iTRAQ":[34],"technology":[35],"was":[36],"first":[37],"used":[38],"identify":[40],"differentially":[41],"expressed":[42],"plasma":[43],"proteins":[44,62,78],"in":[45],"type":[46,88],"2":[47,89],"incipient":[48],"(IDN)":[51],"using":[52],"a":[53,98],"Q-Exactive":[54],"mass":[55],"spectrometer.":[56],"RESULTS:":[57],"Compared":[58],"with":[59],"controls,":[60],"57":[61],"(32":[63],"upregulated":[64],"and":[65,76],"25":[66],"downregulated":[67],"proteins)":[68],"were":[69,79],"identified.":[70],"Furthermore,":[71],"gelsolin,":[73],"collectin-11,":[74],"PTPRJ,":[75],"AKAP-7":[77],"confirmed":[80],"by":[81],"Western":[82],"blots":[83],"as":[84],"candidate":[85],"IDN":[90],"through":[91],"ROC":[92],"analysis.":[93],"CONCLUSIONS:":[94],"These":[95],"findings":[96],"offer":[97],"theoretical":[99],"basis":[100],"treatment":[104],"nephropathy.":[107]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-08-13T00:00:00"}