{"id":"https://openalex.org/W2964446146","doi":"https://doi.org/10.1016/j.lssr.2019.07.011","title":"Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention","display_name":"Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention","publication_year":2019,"publication_date":"2019-08-01","ids":{"openalex":"https://openalex.org/W2964446146","doi":"https://doi.org/10.1016/j.lssr.2019.07.011","mag":"2964446146","pmid":"https://pubmed.ncbi.nlm.nih.gov/31987474"},"language":"en","primary_location":{"id":"doi:10.1016/j.lssr.2019.07.011","doi":"https://doi.org/10.1016/j.lssr.2019.07.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lssr.2019.07.011","pdf_url":null,"source":{"id":"https://openalex.org/S2764866528","display_name":"Life Sciences in Space Research","issn_l":"2214-5524","issn":["2214-5524","2214-5532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences in Space Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6991460","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069713275","display_name":"Krishna Luitel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Luitel","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101887031","display_name":"Sang Bum Kim","orcid":"https://orcid.org/0000-0001-5965-3354","observed_orcids":["https://orcid.org/0000-0001-5965-3354"]},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Sang Bum Kim","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Sevrance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, South Korea","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Sevrance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Sevrance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, South Korea","institution_ids":["https://openalex.org/I193775966","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Sevrance Biomedical Research Institute, Yonsei University College of Medicine, Seoul 03722, South Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048600397","display_name":"Summer Barron","orcid":"https://orcid.org/0000-0001-9337-3778","observed_orcids":["https://orcid.org/0000-0001-9337-3778"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Summer Barron","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113550768","display_name":"James A. Richardson","orcid":"https://orcid.org/0009-0008-1252-3681","observed_orcids":["https://orcid.org/0009-0008-1252-3681"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Richardson","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081012778","display_name":"Jerry W. Shay","orcid":"https://orcid.org/0000-0001-5052-0627","observed_orcids":["https://orcid.org/0000-0001-5052-0627"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerry W. Shay","raw_affiliation_strings":["Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jerry.shay@utsouthwestern.edu","Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jerry.shay@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081012778"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":2200,"currency":"USD","value_usd":2200},"apc_paid":null,"fwci":0.989,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76985861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"24","issue":null,"first_page":"108","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.33059999346733093,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6959999799728394},{"id":"https://openalex.org/keywords/space-radiation","display_name":"space radiation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/whole-body-irradiation","display_name":"whole-body irradiation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.8130000233650208},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8550000190734863},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"adenocarcinoma","score":0.8050000071525574},{"id":"https://openalex.org/keywords/radioprotectors","display_name":"radioprotective agents","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.7975778579711914},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.544431209564209},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.4850582182407379},{"id":"https://openalex.org/C50774322","wikidata":"https://www.wikidata.org/wiki/Q644248","display_name":"Ion