{"id":"https://openalex.org/W2964168407","doi":"https://doi.org/10.1371/journal.pntd.0007560","title":"Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes","display_name":"Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes","publication_year":2019,"publication_date":"2019-07-22","ids":{"openalex":"https://openalex.org/W2964168407","doi":"https://doi.org/10.1371/journal.pntd.0007560","mag":"2964168407","pmid":"https://pubmed.ncbi.nlm.nih.gov/31329594","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6675120"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0007560","doi":"https://doi.org/10.1371/journal.pntd.0007560","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0007560","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007560&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007560&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040669871","display_name":"Emir Salas\u2010Sarduy","orcid":"https://orcid.org/0000-0002-9709-7552","observed_orcids":["https://orcid.org/0000-0002-9709-7552"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Emir Salas-Sarduy","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054325712","display_name":"Lionel Ur\u00e1n Landaburu","orcid":"https://orcid.org/0000-0002-6202-9779","observed_orcids":["https://orcid.org/0000-0002-6202-9779"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Lionel Ur\u00e1n Landaburu","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-6202-9779","affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078684766","display_name":"Adriana K. Carmona","orcid":"https://orcid.org/0000-0003-3311-5456","observed_orcids":["https://orcid.org/0000-0003-3311-5456"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana K. Carmona","raw_affiliation_strings":["Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3311-5456","affiliations":[{"raw_affiliation_string":"Departamento de Biof\u00edsica, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111671234","display_name":"Juan Jos\u00e9 Cazzulo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Juan Jos\u00e9 Cazzulo","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077801542","display_name":"Fern\u00e1n Ag\u00fcero","orcid":"https://orcid.org/0000-0003-1331-5741","observed_orcids":["https://orcid.org/0000-0003-1331-5741"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Fern\u00e1n Ag\u00fcero","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062306850","display_name":"Vanina E. \u00c1lvarez","orcid":"https://orcid.org/0000-0002-9890-6980","observed_orcids":["https://orcid.org/0000-0002-9890-6980"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Vanina E. Alvarez","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080532244","display_name":"Gabriela T. Niemirowicz","orcid":"https://orcid.org/0000-0002-1286-5832","observed_orcids":["https://orcid.org/0000-0002-1286-5832"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I228664971","display_name":"National University of General San Mart\u00edn","ror":"https://ror.org/00v29jp57","country_code":"AR","type":"education","lineage":["https://openalex.org/I228664971"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Gabriela T. Niemirowicz","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina"],"raw_orcid":"https://orcid.org/0000-0002-1286-5832","affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas \"Dr. Rodolfo Ugalde\"-Universidad Nacional de San Mart\u00edn-CONICET, San Mart\u00edn, B1650HMP, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080532244"],"corresponding_institution_ids":["https://openalex.org/I151201029","https://openalex.org/I228664971"],"apc_list":{"value":2350,"currency":"USD","value_usd":2350},"apc_paid":{"value":2350,"currency":"USD","value_usd":2350},"fwci":0.571,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.68082547,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"7","first_page":"e0007560","last_page":"e0007560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.8619999885559082},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":1.0},{"id":"https://openalex.org/keywords/trypanosomatids","display_name":"trypanosomatids","score":0.765999972820282},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.6980000138282776},{"id":"https://openalex.org/keywords/human-african-trypanosomiasis","display_name":"sleeping sickness","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":1.0}],"concepts":[{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6799846291542053},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.6683593988418579},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.5669084787368774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5573062896728516},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.5348630547523499},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.5347354412078857},{"id":"https://openalex.org/C2911037157","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic