{"id":"https://openalex.org/W2963662948","doi":"https://doi.org/10.1083/jcb.201904202","title":"Assembling nuclear domains: Lessons from DNA repair","display_name":"Assembling nuclear domains: Lessons from DNA repair","publication_year":2019,"publication_date":"2019-07-19","ids":{"openalex":"https://openalex.org/W2963662948","doi":"https://doi.org/10.1083/jcb.201904202","mag":"2963662948","pmid":"https://pubmed.ncbi.nlm.nih.gov/31324649","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6683749"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.201904202","doi":"https://doi.org/10.1083/jcb.201904202","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201904202","pdf_url":"https://rupress.org/jcb/article-pdf/218/8/2444/868804/jcb_201904202.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://rupress.org/jcb/article-pdf/218/8/2444/868804/jcb_201904202.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041156272","display_name":"Benjamin R. Schrank","orcid":"https://orcid.org/0000-0001-8138-4250","observed_orcids":["https://orcid.org/0000-0001-8138-4250"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Schrank","raw_affiliation_strings":["Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066167912","display_name":"Jean Gautier","orcid":"https://orcid.org/0000-0002-6348-6023","observed_orcids":["https://orcid.org/0000-0002-6348-6023"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean Gautier","raw_affiliation_strings":["Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY"],"raw_orcid":"https://orcid.org/0000-0002-6348-6023","affiliations":[{"raw_affiliation_string":"Institute for Cancer Genetics, Columbia University Irving Medical Center, New York, NY","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066167912"],"corresponding_institution_ids":["https://openalex.org/I2799503643"],"apc_list":null,"apc_paid":null,"fwci":0.5939,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.53149425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"218","issue":"8","first_page":"2444","last_page":"2455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-domains","display_name":"nuclear domains","score":0.9210000038146973},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.906000018119812},{"id":"https://openalex.org/keywords/topologically-associated-domains","display_name":"topologically associating domains","score":0.906000018119812},{"id":"https://openalex.org/keywords/transcription-factories","display_name":"transcription factories","score":0.6710000038146973},{"id":"https://openalex.org/keywords/actin-filament-nucleation","display_name":"actin filament nucleation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.6610000133514404},{"id":"https://openalex.org/keywords/low-complexity-domain","display_name":"low-complexity domains","score":0.843999981880188},{"id":"https://openalex.org/keywords/liquid-liquid-phase-separation","display_name":"liquid-liquid phase separation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.5658620595932007},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5281881093978882},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5013012886047363},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4711557626724243},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.46582409739494324},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.44537124037742615},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.43755897879600525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.419897198677063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3595951795578003},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31108319759368896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13112899661064148},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.201904202","doi":"https://doi.org/10.1083/jcb.201904202","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201904202","pdf_url":"https://rupress.org/jcb/article-pdf/218/8/2444/868804/jcb_201904202.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5942229","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6683749","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6683749","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6683749","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:31324649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31324649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1083/jcb.201904202","doi":"https://doi.org/10.1083/jcb.201904202","is_oa":true,"landing_page_url":"https://doi.org/10.1083/jcb.201904202","pdf_url":"https://rupress.org/jcb/article-pdf/218/8/2444/868804/jcb_201904202.pdf","source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1395317031","display_name":"DNA double-strand break repair, chromosome translocations and cancer","funder_award_id":"P01CA174653","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2555707797","display_name":"Role of Nuclear Actin Polymerization in Double-Strand Break Mobility and Repair","funder_award_id":"F30CA217049","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8631492618","display_name":"DNA Repair and Genomic Instability in Cancer Development and Therapy","funder_award_id":"R35CA197606","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963662948.pdf","grobid_xml":"https://content.openalex.org/works/W2963662948.