{"id":"https://openalex.org/W2964223247","doi":"https://doi.org/10.1186/s40942-019-0167-x","title":"Diabetic macular edema treated with intravitreal aflibercept injection after treatment with other anti-VEGF agents (SWAP-TWO study): 6-month interim analysis","display_name":"Diabetic macular edema treated with intravitreal aflibercept injection after treatment with other anti-VEGF agents (SWAP-TWO study): 6-month interim analysis","publication_year":2019,"publication_date":"2019-07-22","ids":{"openalex":"https://openalex.org/W2964223247","doi":"https://doi.org/10.1186/s40942-019-0167-x","mag":"2964223247","pmid":"https://pubmed.ncbi.nlm.nih.gov/31367468","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6647124"},"language":"en","primary_location":{"id":"doi:10.1186/s40942-019-0167-x","doi":"https://doi.org/10.1186/s40942-019-0167-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40942-019-0167-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40942-019-0167-x.pdf","source":{"id":"https://openalex.org/S4210178320","display_name":"International Journal of Retina and Vitreous","issn_l":"2056-9920","issn":["2056-9920"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Retina and Vitreous","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s40942-019-0167-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036549169","display_name":"Amy S Babiuch","orcid":"https://orcid.org/0000-0002-0782-2694","observed_orcids":["https://orcid.org/0000-0002-0782-2694"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy S. Babiuch","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086184962","display_name":"Thais F. Conti","orcid":"https://orcid.org/0000-0003-4729-0706","observed_orcids":["https://orcid.org/0000-0003-4729-0706"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thais F. Conti","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000397377","display_name":"Felipe F. Conti","orcid":"https://orcid.org/0000-0002-5387-1462","observed_orcids":["https://orcid.org/0000-0002-5387-1462"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Felipe F. Conti","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","3Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"3Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008785020","display_name":"Fabiana Queiroga de Paula Araujo Silva","orcid":"https://orcid.org/0000-0002-2402-6374","observed_orcids":["https://orcid.org/0000-0002-2402-6374"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabiana Q. Silva","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068534216","display_name":"Aleksandra V Rachitskaya","orcid":"https://orcid.org/0000-0001-5545-9474","observed_orcids":["https://orcid.org/0000-0001-5545-9474"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aleksandra Rachitskaya","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024126113","display_name":"Alex Yuan","orcid":"https://orcid.org/0000-0003-0191-8035","observed_orcids":["https://orcid.org/0000-0003-0191-8035"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Yuan","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085213833","display_name":"Rishi P. Singh","orcid":"https://orcid.org/0000-0001-5859-8162","observed_orcids":["https://orcid.org/0000-0001-5859-8162"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rishi P. Singh","raw_affiliation_strings":["1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","4Case Western Reserve University, Cleveland, USA","Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA"],"raw_orcid":"https://orcid.org/0000-0001-5859-8162","affiliations":[{"raw_affiliation_string":"1Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH 44195 USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"2Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"4Case Western Reserve University, Cleveland, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, i32, Cleveland, OH, 44195, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5085213833"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I58956616"],"apc_list":{"value":809,"currency":"USD","value_usd":809},"apc_paid":{"value":809,"currency":"USD","value_usd":809},"fwci":3.68,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.92412287,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"17","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-macular-edema","display_name":"diabetic macular edema","score":1.0},{"id":"https://openalex.org/keywords/aflibercept","display_name":"aflibercept","score":0.9679999947547913},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.8970000147819519},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.5799999833106995},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/central-subfield-thickness","display_name":"central