{"id":"https://openalex.org/W2963650693","doi":"https://doi.org/10.1016/j.neuroscience.2019.06.038","title":"Minocycline Preserves the Integrity and Permeability of BBB by Altering the Activity of DKK1\u2013Wnt Signaling in ICH Model","display_name":"Minocycline Preserves the Integrity and Permeability of BBB by Altering the Activity of DKK1\u2013Wnt Signaling in ICH Model","publication_year":2019,"publication_date":"2019-07-22","ids":{"openalex":"https://openalex.org/W2963650693","doi":"https://doi.org/10.1016/j.neuroscience.2019.06.038","mag":"2963650693","pmid":"https://pubmed.ncbi.nlm.nih.gov/31344398"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2019.06.038","doi":"https://doi.org/10.1016/j.neuroscience.2019.06.038","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2019.06.038","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0306452219304658/pdf","source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0306452219304658/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100334030","display_name":"Guoqing Wang","orcid":"https://orcid.org/0000-0003-3457-3328","observed_orcids":["https://orcid.org/0000-0003-3457-3328"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqing Wang","raw_affiliation_strings":["Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319837","display_name":"Zhihua Li","orcid":"https://orcid.org/0000-0002-9301-668X","observed_orcids":["https://orcid.org/0000-0002-9301-668X"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihua Li","raw_affiliation_strings":["Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102991854","display_name":"Shujian Li","orcid":"https://orcid.org/0000-0002-8125-4904","observed_orcids":["https://orcid.org/0000-0002-8125-4904"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujian Li","raw_affiliation_strings":["Department of neurology, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), Zhengzhou, China, 450001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), Zhengzhou, China, 450001","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006251408","display_name":"Junling Ren","orcid":"https://orcid.org/0000-0002-8124-102X","observed_orcids":["https://orcid.org/0000-0002-8124-102X"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junling Ren","raw_affiliation_strings":["Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA, 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA, 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027429227","display_name":"Vigneyshwar Suresh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Vigneyshwar Suresh","raw_affiliation_strings":["Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083401184","display_name":"Dingkang Xu","orcid":"https://orcid.org/0000-0002-9153-773X","observed_orcids":["https://orcid.org/0000-0002-9153-773X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingkang Xu","raw_affiliation_strings":["Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008612686","display_name":"Weidong Zang","orcid":"https://orcid.org/0000-0001-8365-4672","observed_orcids":["https://orcid.org/0000-0001-8365-4672"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weidong Zang","raw_affiliation_strings":["Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101751488","display_name":"Xianzhi Liu","orcid":"https://orcid.org/0000-0002-6646-273X","observed_orcids":["https://orcid.org/0000-0002-6646-273X"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianzhi Liu","raw_affiliation_strings":["Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643902","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-6378-7723","observed_orcids":["https://orcid.org/0000-0002-6378-7723"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210133534","display_name":"Henan Provincial People's Hospital","ror":"https://ror.org/03f72zw41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133534"]},{"id":"https://openalex.org/I4210149496","display_name":"Zhengzhou People's Hospital","ror":"https://ror.org/04tgrpw60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210149496"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of neurology, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), Zhengzhou, China, 450001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of neurology, Henan Provincial People's Hospital (Zhengzhou University People's Hospital), Zhengzhou, China, 450001","institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210133534","https://openalex.org/I4210149496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102005196","display_name":"Huizhi Wang","orcid":"https://orcid.org/0000-0001-7692-2106","observed_orcids":["https://orcid.org/0000-0001-7692-2106"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Huizhi Wang","raw_affiliation_strings":["Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA, 40202. Electronic address: huizhi.wang@louisville.edu","Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA, 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA, 40202. Electronic address: huizhi.wang@louisville.edu","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA, 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001927762","display_name":"Fuyou Guo","orcid":"https://orcid.org/0000-0001-9332-8272","observed_orcids":["https://orcid.org/0000-0001-9332-8272"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fuyou Guo","raw_affiliation_strings":["Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052. Electronic address: chyou666@hotmail.com","Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052. Electronic address: chyou666@hotmail.com","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 450052","institution_ids":["https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001927762","https://openalex.org/A5102005196"],"corresponding_institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210156804"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":4.0097,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.94736842,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"415","issue":null,"first_page":"135","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.760699987411499,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.23559999465942383,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":1.0},{"id":"https://openalex.org/keywords/blood-brain-barrier-integrity","display_name":"blood-brain barrier integrity","score":0.8659999966621399},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.984000027179718},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.8820000290870667},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/wnt1","display_name":"Wnt1","score":0.8259999752044678},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/microglial-inflammation","display_name":"microglial inflammation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.7620000243186951},{"id":"https://openalex.org/keywords/neurological-deficit","display_name":"neurological deficit","score":0.9350000023841858},{"id":"https://openalex.org/keywords/collagenase-induced-hemorrhage","display_name":"collagenase-induced