agent","level":2,"score":0.5311777591705322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5181064009666443},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4311652183532715},{"id":"https://openalex.org/C2781421772","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic","level":2,"score":0.41412511467933655},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1723167896270752},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1706828474998474},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058069","descriptor_name":"Neglected Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058069","descriptor_name":"Neglected Diseases","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pntd.0007560","doi":"https://doi.org/10.1371/journal.pntd.0007560","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0007560","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007560&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5631635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6675120","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6675120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6675120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmid:31329594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31329594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:543d4537552f4bd390a287dae8164735","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/543d4537552f4bd390a287dae8164735","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 13, Iss 7, p e0007560 (2019)","raw_type":"article"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/153405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/153405","pdf_url":null,"source":{"id":"https://openalex.org/S4306401400","display_name":"Conicet","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210104196","host_organization_name":"Centro Cient\u00edfico Tecnol\u00f3gico - Nordeste","host_organization_lineage":["https://openalex.org/I4210104196"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.60692/99f9g-n4h48","doi":"https://doi.org/10.60692/99f9g-n4h48","is_oa":true,"landing_page_url":"https://doi.org/10.60692/99f9g-n4h48","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/d13gh-pxv79","doi":"https://doi.org/10.60692/d13gh-pxv79","is_oa":true,"landing_page_url":"https://doi.org/10.60692/d13gh-pxv79","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0007560","doi":"https://doi.org/10.1371/journal.pntd.0007560","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0007560","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007560&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1073546646","display_name":null,"funder_award_id":"PIP 112-201301-00303","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G316576037","display_name":"Reposicionamiento de compuestos bioactivos para el tratamiendo de la Enfermedad de Chagas y laEnfermedad del Sue\u00f1o","funder_award_id":"PICTO-2013-0067","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G360452579","display_name":null,"funder_award_id":"PICT2014","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G5698231462","display_name":"Metalocarboxipeptidasas de la familia M32 en tripanosom\u00e1tidos.","funder_award_id":"11220130100303CO","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"},{"id":"https://openalex.org/G7378882120","display_name":null,"funder_award_id":"CONICET","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G8290971105","display_name":"Metalocarboxipeptidasas de la familia M32 en tripanosom\u00e1tidos.","funder_award_id":"PICT-2014-3510","funder_id":"https://openalex.org/F4320334832","funder_display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica"},{"id":"https://openalex.org/G849230359","display_name":null,"funder_award_id":"PICT 2014","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320334832","display_name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","ror":"https://ror.org/03stxzb56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964168407.pdf","grobid_xml":"https://content.openalex.org/works/W2964168407.