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W51164494","https://openalex.org/W245024104","https://openalex.org/W956467488","https://openalex.org/W1520255714","https://openalex.org/W1557080454","https://openalex.org/W1559385063","https://openalex.org/W1574083126","https://openalex.org/W1923618315","https://openalex.org/W1968469516","https://openalex.org/W1972984145","https://openalex.org/W1975030858","https://openalex.org/W1981946886","https://openalex.org/W1982530074","https://openalex.org/W1986141440","https://openalex.org/W1992786086","https://openalex.org/W1997611686","https://openalex.org/W2002457457","https://openalex.org/W2007369689","https://openalex.org/W2009199987","https://openalex.org/W2011902133","https://openalex.org/W2017275209","https://openalex.org/W2024060173","https://openalex.org/W2026180423","https://openalex.org/W2028270913","https://openalex.org/W2030545747","https://openalex.org/W2033651349","https://openalex.org/W2034502973","https://openalex.org/W2035288465","https://openalex.org/W2036685117","https://openalex.org/W2041251646","https://openalex.org/W2043168782","https://openalex.org/W2043895957","https://openalex.org/W2050164609","https://openalex.org/W2052178337","https://openalex.org/W2052258172","https://openalex.org/W2054889035","https://openalex.org/W2060247906","https://openalex.org/W2060485452","https://openalex.org/W2063516083","https://openalex.org/W2066999586","https://openalex.org/W2068668324","https://openalex.org/W2070660722","https://openalex.org/W2073378063","https://openalex.org/W2079099921","https://openalex.org/W2081383642","https://openalex.org/W2084969545","https://openalex.org/W2085544302","https://openalex.org/W2086897927","https://openalex.org/W2091243328","https://openalex.org/W2094020226","https://openalex.org/W2096973725","https://openalex.org/W2097027640","https://openalex.org/W2097609314","https://openalex.org/W2097863662","https://openalex.org/W2104994400","https://openalex.org/W2110817748","https://openalex.org/W2112348939","https://openalex.org/W2113688148","https://openalex.org/W2122782850","https://openalex.org/W2124561611","https://openalex.org/W2124599642","https://openalex.org/W2126589892","https://openalex.org/W2130628767","https://openalex.org/W2131554707","https://openalex.org/W2131571249","https://openalex.org/W2131604076","https://openalex.org/W2131978108","https://openalex.org/W2137017491","https://openalex.org/W2139676849","https://openalex.org/W2140345256","https://openalex.org/W2144252460","https://openalex.org/W2146427646","https://openalex.org/W2149438959","https://openalex.org/W2152440925","https://openalex.org/W2152531901","https://openalex.org/W2158602985","https://openalex.org/W2159096018","https://openalex.org/W2161458929","https://openalex.org/W2164648414","https://openalex.org/W2169727662","https://openalex.org/W2180452931","https://openalex.org/W2256829667","https://openalex.org/W2259836065","https://openalex.org/W2265406928","https://openalex.org/W2267962174","https://openalex.org/W2271817176","https://openalex.org/W2275231116","https://openalex.org/W2297808341","https://openalex.org/W2404978503","https://openalex.org/W2463357221","https://openalex.org/W2464252485","https://openalex.org/W2472573606","https://openalex.org/W2494174731","https://openalex.org/W2549017129","https://openalex.org/W2552364309","https://openalex.org/W2576246387","https://openalex.org/W2584582097","https://openalex.org/W2585920126","https://openalex.org/W2594432738","https://openalex.org/W2609212870","https://openalex.org/W2622198710","https://openalex.org/W2736244299","https://openalex.org/W2744226975","https://openalex.org/W2768632776","https://openalex.org/W2774074031","https://openalex.org/W2778217919","https://openalex.org/W2789933479","https://openalex.org/W2796208126","https://openalex.org/W2796408191","https://openalex.org/W2798187866","https://openalex.org/W2808847099","https://openalex.org/W2808968889","https://openalex.org/W2809057270","https://openalex.org/W2809439755","https://openalex.org/W2810937503","https://openalex.org/W2888742489","https://openalex.org/W2889851170","https://openalex.org/W2899072610","https://openalex.org/W2901781473","https://openalex.org/W2913719958","https://openalex.org/W2928981533","https://openalex.org/W2937151182","https://openalex.org/W2943959526","https://openalex.org/W2953679327"],"related_works":["https://openalex.org/W2960744074","https://openalex.org/W4388741461","https://openalex.org/W3175454715","https://openalex.org/W2928981533","https://openalex.org/W7106227266","https://openalex.org/W2536900607","https://openalex.org/W2997999604","https://openalex.org/W2041151229","https://openalex.org/W2953746643","https://openalex.org/W2483125046"],"abstract_inverted_index":{"Eukaryotic":[0],"nuclei":[1],"are":[2,16,67,82],"organized":[3],"into":[4],"nuclear":[5,62,119,136],"domains":[6,15,28,63,93,120,137],"that":[7,30,66],"unite":[8],"loci":[9],"sharing":[10],"a":[11,132],"common":[12],"function.":[13],"These":[14],"essential":[17],"for":[18,57,134],"diverse":[19],"processes":[20],"including":[21],"(1)":[22],"the":[23,36,46,73,116],"formation":[24,37,117,130],"of":[25,38,48,61,75,102,118],"topologically":[26],"associated":[27],"(TADs)":[29],"coordinate":[31],"replication":[32],"and":[33,41,44,80,90,104,112],"transcription,":[34],"(2)":[35],"specialized":[39],"transcription":[40,103],"splicing":[42],"factories,":[43],"(3)":[45],"clustering":[47,81],"DNA":[49,56,76,78],"double-strand":[50],"breaks":[51],"(DSBs),":[52],"which":[53],"concentrates":[54],"damaged":[55],"repair.":[58,105],"The":[59,106],"generation":[60],"requires":[64],"forces":[65],"beginning":[68],"to":[69],"be":[70],"identified.":[71],"In":[72],"case":[74],"DSBs,":[77],"movement":[79],"driven":[83],"by":[84],"actin":[85,113],"filament":[86],"nucleators.":[87],"Furthermore,":[88],"RNAs":[89],"low-complexity":[91],"protein":[92],"such":[94],"as":[95,131],"RNA-binding":[96],"proteins":[97],"also":[98],"accumulate":[99],"around":[100],"sites":[101],"link":[107],"between":[108],"liquid-liquid":[109],"phase":[110],"separation":[111],"nucleation":[114],"in":[115,138],"is":[121],"still":[122],"unknown.":[123],"This":[124],"review":[125],"discusses":[126],"DSB":[127],"repair":[128],"domain":[129],"model":[133],"functional":[135],"other":[139],"genomic":[140],"contexts.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-30T00:00:00"}
