{"id":"https://openalex.org/W2963873198","doi":"https://doi.org/10.1200/jop.18.00781","title":"Mental Health Comorbidities and Elevated Risk of Opioid Use in Elderly Breast Cancer Survivors Using Adjuvant Endocrine Treatments","display_name":"Mental Health Comorbidities and Elevated Risk of Opioid Use in Elderly Breast Cancer Survivors Using Adjuvant Endocrine Treatments","publication_year":2019,"publication_date":"2019-07-19","ids":{"openalex":"https://openalex.org/W2963873198","doi":"https://doi.org/10.1200/jop.18.00781","mag":"2963873198","pmid":"https://pubmed.ncbi.nlm.nih.gov/31322988"},"language":"en","primary_location":{"id":"doi:10.1200/jop.18.00781","doi":"https://doi.org/10.1200/jop.18.00781","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jop.18.00781","pdf_url":null,"source":{"id":"https://openalex.org/S131102849","display_name":"Journal of Oncology Practice","issn_l":"1554-7477","issn":["1554-7477","1935-469X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Practice","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053637761","display_name":"Raj A. Desai","orcid":"https://orcid.org/0000-0003-3010-820X","observed_orcids":["https://orcid.org/0000-0003-3010-820X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj Desai","raw_affiliation_strings":["University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046182172","display_name":"FABIAN T. CAMACHO","orcid":"https://orcid.org/0000-0002-4878-0283","observed_orcids":["https://orcid.org/0000-0002-4878-0283"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabian Camacho","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014838410","display_name":"Xi Tan","orcid":"https://orcid.org/0000-0002-2409-5927","observed_orcids":["https://orcid.org/0000-0002-2409-5927"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Tan","raw_affiliation_strings":["West Virginia University, Morgantown, WV"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"West Virginia University, Morgantown, WV","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012289666","display_name":"Virginia Townsend LeBaron","orcid":"https://orcid.org/0000-0002-1299-4730","observed_orcids":["https://orcid.org/0000-0002-1299-4730"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia LeBaron","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040731215","display_name":"Leslie J. Blackhall","orcid":"https://orcid.org/0000-0002-7536-1658","observed_orcids":["https://orcid.org/0000-0002-7536-1658"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Blackhall","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015605411","display_name":"Rajesh Balkrishnan","orcid":"https://orcid.org/0000-0001-9363-9257","observed_orcids":["https://orcid.org/0000-0001-9363-9257"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Balkrishnan","raw_affiliation_strings":["University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4591,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.83496328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"15","issue":"9","first_page":"e777","last_page":"e786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.4196999967098236,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.3280999958515167,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.1776999980211258,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-use","display_name":"opioid use","score":0.9010000228881836},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.8389999866485596},{"id":"https://openalex.org/keywords/breast-cancer-survivors","display_name":"breast cancer survivors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7369999885559082},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":1.0},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8420000076293945},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.890999972820282},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9112054705619812},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7337671518325806},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.6958182454109192},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6484224200248718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6106377840042114},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49258166551589966},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4877546429634094},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.48683279752731323},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.452594518661499},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4360084533691406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40218162536621094},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.354294091463089},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3185793459415436},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2195320427417755},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000073116","descriptor_name":"Cancer Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008603","descriptor_name":"Mental Health","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015897","descriptor_name":"Comorbidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018931","descriptor_name":"Antineoplastic