{"id":"https://openalex.org/W2963942762","doi":"https://doi.org/10.1007/s11912-019-0819-x","title":"How to Choose the Best Treatment and Testing for Chronic Lymphocytic Leukemia in the Tsunami of New Treatment Options","display_name":"How to Choose the Best Treatment and Testing for Chronic Lymphocytic Leukemia in the Tsunami of New Treatment Options","publication_year":2019,"publication_date":"2019-07-20","ids":{"openalex":"https://openalex.org/W2963942762","doi":"https://doi.org/10.1007/s11912-019-0819-x","mag":"2963942762","pmid":"https://pubmed.ncbi.nlm.nih.gov/31327069"},"language":"en","primary_location":{"id":"doi:10.1007/s11912-019-0819-x","doi":"https://doi.org/10.1007/s11912-019-0819-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11912-019-0819-x","pdf_url":null,"source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064100640","display_name":"Cecilia C.S. Yeung","orcid":"https://orcid.org/0000-0001-6799-2022","observed_orcids":["https://orcid.org/0000-0001-6799-2022"]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cecilia C. S. Yeung","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, G71910, Seattle, WA, 98109, USA. cyeung@fredhutch.org","Department of Pathology, University of Washington, Seattle, WA, USA. cyeung@fredhutch.org","Seattle Cancer Care Alliance, Seattle, WA, USA. cyeung@fredhutch.org","Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA","Department of Pathology, University of Washington, Seattle, USA","Seattle Cancer Care Alliance, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, G71910, Seattle, WA, 98109, USA. cyeung@fredhutch.org","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, WA, USA. cyeung@fredhutch.org","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA, USA. cyeung@fredhutch.org","institution_ids":["https://openalex.org/I1332479046"]},{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, USA","institution_ids":["https://openalex.org/I1332479046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051296565","display_name":"Mazyar S. Shadman","orcid":"https://orcid.org/0000-0002-3365-6562","observed_orcids":["https://orcid.org/0000-0002-3365-6562"]},"institutions":[{"id":"https://openalex.org/I1332479046","display_name":"Seattle Cancer Care Alliance","ror":"https://ror.org/03jq88n71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1332479046"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mazyar Shadman","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, G71910, Seattle, WA, 98109, USA","Department of Medicine, University of Washington, Seattle, WA, USA","Seattle Cancer Care Alliance, Seattle, WA, USA","Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA","Department of Medicine, University of Washington, Seattle, USA","Seattle Cancer Care Alliance, Seattle, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, G71910, Seattle, WA, 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, WA, USA","institution_ids":["https://openalex.org/I1332479046"]},{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Medicine, University of Washington, Seattle, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Cancer Care Alliance, Seattle, USA","institution_ids":["https://openalex.org/I1332479046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064100640"],"corresponding_institution_ids":["https://openalex.org/I1332479046","https://openalex.org/I201448701","https://openalex.org/I4210089486"],"apc_list":{"value":3760,"currency":"USD","value_usd":3760},"apc_paid":null,"fwci":0.3433,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.33591261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"8","first_page":"74","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":1.0},{"id":"https://openalex.org/keywords/treatment-selection","display_name":"treatment selection","score":0.7129999995231628},{"id":"https://openalex.org/keywords/b-cell-receptor-inhibitor","display_name":"B-cell receptor inhibitor","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ibrutinib","display_name":"ibrutinib","score":0.9760000109672546},{"id":"https://openalex.org/keywords/idelalisib","display_name":"idelalisib","score":0.9890000224113464},{"id":"https://openalex.org/keywords/duvelisib","display_name":"duvelisib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.9049999713897705},{"id":"https://openalex.org/keywords/obinutuzumab","display_name":"obinutuzumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ofatumumab","display_name":"ofatumumab","score":1.0},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/relapsed-cll","display_name":"relapsed