subfield thickness","score":0.7929999828338623},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/optical-coherence-tomography-angiography","display_name":"optical coherence tomography angiography","score":0.6370000243186951},{"id":"https://openalex.org/keywords/nonproliferative-diabetic-retinopathy","display_name":"non-proliferative diabetic retinopathy","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C2778749236","wikidata":"https://www.wikidata.org/wiki/Q4689286","display_name":"Aflibercept","level":4,"score":0.9648182392120361},{"id":"https://openalex.org/C2985127711","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic macular edema","level":4,"score":0.7480249404907227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6441951394081116},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5699386596679688},{"id":"https://openalex.org/C99821215","wikidata":"https://www.wikidata.org/wiki/Q1136583","display_name":"Swap (finance)","level":2,"score":0.5670232176780701},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.553745448589325},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.5191880464553833},{"id":"https://openalex.org/C2776957806","wikidata":"https://www.wikidata.org/wiki/Q4895105","display_name":"Interim","level":2,"score":0.4859956204891205},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.46681997179985046},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.28050145506858826},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.24940764904022217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15745314955711365},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.15675461292266846},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.12009057402610779},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0866437554359436},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.055559366941452026},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.043582260608673096},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s40942-019-0167-x","doi":"https://doi.org/10.1186/s40942-019-0167-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40942-019-0167-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40942-019-0167-x.pdf","source":{"id":"https://openalex.org/S4210178320","display_name":"International Journal of Retina and Vitreous","issn_l":"2056-9920","issn":["2056-9920"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Retina and Vitreous","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6647124","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6647124","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Retina Vitreous","raw_type":"Text"},{"id":"pmid:31367468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31367468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of retina and vitreous","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ba2bc3582a1b4399b6a8364bcda8c1a1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ba2bc3582a1b4399b6a8364bcda8c1a1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Retina and Vitreous, Vol 5, Iss 1, Pp 1-8 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40942-019-0167-x","doi":"https://doi.org/10.1186/s40942-019-0167-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40942-019-0167-x","pdf_url":"https://link.springer.com/content/pdf/10.1186/s40942-019-0167-x.pdf","source":{"id":"https://openalex.org/S4210178320","display_name":"International Journal of Retina and Vitreous","issn_l":"2056-9920","issn":["2056-9920"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","norway-1","oarl","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Retina and Vitreous","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964223247.pdf","grobid_xml":"https://content.openalex.org/works/W2964223247.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1786299986","https://openalex.org/W1816809098","https://openalex.org/W1966206262","https://openalex.org/W1973545783","https://openalex.org/W1975028551","https://openalex.org/W1981489086","https://openalex.org/W1982179488","https://openalex.org/W1988101251","https://openalex.org/W2026418978","https://openalex.org/W2036712095","https://openalex.org/W2050020278","https://openalex.org/W2058312539","https://openalex.org/W2065679638","https://openalex.org/W2068859423","https://openalex.org/W2092619571","https://openalex.org/W2093044616","https://openalex.org/W2102463203","https://openalex.org/W2103965396","https://openalex.org/W2121784482","https://openalex.org/W2123123877","https://openalex.org/W2123241447","https://openalex.org/W2127013658","https://openalex.org/W2161279821","https://openalex.org/W2177844192","https://openalex.org/W2251610588","https://openalex.org/W2263239427","https://openalex.org/W2289075344","https://openalex.org/W2330075117","https://openalex.org/W2333158451","https://openalex.org/W2399777411","https://openalex.org/W2466029418","https://openalex.org/W2473184791","https://openalex.org/W2497936582","https://openalex.org/W2518773623","https://openalex.org/W2528599938","https://openalex.org/W2531696070","https://openalex.org/W2551774110","https://openalex.org/W2554093589","https://openalex.org/W2579924150","https://openalex.org/W2590312224","https://openalex.org/W2590420971","https://openalex.org/W2593827895","https://openalex.org/W2594873712","https://openalex.org/W2602805105","https://openalex.org/W2607266578","https://openalex.org/W2616361514","https://openalex.org/W2692245162","https://openalex.org/W2754479756","https://openalex.org/W2765838647","https://openalex.org/W2767766431","https://openalex.org/W2768132506","https://openalex.org/W2789784671","https://openalex.org/W2883839415","https://openalex.org/W2890581815"],"related_works":["https://openalex.org/W4255326728","https://openalex.org/W2263239427","https://openalex.org/W2593827895","https://openalex.org/W2590420971","https://openalex.org/W2594873712","https://openalex.org/W7164843222","https://openalex.org/W2791305698","https://openalex.org/W2803449795","https://openalex.org/W2913577870","https://openalex.org/W3011240125"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Diabetic":[2,263],"macular":[3],"edema":[4],"(DME)":[5],"is":[6,39],"an":[7],"important":[8],"cause":[9],"of":[10,26,30,36,44,79,101,114,131,262,282],"vision":[11],"loss":[12],"and":[13,17,159,192],"despite":[14],"the":[15,42,132,228],"anatomical":[16],"functional":[18],"improvement":[19],"achieved":[20],"with":[21,46,50,74,76,83,242],"treatment,":[22,208],"there":[23],"are":[24,55],"reports":[25],"persistent":[27],"DME":[28,47,75],"regardless":[29],"continuous":[31],"anti-VEGF":[32,52,81,244],"therapy.":[33],"The":[34],"purpose":[35],"this":[37],"study":[38,69],"to":[40,57,173,194,249],"examine":[41],"effect":[43],"patients":[45,72],"previously":[48],"treated":[49],"other":[51],"agents":[53],"who":[54,246],"transitioned":[56,248],"intravitreal":[58],"aflibercept":[59],"(IAI)":[60],"on":[61,184],"a":[62,77,89,110,127],"fixed":[63,111],"dosing":[64,112],"regimen.":[65],"Methods":[66],"This":[67],"prospective":[68],"included":[70,150],"20":[71],"presenting":[73],"history":[78],"previous":[80],"treatment":[82],"ranibizumab":[84],"or":[85,274],"bevacizumab.":[86],"Patients":[87,241],"received":[88],"2":[90,115],"mg":[91,116],"(0.05":[92],"mL)":[93],"IAI":[94,117,174,207,250],"every":[95,119],"4":[96],"weeks":[97,121],"until":[98],"no":[99],"evidence":[100],"fluid":[102],"by":[103,109,146],"optical":[104],"coherence":[105],"tomography":[106,164],"(OCT)":[107],"followed":[108],"schedule":[113],"once":[118],"8":[120],"through":[122,256],"24":[123],"months.":[124,258],"There":[125],"was":[126,188],"pre-planned":[128],"interim":[129],"analysis":[130,221],"mean":[133,151],"absolute":[134],"change":[135,152],"from":[136,153,214,225],"baseline":[137,154,187,215,226],"central":[138,181],"foveal":[139,229],"thickness":[140,183],"at":[141,186,198],"month":[142],"6":[143,204,257],"as":[144],"measured":[145],"OCT.":[147],"Secondary":[148],"outcomes":[149],"in":[155,227,232,268],"ETDRS":[156],"visual":[157],"acuity":[158],"anatomic":[160,254],"parameters.":[161],"Optical":[162],"Coherence":[163],"angiography":[165],"(OCTA)":[166],"capillary":[167],"perfusion":[168],"density":[169],"(CPD)":[170],"after":[171,206],"transitioning":[172],"therapy":[175,245,251],"were":[176,247],"also":[177],"reported.":[178],"Results":[179],"Average":[180],"subfield":[182],"OCT":[185],"419.7":[189],"\u00b1":[190,196],"92.0":[191],"improved":[193],"303.8":[195],"73.1":[197],"6-months":[199],"(p":[200,216,237],"<":[201],"0.001).":[202],"At":[203],"months":[205],"BCVA":[209],"increased":[210],"+":[211],"1.5":[212],"letters":[213],"=":[217,238],"0.38).":[218],"OCTA":[219],"CPD":[220],"revealed":[222,252],"significant":[223,253],"increase":[224],"avascular":[230],"zone":[231],"non-proliferative":[233],"diabetic":[234],"retinopathy":[235],"group":[236],"0.02).":[239],"Conclusions":[240],"prior":[243],"improvements":[255],"Trial":[259,277],"registration":[260,278],"Treatment":[261],"Macular":[264],"Edema":[265],"With":[266,272],"Aflibercept":[267],"Subjects":[269],"Previously":[270],"Treated":[271],"Ranibizumab":[273],"Bevacizumab":[275],"(SwapTwo),":[276],"number:":[279],"NCT02559180.":[280],"Date":[281],"registration:":[283],"September":[284],"24,":[285],"2015.":[286],"https://clinicaltrials.gov/ct2/show/NCT02559180":[287]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-07-30T00:00:00"}