{"id":"https://openalex.org/W2963544611","doi":"https://doi.org/10.5061/dryad.n0cg254","title":"Data from: Effect of dimethyl fumarate on lymphocytes in RRMS: implications for clinical practice","display_name":"Data from: Effect of dimethyl fumarate on lymphocytes in RRMS: implications for clinical practice","publication_year":2018,"publication_date":"2018-11-19","ids":{"openalex":"https://openalex.org/W2963544611","doi":"https://doi.org/10.5061/dryad.n0cg254","mag":"2963544611"},"language":"en","primary_location":{"id":"doi:10.5061/dryad.n0cg254","doi":"https://doi.org/10.5061/dryad.n0cg254","is_oa":true,"landing_page_url":"https://doi.org/10.5061/dryad.n0cg254","pdf_url":null,"source":{"id":"https://openalex.org/S7407051161","display_name":"DRYAD","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5061/dryad.n0cg254","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109410605","display_name":"Devangi S. Mehta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehta, Devangi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Taylor, Catherine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taylor, Catherine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065754098","display_name":"Douglas Lorne Arnold","orcid":"https://orcid.org/0000-0003-4266-0106","observed_orcids":["https://orcid.org/0000-0003-4266-0106","https://orcid.org/0000-0002-0805-7672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnold, Douglas L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059770824","display_name":"Eris Bame","orcid":"https://orcid.org/0009-0007-6289-0562","observed_orcids":["https://orcid.org/0009-0007-6289-0562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bame, Eris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077310868","display_name":"Amit Bar\u2010Or","orcid":"https://orcid.org/0000-0001-7179-0335","observed_orcids":["https://orcid.org/0000-0001-7179-0335","https://orcid.org/0000-0003-2931-1585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bar-Or, Amit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062220148","display_name":"Ralf Gold","orcid":"https://orcid.org/0000-0002-7223-3052","observed_orcids":["https://orcid.org/0000-0002-7223-3052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gold, Ralf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110617052","display_name":"Jerome Hanna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna, Jerome","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054874316","display_name":"Ludwig Kappos","orcid":"https://orcid.org/0000-0003-4175-5509","observed_orcids":["https://orcid.org/0000-0003-4175-5509"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kappos, Ludwig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104652552","display_name":"Shifang Liu","orcid":"https://orcid.org/0009-0003-9037-4902","observed_orcids":["https://orcid.org/0009-0003-9037-4902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Shifang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022129253","display_name":"Andr\u00e9 Palma da Cunha Matta","orcid":"https://orcid.org/0000-0001-6015-7809","observed_orcids":["https://orcid.org/0000-0001-6015-7809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matta, Andr\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109926908","display_name":"J. Theodore Phillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillips, J. Theodore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049160943","display_name":"Derrick S. Robertson","orcid":"https://orcid.org/0000-0001-8993-0981","observed_orcids":["https://orcid.org/0000-0001-8993-0981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robertson, Derrick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083153157","display_name":"Christian A. von Hehn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"von Hehn, Christian A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109437325","display_name":"Jordana Campbell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Campbell, Jordana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071923817","display_name":"Karen M. Spach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Spach, Karen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101435274","display_name":"Lili Yang","orcid":"https://orcid.org/0000-0002-6975-3145","observed_orcids":["https://orcid.org/0000-0002-6975-3145"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang, Lili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029734617","display_name":"Robert James Fox","orcid":"https://orcid.org/0000-0002-4263-3717","observed_orcids":["https://orcid.org/0000-0002-4263-3717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fox, Robert J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethyl-fumarate","display_name":"dimethyl fumarate","score":1.0},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.675000011920929},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.968999981880188},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.7770000100135803},{"id":"https://openalex.org/keywords/b-cell-subsets","display_name":"B cell