{"id":"https://openalex.org/W2963585748","doi":"https://doi.org/10.1128/jb.00401-19","title":"Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae","display_name":"Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae","publication_year":2019,"publication_date":"2019-07-23","ids":{"openalex":"https://openalex.org/W2963585748","doi":"https://doi.org/10.1128/jb.00401-19","mag":"2963585748","pmid":"https://pubmed.ncbi.nlm.nih.gov/31331979","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6755732"},"language":"en","primary_location":{"id":"doi:10.1128/jb.00401-19","doi":"https://doi.org/10.1128/jb.00401-19","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00401-19","pdf_url":"https://jb.asm.org/content/jb/201/20/e00401-19.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jb.asm.org/content/jb/201/20/e00401-19.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090930856","display_name":"Grace A. Beggs","orcid":"https://orcid.org/0000-0003-3537-913X","observed_orcids":["https://orcid.org/0000-0003-3537-913X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace A. Beggs","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013569765","display_name":"Yaramah M. Zalucki","orcid":"https://orcid.org/0000-0001-7947-8143","observed_orcids":["https://orcid.org/0000-0001-7947-8143"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaramah M. Zalucki","raw_affiliation_strings":["Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA","Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085596530","display_name":"Nicholas Gene Brown","orcid":"https://orcid.org/0000-0002-6141-0164","observed_orcids":["https://orcid.org/0000-0002-6141-0164"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Gene Brown","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA","Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032487641","display_name":"Sheila Rastegari","orcid":"https://orcid.org/0000-0001-8847-9930","observed_orcids":["https://orcid.org/0000-0001-8847-9930"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheila Rastegari","raw_affiliation_strings":["Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA","Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA","Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047830932","display_name":"Rebecca K. Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca K. Phillips","raw_affiliation_strings":["Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA","Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050982810","display_name":"Timothy Gerald Palzkill","orcid":"https://orcid.org/0000-0002-5267-0001","observed_orcids":["https://orcid.org/0000-0002-5267-0001"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Palzkill","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA","Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018104424","display_name":"William Maurice Shafer","orcid":"https://orcid.org/0000-0001-9303-8777","observed_orcids":["https://orcid.org/0000-0001-9303-8777"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Shafer","raw_affiliation_strings":["Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA","Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA","Laboratories of Microbial Pathogenesis, VA Medical Research Service, Veterans Affairs Medical Center, Decatur, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Laboratories of Microbial Pathogenesis, VA Medical Research Service, Veterans Affairs Medical Center, Decatur, Georgia, USA","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027989030","display_name":"Muthiah Kumaraswami","orcid":"https://orcid.org/0000-0002-9959-5598","observed_orcids":["https://orcid.org/0000-0002-9959-5598"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]},{"id":"https://openalex.org/I4405286254","display_name":"Houston Methodist Research Institute","ror":"https://ror.org/01mcrxx35","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Muthiah Kumaraswami","raw_affiliation_strings":["Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA","Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA"],"raw_orcid":"https://orcid.org/0000-0002-9959-5598","affiliations":[{"raw_affiliation_string":"Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I4405286254"]},{"raw_affiliation_string":"Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045847541","display_name":"Richard G. Brennan","orcid":"https://orcid.org/0000-0001-7647-485X","observed_orcids":["https://orcid.org/0000-0001-7647-485X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard G. Brennan","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0001-7647-485X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5027989030","https://openalex.org/A5045847541"],"corresponding_institution_ids":["https://openalex.org/I1295876152","https://openalex.org/I170897317","https://openalex.org/I4210126298","https://openalex.org/I4405286254"],"apc_list":null,"apc_paid":null,"fwci":0.7589,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.61781694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"201","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.057999998331069946,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mtrr","display_name":"MTRR","score":0.9810000061988831},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.8529999852180481},{"id":"https://openalex.org/keywords/transcriptional-derepression","display_name":"transcriptional derepression","score":0.7549999952316284},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8930000066757202},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5440000295639038},{"id":"https://openalex.org/keywords/gonorrhea","display_name":"gonorrhea","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C2779166590","wikidata":"https://www.wikidata.org/wiki/Q131129","display_name":"Neisseria gonorrhoeae","level":2,"score":0.9396477937698364},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8848505020141602},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7752281427383423},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.650725245475769},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.638145387172699},{"id":"https://openalex.org/C2778087339","wikidata":"https://www.wikidata.org/wiki/Q18029587","display_name":"MTRR","level":5,"score":0.624173641204834},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5514100193977356},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5483917593955994},{"id":"https://openalex.org/C2776983828","wikidata":"https://www.wikidata.org/wiki/Q1974989","display_name":"Neisseriaceae","level":3,"score":0.544550895690918},{"id":"https://openalex.org/C2777954195","wikidata":"https://www.wikidata.org/wiki/Q132209","display_name":"Neisseria","level":3,"score":0.5413285493850708},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4960378110408783},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47986119985580444},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.4326742887496948},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3340217173099518},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.26496583223342896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1964832842350006},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12750244140625},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10869044065475464},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.07389956712722778},{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002635","descriptor_name":"Chenodeoxycholic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013657","descriptor_name":"Taurodeoxycholic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/jb.00401-19","doi":"https://doi.org/10.1128/jb.00401-19","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00401-19","pdf_url":"https://jb.asm.org/content/jb/201/20/e00401-19.