{"id":"https://openalex.org/W2964360771","doi":"https://doi.org/10.1007/s00018-019-03250-x","title":"DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools","display_name":"DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools","publication_year":2019,"publication_date":"2019-08-03","ids":{"openalex":"https://openalex.org/W2964360771","doi":"https://doi.org/10.1007/s00018-019-03250-x","mag":"2964360771","pmid":"https://pubmed.ncbi.nlm.nih.gov/31377845","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7162842"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-019-03250-x","doi":"https://doi.org/10.1007/s00018-019-03250-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-019-03250-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-019-03250-x.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00018-019-03250-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067619229","display_name":"Blanca Mart\u00ednez-Arribas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Blanca Mart\u00ednez-Arribas","raw_affiliation_strings":["Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077682208","display_name":"Cristina E. Requena","orcid":"https://orcid.org/0000-0001-5239-9162","observed_orcids":["https://orcid.org/0000-0001-5239-9162"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Cristina E. Requena","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, Du Cane Road, London, W12 0NN, UK","Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, Du Cane Road, London, W12 0NN, UK","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]},{"raw_affiliation_string":"MRC London Institute of Medical Sciences, Du Cane Road, London, W12 0NN, UK","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023299622","display_name":"Guiomar P\u00e9rez\u2010Moreno","orcid":"https://orcid.org/0000-0002-6892-6083","observed_orcids":["https://orcid.org/0000-0002-6892-6083"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Guiomar P\u00e9rez-Moreno","raw_affiliation_strings":["Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090697596","display_name":"Luis Miguel Ruiz-P\u00e9rez","orcid":"https://orcid.org/0000-0001-7681-4471","observed_orcids":["https://orcid.org/0000-0001-7681-4471"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis M. Ru\u00edz-P\u00e9rez","raw_affiliation_strings":["Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003166572","display_name":"Antonio E. Vidal","orcid":"https://orcid.org/0000-0001-9491-8901","observed_orcids":["https://orcid.org/0000-0001-9491-8901"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio E. Vidal","raw_affiliation_strings":["Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032762018","display_name":"Dolores Gonz\u00e1lez\u2010Pacanowska","orcid":"https://orcid.org/0000-0002-4303-5209","observed_orcids":["https://orcid.org/0000-0002-4303-5209"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210153588","display_name":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez - Neyra\"","ror":"https://ror.org/05ncvzk72","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Dolores Gonz\u00e1lez-Pacanowska","raw_affiliation_strings":["Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain. dgonzalez@ipb.csic.es","Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4303-5209","affiliations":[{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain. dgonzalez@ipb.csic.es","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]},{"raw_affiliation_string":"Instituto de Parasitolog\u00eda y Biomedicina \"L\u00f3pez-Neyra\", Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Parque Tecnol\u00f3gico de Ciencias de la Salud, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032762018"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210153588"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":{"value":3760,"currency":"USD","value_usd":3760},"fwci":0.6548,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.61513301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"77","issue":"8","first_page":"1645","last_page":"1660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutator-phenotype","display_name":"mutator phenotype","score":0.7419999837875366},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.972000002861023},{"id":"https://openalex.org/keywords/mitochondrial-mutagenesis","display_name":"mitochondrial mutagenesis","score":0.550000011920929},{"id":"https://openalex.org/keywords/nucleotide-salvage","display_name":"nucleotide salvage","score":0.6830000281333923},{"id":"https://openalex.org/keywords/thymidine","display_name":"thymidine","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dutpase","display_name":"dUTPase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/uracil-dna-glycosylase","display_name":"uracil-DNA glycosylase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thymidylate-biosynthesis","display_name":"thymidylate synthesis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6429812908172607},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6134817004203796},{"id":"https://openalex.org/C2779554091","wikidata":"https://www.wikidata.org/wiki/Q182990","display_name":"Uracil","level":3,"score":0.6003752946853638},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.5124219059944153},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5099085569381714},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5078907608985901},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4711921215057373},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.4687903821468353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44827577471733093},{"id":"https://openalex.org/C192396546","wikidata":"https://www.wikidata.org/wiki/Q413156","display_name":"DNA glycosylase","level":4,"score":0.43026259541511536},{"id":"https://openalex.org/C115960442","wikidata":"https://www.wikidata.org/wiki/Q769863","display_name":"Nuclear DNA","level":4,"score":0.42942890524864197},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.4113805890083313},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38561302423477173},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.37464433908462524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12836623191833496}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003845","descriptor_name":"Deoxycytosine Nucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003845","descriptor_name":"Deoxycytosine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003856","descriptor_name":"Deoxyuracil Nucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003856","descriptor_name":"Deoxyuracil Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011755","descriptor_name":"Pyrophosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011755","descriptor_name":"Pyrophosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013942","descriptor_name":"Thymine Nucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013942","descriptor_name":"Thymine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00018-019-03250-x","doi":"https://doi.org/10.1007/s00018-019-03250-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-019-03250-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-019-03250-x.