{"id":"https://openalex.org/W2964411848","doi":"https://doi.org/10.1038/s41598-019-47354-7","title":"A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1","display_name":"A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1","publication_year":2019,"publication_date":"2019-07-29","ids":{"openalex":"https://openalex.org/W2964411848","doi":"https://doi.org/10.1038/s41598-019-47354-7","mag":"2964411848","pmid":"https://pubmed.ncbi.nlm.nih.gov/31358819","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6662813"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-019-47354-7","doi":"https://doi.org/10.1038/s41598-019-47354-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-47354-7","pdf_url":"https://www.nature.com/articles/s41598-019-47354-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-019-47354-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100698575","display_name":"Sung Wook Park","orcid":"https://orcid.org/0000-0002-3393-8826","observed_orcids":["https://orcid.org/0000-0002-3393-8826"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sung Wook Park","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059370818","display_name":"Jennifer Nhieu","orcid":"https://orcid.org/0000-0002-2448-6127","observed_orcids":["https://orcid.org/0000-0002-2448-6127"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Nhieu","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037660622","display_name":"Shawna D. Persaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawna D. Persaud","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048973709","display_name":"Michelle C. Miller","orcid":"https://orcid.org/0000-0002-7860-5785","observed_orcids":["https://orcid.org/0000-0002-7860-5785"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle C. Miller","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044788584","display_name":"Youlin Xia","orcid":"https://orcid.org/0000-0001-7255-5425","observed_orcids":["https://orcid.org/0000-0001-7255-5425"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youlin Xia","raw_affiliation_strings":["Minnesota NMR Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minnesota NMR Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110500981","display_name":"Yi-Wei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Wei Lin","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008095508","display_name":"Yu\u2010Lung Lin","orcid":"https://orcid.org/0000-0001-5437-9958","observed_orcids":["https://orcid.org/0000-0001-5437-9958"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Lung Lin","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033725334","display_name":"Hiroyuki Kagechika","orcid":"https://orcid.org/0000-0002-6747-1013","observed_orcids":["https://orcid.org/0000-0002-6747-1013"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kagechika","raw_affiliation_strings":["Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012810451","display_name":"Kevin H. Mayo","orcid":"https://orcid.org/0000-0001-5399-6719","observed_orcids":["https://orcid.org/0000-0001-5399-6719"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin H. Mayo","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034365665","display_name":"Li\u2010Na Wei","orcid":"https://orcid.org/0000-0002-6376-8506","observed_orcids":["https://orcid.org/0000-0002-6376-8506"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Na Wei","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA. weixx009@umn.edu","Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA. weixx009@umn.edu","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034365665"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":1790,"currency":"USD","value_usd":1790},"apc_paid":{"value":1790,"currency":"USD","value_usd":1790},"fwci":1.6537,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.83971382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"10929","last_page":"10929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.19789999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9070000052452087},{"id":"https://openalex.org/keywords/crabp1","display_name":"CRABP1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ras-binding-domain","display_name":"Ras-binding domain","score":0.8199999928474426},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ras-raf-pathway","display_name":"RAS/RAF pathway","score":0.7239999771118164},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.8109999895095825},{"id":"https://openalex.org/keywords/scaffold-proteins","display_name":"scaffold proteins","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cell-growth-regulation","display_name":"cell growth regulation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/retinoid-toxicity","display_name":"retinoid toxicity","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6037381291389465},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6034672856330872},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5983009338378906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4840649664402008},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4761647880077362},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4750276207923889},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40653958916664124},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.17801687121391296},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1393871009349823}],"mesh":[{"descriptor_ui":"D000072757","descriptor_name":"Protein Conformation, beta-Strand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D048490","descriptor_name":"raf Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048490","descriptor_name":"raf Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-019-47354-7","doi":"https://doi.org/10.1038/s41598-019-47354-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-47354-7","pdf_url":"https://www.nature.com/articles/s41598-019-47354-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5625363","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6662813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6662813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6662813","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:31358819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31358819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c4e4d1bef0454f368484f8e4f0a35ce2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c4e4d1bef0454f368484f8e4f0a35ce2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-019-47354-7","doi":"https://doi.org/10.1038/s41598-019-47354-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-019-47354-7","pdf_url":"https://www.nature.com/articles/s41598-019-47354-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1122316658","display_name":"Studies