beam","level":3,"score":0.4832921326160431},{"id":"https://openalex.org/C153385146","wikidata":"https://www.wikidata.org/wiki/Q18335","display_name":"Radiation","level":2,"score":0.4540371298789978},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4080848693847656},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3951157331466675},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.39126351475715637},{"id":"https://openalex.org/C168834538","wikidata":"https://www.wikidata.org/wiki/Q3705329","display_name":"Beam (structure)","level":2,"score":0.36390402913093567},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.3535565733909607},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.3358073830604553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2767409384250641},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2114177644252777},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.16893449425697327},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10132592916488647},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009381","descriptor_name":"Neoplasms, Radiation-Induced","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011835","descriptor_name":"Radiation Protection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011835","descriptor_name":"Radiation Protection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011835","descriptor_name":"Radiation Protection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011839","descriptor_name":"Radiation, Ionizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014916","descriptor_name":"Whole-Body Irradiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.lssr.2019.07.011","doi":"https://doi.org/10.1016/j.lssr.2019.07.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lssr.2019.07.011","pdf_url":null,"source":{"id":"https://openalex.org/S2764866528","display_name":"Life Sciences in Space Research","issn_l":"2214-5524","issn":["2214-5524","2214-5532"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences in Space Research","raw_type":"journal-article"},{"id":"pmid:31987474","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31987474","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences in space research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:6754682","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6991460","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6991460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6991460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Sci Space Res (Amst)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6991460","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6991460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Sci Space Res (Amst)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Life below water","score":0.47999998927116394,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2688122777","display_name":"Cell Biology Research Improvements and Renovations","funder_award_id":"C06RR030414","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2717061693","display_name":null,"funder_award_id":"T32CA124334","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G3632285766","display_name":"CONSIDERING THE HIGH SPONTANEOUS INCIDENCE OF GASTROINTESTINAL (GI) CANCER AND HIGHER INCIDENCE OF PREMALIGNANT COLONIC POLYPS  AN EVEN MODEST INCREASE BY SPACE RADIATION EXPOSURE COULD HAVE A SIGNIFICANT EFFECT ON ASTRONAUTS  HEALTH RISK ESTIMATES DURING AND AFTER LONG-DURATION MANNED SPACE FLIGHTS. HOWEVER  THERE IS SUBSTANTIAL UNCERTAINTY FOR GI CANCER RISK ESTIMATION FROM SPACE RADIATION DUE TO THE LACK OF IN VIVO HUMAN DATA.  THIS PROPOSAL ADDRESSES THE CATEGORY IN THE CURRENT SOLICITATION INVOLVING `NEW APPROACHES TOWARDS `MECHANISTIC UNDERSTANDING  OF GI CANCER RISK USING `NEW BIOLOGICAL MODELS  FOR `STUDIES OF RADIATION QUALITY AND DOSE-RATE EFFECTS  IN RELATION TO `INDIVIDUAL RADIATION SENSITIVITY .  THE OVERARCHING GOAL OF THE CURRENT PROPOSAL IS TO SPECIFICALLY INVESTIGATE CELLULAR AND MOLECULAR HYPOTHESIS DRIVEN MECHANISMS IN RELEVANT MOUSE MODELS THAT WILL CONTRIBUTE TO CARCINOGENIC RISK ESTIMATES OF GI CANCER AFTER EXPOSURE TO SPACE RADIATION BEAMS PRIORITIZED IN THE CURRENT SOLICITATION.  WE HAVE CHOSEN HIGH PRIORITY HZE BEAMS.  SINCE MAXIMAL EFFECTS HAVE ALREADY BEEN SEEN WITH 28SI IONS  THIS WILL BE A PRIORITY AND WE WILL EXTEND TO LOWER Z AT SIMILAR ENERGY USING 16O AND 4HE IONS.  