{"id":"https://openalex.org/W2963956782","doi":"https://doi.org/10.1093/hmg/ddz163","title":"Genes, pathways and risk prediction in Alzheimer\u2019s disease","display_name":"Genes, pathways and risk prediction in Alzheimer\u2019s disease","publication_year":2019,"publication_date":"2019-07-19","ids":{"openalex":"https://openalex.org/W2963956782","doi":"https://doi.org/10.1093/hmg/ddz163","mag":"2963956782","pmid":"https://pubmed.ncbi.nlm.nih.gov/31332445"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/ddz163","doi":"https://doi.org/10.1093/hmg/ddz163","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddz163","pdf_url":"https://academic.oup.com/hmg/article-pdf/28/R2/R235/31081055/ddz163.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/hmg/article-pdf/28/R2/R235/31081055/ddz163.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423","observed_orcids":["https://orcid.org/0000-0002-3122-0423"]},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John Hardy","raw_affiliation_strings":["Reta Lilla Research Laboratories, Department of Molecular Neuroscience, University College London Institute of Neurology and UK Dementia Research Institute, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reta Lilla Research Laboratories, Department of Molecular Neuroscience, University College London Institute of Neurology and UK Dementia Research Institute, University College London, London, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027152344","display_name":"Valentina Escott\u2010Price","orcid":"https://orcid.org/0000-0003-1784-5483","observed_orcids":["https://orcid.org/0000-0003-1784-5483"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Valentina Escott-Price","raw_affiliation_strings":["Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences and Dementia Research Institute, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences and Dementia Research Institute, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020514779"],"corresponding_institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I4405260083","https://openalex.org/I45129253"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.3656,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.33180026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"28","issue":"R2","first_page":"R235","last_page":"R240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/late-onset-alzheimer-s-disease","display_name":"late-onset Alzheimer's disease","score":0.8830000162124634},{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.734000027179718},{"id":"https://openalex.org/keywords/lipid-metabolism-genes","display_name":"lipid metabolism genes","score":0.6740000247955322},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.9459999799728394},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.6549999713897705},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.8072761297225952},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5435339212417603},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5024538040161133},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4600612223148346},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.45088091492652893},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4420246183872223},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4314281642436981},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41805386543273926},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4122084975242615},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36519378423690796},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34711402654647827},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16824975609779358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16388928890228271},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.1373474895954132},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053766","descriptor_name":"Presenilin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/hmg/ddz163","doi":"https://doi.org/10.1093/hmg/ddz163","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddz163","pdf_url":"https://academic.oup.com/hmg/article-pdf/28/R2/R235/31081055/ddz163.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:31332445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31332445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"},{"id":"pmh:oai:http://orca.cardiff.ac.uk:125194","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/125194/1/Genes%2C%20pathways%20and%20risk.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/125194/1/Genes%2C%20pathways%20and%20risk.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:125194","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/125194/1/Genes%2C%20pathways%20and%20risk.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/125194/1/Genes%2C%20pathways%20and%20risk.