of nuclear receptor corepressor, NRIP1, in vitamin A signaling pathways","funder_award_id":"R01DK060521","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1123519411","display_name":null,"funder_award_id":"[DK54733","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1554242968","display_name":null,"funder_award_id":"DK54733","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G3263060740","display_name":null,"funder_award_id":"DK54733","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G3935645064","display_name":null,"funder_award_id":"DK-60521","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4547986268","display_name":null,"funder_award_id":"DK60521","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G799171626","display_name":null,"funder_award_id":"DK60521","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G8191673356","display_name":"TR2 nuclear receptor in vitamin A signaling","funder_award_id":"R01DK054733","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964411848.pdf","grobid_xml":"https://content.openalex.org/works/W2964411848.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W384689730","https://openalex.org/W1491275120","https://openalex.org/W1499303660","https://openalex.org/W1862596007","https://openalex.org/W1967849828","https://openalex.org/W1969179779","https://openalex.org/W2000581759","https://openalex.org/W2001068122","https://openalex.org/W2002168534","https://openalex.org/W2009372928","https://openalex.org/W2015219861","https://openalex.org/W2018045749","https://openalex.org/W2027575557","https://openalex.org/W2033185023","https://openalex.org/W2039122427","https://openalex.org/W2039455906","https://openalex.org/W2040213004","https://openalex.org/W2041580355","https://openalex.org/W2045506400","https://openalex.org/W2054946171","https://openalex.org/W2055380229","https://openalex.org/W2056634688","https://openalex.org/W2058374133","https://openalex.org/W2065729763","https://openalex.org/W2073274300","https://openalex.org/W2075392290","https://openalex.org/W2079266078","https://openalex.org/W2080259897","https://openalex.org/W2081990599","https://openalex.org/W2082176639","https://openalex.org/W2083947067","https://openalex.org/W2085800054","https://openalex.org/W2086403021","https://openalex.org/W2093691792","https://openalex.org/W2097544945","https://openalex.org/W2106607972","https://openalex.org/W2107495112","https://openalex.org/W2111911402","https://openalex.org/W2117198713","https://openalex.org/W2129574905","https://openalex.org/W2135184154","https://openalex.org/W2136332525","https://openalex.org/W2138365237","https://openalex.org/W2147034045","https://openalex.org/W2151366572","https://openalex.org/W2151575007","https://openalex.org/W2169821755","https://openalex.org/W2290171244","https://openalex.org/W2339828620","https://openalex.org/W2567682222","https://openalex.org/W2582538856","https://openalex.org/W2597182072","https://openalex.org/W2604740042","https://openalex.org/W2647519705","https://openalex.org/W2740132893","https://openalex.org/W2769477663","https://openalex.org/W2793200565"],"related_works":["https://openalex.org/W2147034045","https://openalex.org/W2290171244","https://openalex.org/W3013525167","https://openalex.org/W2963427692","https://openalex.org/W3129822792","https://openalex.org/W4223634323","https://openalex.org/W2122256734","https://openalex.org/W1972411568","https://openalex.org/W4394749619","https://openalex.org/W2647519705"],"abstract_inverted_index":{"The":[0,204],"rapidly":[1,52],"accelerated":[2],"fibrosarcoma":[3],"(Raf)":[4],"kinase":[5,19,28,89],"is":[6,66],"canonically":[7],"activated":[8],"by":[9,68,139,212],"growth":[10,110,131,189,218],"factors":[11],"that":[12,47,171],"regulate":[13],"multiple":[14],"cellular":[15,69],"processes.":[16],"In":[17],"this":[18],"cascade":[20],"Raf":[21,88,133],"activation":[22],"ultimately":[23],"results":[24],"in":[25,62,107],"extracellular":[26],"regulated":[27,80],"1/2":[29],"(Erk1/2)":[30],"activation,":[31,134],"which":[32,65,135],"requires":[33],"Ras":[34,38,119],"binding":[35,39,72,141],"to":[36,57,142,216],"the":[37,91,124,152],"domain":[40],"(RBD)":[41],"of":[42,94,126,156,201],"Raf.":[43],"We":[44,85,162],"recently":[45],"reported":[46],"all-trans":[48],"retinoic":[49,70],"acid":[50,71],"(atRA)":[51],"(within":[53],"minutes)":[54],"activates":[55],"Erk1/2":[56,81],"modulate":[58],"cell":[59,202],"cycle":[60],"progression":[61],"stem":[63],"cells,":[64],"mediated":[67],"protein":[73,104],"1":[74],"(Crabp1).":[75],"But":[76],"how":[77],"atRA-bound":[78],"Crabp1":[79,97,114,157],"activity":[82],"remained":[83],"unclear.":[84],"now":[86],"report":[87],"as":[90,99,158,197],"direct":[92,121],"target":[93],"atRA-Crabp1.":[95],"Molecularly,":[96],"acts":[98],"a":[100,164,181,198,208],"novel":[101,199],"atRA-inducible":[102],"scaffold":[103],"for":[105,120,195],"Raf/Mek/Erk":[106],"cells":[108],"without":[109],"factor":[111,190,219],"stimulation.":[112],"However,":[113],"can":[115,136,172],"also":[116,173,206],"compete":[117],"with":[118,123],"interaction":[122],"RBD":[125],"Raf,":[127],"thereby":[128],"negatively":[129],"modulating":[130],"factor-stimulated":[132],"be":[137],"enhanced":[138],"atRA":[140],"Crabp1.":[143],"NMR":[144],"heteronuclear":[145],"single":[146],"quantum":[147],"coherence":[148],"(HSQC)":[149],"analyses":[150],"reveal":[151],"6-strand":[153],"\u03b2-sheet":[154],"face":[155],"its":[159],"Raf-interaction":[160],"surface.":[161],"identify":[163],"new":[165,182,209],"atRA-mimicking":[166],"and":[167,188],"Crabp1-selective":[168,214],"compound,":[169],"C3,":[170],"elicit":[174],"such":[175],"an":[176],"activity.":[177],"This":[178],"study":[179,205],"uncovers":[180],"signal":[183],"crosstalk":[184],"between":[185],"endocrine":[186],"(atRA-Crabp1)":[187],"(Ras-Raf)":[191],"pathways,":[192],"providing":[193],"evidence":[194],"atRA-Crabp1":[196],"modulator":[200],"growth.":[203],"suggests":[207],"therapeutic":[210],"strategy":[211],"employing":[213],"compounds":[215],"dampen":[217],"stimulation":[220],"while":[221],"circumventing":[222],"RAR-mediated":[223],"retinoid":[224],"toxicity.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-08-13T00:00:00"}