HAVING FOUND MODEST EFFECTS IN SOME STUDIES WITH PROTONS AND CONSIDERING THE IMPORTANCE OF ASSESSING THE EFFECTS OF MIXED BEAMS  WE WILL TAKE ADVANTAGE OF THE AVAILABILITY OF THE SEQUENTIAL FIELD PROTON/56FE (0.2/150 KEV/M) BEAM TO START TO REPRESENT THE MIXED PARTICLE RADIATION IN SPACE.  WE WILL CONSULT WITH NASA ON BEAM PRIORITIZATION AND CONSIDER THE GCR SIMULATOR AS THE STUDY PROGRESSES. SPECIFICALLY  THIS PROPOSAL SEEKS TO DETERMINE INCIDENCE AND GRADE AS WELL AS IDENTIFY MOLECULAR PERTURBATIONS AND TARGET CELLS ASSOCIATED WITH INTESTINAL AND GASTRIC (STOMACH) TUMORS THROUGH MONITORING OF CHANGES IN THE TUMOR NUMBER  HISTOLOGY  GENE EXPRESSION  METABOLOME AND IN THE GENOME OF THE PROPOSED MODEL SYSTEM AFTER EXPOSURE TO THESE SPACE-RADIATION BEAMS.  WE ARE PROPOSING FOUR COMPLEMENTARY AIMS (AND PROJECTS) THAT WILL HAVE A COMMON OBJECTIVE TO DEVELOP A MORE RELIABLE GI CANCER RISK PREDICTION MODEL. 1] QUANTITATIVELY ASSESS GI TUMORIGENESIS IN MOUSE MODELS OF GI CANCER AND COLLECT SAMPLES FOR QUALITATIVE ANALYSIS (PROJECT 1) 2] DISSECTION OF THE SIGNALING EVENTS AND CONSEQUENCES IN GASTROINTESTINAL CELLS OF THE PERSISTENT EFFECTS OF SPACE RADIATION (PROJECT 2)  3] CHARACTERIZATION OF RADIATION-INDUCED NEOPLASTIC EVENTS IN NORMAL DIPLOID HUMAN COLONOCYTES (PROJECT 3)  4] DEVELOPMENT OF SYSTEMS BIOLOGY (PROJECT 4A) AND MATHEMATICAL MODELING (PROJECT 4B) APPROACHES FOR GI CANCER RISK ASSESSMENT.","funder_award_id":"NNX15AI21G","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G5028114694","display_name":null,"funder_award_id":"T32-CA124334","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6017890110","display_name":"Cancer Biology Training Grant","funder_award_id":"5t32ca124334-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8011449143","display_name":null,"funder_award_id":"C06 RR30414","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G8963969454","display_name":"OVERALL HYPOTHESIS.. LOW DOSE RADIATION INDUCES MOLECULAR MANIFESTATIONS OF A PRO INFLAMMATORY RESPONSE AS A FUNCTION OF RADIATION TYPE, RADIATION DO","funder_award_id":"NNX16AE08G","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G9000020410","display_name":null,"funder_award_id":"CA142543","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000179152","display_name":null,"funder_award_id":"T32 CA124334","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000898154","display_name":"UT Southwestern Medical Center Simmons Comprehensive Cancer Center","funder_award_id":"P30CA142543","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320338289","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1611210979","https://openalex.org/W1965606122","https://openalex.org/W1968762101","https://openalex.org/W1971848700","https://openalex.org/W1976096611","https://openalex.org/W1986311655","https://openalex.org/W1989687673","https://openalex.org/W2001484982","https://openalex.org/W2024215564","https://openalex.org/W2045660560","https://openalex.org/W2065361994","https://openalex.org/W2083675699","https://openalex.org/W2086097179","https://openalex.org/W2089423309","https://openalex.org/W2092723840","https://openalex.org/W2100018419","https://openalex.org/W2101733145","https://openalex.org/W2111211230","https://openalex.org/W2112948259","https://openalex.org/W2122998527","https://openalex.org/W2124435581","https://openalex.org/W2129847925","https://openalex.org/W2142981400","https://openalex.org/W2145911077","https://openalex.org/W2152558985","https://openalex.org/W2157512479","https://openalex.org/W2159304945","https://openalex.org/W2164223269","https://openalex.org/W2174570955","https://openalex.org/W2239984495","https://openalex.org/W2302322994","https://openalex.org/W2401919727","https://openalex.org/W2423203177","https://openalex.org/W2551570335","https://openalex.org/W2583594052","https://openalex.org/W2758270170","https://openalex.org/W2766730748","https://openalex.org/W2885824775","https://openalex.org/W2911188335","https://openalex.org/W3102806836","https://openalex.org/W6717567109"],"related_works":["https://openalex.org/W2792022317","https://openalex.org/W2035286355","https://openalex.org/W1974283415","https://openalex.org/W2036853086","https://openalex.org/W2029110214","https://openalex.org/W1985871717","https://openalex.org/W2000949875","https://openalex.org/W2054065781","https://openalex.org/W2066704958","https://openalex.org/W1994721606"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}