{"id":"https://openalex.org/W2964050601","doi":"https://doi.org/10.3389/fphys.2019.00887","title":"Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation","display_name":"Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation","publication_year":2019,"publication_date":"2019-07-23","ids":{"openalex":"https://openalex.org/W2964050601","doi":"https://doi.org/10.3389/fphys.2019.00887","mag":"2964050601","pmid":"https://pubmed.ncbi.nlm.nih.gov/31396094","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6664290"},"language":"en","primary_location":{"id":"doi:10.3389/fphys.2019.00887","doi":"https://doi.org/10.3389/fphys.2019.00887","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.00887","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00887/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00887/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021831966","display_name":"Rishi R. Dhingra","orcid":"https://orcid.org/0000-0002-4684-5215","observed_orcids":["https://orcid.org/0000-0002-4684-5215"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Rishi R. Dhingra","raw_affiliation_strings":["Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077116148","display_name":"Werner Issao Furuya","orcid":"https://orcid.org/0000-0002-7244-2313","observed_orcids":["https://orcid.org/0000-0002-7244-2313"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Werner I. Furuya","raw_affiliation_strings":["Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048192413","display_name":"Tara G. Bautista","orcid":"https://orcid.org/0000-0001-6514-7685","observed_orcids":["https://orcid.org/0000-0001-6514-7685"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tara G. Bautista","raw_affiliation_strings":["Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011262817","display_name":"Thomas E. Dick","orcid":"https://orcid.org/0000-0003-3287-8566","observed_orcids":["https://orcid.org/0000-0003-3287-8566"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Dick","raw_affiliation_strings":["Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Critical Care and Sleep, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013355300","display_name":"Roberto F. Gal\u00e1n","orcid":"https://orcid.org/0000-0003-1426-1917","observed_orcids":["https://orcid.org/0000-0003-1426-1917"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto F. Gal\u00e1n","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH, United States","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021487531","display_name":"Mathias Dutschmann","orcid":"https://orcid.org/0000-0002-0692-746X","observed_orcids":["https://orcid.org/0000-0002-0692-746X"]},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Mathias Dutschmann","raw_affiliation_strings":["Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Systems Neurophysiology, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021487531","https://openalex.org/A5021831966"],"corresponding_institution_ids":["https://openalex.org/I242743682"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.9715,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.96274118,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"887","last_page":"887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/respiratory-central-pattern-generator","display_name":"respiratory central pattern generator","score":0.9769999980926514},{"id":"https://openalex.org/keywords/prebotzinger-complex","display_name":"pre-B\u00f6tzinger complex","score":0.9300000071525574},{"id":"https://openalex.org/keywords/botzinger-complex","display_name":"B\u00f6tzinger complex","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.9020000100135803},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bicuculline","display_name":"bicuculline","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gabaergic-disinhibition","display_name":"GABAergic disinhibition","score":0.6600000262260437},{"id":"https://openalex.org/keywords/phase-synchronization","display_name":"phase synchronization","score":0.8700000047683716},{"id":"https://openalex.org/keywords/phrenic-nerve","display_name":"phrenic nerve","score":0.7710000276565552},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"vagus nerve","score":0.9850000143051147},{"id":"https://openalex.org/keywords/excitation-inhibition-balance","display_name":"excitation-inhibition balance","score":0.8209999799728394},{"id":"https://openalex.org/keywords/respiratory-rhythm","display_name":"respiratory rhythm","score":0.531000018119812},{"id":"https://openalex.org/keywords/brainstem-respiratory-network","display_name":"brainstem respiratory