Agents, Hormonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062486","descriptor_name":"Public Health Surveillance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jop.18.00781","doi":"https://doi.org/10.1200/jop.18.00781","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jop.18.00781","pdf_url":null,"source":{"id":"https://openalex.org/S131102849","display_name":"Journal of Oncology Practice","issn_l":"1554-7477","issn":["1554-7477","1935-469X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Oncology Practice","raw_type":"journal-article"},{"id":"pmid:31322988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31322988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of oncology practice","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W958581459","https://openalex.org/W1508694356","https://openalex.org/W1988363879","https://openalex.org/W2000991311","https://openalex.org/W2006100396","https://openalex.org/W2023708885","https://openalex.org/W2036193982","https://openalex.org/W2048565444","https://openalex.org/W2051866975","https://openalex.org/W2096511721","https://openalex.org/W2110108956","https://openalex.org/W2112678077","https://openalex.org/W2115395024","https://openalex.org/W2134822987","https://openalex.org/W2152488600","https://openalex.org/W2163003999","https://openalex.org/W2165411984","https://openalex.org/W2166341909","https://openalex.org/W2171965579","https://openalex.org/W2193066862","https://openalex.org/W2257519579","https://openalex.org/W2261932613","https://openalex.org/W2283559195","https://openalex.org/W2330979849","https://openalex.org/W2495724511","https://openalex.org/W2547811651","https://openalex.org/W2563793610","https://openalex.org/W2611404165","https://openalex.org/W2628416581","https://openalex.org/W2735812822","https://openalex.org/W2739081735","https://openalex.org/W2757888794","https://openalex.org/W2781525129","https://openalex.org/W2791194683","https://openalex.org/W2805805580"],"related_works":["https://openalex.org/W2906403890","https://openalex.org/W4411235543","https://openalex.org/W2955204110","https://openalex.org/W4311566300","https://openalex.org/W7131622596","https://openalex.org/W4403384505","https://openalex.org/W4379280760","https://openalex.org/W3030175759","https://openalex.org/W2765533219","https://openalex.org/W3084640602"],"abstract_inverted_index":{"PURPOSE:":[0],"Prolonged":[1],"opioid":[2,19,193,253],"use":[3,20,194,254],"is":[4],"common":[5],"and":[6,62,106,117,140,178,255],"associated":[7,218],"with":[8,89,123,200,219],"lower":[9],"survival":[10,47,142],"rates":[11],"in":[12,21,42,48,112,198,226,244],"breast":[13,23,98,155,245],"cancer":[14,24,156,246],"survivors.":[15],"We":[16,119],"explored":[17],"whether":[18,121],"elderly":[22],"survivors":[25,157,247],"using":[26],"adjuvant":[27],"endocrine":[28],"therapy":[29],"(AET)":[30],"regimens":[31],"was":[32,195,217],"affected":[33,46],"by":[34],"the":[35,71,76,136,144,147,166,250,259],"prevalence":[36],"of":[37,127,138,146,153,224,240,252,264],"mental":[38,129,170,202,214,241,266],"health":[39,130,171,203,215,242,267],"comorbidity":[40,204,216,243],"and,":[41],"turn,":[43],"how":[44],"this":[45,49,227],"population.":[50],"METHODS:":[51],"This":[52],"retrospective":[53],"study":[54,85,148],"analyzed":[55],"2006":[56],"to":[57,96,210,235],"2012":[58],"SEER-Medicare":[59],"data":[60],"sets":[61],"followed":[63],"patients":[64,122],"for":[65,261],"at":[66,143],"least":[67],"2":[68],"years":[69],"from":[70],"index":[72],"date,":[73],"defined":[74],"as":[75],"first":[77],"date":[78],"they":[79],"filled":[80],"an":[81],"AET":[82,104,139,160],"prescription.":[83],"The":[84,238],"included":[86],"adult":[87],"women":[88,199],"incident,":[90],"primary,":[91],"hormone":[92],"receptor-positive,":[93],"stage":[94],"I":[95],"III":[97],"cancer.":[99],"They":[100],"were":[101,162,173],"also":[102],"first-time":[103],"users":[105],"fee-for-service":[107],"Medicare":[108,113],"enrollees":[109],"continuously":[110],"enrolled":[111],"Parts":[114],"A,":[115],"B,":[116],"D.":[118],"measured":[120],"a":[124,128,184,201,220],"clinical":[125],"diagnosis":[126],"comorbid":[131,265],"condition":[132],"used":[133],"opioids":[134],"after":[135],"initiation":[137],"their":[141],"end":[145],"period.":[149],"RESULTS:":[150],"A":[151],"total":[152],"10,452":[154],"who":[158],"began":[159],"treatments":[161],"identified,":[163],"among":[164],"whom":[165],"most":[167],"commonly":[168],"diagnosed":[169],"comorbidities":[172],"depression":[174],"(n":[175,180],"=":[176,181],"554)":[177],"anxiety":[179],"246).":[182],"Using":[183],"propensity":[185],"score":[186],"risk":[187,251],"adjustment":[188],"model,":[189],"we":[190],"found":[191],"that":[192],"significantly":[196,221,248],"higher":[197],"(odds":[205],"ratio,1.33;":[206],"95%":[207,232],"CI,":[208,233],"1.06":[209],"1.68).":[211],"In":[212],"addition,":[213],"increased":[222],"hazard":[223],"mortality":[225],"population":[228],"(hazard":[229],"ratio,":[230],"1.49;":[231],"1.02":[234],"2.18).":[236],"CONCLUSION:":[237],"presence":[239],"increases":[249],"mortality,":[256],"which":[257],"highlights":[258],"need":[260],"better":[262],"management":[263],"conditions.":[268]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-30T00:00:00"}