subsets","score":0.7419999837875366},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.843999981880188},{"id":"https://openalex.org/keywords/naive-t-cells","display_name":"naive T cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pharmacovigilance","display_name":"pharmacovigilance","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2776819417","wikidata":"https://www.wikidata.org/wiki/Q418123","display_name":"Dimethyl fumarate","level":3,"score":0.9261041879653931},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46924877166748047},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.4440818428993225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3320106267929077},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25391829013824463},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.17303365468978882},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.11031192541122437}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5061/dryad.n0cg254","doi":"https://doi.org/10.5061/dryad.n0cg254","is_oa":true,"landing_page_url":"https://doi.org/10.5061/dryad.n0cg254","pdf_url":null,"source":{"id":"https://openalex.org/S7407051161","display_name":"DRYAD","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"mag:2963544611","doi":null,"is_oa":false,"landing_page_url":"https://dryad.figshare.com/collections/Data_from_Effect_of_dimethyl_fumarate_on_lymphocytes_in_RRMS_implications_for_clinical_practice/4588556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.5061/dryad.n0cg254","doi":"https://doi.org/10.5061/dryad.n0cg254","is_oa":true,"landing_page_url":"https://doi.org/10.5061/dryad.n0cg254","pdf_url":null,"source":{"id":"https://openalex.org/S7407051161","display_name":"DRYAD","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2922559180","https://openalex.org/W2153193872","https://openalex.org/W2314741982","https://openalex.org/W6902827586","https://openalex.org/W3022692631","https://openalex.org/W2478946859","https://openalex.org/W2283213708","https://openalex.org/W3046004853","https://openalex.org/W2604858210","https://openalex.org/W4389444706"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"assess":[2],"functional":[3,90],"changes":[4],"in":[5,18,82,86,159,203,237],"lymphocyte":[6,44,67,91,172,186],"repertoire":[7],"and":[8,57,100,104,162,180,249],"subsequent":[9],"clinical":[10,29],"implications":[11],"during":[12],"delayed-release":[13],"dimethyl":[14],"fumarate":[15],"(DMF)":[16],"treatment":[17],"patients":[19,119,133,204,219],"with":[20,121,157,178,205],"multiple":[21],"sclerosis.":[22],"Methods:":[23],"Using":[24],"peripheral":[25],"blood":[26],"from":[27],"several":[28],"trials":[30],"of":[31,52,73,88,96,111,170,198,217,222],"DMF,":[32,122],"immune":[33],"cell":[34],"subsets":[35,154],"were":[36,46,175],"quantified":[37],"using":[38],"flow":[39],"cytometry.":[40],"For":[41,132],"some":[42],"patients,":[43,65],"counts":[45,68],"assessed":[47],"after":[48,142],"DMF":[49,136,143,166],"discontinuation.":[50,152],"Incidence":[51],"adverse":[53],"events,":[54],"including":[55],"serious":[56,112,199],"opportunistic":[58],"infections,":[59],"was":[60,80,116,201],"assessed.":[61],"Results:":[62],"In":[63],"DMF-treated":[64,238],"absolute":[66],"(ALCs)":[69],"demonstrated":[70],"a":[71,230],"pattern":[72],"decline":[74],"followed":[75],"by":[76,126,148],"stabilization,":[77],"which":[78],"also":[79],"reflected":[81],"the":[83,168,213],"global":[84],"reduction":[85],"numbers":[87],"circulating":[89,97,171],"subsets.":[92,173],"The":[93],"relative":[94],"frequencies":[95],"memory":[98],"T-":[99],"B-cell":[101],"populations":[102],"declined":[103],"naive":[105],"cells":[106],"increased.":[107],"No":[108,195],"increased":[109,141,196],"incidence":[110],"infection":[113,200],"or":[114,128],"malignancy":[115],"observed":[117,202],"for":[118,192,233],"treated":[120],"even":[123],"when":[124],"stratified":[125],"ALC":[127,149,211],"T-cell":[129,153,182,207],"subset":[130,187,208],"frequencies.":[131],"who":[134],"discontinued":[135],"due":[137],"to":[138,227],"lymphopenia,":[139,229],"ALCs":[140,158,174],"discontinuation;":[144],"recovery":[145],"time":[146],"varied":[147],"level":[150],"at":[151,220],"closely":[155,176],"correlated":[156,177],"both":[160],"longitudinal":[161],"cross-sectional":[163],"analyses.":[164],"Conclusions:":[165],"shifted":[167],"immunophenotype":[169],"CD4+":[179],"CD8+":[181],"counts,":[183],"indicating":[184],"that":[185],"monitoring":[188],"is":[189],"not":[190],"required":[191],"safety":[193],"vigilance.":[194],"risk":[197,221,231],"low":[206],"counts.":[209],"Monitoring":[210],"remains":[212],"most":[214],"effective":[215],"way":[216],"identifying":[218],"subsequently":[223],"developing":[224],"prolonged":[225],"moderate":[226],"severe":[228],"factor":[232],"progressive":[234],"multifocal":[235],"leukoencephalopathy":[236],"patients.":[239],"Trial":[240],"registration":[241],"numbers:":[242],"EUDRA":[243],"CT":[244],"2015-001973-42,":[245],"NCT00168701,":[246],"NCT00420212,":[247],"NCT00451451,":[248],"NCT00835770":[250]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2019-07-30T00:00:00"}