CLL","score":0.6790000200271606},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.5249999761581421},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.8679999709129333},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C2779260929","wikidata":"https://www.wikidata.org/wiki/Q5908266","display_name":"Idelalisib","level":5,"score":0.9347629547119141},{"id":"https://openalex.org/C2778714382","wikidata":"https://www.wikidata.org/wiki/Q410656","display_name":"Ofatumumab","level":4,"score":0.910099983215332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8850395679473877},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.8798874616622925},{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.850212037563324},{"id":"https://openalex.org/C2777607594","wikidata":"https://www.wikidata.org/wiki/Q389496","display_name":"Obinutuzumab","level":4,"score":0.829871654510498},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.8040158152580261},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7621698379516602},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.6311758756637573},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4935711622238159},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.3909264802932739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3864676356315613},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3782190978527069},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015451","descriptor_name":"Leukemia, Lymphocytic, Chronic, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059786","descriptor_name":"Abnormal Karyotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11912-019-0819-x","doi":"https://doi.org/10.1007/s11912-019-0819-x","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11912-019-0819-x","pdf_url":null,"source":{"id":"https://openalex.org/S83206718","display_name":"Current Oncology Reports","issn_l":"1523-3790","issn":["1523-3790","1534-6269"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Oncology Reports","raw_type":"journal-article"},{"id":"pmid:31327069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31327069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current oncology reports","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W8702881","https://openalex.org/W966445620","https://openalex.org/W1026324699","https://openalex.org/W1938828834","https://openalex.org/W1957256977","https://openalex.org/W1965851569","https://openalex.org/W1992857313","https://openalex.org/W2008785727","https://openalex.org/W2015299436","https://openalex.org/W2018169128","https://openalex.org/W2027648780","https://openalex.org/W2027971058","https://openalex.org/W2038394968","https://openalex.org/W2040168338","https://openalex.org/W2054943699","https://openalex.org/W2066564017","https://openalex.org/W2070487917","https://openalex.org/W2081412549","https://openalex.org/W2086323499","https://openalex.org/W2108206643","https://openalex.org/W2120319857","https://openalex.org/W2131078883","https://openalex.org/W2140052555","https://openalex.org/W2140880663","https://openalex.org/W2171771895","https://openalex.org/W2192121806","https://openalex.org/W2233614027","https://openalex.org/W2275847773","https://openalex.org/W2295348655","https://openalex.org/W2314283002","https://openalex.org/W2316021978","https://openalex.org/W2318933236","https://openalex.org/W2337485820","https://openalex.org/W2369297677","https://openalex.org/W2464849601","https://openalex.org/W2467680685","https://openalex.org/W2468012994","https://openalex.org/W2469555883","https://openalex.org/W2547701137","https://openalex.org/W2570052812","https://openalex.org/W2594646846","https://openalex.org/W2595396118","https://openalex.org/W2611243937","https://openalex.org/W2623762297","https://openalex.org/W2735691291","https://openalex.org/W2773047201","https://openalex.org/W2774522106","https://openalex.org/W2787863642","https://openalex.org/W2787916641","https://openalex.org/W2790385276","https://openalex.org/W2790448887","https://openalex.org/W2791493878","https://openalex.org/W2792666902","https://openalex.org/W2800186514","https://openalex.org/W2806285688","https://openalex.org/W2872810444","https://openalex.org/W2895287765","https://openalex.org/W2900467419","https://openalex.org/W2900949333","https://openalex.org/W2901026782","https://openalex.org/W2902460563","https://openalex.org/W2902484351","https://openalex.org/W2902706178","https://openalex.org/W2908507733","https://openalex.org/W2909134655","https://openalex.org/W2909557351","https://openalex.org/W2910563260","https://openalex.org/W2911188335","https://openalex.org/W3157403146"],"related_works":["https://openalex.org/W2915642235","https://openalex.org/W2326768532","https://openalex.org/W3160398752","https://openalex.org/W2105336098","https://openalex.org/W3049649894","https://openalex.org/W3164227135","https://openalex.org/W4223936077","https://openalex.org/W1954369205","https://openalex.org/W2059384145","https://openalex.org/W2586959316"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}
