{"id":"https://openalex.org/W2964287590","doi":"https://doi.org/10.1177/1099800419863160","title":"Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia","display_name":"Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia","publication_year":2019,"publication_date":"2019-07-17","ids":{"openalex":"https://openalex.org/W2964287590","doi":"https://doi.org/10.1177/1099800419863160","mag":"2964287590","pmid":"https://pubmed.ncbi.nlm.nih.gov/31315444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6854429"},"language":"en","primary_location":{"id":"doi:10.1177/1099800419863160","doi":"https://doi.org/10.1177/1099800419863160","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1099800419863160","pdf_url":null,"source":{"id":"https://openalex.org/S144954103","display_name":"Biological Research For Nursing","issn_l":"1099-8004","issn":["1099-8004","1552-4175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Research For Nursing","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051061458","display_name":"Marilyn J. Hockenberry","orcid":"https://orcid.org/0000-0002-3456-3763","observed_orcids":["https://orcid.org/0000-0002-3456-3763"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marilyn J. Hockenberry","raw_affiliation_strings":["School of Nursing, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045127946","display_name":"Wei Pan","orcid":"https://orcid.org/0000-0003-2410-9935","observed_orcids":["https://orcid.org/0000-0003-2410-9935"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Pan","raw_affiliation_strings":["School of Nursing, Duke University, Durham, NC, USA"],"raw_orcid":"https://orcid.org/0000-0003-2410-9935","affiliations":[{"raw_affiliation_string":"School of Nursing, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006630838","display_name":"Michael E. Scheurer","orcid":"https://orcid.org/0000-0002-8379-6088","observed_orcids":["https://orcid.org/0000-0002-8379-6088"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael E. Scheurer","raw_affiliation_strings":["Baylor College of Medicine, Houston, TX, USA","Texas Children\u2019s Cancer and Hematology Centers, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Children\u2019s Cancer and Hematology Centers, Houston, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082305273","display_name":"Mary C. Hooke","orcid":"https://orcid.org/0000-0002-6137-9224","observed_orcids":["https://orcid.org/0000-0002-6137-9224"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary C. Hooke","raw_affiliation_strings":["School of Nursing, University of Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, University of Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075211978","display_name":"Olga A. Taylor","orcid":"https://orcid.org/0000-0002-5801-8639","observed_orcids":["https://orcid.org/0000-0002-5801-8639"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga Taylor","raw_affiliation_strings":["Baylor College of Medicine, Houston, TX, USA","Texas Children\u2019s Cancer and Hematology Centers, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Texas Children\u2019s Cancer and Hematology Centers, Houston, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110499045","display_name":"Kari M. Koerner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kari Koerner","raw_affiliation_strings":["College of Nursing, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022244089","display_name":"David W. Montgomery","orcid":"https://orcid.org/0000-0001-8112-8695","observed_orcids":["https://orcid.org/0000-0001-8112-8695"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Montgomery","raw_affiliation_strings":["College of Nursing, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057321500","display_name":"Susan A. Whitman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Whitman","raw_affiliation_strings":["College of Nursing, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018314699","display_name":"Pauline A. Mitby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210132437","display_name":"Children's Minnesota","ror":"https://ror.org/03d543283","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210132437"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline Mitby","raw_affiliation_strings":["Children\u2019s Minnesota, Minneapolis, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Minnesota, Minneapolis, MN, USA","institution_ids":["https://openalex.org/I4210132437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111597002","display_name":"Ida Marie Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ida Moore","raw_affiliation_strings":["College of Nursing, University of Arizona, Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Nursing, University of Arizona, Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051061458"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.0125,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75919907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"21","issue":"5","first_page":"458","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/symptom-trajectories","display_name":"symptom trajectories","score":0.6100000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8169999718666077},{"id":"https://openalex.org/keywords/f2-isoprostanes","display_name":"F2-isoprostanes","score":0.8949999809265137},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9890000224113464},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.8659999966621399},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pain","display_name":"pain","score":0.9890000224113464},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.9990000128746033},{"id":"https://openalex.org/keywords/symptom-clusters","display_name":"symptom clusters","score":0.7929999828338623},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6420000195503235},{"id":"https://openalex.org/keywords/pediatric-cancer-treatment","display_name":"childhood cancer