{"id":"https://openalex.org/W2963833028","doi":"https://doi.org/10.1155/2019/3614960","title":"Antidepressant and Antiaging Effects of A\u00e7a\u00ed (Euterpe oleracea Mart.) in Mice","display_name":"Antidepressant and Antiaging Effects of A\u00e7a\u00ed (Euterpe oleracea Mart.) in Mice","publication_year":2019,"publication_date":"2019-07-24","ids":{"openalex":"https://openalex.org/W2963833028","doi":"https://doi.org/10.1155/2019/3614960","mag":"2963833028","pmid":"https://pubmed.ncbi.nlm.nih.gov/31428223","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6681600"},"language":"en","primary_location":{"id":"doi:10.1155/2019/3614960","doi":"https://doi.org/10.1155/2019/3614960","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/3614960","pdf_url":"https://downloads.hindawi.com/journals/omcl/2019/3614960.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/omcl/2019/3614960.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016754764","display_name":"Jos\u00e9 Rog\u00e9rio Souza Monteiro","orcid":"https://orcid.org/0000-0002-4511-7312","observed_orcids":["https://orcid.org/0000-0002-4511-7312"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Rog\u00e9rio Souza-Monteiro","raw_affiliation_strings":["Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048878839","display_name":"Gabriela de Paula Arrifano","orcid":"https://orcid.org/0000-0003-2817-3539","observed_orcids":["https://orcid.org/0000-0003-2817-3539"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR","GB"],"is_corresponding":false,"raw_author_name":"Gabriela P. F. Arrifano","raw_affiliation_strings":["Laboratory of Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK","Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060193707","display_name":"Ana Isabelle de G\u00f3is Queiroz","orcid":"https://orcid.org/0000-0002-1289-0675","observed_orcids":["https://orcid.org/0000-0002-1289-0675"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Isabelle D. G. Queiroz","raw_affiliation_strings":["Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1289-0675","affiliations":[{"raw_affiliation_string":"Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109363148","display_name":"Bruna Stef\u00e2nia Ferreira Mello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna S. F. Mello","raw_affiliation_strings":["Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111595550","display_name":"Charllyany Sabino Cust\u00f3dio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Charllyany S. Cust\u00f3dio","raw_affiliation_strings":["Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091386196","display_name":"Danielle S. Mac\u00eado","orcid":"https://orcid.org/0000-0001-8980-9970","observed_orcids":["https://orcid.org/0000-0001-8980-9970"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Danielle S. Mac\u00eado","raw_affiliation_strings":["Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Brazil","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032525314","display_name":"Mois\u00e9s Hamoy","orcid":"https://orcid.org/0000-0002-2931-4324","observed_orcids":["https://orcid.org/0000-0002-2931-4324"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mois\u00e9s Hamoy","raw_affiliation_strings":["Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology and Toxicology of Natural Products, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031786968","display_name":"Ricardo Sousa de Oliveira Paraense","orcid":"https://orcid.org/0000-0001-6774-2699","observed_orcids":["https://orcid.org/0000-0001-6774-2699"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ricardo S. O. Paraense","raw_affiliation_strings":["Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057315795","display_name":"Leonardo Oliveira Bittencourt","orcid":"https://orcid.org/0000-0002-9525-2723","observed_orcids":["https://orcid.org/0000-0002-9525-2723"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leonardo O. Bittencourt","raw_affiliation_strings":["Laboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-9525-2723","affiliations":[{"raw_affiliation_string":"Laboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018144501","display_name":"Rafael Rodrigues Lima","orcid":"https://orcid.org/0000-0003-1486-4013","observed_orcids":["https://orcid.org/0000-0003-1486-4013"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafael R. Lima","raw_affiliation_strings":["Laboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1486-4013","affiliations":[{"raw_affiliation_string":"Laboratory of Structural and Functional Biology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036903323","display_name":"Rommel M\u00e1rio Rodr\u00edguez Burbano","orcid":"https://orcid.org/0000-0002-4872-234X","observed_orcids":["https://orcid.org/0000-0002-4872-234X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rommel