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},{"id":"pmid:31377845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31377845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7162842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7162842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/213445","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/213445","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1007/s00018-019-03250-x","doi":"https://doi.org/10.1007/s00018-019-03250-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00018-019-03250-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00018-019-03250-x.pdf","source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4040936543","display_name":null,"funder_award_id":"SAF2016-79957-R","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G5773269393","display_name":null,"funder_award_id":"BIO 2059","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G6385750867","display_name":null,"funder_award_id":"BIO-199","funder_id":"https://openalex.org/F4320326754","funder_display_name":"Junta de Andaluc\u00eda"},{"id":"https://openalex.org/G7452302894","display_name":null,"funder_award_id":"SAF2016-79957-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964360771.pdf","grobid_xml":"https://content.openalex.org/works/W2964360771.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1444776473","https://openalex.org/W1604568473","https://openalex.org/W1864133223","https://openalex.org/W1907989564","https://openalex.org/W1965749659","https://openalex.org/W1968291566","https://openalex.org/W1970838318","https://openalex.org/W1971558110","https://openalex.org/W2004142027","https://openalex.org/W2005981645","https://openalex.org/W2014430898","https://openalex.org/W2020062312","https://openalex.org/W2029030998","https://openalex.org/W2037576550","https://openalex.org/W2061567285","https://openalex.org/W2068756510","https://openalex.org/W2084406358","https://openalex.org/W2087293292","https://openalex.org/W2098245177","https://openalex.org/W2101282905","https://openalex.org/W2115662328","https://openalex.org/W2115698515","https://openalex.org/W2118967129","https://openalex.org/W2122763703","https://openalex.org/W2125437101","https://openalex.org/W2130309413","https://openalex.org/W2138009128","https://openalex.org/W2138433742","https://openalex.org/W2139412554","https://openalex.org/W2139697903","https://openalex.org/W2144927195","https://openalex.org/W2155314424","https://openalex.org/W2162783612","https://openalex.org/W2164123369","https://openalex.org/W2164691877","https://openalex.org/W2171529184","https://openalex.org/W2268703273","https://openalex.org/W2272000266","https://openalex.org/W2313595807","https://openalex.org/W2416194960","https://openalex.org/W2473007552","https://openalex.org/W2495200680","https://openalex.org/W2495523890","https://openalex.org/W2511234198","https://openalex.org/W2584337371","https://openalex.org/W2584792145","https://openalex.org/W2600657762","https://openalex.org/W2614459201","https://openalex.org/W2739675422","https://openalex.org/W2781709225","https://openalex.org/W2800104946"],"related_works":["https://openalex.org/W2313595807","https://openalex.org/W7038162025","https://openalex.org/W3098648166","https://openalex.org/W7140420833","https://openalex.org/W2088326619","https://openalex.org/W3035548643","https://openalex.org/W2999691151","https://openalex.org/W2044480169","https://openalex.org/W1942986498","https://openalex.org/W2734622020"],"abstract_inverted_index":{"To":[0],"maintain":[1],"dNTP":[2,33,157],"pool":[3],"homeostasis":[4,63],"and":[5,11,16,40,67,71,97,101,159],"preserve":[6],"genetic":[7],"integrity":[8],"of":[9,18,64,85,92,129,143,155,162],"nuclear":[10,102],"mitochondrial":[12,100],"genomes,":[13],"the":[14,62,72,90,93,141,153,160],"synthesis":[15],"degradation":[17],"DNA":[19,94,106],"precursors":[20],"must":[21],"be":[22,109],"precisely":[23],"regulated.":[24],"Human":[25],"all-alpha":[26],"dCTP":[27,39,42],"pyrophosphatase":[28,34],"1":[29],"(DCTPP1)":[30],"is":[31,51,137],"a":[32,56,99,149],"with":[35,113],"high":[36],"affinity":[37],"for":[38,59,145],"5'-modified":[41],"derivatives,":[43],"but":[44],"its":[45],"contribution":[46],"to":[47,127],"overall":[48],"nucleotide":[49],"metabolism":[50],"controversial.":[52],"Here,":[53],"we":[54],"identify":[55],"central":[57],"role":[58],"DCTPP1":[60,136],"in":[61,78,87,140,152],"dCTP,":[65],"dTTP":[66],"dUTP.":[68],"Nucleotide":[69],"pools":[70],"dUTP/dTTP":[73],"ratio":[74],"are":[75,124],"severely":[76],"altered":[77],"DCTPP1-deficient":[79,122],"cells,":[80],"which":[81],"exhibit":[82],"an":[83],"accumulation":[84],"uracil":[86],"genomic":[88,163],"DNA,":[89],"activation":[91],"damage":[95,107],"response":[96],"both":[98],"hypermutator":[103],"phenotype.":[104],"Notably,":[105],"can":[108],"reverted":[110],"by":[111],"incubation":[112],"thymidine,":[114],"dUTPase":[115],"overexpression":[116],"or":[117],"uracil-DNA":[118],"glycosylase":[119],"suppression.":[120],"Moreover,":[121],"cells":[123],"highly":[125],"sensitive":[126],"down-regulation":[128],"nucleoside":[130],"salvage.":[131],"Our":[132],"data":[133],"indicate":[134],"that":[135],"crucially":[138],"involved":[139],"provision":[142],"dCMP":[144],"thymidylate":[146],"biosynthesis,":[147],"introducing":[148],"new":[150],"player":[151],"regulation":[154],"pyrimidine":[156],"levels":[158],"maintenance":[161],"integrity.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-08-13T00:00:00"}