treatment","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7218841314315796},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.6781885623931885},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.6404272317886353},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5706554651260376},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5557761788368225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5130795240402222},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45225784182548523},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35959187150001526},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3228027820587158},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12554728984832764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005221","descriptor_name":"Fatigue","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013577","descriptor_name":"Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D028441","descriptor_name":"F2-Isoprostanes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1177/1099800419863160","doi":"https://doi.org/10.1177/1099800419863160","is_oa":false,"landing_page_url":"https://doi.org/10.1177/1099800419863160","pdf_url":null,"source":{"id":"https://openalex.org/S144954103","display_name":"Biological Research For Nursing","issn_l":"1099-8004","issn":["1099-8004","1552-4175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Research For Nursing","raw_type":"journal-article"},{"id":"pmid:31315444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31315444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological research for nursing","raw_type":"Journal Article"},{"id":"pmh:oai:repository.arizona.edu:10150/634135","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1177/1099800419863160","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biological research for nursing","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G248810425","display_name":"Rational Combined Inhibition of NF-kB and EGFR to Optimize Lung Cancer Treatment","funder_award_id":"R01CA169338","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G604381740","display_name":null,"funder_award_id":"R01CA1693398","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1503411959","https://openalex.org/W1516892952","https://openalex.org/W1737014051","https://openalex.org/W1899606784","https://openalex.org/W1936038923","https://openalex.org/W1967231411","https://openalex.org/W1968332511","https://openalex.org/W1968855100","https://openalex.org/W1971120748","https://openalex.org/W1979713804","https://openalex.org/W1983743485","https://openalex.org/W1984153538","https://openalex.org/W1987036493","https://openalex.org/W1987235019","https://openalex.org/W1992158986","https://openalex.org/W1999142774","https://openalex.org/W2006872818","https://openalex.org/W2007290329","https://openalex.org/W2008095881","https://openalex.org/W2015029600","https://openalex.org/W2045940397","https://openalex.org/W2046211041","https://openalex.org/W2048519644","https://openalex.org/W2050141335","https://openalex.org/W2055197036","https://openalex.org/W2056647791","https://openalex.org/W2059565688","https://openalex.org/W2067623167","https://openalex.org/W2070046033","https://openalex.org/W2071666535","https://openalex.org/W2078965693","https://openalex.org/W2083811181","https://openalex.org/W2084479701","https://openalex.org/W2090133346","https://openalex.org/W2093975594","https://openalex.org/W2118338381","https://openalex.org/W2118742454","https://openalex.org/W2124190085","https://openalex.org/W2126544407","https://openalex.org/W2131347780","https://openalex.org/W2134118606","https://openalex.org/W2149612038","https://openalex.org/W2153929145","https://openalex.org/W2164331874","https://openalex.org/W2269689630","https://openalex.org/W2285051750","https://openalex.org/W2331874477","https://openalex.org/W2357979658","https://openalex.org/W2480680997","https://openalex.org/W2525738751","https://openalex.org/W2605889511","https://openalex.org/W2625148965","https://openalex.org/W2788238268","https://openalex.org/W2791794135","https://openalex.org/W2791814677","https://openalex.org/W4290414339"],"related_works":["https://openalex.org/W2014401817","https://openalex.org/W3010093524","https://openalex.org/W1983743485","https://openalex.org/W3206249278","https://openalex.org/W4365444095","https://openalex.org/W2802064441","https://openalex.org/W2605889511","https://openalex.org/W2584466550","https://openalex.org/W1974795636","https://openalex.org/W4416322225"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,101],"purpose":[2],"of":[3,11,28,61,74,104,129,148,157,165,206,214,224,234],"this":[4],"study":[5],"was":[6,36,54],"to":[7,38,152],"explore":[8],"the":[9,24,72,97,108,114,126,145,158,162,170,179,204,225],"influence":[10],"oxidative":[12,215],"stress":[13,216],"(F2-isoprostanes)":[14],"and":[15,52,65,71,81,94,120,131,209,217,237],"inflammatory":[16,218],"(interleukin":[17],"[IL]-8)":[18],"biomarkers":[19,106,159,171,186,219],"on":[20],"symptom":[21,48,109,221,235],"trajectories":[22],"during":[23,45,125,134,161,178,228],"first":[25],"18":[26],"months":[27,67,78],"childhood":[29],"leukemia":[30,207],"treatment.":[31,46,166],"METHOD:":[32],"A":[33,47],"repeated-measures":[34],"design":[35],"used":[37],"evaluate":[39],"symptoms":[40,177,193,202],"experienced":[41,190,201],"by":[42],"218":[43],"children":[44,150,200,240],"cluster":[49,110],"(fatigue,":[50],"pain,":[51],"nausea)":[53],"explored":[55],"over":[56,187,194],"four":[57,98],"time":[58,99,188],"periods:":[59],"initiation":[60],"post-induction":[62,69,127,163],"therapy,":[63,70,136],"4":[64],"8":[66],"into":[68],"beginning":[73],"maintenance":[75,135],"therapy":[76],"(12":[77],"postinduction).":[79],"F2-isoprostanes":[80],"IL-8":[82],"were":[83,111,123,140,172],"evaluated":[84],"in":[85,144,169],"cerebrospinal":[86],"fluid":[87],"(CSF)":[88],"samples":[89],"collected":[90],"at":[91,96,242],"baseline":[92],"(diagnosis)":[93],"then":[95],"periods.":[100],"longitudinal":[102,115,212],"relationships":[103,213],"these":[105],"with":[107,174,220],"examined":[112],"using":[113],"parallel":[116],"process.":[117],"RESULTS:":[118],"Pain":[119],"fatigue":[121],"levels":[122,156],"highest":[124],"phases":[128,147,164],"treatment":[130,208,229],"decreased":[132],"slightly":[133],"while":[137],"nausea":[138],"scores":[139],"relatively":[141],"stable.":[142],"Even":[143],"later":[146],"treatment,":[149],"continued":[151],"experience":[153],"symptoms.":[154,246],"CSF":[155],"increased":[160,185],"Early":[167],"increases":[168],"associated":[173],"more":[175,191],"severe":[176,192,245],"same":[180],"period;":[181],"patients":[182],"who":[183],"had":[184],"also":[189],"time.":[195],"CONCLUSIONS:":[196],"Findings":[197],"reveal":[198],"that":[199],"throughout":[203],"course":[205],"support":[210],"hypothesized":[211],"severity.":[222],"Activation":[223],"biomarker":[226],"pathways":[227],"may":[230],"explain":[231],"underlying":[232],"mechanisms":[233],"experiences":[236],"identify":[238],"which":[239],"are":[241],"risk":[243],"for":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2019-07-30T00:00:00"}