R. Burbano","raw_affiliation_strings":["Laboratory of Molecular Biology, Ophir Loyola Hospital, Bel\u00e9m, Par\u00e1, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Ophir Loyola Hospital, Bel\u00e9m, Par\u00e1, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047936976","display_name":"Herve Louis Ghislain Rogez","orcid":"https://orcid.org/0000-0001-8925-8881","observed_orcids":["https://orcid.org/0000-0001-8925-8881"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Rogez","raw_affiliation_strings":["Centre for Valorisation of Amazonian Bioactive Compounds (CVACBA) and Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Valorisation of Amazonian Bioactive Compounds (CVACBA) and Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005687671","display_name":"Cristiane do Socorro Ferraz Maia","orcid":"https://orcid.org/0000-0003-4493-7375","observed_orcids":["https://orcid.org/0000-0003-4493-7375"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Cristiane F. Maia","raw_affiliation_strings":["Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, PA, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4493-7375","affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m, PA, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039194866","display_name":"Barbarella de Matos Macchi","orcid":"https://orcid.org/0000-0002-8667-1942","observed_orcids":["https://orcid.org/0000-0002-8667-1942"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Barbarella M. Macchi","raw_affiliation_strings":["Laboratory of Molecular and Cellular Neurochemistry, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neurochemistry, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jos\u00e9 Luiz M. do Nascimento","orcid":"https://orcid.org/0000-0003-3475-4778","observed_orcids":["https://orcid.org/0000-0003-3475-4778"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luiz M. do Nascimento","raw_affiliation_strings":["Laboratory of Molecular and Cellular Neurochemistry, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3475-4778","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Cellular Neurochemistry, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086745623","display_name":"Maria Elena Crespo Lopez","orcid":"https://orcid.org/0000-0002-1335-6853","observed_orcids":["https://orcid.org/0000-0002-1335-6853"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maria Elena Crespo-L\u00f3pez","raw_affiliation_strings":["Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1335-6853","affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Par\u00e1, Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5086745623"],"corresponding_institution_ids":["https://openalex.org/I59606676"],"apc_list":{"value":2680,"currency":"USD","value_usd":2680},"apc_paid":{"value":2680,"currency":"USD","value_usd":2680},"fwci":6.9769,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.96978997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2019","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.21299999952316284,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.04390000179409981,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acai","display_name":"a\u00e7a\u00ed","score":0.9620000123977661},{"id":"https://openalex.org/keywords/euterpe-oleracea","display_name":"Euterpe oleracea","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.859000027179718},{"id":"https://openalex.org/keywords/anti-aging-effects","display_name":"anti-aging effects","score":0.8790000081062317},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8650000095367432},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7749999761581421},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7870000004768372},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6430000066757202},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.875},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8930000066757202},{"id":"https://openalex.org/keywords/lipopolysaccharide-induced-depression","display_name":"lipopolysaccharide-induced depression","score":0.8650000095367432},{"id":"https://openalex.org/keywords/anhedonia","display_name":"anhedonia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/despair-like-behavior","display_name":"despair-like behavior","score":0.7379999756813049},{"id":"https://openalex.org/keywords/imipramine","display_name":"imipramine","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8339999914169312},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7121009826660156},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4890187680721283},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43372148275375366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41637223958969116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36387157440185547},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10022088885307312},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005638","descriptor_name":"Fruit","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065748","descriptor_name":"Euterpe","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065748","descriptor_name":"Euterpe","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1155/2019/3614960","doi":"https://doi.org/10.1155/2019/3614960","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/3614960","pdf_url":"https://downloads.hindawi.com/journals/omcl/2019/3614960.