{"id":"https://openalex.org/W2964199853","doi":"https://doi.org/10.1016/j.aquaculture.2019.734336","title":"CRISPR/Cas9-mediated myostatin disruption enhances muscle mass in the olive flounder Paralichthys olivaceus","display_name":"CRISPR/Cas9-mediated myostatin disruption enhances muscle mass in the olive flounder Paralichthys olivaceus","publication_year":2019,"publication_date":"2019-07-23","ids":{"openalex":"https://openalex.org/W2964199853","doi":"https://doi.org/10.1016/j.aquaculture.2019.734336","mag":"2964199853"},"language":"en","primary_location":{"id":"doi:10.1016/j.aquaculture.2019.734336","doi":"https://doi.org/10.1016/j.aquaculture.2019.734336","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.aquaculture.2019.734336","pdf_url":null,"source":{"id":"https://openalex.org/S104261359","display_name":"Aquaculture","issn_l":"0044-8486","issn":["0044-8486","1873-5622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquaculture","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018223339","display_name":"Julan Kim","orcid":"https://orcid.org/0000-0003-1964-9486","observed_orcids":["https://orcid.org/0000-0003-1964-9486"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Julan Kim","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086907938","display_name":"Ja Young Cho","orcid":"https://orcid.org/0000-0002-4549-7570","observed_orcids":["https://orcid.org/0000-0002-4549-7570"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ja Young Cho","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100665644","display_name":"Ju-Won Kim","orcid":"https://orcid.org/0000-0002-4220-711X","observed_orcids":["https://orcid.org/0000-0002-4220-711X"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ju-Won Kim","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100678504","display_name":"Hyunchul Kim","orcid":"https://orcid.org/0000-0002-9322-725X","observed_orcids":["https://orcid.org/0000-0002-9322-725X"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun-Chul Kim","raw_affiliation_strings":["Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022707218","display_name":"Jae Koo Noh","orcid":"https://orcid.org/0000-0002-9010-6225","observed_orcids":["https://orcid.org/0000-0002-9010-6225"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Koo Noh","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101676162","display_name":"Young\u2010Ok Kim","orcid":"https://orcid.org/0000-0001-8719-0764","observed_orcids":["https://orcid.org/0000-0001-8719-0764"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young-Ok Kim","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109317386","display_name":"Hyung-Kyu Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Kyu Hwang","raw_affiliation_strings":["Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100452354","display_name":"Woo\u2010Jin Kim","orcid":"https://orcid.org/0000-0002-0921-2312","observed_orcids":["https://orcid.org/0000-0002-0921-2312"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo-Jin Kim","raw_affiliation_strings":["Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetics and Breeding Research Center, National Institute of Fisheries Science, Geoje 53334, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065315410","display_name":"Sang\u2010Yeob Yeo","orcid":"https://orcid.org/0000-0002-1697-5641","observed_orcids":["https://orcid.org/0000-0002-1697-5641"]},"institutions":[{"id":"https://openalex.org/I145808223","display_name":"Hanbat National University","ror":"https://ror.org/00x514t95","country_code":"KR","type":"education","lineage":["https://openalex.org/I145808223"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang-Yeob Yeo","raw_affiliation_strings":["Division of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon 34158, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon 34158, Republic of Korea","institution_ids":["https://openalex.org/I145808223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023623367","display_name":"Cheul Min An","orcid":"https://orcid.org/0000-0002-5033-2498","observed_orcids":["https://orcid.org/0000-0002-5033-2498"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Cheul Min An","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077283311","display_name":"Jung Youn Park","orcid":"https://orcid.org/0000-0002-6948-6059","observed_orcids":["https://orcid.org/0000-0002-6948-6059"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung Youn Park","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074985971","display_name":"Hee Jeong Kong","orcid":"https://orcid.org/0000-0001-6524-6544","observed_orcids":["https://orcid.org/0000-0001-6524-6544"]},"institutions":[{"id":"https://openalex.org/I4210118585","display_name":"National Institute of Fisheries Science","ror":"https://ror.org/02chzeh21","country_code":"KR","type":"government","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210090853","https://openalex.org/I4210118585"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hee Jeong Kong","raw_affiliation_strings":["Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea","institution_ids":["https://openalex.org/I4210118585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074985971"],"corresponding_institution_ids":["https://openalex.org/I4210118585"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":2.344,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.90104976,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"512","issue":null,"first_page":"734336","last_page":"734336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.35600000619888306,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.04569999873638153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin","display_name":"myostatin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/olive-flounder","display_name":"Paralichthys