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1544898357","https://openalex.org/W1567730256","https://openalex.org/W1964789691","https://openalex.org/W1980481704","https://openalex.org/W1989806335","https://openalex.org/W1991001144","https://openalex.org/W1995865180","https://openalex.org/W1998954104","https://openalex.org/W2004390050","https://openalex.org/W2008000894","https://openalex.org/W2016076109","https://openalex.org/W2028911490","https://openalex.org/W2035555452","https://openalex.org/W2036388292","https://openalex.org/W2036732421","https://openalex.org/W2045284802","https://openalex.org/W2046276421","https://openalex.org/W2053195279","https://openalex.org/W2061800084","https://openalex.org/W2067442540","https://openalex.org/W2078611842","https://openalex.org/W2089966673","https://openalex.org/W2090171663","https://openalex.org/W2099308584","https://openalex.org/W2100207828","https://openalex.org/W2119461394","https://openalex.org/W2128879247","https://openalex.org/W2131012576","https://openalex.org/W2135945518","https://openalex.org/W2141746615","https://openalex.org/W2145546477","https://openalex.org/W2158427156","https://openalex.org/W2169678694","https://openalex.org/W2306757767","https://openalex.org/W2334184216","https://openalex.org/W2474522617","https://openalex.org/W2498938096","https://openalex.org/W2559772075","https://openalex.org/W2583561343","https://openalex.org/W2589958932","https://openalex.org/W2617445492","https://openalex.org/W2747403209","https://openalex.org/W2755085907","https://openalex.org/W2774316038","https://openalex.org/W2775643792","https://openalex.org/W2801696527","https://openalex.org/W2903988300","https://openalex.org/W2950406612","https://openalex.org/W4366064573"],"related_works":["https://openalex.org/W2498938096","https://openalex.org/W2774316038","https://openalex.org/W2046276421","https://openalex.org/W2042175198","https://openalex.org/W3184929626","https://openalex.org/W3216454242","https://openalex.org/W2617445492","https://openalex.org/W2952855967","https://openalex.org/W2091046429","https://openalex.org/W2033083241"],"abstract_inverted_index":{"Enzymes":[0],"of":[1,28,68,71,127,134,197],"the":[2,25,66,87,125,132,138,167,190],"M32":[3,49,79,186,222],"family":[4,196],"are":[5,37],"Zn-dependent":[6],"metallocarboxypeptidases":[7],"(MCPs)":[8],"widely":[9],"distributed":[10],"among":[11],"prokaryotic":[12],"organisms":[13],"and":[14,22,31,41,75,90,106,122,171,199,203,217],"just":[15],"a":[16,69,119,143,179,209],"few":[17],"eukaryotes":[18],"including":[19],"Trypanosoma":[20,23],"brucei":[21],"cruzi,":[24],"causative":[26],"agents":[27],"sleeping":[29],"sickness":[30],"Chagas":[32],"disease,":[33],"respectively.":[34],"These":[35],"enzymes":[36,80],"absent":[38],"in":[39,166],"humans":[40],"several":[42],"functions":[43],"have":[44,55],"been":[45,56],"proposed":[46],"for":[47,60,73,137,150,162,194],"trypanosomatid":[48,78,225],"MCPs.":[50,187],"However,":[51],"no":[52],"synthetic":[53],"inhibitors":[54,72,147],"reported":[57,193],"so":[58],"far":[59],"these":[61],"enzymes.":[62,154],"Here,":[63],"we":[64,112],"present":[65],"identification":[67],"set":[70],"TcMCP-1":[74],"TbMCP-1":[76,165],"(two":[77],"sharing":[81],"71%":[82],"protein":[83],"sequence":[84],"identity)":[85],"from":[86,224],"GlaxoSmithKline":[88],"HAT":[89],"CHAGAS":[91],"chemical":[92,219],"boxes;":[93],"two":[94],"collections":[95],"grouping":[96],"404":[97],"compounds":[98],"with":[99],"high":[100],"antiparasitic":[101],"potency,":[102],"drug-likeness,":[103],"structural":[104],"diversity":[105],"scientific":[107],"novelty.":[108],"For":[109],"this":[110,195],"purpose,":[111],"adapted":[113],"continuous":[114],"fluorescent":[115],"enzymatic":[116],"assays":[117],"to":[118,185,207,213],"medium-throughput":[120],"format":[121],"carried":[123],"out":[124],"screening":[126],"both":[128,153],"collections,":[129],"followed":[130],"by":[131],"construction":[133],"dose-response":[135],"curves":[136],"most":[139],"promising":[140],"hits.":[141],"As":[142],"result,":[144],"30":[145],"micromolar-range":[146],"were":[148],"discovered":[149],"one":[151],"or":[152],"The":[155],"best":[156],"hit,":[157],"TCMDC-143620,":[158],"showed":[159],"sub-micromolar":[160],"affinity":[161],"TcMCP-1,":[163],"inhibited":[164],"low":[168],"micromolar":[169],"range":[170],"was":[172],"inactive":[173],"against":[174],"angiotensin":[175],"I-converting":[176],"enzyme":[177],"(ACE),":[178],"potential":[180],"mammalian":[181],"off-target":[182],"structurally":[183],"related":[184],"This":[188],"is":[189],"first":[191],"inhibitor":[192],"MCPs":[198,223],"considering":[200],"its":[201],"potency":[202],"specificity,":[204],"TCMDC-143620":[205],"seems":[206],"be":[208],"promissory":[210],"starting":[211],"point":[212],"develop":[214],"more":[215],"specific":[216],"potent":[218],"tools":[220],"targeting":[221],"parasites.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-30T00:00:00"}