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5649677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6681600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:31428223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31428223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative medicine and cellular longevity","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6681600","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6681600/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxid Med Cell Longev","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fe3c2949b52542e3a18f81f7d8c712c3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fe3c2949b52542e3a18f81f7d8c712c3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2019/3614960","doi":"https://doi.org/10.1155/2019/3614960","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/3614960","pdf_url":"https://downloads.hindawi.com/journals/omcl/2019/3614960.pdf","source":{"id":"https://openalex.org/S20935308","display_name":"Oxidative Medicine and Cellular Longevity","issn_l":"1942-0994","issn":["1942-0994","1942-0900"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","medline","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oxidative Medicine and Cellular Longevity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G138744373","display_name":null,"funder_award_id":"427784/2018\u20132","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G265401244","display_name":null,"funder_award_id":"467143/2014-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G2747186157","display_name":null,"funder_award_id":"427784/2018-2","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G2854888315","display_name":null,"funder_award_id":"307564/2017-7","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G3072403569","display_name":null,"funder_award_id":"467143/2014-5","funder_id":"https://openalex.org/F4320324376","funder_display_name":"Universidade Federal do Par\u00e1"},{"id":"https://openalex.org/G429285467","display_name":null,"funder_award_id":"2014-5","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G4454986608","display_name":null,"funder_award_id":"307564/2017-7","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G5535719133","display_name":null,"funder_award_id":"467143/2014-5","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G7418193128","display_name":null,"funder_award_id":"2014-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320324376","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963833028.pdf","grobid_xml":"https://content.openalex.org/works/W2963833028.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W110281485","https://openalex.org/W765193835","https://openalex.org/W1697553032","https://openalex.org/W1733523167","https://openalex.org/W1913186869","https://openalex.org/W1932910075","https://openalex.org/W1967985498","https://openalex.org/W1976872778","https://openalex.org/W1977886842","https://openalex.org/W1978184422","https://openalex.org/W1978830885","https://openalex.org/W1978941262","https://openalex.org/W1986366688","https://openalex.org/W1990793436","https://openalex.org/W1990802251","https://openalex.org/W2005453919","https://openalex.org/W2007739324","https://openalex.org/W2009192435","https://openalex.org/W2015575129","https://openalex.org/W2027737927","https://openalex.org/W2027829984","https://openalex.org/W2029574067","https://openalex.org/W2030737802","https://openalex.org/W2031558203","https://openalex.org/W2031677268","https://openalex.org/W2036402050","https://openalex.org/W2040064764","https://openalex.org/W2041055523","https://openalex.org/W2048211160","https://openalex.org/W2049815384","https://openalex.org/W2050508296","https://openalex.org/W2053589947","https://openalex.org/W2056994786","https://openalex.org/W2064965507","https://openalex.org/W2066364269","https://openalex.org/W2073924899","https://openalex.org/W2075006430","https://openalex.org/W2080546926","https://openalex.org/W2080818154","https://openalex.org/W2081306572","https://openalex.org/W2083254291","https://openalex.org/W2094964312","https://openalex.org/W2114730288","https://openalex.org/W2120423982","