{"id":"https://openalex.org/W2964227286","doi":"https://doi.org/10.1021/acs.jnatprod.8b00977","title":"High-Resolution Liquid Chromatography\u2013Mass Spectrometry-Based Metabolomic Discrimination of Citrus-Type Crude Drugs and Comparison with Nuclear Magnetic Resonance Spectroscopy-Based Metabolomics","display_name":"High-Resolution Liquid Chromatography\u2013Mass Spectrometry-Based Metabolomic Discrimination of Citrus-Type Crude Drugs and Comparison with Nuclear Magnetic Resonance Spectroscopy-Based Metabolomics","publication_year":2019,"publication_date":"2019-07-19","ids":{"openalex":"https://openalex.org/W2964227286","doi":"https://doi.org/10.1021/acs.jnatprod.8b00977","mag":"2964227286","pmid":"https://pubmed.ncbi.nlm.nih.gov/31322883"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jnatprod.8b00977","doi":"https://doi.org/10.1021/acs.jnatprod.8b00977","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.8b00977","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103156357","display_name":"Takashi Tsujimoto","orcid":"https://orcid.org/0000-0002-7897-0221","observed_orcids":["https://orcid.org/0000-0002-7897-0221"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Tsujimoto","raw_affiliation_strings":["Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7897-0221","affiliations":[{"raw_affiliation_string":"Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074662575","display_name":"Taichi Yoshitomi","orcid":"https://orcid.org/0000-0002-2296-0868","observed_orcids":["https://orcid.org/0000-0002-2296-0868"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taichi Yoshitomi","raw_affiliation_strings":["Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2296-0868","affiliations":[{"raw_affiliation_string":"Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101981161","display_name":"Takuro Maruyama","orcid":"https://orcid.org/0000-0002-6393-3989","observed_orcids":["https://orcid.org/0000-0002-6393-3989"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuro Maruyama","raw_affiliation_strings":["Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114888565","display_name":"Yutaka Yamamoto","orcid":"https://orcid.org/0000-0002-7555-6295","observed_orcids":["https://orcid.org/0000-0002-7555-6295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaka Yamamoto","raw_affiliation_strings":["Tochimoto Tenkaido Co., Ltd., Oniya Kaibara-cho, Tamba, Hyogo 669-3315, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tochimoto Tenkaido Co., Ltd., Oniya Kaibara-cho, Tamba, Hyogo 669-3315, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013921441","display_name":"Takashi Hakamatsuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Hakamatsuka","raw_affiliation_strings":["Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052647444","display_name":"Nahoko Uchiyama","orcid":"https://orcid.org/0009-0000-0977-2056","observed_orcids":["https://orcid.org/0009-0000-0977-2056"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Nahoko Uchiyama","raw_affiliation_strings":["Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan","institution_ids":["https://openalex.org/I4210151964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052647444"],"corresponding_institution_ids":["https://openalex.org/I4210151964"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.3256,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.86074502,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"82","issue":"8","first_page":"2116","last_page":"2123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.9193999767303467,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13128","display_name":"Chromatography in Natural Products","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavonoid-derivatives","display_name":"flavonoid derivatives","score":0.8220000267028809},{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/naringin","display_name":"naringin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/neohesperidin","display_name":"neohesperidin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.8100000023841858},{"id":"https://openalex.org/keywords/herbal-medicine-authentication","display_name":"herbal medicine authentication","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8140958547592163},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7450242638587952},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7022794485092163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5587838888168335},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.5565348863601685},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5551851391792297},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.4747614860534668},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3315272927284241},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11874616146087646},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002957","descriptor_name":"Citrus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jnatprod.8b00977","doi":"https://doi.org/10.1021/acs.jnatprod.8b00977","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.8b00977","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:31322883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31322883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2231846936","display_name":null,"funder_award_id":"JP18mk0101102j0101","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1967297189","https://openalex.org/W1984271638","https://openalex.org/W2014857819","https://openalex.org/W2015375793","https://openalex.org/W2032389654","https://openalex.org/W2044352382","https://openalex.org/W2045754603","https://openalex.org/W2047773167","https://openalex.org/W2071388901","https://openalex.org/W2085971050","https://openalex.org/W2150966505","https://openalex.org/W2213605612","https://openalex.org/W2265188196","https://openalex.org/W2269364781","https://openalex.org/W2395403721","https://openalex.org/W2752521700","https://openalex.org/W2796317323","https://openalex.org/W2806146607","https://openalex.org/W2809712621","https://openalex.org/W2888990708"],"related_works":["https://openalex.org/W2888990708","https://openalex.org/W3000531370","https://openalex.org/W3165397946","https://openalex.org/W2173641997","https://openalex.org/W4408864643","https://openalex.org/W2294978440","https://openalex.org/W2917963327","https://openalex.org/W2762352461","https://openalex.org/W4400336734","https://openalex.org/W2078627498"],"abstract_inverted_index":{"Five":[0],"Citrus":[1,103],"-type":[2,104],"crude":[3,105],"drugs":[4,106],"(40":[5],"samples)":[6],"were":[7,20,75,107,166],"classified":[8],"using":[9,168],"liquid":[10],"chromatography\u2013mass":[11],"spectrometry":[12],"(LC-MS)-based":[13],"metabolomics.":[14,126],"The":[15,127],"following":[16],"six":[17],"flavonoid":[18],"derivatives":[19],"identified":[21,77],"as":[22,78],"contributors":[23,115],"from":[24],"the":[25,97,102,110,114,118,138,141],"loading":[26],"plots":[27],"of":[28,131,137,160],"multivariate":[29],"analysis:":[30],"naringin":[31],"(":[32,36,40,44,48,53,61,66,72,88],"1":[33,89,119],"),":[34,38,42,46,50,63,68,74],"neohesperidin":[35],"2":[37],"neoeriocitrin":[39],"3":[41],"narirutin":[43],"9":[45],"hesperidin":[47],"10":[49],"and":[51,69,91,121,143],"3,5,6,7,8,3\u2032,4\u2032-heptamethoxyflavone":[52],"12":[54],").":[55],"Three":[56],"coumarin":[57],"derivatives,":[58],"namely,":[59],"meranzin":[60,64,70],"6":[62],"hydrate":[65],"7":[67],"glucoside":[71],"8":[73],"also":[76],"contributors.":[79],"Furthermore,":[80],"compared":[81],"with":[82,109,156],"our":[83],"previous":[84],"studies":[85],"on":[86],"proton":[87],"H)":[90],"13":[92,122],"C":[93,123],"NMR":[94,124,132,169],"spectroscopy-based":[95,125],"metabolomics,":[96],"present":[98],"study":[99],"revealed":[100],"that":[101,165],"distinguished":[108],"same":[111],"pattern;":[112],"however,":[113],"differed":[116],"between":[117],"H":[120],"high":[128,157],"dynamic":[129],"range":[130],"spectroscopy":[133],"provided":[134],"broad":[135],"coverage":[136],"metabolomes":[139],"including":[140],"primary":[142],"secondary":[144,154],"metabolites.":[145],"However,":[146],"LC-MS":[147],"appeared":[148],"to":[149],"be":[150],"superior":[151],"in":[152,163],"detecting":[153],"metabolites":[155],"sensitivity,":[158],"some":[159],"which":[161],"occurred":[162],"quantities":[164],"undetectable":[167],"spectroscopy.":[170]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-07-30T00:00:00"}