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6755732","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6755732","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:31331979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31331979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1626068","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/servlets/purl/1626068","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/401369","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10072/401369","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1128/jb.00401-19","doi":"https://doi.org/10.1128/jb.00401-19","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.00401-19","pdf_url":"https://jb.asm.org/content/jb/201/20/e00401-19.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1707837083","display_name":"Gonococci:  Genetics of Resistance to PMN Proteins","funder_award_id":"R37AI021150","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2029704955","display_name":"X-RAY STUDIES ON BACTERIAL MDR REGULATORS","funder_award_id":"R01AI048593","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3549503347","display_name":"Molecular mechanism of virulence regulation in Streptococcus pyogenes","funder_award_id":"R01AI109096","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8795230287","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1644868","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000896501","display_name":"BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE","funder_award_id":"R01AI032956","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963585748.pdf","grobid_xml":"https://content.openalex.org/works/W2963585748.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W2630664","https://openalex.org/W255996521","https://openalex.org/W1540502358","https://openalex.org/W1632099083","https://openalex.org/W1726597626","https://openalex.org/W1970215763","https://openalex.org/W1970727566","https://openalex.org/W1975300709","https://openalex.org/W1988972551","https://openalex.org/W1993063963","https://openalex.org/W1997168562","https://openalex.org/W2001641653","https://openalex.org/W2001912852","https://openalex.org/W2017215141","https://openalex.org/W2025192657","https://openalex.org/W2048632351","https://openalex.org/W2049859919","https://openalex.org/W2053397911","https://openalex.org/W2053434099","https://openalex.org/W2058975651","https://openalex.org/W2062167657","https://openalex.org/W2066063785","https://openalex.org/W2069805306","https://openalex.org/W2082055834","https://openalex.org/W2082295788","https://openalex.org/W2087516009","https://openalex.org/W2087952394","https://openalex.org/W2098167941","https://openalex.org/W2105331097","https://openalex.org/W2109489214","https://openalex.org/W2110893691","https://openalex.org/W2112484114","https://openalex.org/W2113473357","https://openalex.org/W2113556104","https://openalex.org/W2113583273","https://openalex.org/W2115632790","https://openalex.org/W2116525565","https://openalex.org/W2120385129","https://openalex.org/W2128068892","https://openalex.org/W2128402268","https://openalex.org/W2134809564","https://openalex.org/W2143306785","https://openalex.org/W2143544498","https://openalex.org/W2144081223","https://openalex.org/W2145401003","https://openalex.org/W2154197653","https://openalex.org/W2154714625","https://openalex.org/W2162904770","https://openalex.org/W2163341755","https://openalex.org/W2165695900","https://openalex.org/W2167279371","https://openalex.org/W2167722481","https://openalex.org/W2171535756","https://openalex.org/W2171745848","https://openalex.org/W2180229411","https://openalex.org/W2216986168","https://openalex.org/W2237647745","https://openalex.org/W2341783622","https://openalex.org/W2463322101","https://openalex.org/W2580035316","https://openalex.org/W2601265751","https://openalex.org/W2725319213","https://openalex.org/W2813910014","https://openalex.org/W2913186510","https://openalex.org/W2917291883","https://openalex.org/W4239755150","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4289443401","https://openalex.org/W2167722481","https://openalex.org/W2143544498","https://openalex.org/W1966616536","https://openalex.org/W7097282525","https://openalex.org/W1970727566","https://openalex.org/W2611425888","https://openalex.org/W1988972551","https://openalex.org/W1975300709","https://openalex.org/W1990949770"],"abstract_inverted_index":{"Neisseria":[0],"gonorrhoeae":[1],"causes":[2],"a":[3,9,96],"significant":[4],"disease":[5],"burden":[6],"worldwide,":[7],"and":[8,39,46,80,102,117],"meteoric":[10],"rise":[11],"in":[12],"its":[13],"multidrug":[14,32],"resistance":[15],"has":[16],"reduced":[17],"the":[18,43,51,54,58,67,75,108],"efficacy":[19],"of":[20,28,57,70,77,91,110],"antibiotics":[21],"previously":[22],"or":[23],"currently":[24],"approved":[25],"for":[26,99],"therapy":[27],"gonorrheal":[29],"infections.":[30],"The":[31],"efflux":[33],"pump":[34,59],"MtrCDE":[35],"transports":[36],"multiple":[37],"drugs":[38],"host-derived":[40],"antimicrobials":[41],"from":[42],"bacterial":[44],"cell":[45],"confers":[47],"survival":[48],"advantage":[49],"on":[50],"pathogen":[52],"within":[53],"host.":[55],"Transcription":[56],"is":[60],"repressed":[61],"by":[62,66,105],"MtrR":[63,79,106],"but":[64],"relieved":[65],"cytosolic":[68],"influx":[69],"antimicrobials.":[71,120],"Here,":[72],"we":[73],"describe":[74],"structure":[76,83],"induced":[78],"use":[81],"this":[82],"to":[84,115],"identify":[85],"bile":[86],"salts":[87],"as":[88],"physiological":[89],"inducers":[90],"MtrR.":[92],"These":[93],"findings":[94],"provide":[95],"mechanistic":[97],"basis":[98],"antimicrobial":[100],"sensing":[101],"gonococcal":[103],"protection":[104],"through":[107],"derepression":[109],"mtrCDE":[111],"expression":[112],"after":[113],"exposure":[114],"intrinsic":[116],"clinically":[118],"applied":[119]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}