olivaceus","score":1.0},{"id":"https://openalex.org/keywords/crispr-cas9-genome-editing","display_name":"CRISPR/Cas9 genome editing","score":0.8759999871253967},{"id":"https://openalex.org/keywords/muscle-mass","display_name":"muscle mass","score":0.765999972820282},{"id":"https://openalex.org/keywords/muscle-hyperplasia","display_name":"muscle hyperplasia","score":0.8659999966621399},{"id":"https://openalex.org/keywords/myogenic-regulatory-factors","display_name":"myogenic regulatory factors","score":0.7720000147819519},{"id":"https://openalex.org/keywords/myogenin","display_name":"myogenin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myf5","display_name":"Myf5","score":0.9959999918937683},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.6039999723434448},{"id":"https://openalex.org/keywords/fish-breeding","display_name":"fish breeding","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.939024031162262},{"id":"https://openalex.org/C2776459645","wikidata":"https://www.wikidata.org/wiki/Q3011327","display_name":"Paralichthys","level":3,"score":0.7557176351547241},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.5406560301780701},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.48567473888397217},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47296351194381714},{"id":"https://openalex.org/C2778463287","wikidata":"https://www.wikidata.org/wiki/Q18029725","display_name":"MYF5","level":5,"score":0.4708656370639801},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46075400710105896},{"id":"https://openalex.org/C2776533291","wikidata":"https://www.wikidata.org/wiki/Q1322753","display_name":"Olive flounder","level":3,"score":0.45951712131500244},{"id":"https://openalex.org/C73247094","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Transgenesis","level":5,"score":0.43321698904037476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32200461626052856},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.26680535078048706},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.09273412823677063},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.08439689874649048},{"id":"https://openalex.org/C2994278967","wikidata":"https://www.wikidata.org/wiki/Q7314318","display_name":"Reproductive technology","level":4,"score":0.07403674721717834},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.aquaculture.2019.734336","doi":"https://doi.org/10.1016/j.aquaculture.2019.734336","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.aquaculture.2019.734336","pdf_url":null,"source":{"id":"https://openalex.org/S104261359","display_name":"Aquaculture","issn_l":"0044-8486","issn":["0044-8486","1873-5622"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquaculture","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.6875,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G673938616","display_name":null,"funder_award_id":"R2019018","funder_id":"https://openalex.org/F4320325374","funder_display_name":"National Institute of Fisheries Science"}],"funders":[{"id":"https://openalex.org/F4320323155","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750"},{"id":"https://openalex.org/F4320325374","display_name":"National Institute of Fisheries Science","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W61071114","https://openalex.org/W122852190","https://openalex.org/W1500385339","https://openalex.org/W1608084731","https://openalex.org/W1749960549","https://openalex.org/W1966610449","https://openalex.org/W1971501722","https://openalex.org/W1975819842","https://openalex.org/W1991580130","https://openalex.org/W1995175641","https://openalex.org/W1999624391","https://openalex.org/W2002354353","https://openalex.org/W2009885803","https://openalex.org/W2011227099","https://openalex.org/W2012437499","https://openalex.org/W2023407519","https://openalex.org/W2029688958","https://openalex.org/W2041602192","https://openalex.org/W2041693077","https://openalex.org/W2046081464","https://openalex.org/W2051094259","https://openalex.org/W2053079324","https://openalex.org/W2058087168","https://openalex.org/W2069740469","https://openalex.org/W2074905529","https://openalex.org/W2079826520","https://openalex.org/W2080042397","https://openalex.org/W2092820431","https://openalex.org/W2097464871","https://openalex.org/W2130122556","https://openalex.org/W2134406094","https://openalex.org/W2143263348","https://openalex.org/W2155726340","https://openalex.org/W2166877291","https://openalex.org/W2182456467","https://openalex.org/W2298105180","https://openalex.org/W2302024196","https://openalex.org/W2560662711","https://openalex.org/W2565555627","https://openalex.org/W2594626182","https://openalex.org/W2605718767","https://openalex.org/W2741956075","https://openalex.org/W2764165019","https://openalex.org/W2766221680","https://openalex.org/W2805377061","https://openalex.org/W2896388444","https://openalex.org/W2936014793","https://openalex.org/W4205867254","https://openalex.org/W4206030987","https://openalex.org/W4245053291","https://openalex.org/W6602528195","https://openalex.org/W6697650511","https://openalex.org/W6760934711"],"related_works":["https://openalex.org/W4396238302","https://openalex.org/W4379259002","https://openalex.org/W7214463329","https://openalex.org/W2753521341","https://openalex.org/W3177231177","https://openalex.org/W4414420944","https://openalex.org/W3036241083","https://openalex.org/W2741956075","https://openalex.org/W2805377061","https://openalex.org/W4225264229"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}