hemorrhage","score":0.8169999718666077},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.9063364267349243},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5984857082366943},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5214799642562866},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.48312899470329285},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45822465419769287},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.44797295331954956},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42894574999809265},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4266626238822937},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.42443227767944336},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.4193817973136902},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3915106952190399},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3220096230506897},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.28097981214523315},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22596392035484314},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1936509609222412},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18977171182632446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1681443750858307},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14272382855415344},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.1408492624759674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1082618236541748},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.08836346864700317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.06177768111228943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001929","descriptor_name":"Brain Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002543","descriptor_name":"Cerebral Hemorrhage","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003012","descriptor_name":"Microbial Collagenase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051155","descriptor_name":"Wnt1 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroscience.2019.06.038","doi":"https://doi.org/10.1016/j.neuroscience.2019.06.038","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2019.06.038","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0306452219304658/pdf","source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:31344398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31344398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroscience.2019.06.038","doi":"https://doi.org/10.1016/j.neuroscience.2019.06.038","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2019.06.038","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0306452219304658/pdf","source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3309974911","display_name":null,"funder_award_id":"U 1204807","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8815767492","display_name":null,"funder_award_id":"81600973","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8931075781","display_name":null,"funder_award_id":"17A310008","funder_id":"https://openalex.org/F4320325625","funder_display_name":"Education Department of Henan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325625","display_name":"Education Department of Henan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963650693.pdf","grobid_xml":"https://content.openalex.org/works/W2963650693.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1967030433","https://openalex.org/W1967290285","https://openalex.org/W1967386798","https://openalex.org/W1969467371","https://openalex.org/W1973763077","https://openalex.org/W1975857820","https://openalex.org/W1980767418","https://openalex.org/W1992759272","https://openalex.org/W1993862136","https://openalex.org/W1995126673","https://openalex.org/W1996003447","https://openalex.org/W2006660401","https://openalex.org/W2017063754","https://openalex.org/W2046170896","https://openalex.org/W2050913584","https://openalex.org/W2063885093","https://openalex.org/W2072074272","https://openalex.org/W2075069825","https://openalex.org/W2085974262","https://openalex.org/W2087251699","https://openalex.org/W2100167607","https://openalex.org/W2114862320","https://openalex.org/W2117765445","https://openalex.org/W2119284420","https://openalex.org/W2122276247","https://openalex.org/W2133961780","https://openalex.org/W2148361878","https://openalex.org/W2150626397","https://openalex.org/W2158230836","https://openalex.org/W2227816066","https://openalex.org/W2254072432","https://openalex.org/W2414939366","https://openalex.org/W2486296887","https://openalex.org/W2519067248","https://openalex.org/W2579294647","https://openalex.org/W2591562531","https://openalex.org/W2604481254","https://openalex.org/W2747277101","https://openalex.org/W2750717426","https://openalex.org/W2761891055","https://openalex.org/W2913027830","https://openalex.org/W4230173358"],"related_works":["https://openalex.org/W3206770144","https://openalex.org/W56718582","https://openalex.org/W2046170896","https://openalex.org/W2353797015","https://openalex.org/W2803364980","https://openalex.org/W2974931528","https://openalex.org/W166005134","https://openalex.org/W4220915708","https://openalex.org/W1131372458","https://openalex.org/W2048237213"],"abstract_inverted_index":{"Disruption":[0],"of":[1,15,48,74,107,123,158,175],"the":[2,11,34,46,78,105,121,156,176],"blood-brain":[3],"barrier":[4],"(BBB)":[5],"and":[6,55,63,112,129,142,164],"subsequent":[7],"neurological":[8,27,53,90,113],"deficits":[9,114,167],"are":[10],"most":[12],"severe":[13],"consequence":[14],"intracerebral":[16],"hemorrhage":[17],"(ICH).":[18],"Minocycline":[19,101,133],"has":[20],"been":[21],"wildly":[22],"used":[23],"clinically":[24],"as":[25,68],"a":[26,59,71,144,169],"protective":[28],"agent":[29],"in":[30,58,115,168],"clinical":[31],"practice.":[32],"However,":[33],"underlying":[35,65],"mechanisms":[36,67],"by":[37,85,131,147,160],"which":[38],"minocycline":[39,49,119,154],"functions":[40],"remain":[41],"unclear.":[42],"Therefore,":[43],"we":[44],"assessed":[45,84,93],"influence":[47],"on":[50],"BBB":[51,81,108,162],"structure,":[52],"function,":[54],"inflammatory":[56,124],"responses":[57],"collagenase-induced":[60],"ICH":[61,116,159],"model,":[62],"elucidated":[64],"molecular":[66],"well.":[69],"Following":[70],"single":[72],"injection":[73],"collagenase":[75],"VII-S":[76],"into":[77],"basal":[79],"ganglia,":[80],"integrity":[82,163],"was":[83,92],"Evans":[86],"blue":[87],"extravasation":[88],"while":[89],"function":[91,98],"using":[94],"an":[95],"established":[96],"neurologic":[97,166],"scoring":[99],"system.":[100],"treatment":[102,134],"significantly":[103],"alleviated":[104],"severity":[106],"disruption,":[109],"brain":[110],"edema,":[111],"model.":[117],"Moreover,":[118],"decreased":[120,135],"production":[122],"mediators":[125],"including":[126],"TNF,":[127],"IL-6,":[128],"MMP-9,":[130],"microglia.":[132],"DKK1":[136,148],"expression":[137],"but":[138],"increased":[139],"Wnt1,":[140],"\u03b2-catenin":[141],"Occludin,":[143],"phenomenon":[145],"mimicked":[146],"silencing.":[149],"These":[150],"data":[151],"suggest":[152],"that":[153,172],"improves":[155],"consequences":[157],"preserving":[161],"attenuating":[165],"DKK1-related":[170],"manner":[171],"involves":[173],"enhancement":[174],"Wnt1-\u03b2-catenin":[177],"activity.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}