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10084254","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10084254/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Human Molecular Genetics , 28 (R2) R235-R240. (2019)","raw_type":"Article"},{"id":"pmh:oai:http://orca-dev.cardiff.ac.uk:125194","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/125194/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/hmg/ddz163","doi":"https://doi.org/10.1093/hmg/ddz163","is_oa":true,"landing_page_url":"https://doi.org/10.1093/hmg/ddz163","pdf_url":"https://academic.oup.com/hmg/article-pdf/28/R2/R235/31081055/ddz163.pdf","source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1295437841","display_name":"UK Dementias Platform","funder_award_id":"MR/L023784/2","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G241875673","display_name":"Using genetic variability in whole transcriptome expression in cells and tissues to understand the pathogenesis of Parkinson's and Alzheimer's disease","funder_award_id":"MR/K01417X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5805295236","display_name":"MRC Centre for Neuropsychiatric Genetics and Genomics","funder_award_id":"MR/L010305/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5898053883","display_name":"Risk and Modifying factors in Fronto Temporal Dementia","funder_award_id":"MR/L501542/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7979393549","display_name":null,"funder_award_id":"G-1307","funder_id":"https://openalex.org/F4320320021","funder_display_name":"Parkinson's UK"},{"id":"https://openalex.org/G8173906395","display_name":"Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis - The International IBM Consortium Genetic Study","funder_award_id":"MR/J004758/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320320021","display_name":"Parkinson's UK","ror":"https://ror.org/02417p338"},{"id":"https://openalex.org/F4320320320","display_name":"Rosetrees Trust","ror":"https://ror.org/04e3zg361"},{"id":"https://openalex.org/F4320329730","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963956782.pdf"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1482580692","https://openalex.org/W1585083630","https://openalex.org/W1672729420","https://openalex.org/W1928655587","https://openalex.org/W1974300727","https://openalex.org/W1979004999","https://openalex.org/W1990700240","https://openalex.org/W2003958717","https://openalex.org/W2010192073","https://openalex.org/W2011041653","https://openalex.org/W2016787780","https://openalex.org/W2030176492","https://openalex.org/W2034937783","https://openalex.org/W2041789591","https://openalex.org/W2047565527","https://openalex.org/W2050252352","https://openalex.org/W2058880763","https://openalex.org/W2061953902","https://openalex.org/W2063575312","https://openalex.org/W2070137740","https://openalex.org/W2078524519","https://openalex.org/W2097750046","https://openalex.org/W2123971761","https://openalex.org/W2124490243","https://openalex.org/W2128613449","https://openalex.org/W2133541776","https://openalex.org/W2138657570","https://openalex.org/W2139400673","https://openalex.org/W2148641246","https://openalex.org/W2152119060","https://openalex.org/W2154755614","https://openalex.org/W2160264227","https://openalex.org/W2164765564","https://openalex.org/W2166511841","https://openalex.org/W2169892526","https://openalex.org/W2193207784","https://openalex.org/W2265799967","https://openalex.org/W2289147497","https://openalex.org/W2302218937","https://openalex.org/W2329336071","https://openalex.org/W2592518050","https://openalex.org/W2600084629","https://openalex.org/W2603633491","https://openalex.org/W2620116489","https://openalex.org/W2634812549","https://openalex.org/W2638580840","https://openalex.org/W2774903942","https://openalex.org/W2789746048","https://openalex.org/W2792688330","https://openalex.org/W2838757955","https://openalex.org/W2894984069","https://openalex.org/W2914435310","https://openalex.org/W2914685835","https://openalex.org/W2914697151","https://openalex.org/W2917906486","https://openalex.org/W2950828186","https://openalex.org/W3214092816","https://openalex.org/W6648098093","https://openalex.org/W6758996357"],"related_works":["https://openalex.org/W4411931961","https://openalex.org/W4206844764","https://openalex.org/W2101818220","https://openalex.org/W3197290161","https://openalex.org/W2355760844","https://openalex.org/W2986755863","https://openalex.org/W2054654417","https://openalex.org/W4244964014","https://openalex.org/W1965151684","https://openalex.org/W2562127498"],"abstract_inverted_index":{"The":[0,48],"failure":[1],"of":[2,16,21,24,53,80,83,133,139],"recent":[3,73],"clinical":[4],"trials":[5],"in":[6,40,77,92,115,130,141],"Alzheimer's":[7],"disease":[8,42,55,86,116,140],"has":[9],"highlighted":[10],"the":[11,14,22,25,41,54,72,81,120,131,142],"need":[12],"for":[13],"development":[15],"a":[17,29,65,112],"more":[18,66],"complete":[19],"understanding":[20],"pathogenesis":[23],"disorder":[26],"and":[27,103,117],"also":[28,118],"belief":[30],"that":[31,105,122],"therapies":[32],"may":[33,110],"only":[34],"work":[35],"if":[36],"given":[37],"very":[38],"early":[39,50],"process":[43],"before":[44],"overt":[45],"symptoms":[46],"occur.":[47],"rare,":[49],"onset":[51,85],"forms":[52],"are":[56],"all":[57],"caused":[58],"by":[59,89,97],"mutations":[60],"which":[61],"make":[62],"amyloid":[63,106],"deposition":[64],"likely":[67],"event.":[68],"Here":[69],"we":[70],"discuss":[71,100],"data":[74],"showing":[75],"that,":[76],"contrast,":[78],"much":[79],"risk":[82,138],"late":[84],"is":[87],"encoded":[88,96],"loci":[90],"involved":[91],"lipid":[93],"metabolism":[94],"and/or":[95],"microglia.":[98],"We":[99],"these":[101],"finding":[102],"suggest":[104],"induced":[107],"membrane":[108],"damage":[109],"be":[111],"key":[113],"factor":[114],"review":[119],"evidence":[121],"genome":[123],"wide":[124],"genetic":[125],"analysis":[126],"can":[127],"substantially":[128],"help":[129],"prediction":[132],"those":[134],"individuals":[135],"at":[136],"high":[137],"general":[143],"population.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}