network","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.7771764993667603},{"id":"https://openalex.org/C2776599063","wikidata":"https://www.wikidata.org/wiki/Q5282244","display_name":"Disinhibition","level":2,"score":0.7595607042312622},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.6466119289398193},{"id":"https://openalex.org/C2778110749","wikidata":"https://www.wikidata.org/wiki/Q189033","display_name":"Medulla oblongata","level":3,"score":0.6119158864021301},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6013519167900085},{"id":"https://openalex.org/C2780763569","wikidata":"https://www.wikidata.org/wiki/Q3639734","display_name":"Bicuculline","level":4,"score":0.565359890460968},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.551175057888031},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.4418239891529083},{"id":"https://openalex.org/C169453685","wikidata":"https://www.wikidata.org/wiki/Q1054066","display_name":"Central pattern generator","level":3,"score":0.43664997816085815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3761441111564636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37483853101730347},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35532477498054504},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.30759137868881226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27724897861480713},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.26699864864349365},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.1436346471309662},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.07757642865180969},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06404149532318115}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fphys.2019.00887","doi":"https://doi.org/10.3389/fphys.2019.00887","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.00887","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00887/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6664290","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6664290","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Physiol","raw_type":"Text"},{"id":"pmid:31396094","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31396094","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in physiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:42ff993a9e5f4cb7b8d18f0918d716ed","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/42ff993a9e5f4cb7b8d18f0918d716ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Physiology, Vol 10 (2019)","raw_type":"article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/250097","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/250097","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3389/fphys.2019.00887","doi":"https://doi.org/10.3389/fphys.2019.00887","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphys.2019.00887","pdf_url":"https://www.frontiersin.org/articles/10.3389/fphys.2019.00887/pdf","source":{"id":"https://openalex.org/S52732750","display_name":"Frontiers in Physiology","issn_l":"1664-042X","issn":["1664-042X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3798422207","display_name":"Inhibition of sensory relay mechanisms","funder_award_id":"DP170104861","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2964050601.pdf","grobid_xml":"https://content.openalex.org/works/W2964050601.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1481508412","https://openalex.org/W1558119278","https://openalex.org/W1559719156","https://openalex.org/W1824021067","https://openalex.org/W1840672965","https://openalex.org/W1902151435","https://openalex.org/W1926041874","https://openalex.org/W1974464826","https://openalex.org/W1976173385","https://openalex.org/W1978157032","https://openalex.org/W1988314059","https://openalex.org/W1990257628","https://openalex.org/W1991186988","https://openalex.org/W1991282027","https://openalex.org/W1998145664","https://openalex.org/W2006704818","https://openalex.org/W2008230320","https://openalex.org/W2009942054","https://openalex.org/W2016151414","https://openalex.org/W2016624327","https://openalex.org/W2025872245","https://openalex.org/W2037688283","https://openalex.org/W2037828425","https://openalex.org/W2037960408","https://openalex.org/W2041660793","https://openalex.org/W2044629430","https://openalex.org/W2049944651","https://openalex.org/W2054379597","https://openalex.org/W2057705491","https://openalex.org/W2058416358","https://openalex.org/W2063630842","https://openalex.org/W2063812431","https://openalex.org/W2064257383","https://openalex.org/W2069194632","https://openalex.org/W2072740770","https://openalex.org/W2074475623","https://openalex.org/W2076847916","https://openalex