{"id":"https://openalex.org/W2964480752","doi":"https://doi.org/10.1242/bio.042812","title":"Three-dimensional analysis of single molecule FISH in human colon organoids","display_name":"Three-dimensional analysis of single molecule FISH in human colon organoids","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2964480752","doi":"https://doi.org/10.1242/bio.042812","mag":"2964480752","pmid":"https://pubmed.ncbi.nlm.nih.gov/31362950","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6737975"},"language":"en","primary_location":{"id":"doi:10.1242/bio.042812","doi":"https://doi.org/10.1242/bio.042812","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.042812","pdf_url":"https://bio.biologists.org/content/biolopen/8/8/bio042812.full.pdf","source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bio.biologists.org/content/biolopen/8/8/bio042812.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019394189","display_name":"Manja Omerzu","orcid":"https://orcid.org/0000-0003-0045-0813","observed_orcids":["https://orcid.org/0000-0003-0045-0813"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Manja Omerzu","raw_affiliation_strings":["Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-0045-0813","affiliations":[{"raw_affiliation_string":"Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029743412","display_name":"Nicola Fenderico","orcid":"https://orcid.org/0000-0003-3599-7931","observed_orcids":["https://orcid.org/0000-0003-3599-7931"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicola Fenderico","raw_affiliation_strings":["Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3599-7931","affiliations":[{"raw_affiliation_string":"Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028105530","display_name":"Buys de Barbanson","orcid":"https://orcid.org/0000-0002-6967-5757","observed_orcids":["https://orcid.org/0000-0002-6967-5757"]},"institutions":[{"id":"https://openalex.org/I1322597698","display_name":"Royal Netherlands Academy of Arts and Sciences","ror":"https://ror.org/043c0p156","country_code":"NL","type":"government","lineage":["https://openalex.org/I1322597698"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Buys de Barbanson","raw_affiliation_strings":["Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands","Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands","institution_ids":["https://openalex.org/I1322597698","https://openalex.org/I3018483916","https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017100786","display_name":"Joep Sprangers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joep Sprangers","raw_affiliation_strings":["Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210111138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071483953","display_name":"Jeroen de Ridder","orcid":"https://orcid.org/0000-0002-0828-3477","observed_orcids":["https://orcid.org/0000-0002-0828-3477"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen de Ridder","raw_affiliation_strings":["Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044269827","display_name":"Madelon M. Maurice","orcid":"https://orcid.org/0000-0001-6885-5361","observed_orcids":["https://orcid.org/0000-0001-6885-5361"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Madelon M. Maurice","raw_affiliation_strings":["Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-6885-5361","affiliations":[{"raw_affiliation_string":"Oncode Institute and Department of Cell Biology, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210111138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044269827"],"corresponding_institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I4210111138"],"apc_list":{"value":1995,"currency":"USD","value_usd":1995},"apc_paid":{"value":1995,"currency":"USD","value_usd":1995},"fwci":0.6592,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.6307118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-molecule-fish","display_name":"single-molecule FISH","score":0.7929999828338623},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8899999856948853},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.6909999847412109},{"id":"https://openalex.org/keywords/organogenesis","display_name":"organogenesis","score":0.492000013589859},{"id":"https://openalex.org/keywords/tissue-self-organization","display_name":"tissue self-organization","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.9263988733291626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8719531297683716},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.6822924017906189},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48095813393592834},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3626973628997803},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.2783096730709076},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1879250407218933}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1242/bio.042812","doi":"https://doi.org/10.1242/bio.042812","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.042812","pdf_url":"https://bio.biologists.org/content/biolopen/8/8/bio042812.full.pdf","source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6737975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6737975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biol Open","raw_type":"Text"},{"id":"pmid:31362950","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31362950","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology open","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9226094706034df89dcae42c9db95f36","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9226094706034df89dcae42c9db95f36","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Open, Vol 8, Iss 8 (2019)","raw_type":"article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/390538","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/390538","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:biolopen:8/8/bio042812","doi":null,"is_oa":false,"landing_page_url":"http://bio.biologists.org/cgi/content/short/8/8/bio042812","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/390538","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/390538","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology Open, 8(8). Company of Biologists Ltd","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1242/bio.042812","doi":"https://doi.org/10.1242/bio.042812","is_oa":true,"landing_page_url":"https://doi.org/10.1242/bio.042812","pdf_url":"https://bio.biologists.org/content/biolopen/8/8/bio042812.full.pdf","source":{"id":"https://openalex.org/S2738063279","display_name":"Biology Open","issn_l":"2046-6390","issn":["2046-6390"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Open","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3316466445","display_name":null,"funder_award_id":"91815604","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G4149741635","display_name":null,"funder_award_id":"608180","funder_id":"https://openalex.org/F4320338368","funder_display_name":"FP7 People: Marie-Curie Actions"},{"id":"https://openalex.org/G4833273754","display_name":null,"funder_award_id":"242958","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338368","display_name":"FP7 People: Marie-Curie Actions","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964480752.pdf","grobid_xml":"https://content.openalex.org/works/W2964480752.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W16623706","https://openalex.org/W77265774","https://openalex.org/W1483496013","https://openalex.org/W1741548448","https://openalex.org/W1837455343","https://openalex.org/W1965157206","https://openalex.org/W1988058295","https://openalex.org/W1988075836","https://openalex.org/W1988658871","https://openalex.org/W1997179616","https://openalex.org/W2002513358","https://openalex.org/W2024876545","https://openalex.org/W2027267723","https://openalex.org/W2080157242","https://openalex.org/W2082493388","https://openalex.org/W2085652695","https://openalex.org/W2086629747","https://openalex.org/W2088245621","https://openalex.org/W2099434983","https://openalex.org/W2101889783","https://openalex.org/W2102512718","https://openalex.org/W2102944297","https://openalex.org/W2107429180","https://openalex.org/W2112562104","https://openalex.org/W2123273050","https://openalex.org/W2141915435","https://openalex.org/W2155545276","https://openalex.org/W2163173465","https://openalex.org/W2174254214","https://openalex.org/W2221253621","https://openalex.org/W2239511084","https://openalex.org/W2255555283","https://openalex.org/W2271458278","https://openalex.org/W2398933044","https://openalex.org/W2441337908","https://openalex.org/W2465114161","https://openalex.org/W2544045364","https://openalex.org/W2560529146","https://openalex.org/W2594543006","https://openalex.org/W2601634034","https://openalex.org/W2611779918","https://openalex.org/W2621634225","https://openalex.org/W2648666748","https://openalex.org/W2786316660","https://openalex.org/W2811479062","https://openalex.org/W2892107476","https://openalex.org/W4256266823"],"related_works":["https://openalex.org/W3043909790","https://openalex.org/W4299905364","https://openalex.org/W2903001230","https://openalex.org/W2899985168","https://openalex.org/W4319917033","https://openalex.org/W2197853261","https://openalex.org/W2014251289","https://openalex.org/W2807437878","https://openalex.org/W4376881056","https://openalex.org/W2610726090"],"abstract_inverted_index":{"The":[0],"culturing":[1],"of":[2,32,43,56,62,105,134,145,150,157],"mini-organs":[3],"(organoids)":[4],"in":[5,25,75,124,126,161,163],"3-dimensions":[6],"(3D)":[7],"presents":[8],"a":[9,40,80,115,132],"simple":[10],"and":[11,22,28,48,64,85,118,154],"powerful":[12],"tool":[13],"to":[14,66,95,121,136],"investigate":[15],"the":[16,44,54,60,109,138,142,155],"principles":[17],"underlying":[18,46],"human":[19,128],"organ":[20,49],"development":[21],"tissue":[23,47,68],"self-organization":[24],"both":[26],"healthy":[27],"diseased":[29],"states.":[30],"Applications":[31],"single":[33,57],"molecule":[34,58],"analysis":[35],"are":[36],"highly":[37],"informative":[38],"for":[39,83,141],"comprehensive":[41],"understanding":[42],"complexity":[45],"physiology.":[50],"To":[51],"fully":[52],"exploit":[53],"potential":[55],"technologies,":[59],"adjustment":[61],"protocols":[63],"tools":[65],"3D":[67,125,162],"culture":[69],"is":[70,79],"required.":[71],"Single-molecule":[72],"RNA":[73],"fluorescence":[74],"situ":[76],"hybridization":[77],"(smFISH)":[78],"robust":[81],"technique":[82],"visualizing":[84],"quantifying":[86],"individual":[87],"transcripts.":[88],"In":[89],"addition,":[90],"smFISH":[91,123],"can":[92],"be":[93],"employed":[94],"study":[96],"splice":[97],"variants,":[98],"fusion":[99],"transcripts":[100,104],"as":[101,103],"well":[102],"multiple":[106],"genes":[107],"at":[108],"same":[110],"time.":[111],"Here,":[112],"we":[113],"develop":[114],"3-day":[116],"protocol":[117],"validation":[119],"method":[120],"perform":[122],"whole":[127],"organoids.":[129,164],"We":[130],"provide":[131],"number":[133],"applications":[135],"exemplify":[137],"diverse":[139],"possibilities":[140],"simultaneous":[143],"detection":[144],"distinct":[146],"mRNA":[147],"transcripts,":[148],"evaluation":[149],"their":[151],"spatial":[152],"distribution":[153],"identification":[156],"divergent":[158],"cell":[159],"lineages":[160]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-08-13T00:00:00"}