https://openalex.org/W2126795224","https://openalex.org/W2133466547","https://openalex.org/W2146758523","https://openalex.org/W2156691196","https://openalex.org/W2168660034","https://openalex.org/W2202151581","https://openalex.org/W2233387572","https://openalex.org/W2293108050","https://openalex.org/W2335901042","https://openalex.org/W2394787237","https://openalex.org/W2435264331","https://openalex.org/W2560188668","https://openalex.org/W2573613285","https://openalex.org/W2608351314","https://openalex.org/W2745400272","https://openalex.org/W2745518975","https://openalex.org/W2748360531","https://openalex.org/W2759503543","https://openalex.org/W2766918849","https://openalex.org/W2768665331","https://openalex.org/W2789400779","https://openalex.org/W2790575937","https://openalex.org/W2791951533","https://openalex.org/W2801404125","https://openalex.org/W2892030795","https://openalex.org/W2904962342","https://openalex.org/W2981971294","https://openalex.org/W3011556691"],"related_works":["https://openalex.org/W7119448026","https://openalex.org/W4407953536","https://openalex.org/W7123348415","https://openalex.org/W7119486837","https://openalex.org/W2332770077","https://openalex.org/W2182786403","https://openalex.org/W4385688505","https://openalex.org/W2807368874","https://openalex.org/W4410056398","https://openalex.org/W4385250620"],"abstract_inverted_index":{"Depression":[0],"is":[1,128],"a":[2,262],"mental":[3],"disorder":[4],"that":[5,192,269],"affects":[6],"300":[7],"million":[8],"people":[9],"of":[10,18,34,38,45,56,60,72,85,109,116,119,167,187,193,245],"all":[11],"ages":[12],"worldwide,":[13],"but":[14],"fewer":[15],"than":[16],"half":[17],"those":[19],"with":[20,49,95,141,153,197,234],"the":[21,28,43,73,78,86,106,110,173,235,259,267],"condition":[22,51],"receive":[23],"adequate":[24],"treatment.":[25],"In":[26,135],"addition,":[27],"high":[29,58],"pharmacological":[30],"refractoriness":[31],"(affecting":[32],"30%-50%":[33],"patients)":[35],"and":[36,63,70,91,113,132,151,175,178,195,199,205,221,238],"toxicity":[37],"some":[39],"classical":[40],"antidepressants":[41],"support":[42],"pursuit":[44],"new":[46],"therapies.":[47],"People":[48],"this":[50,136],"show":[52],"depressed":[53],"mood,":[54],"loss":[55,232],"pleasure,":[57],"levels":[59],"oxidative":[61,92],"stress,":[62,93],"accelerated":[64],"biological":[65],"aging":[66],"(decreased":[67],"telomere":[68,82],"length":[69],"expression":[71],"telomerase":[74],"reverse":[75],"transcriptase":[76],"(TERT),":[77],"enzyme":[79],"responsible":[80],"for":[81,101,148,258],"maintenance).":[83],"Because":[84],"close":[87],"relationship":[88],"between":[89],"depression":[90,218],"nutraceuticals":[94],"antioxidant":[96,198],"properties":[97],"are":[98],"excellent":[99],"candidates":[100],"therapy.":[102],"This":[103,126],"study":[104],"represents":[105],"first":[107,260],"investigation":[108],"possible":[111],"antidepressant":[112],"antiaging":[114,200,264],"effects":[115,201],"commercial":[117],"samples":[118],"clarified":[120],"a\u00e7a\u00ed":[121],"(Euterpe":[122],"oleracea)":[123],"juice":[124],"(EO).":[125],"fruit":[127],"rich":[129],"in":[130,181,211,217,266],"antioxidants":[131],"widely":[133],"consumed.":[134],"study,":[137],"mice":[138],"were":[139,169],"treated":[140],"saline":[142,154],"or":[143,155],"EO":[144,168,188,225,250],"(10":[145],"\u03bcL/g,":[146],"oral)":[147],"4":[149],"days":[150],"then":[152],"lipopolysaccharide":[156],"(0.5":[157],"mg/kg,":[158],"i.p.)":[159],"to":[160,171,191],"induce":[161],"depressive-like":[162,236],"behavior.":[163],"Only":[164],"four":[165],"doses":[166],"enough":[170],"abolish":[172],"despair-like":[174],"anhedonia":[176],"behaviors":[177],"alterations":[179],"observed":[180],"electromyographic":[182],"measurements.":[183],"The":[184],"antidepression":[185],"effect":[186],"was":[189],"similar":[190],"imipramine":[194],"associated":[196,233],"(preventing":[202],"lipid":[203],"peroxidation":[204],"increasing":[206],"TERT":[207,254],"mRNA":[208,255],"expression,":[209,256],"respectively)":[210],"three":[212],"major":[213],"brain":[214,268],"regions":[215],"involved":[216],"(hippocampus,":[219],"striatum,":[220],"prefrontal":[222],"cortex).":[223],"Additionally,":[224],"significantly":[226,252],"protected":[227],"hippocampal":[228],"cells,":[229],"preventing":[230],"neuronal":[231],"state":[237],"nitrite":[239],"level":[240],"increases":[241],"(an":[242],"indirect":[243],"marker":[244],"nitric":[246],"oxide":[247],"production).":[248],"Moreover,":[249],"alone":[251],"increased":[253],"revealing":[257],"time":[261],"potent":[263],"action":[265],"suggests":[270],"neuroprotection":[271],"against":[272],"long-term":[273],"age-related":[274],"consequences.":[275]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2019-07-30T00:00:00"}