.org/W2079104859","https://openalex.org/W2079926066","https://openalex.org/W2082405299","https://openalex.org/W2084797167","https://openalex.org/W2090054612","https://openalex.org/W2099968607","https://openalex.org/W2100438317","https://openalex.org/W2106700142","https://openalex.org/W2107979694","https://openalex.org/W2110756853","https://openalex.org/W2124360135","https://openalex.org/W2124865189","https://openalex.org/W2126852048","https://openalex.org/W2145932718","https://openalex.org/W2148200514","https://openalex.org/W2148399999","https://openalex.org/W2155158475","https://openalex.org/W2156302632","https://openalex.org/W2158003471","https://openalex.org/W2159749299","https://openalex.org/W2167793278","https://openalex.org/W2196025130","https://openalex.org/W2243427678","https://openalex.org/W2279395264","https://openalex.org/W2289996588","https://openalex.org/W2320983896","https://openalex.org/W2346625225","https://openalex.org/W2505292440","https://openalex.org/W2521545344","https://openalex.org/W2567136007","https://openalex.org/W2801312539","https://openalex.org/W2885991550","https://openalex.org/W2907054455","https://openalex.org/W2943101695","https://openalex.org/W4210983112","https://openalex.org/W4211230056","https://openalex.org/W4321428406"],"related_works":["https://openalex.org/W3175699259","https://openalex.org/W2124865189","https://openalex.org/W2943101695","https://openalex.org/W2346625225","https://openalex.org/W2108088033","https://openalex.org/W1484834707","https://openalex.org/W2126855527","https://openalex.org/W2109005882","https://openalex.org/W7097965098","https://openalex.org/W1967116367"],"abstract_inverted_index":{"The":[0,196],"core":[1,34,214],"circuit":[2,35],"of":[3,49,75,83,105,116,129,142,164,179,193,199,229],"the":[4,13,18,23,30,50,55,60,69,76,87,106,130,140,143,162,186,191,200,205,212,236],"respiratory":[5,70,89,131,144,201,230,242],"central":[6],"pattern":[7,71,90,132,158,202,245],"generator":[8],"(rCPG)":[9],"is":[10,36],"located":[11],"in":[12,17,134,139],"ventrolateral":[14],"medulla,":[15],"especially":[16],"pre-B\u00f6tzinger":[19],"complex":[20,26],"(pre-B\u00f6tC)":[21],"and":[22,93,97,101,149,169,209,244],"neighboring":[24],"B\u00f6tzinger":[25],"(B\u00f6tC).":[27],"To":[28,153],"test":[29],"hypothesis":[31],"that":[32,176,204,226,239],"this":[33],"embedded":[37],"within":[38],"an":[39],"anatomically":[40],"distributed":[41],"pattern-generating":[42],"network,":[43],"we":[44,85,160],"investigated":[45],"whether":[46],"local":[47,177],"disinhibition":[48,74,115,178],"nucleus":[51],"tractus":[52],"solitarius":[53],"(NTS),":[54],"K\u00f6lliker-Fuse":[56],"nuclei":[57],"(KFn),":[58],"or":[59,120],"midbrain":[61,187],"periaqueductal":[62],"gray":[63],"area":[64],"(PAG)":[65],"can":[66],"similarly":[67],"affect":[68],"compared":[72],"to":[73],"pre-B\u00f6tC/B\u00f6tC":[77],"core.":[78],"In":[79],"arterially-perfused":[80],"brainstem":[81,181],"preparations":[82],"rats,":[84],"recorded":[86],"three-phase":[88],"(inspiration,":[91],"post-inspiration":[92],"late-expiration)":[94],"from":[95,211],"phrenic":[96,168],"vagal":[98,170],"nerves":[99],"before":[100],"after":[102],"bilateral":[103],"microinjections":[104],"GABA(A)R":[107],"antagonist":[108],"bicuculline":[109],"(50":[110],"nl,":[111],"10":[112],"mM).":[113],"Local":[114],"either":[117],"NTS,":[118],"pre-B\u00f6tC/B\u00f6tC,":[119],"KFn,":[121],"but":[122,184,215],"not":[123,185,217],"PAG,":[124,188],"triggered":[125],"qualitatively":[126],"similar":[127],"disruptions":[128],"resulting":[133],"a":[135],"highly":[136],"significant":[137],"increase":[138],"variability":[141],"cycle":[145],"length,":[146],"including":[147],"inspiratory":[148],"expiratory":[150],"phase":[151,165,194],"durations.":[152],"quantitatively":[154],"analyze":[155],"these":[156],"motor":[157,171],"perturbations,":[159],"measured":[161],"strength":[163,192],"synchronization":[166],"between":[167],"outputs.":[172],"This":[173],"analysis":[174],"showed":[175],"all":[180],"target":[182],"nuclei,":[183],"significantly":[189],"decreased":[190],"synchronization.":[195],"convergent":[197],"perturbations":[198],"suggest":[203,225],"rCPG":[206],"expands":[207],"rostrally":[208],"dorsally":[210],"designated":[213],"does":[216],"include":[218],"higher":[219],"mid-brain":[220],"structures.":[221],"Our":[222],"data":[223],"also":[224],"excitation-inhibition":[227],"balance":[228],"network":[231,237],"synaptic":[232],"interactions":[233],"critically":[234],"determines":[235],"dynamics":[238],"underlie":[240],"vital":[241],"rhythm":[243],"formation.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2019-07-30T00:00:00"}