{"id":"https://openalex.org/W2963543751","doi":"https://doi.org/10.1016/j.jhepr.2019.07.002","title":"From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options","display_name":"From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options","publication_year":2019,"publication_date":"2019-07-19","ids":{"openalex":"https://openalex.org/W2963543751","doi":"https://doi.org/10.1016/j.jhepr.2019.07.002","mag":"2963543751","pmid":"https://pubmed.ncbi.nlm.nih.gov/32039382","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7001557"},"language":"en","primary_location":{"id":"doi:10.1016/j.jhepr.2019.07.002","doi":"https://doi.org/10.1016/j.jhepr.2019.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhepr.2019.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210202621","display_name":"JHEP Reports","issn_l":"2589-5559","issn":["2589-5559"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JHEP Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jhepr.2019.07.002","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064556745","display_name":"Amalia Gastaldelli","orcid":"https://orcid.org/0000-0003-2594-1651","observed_orcids":["https://orcid.org/0000-0003-2594-1651"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Amalia Gastaldelli","raw_affiliation_strings":["Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiometabolic Risk Unit, Institute of Clinical Physiology, National Research Council, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086957117","display_name":"Kenneth J. Cusi","orcid":"https://orcid.org/0000-0002-8629-418X","observed_orcids":["https://orcid.org/0000-0002-8629-418X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210104802","display_name":"Malcom Randall VA Medical Center","ror":"https://ror.org/01ew49p77","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104802","https://openalex.org/I4210118777","https://openalex.org/I4210119004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth Cusi","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, The University of Florida, and Malcom Randall Veterans Administration Medical Center, Gainesville, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, The University of Florida, and Malcom Randall Veterans Administration Medical Center, Gainesville, Florida","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4210104802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5064556745","https://openalex.org/A5086957117"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4210104802","https://openalex.org/I4210106076","https://openalex.org/I4210155236"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":4.9706,"has_fulltext":false,"cited_by_count":470,"citation_normalized_percentile":{"value":0.98028169,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"1","issue":"4","first_page":"312","last_page":"328"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5640000104904175},{"id":"https://openalex.org/keywords/hepatic-insulin-sensitivity","display_name":"hepatic insulin sensitivity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7139999866485596},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/end-stage-liver-disease","display_name":"end-stage liver disease","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/glucotoxicity","display_name":"glucotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/adipose-tissue-dysfunction","display_name":"adipose tissue dysfunction","score":0.9670000076293945},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6539999842643738},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.8990998268127441},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.7942057847976685},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7708132266998291},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.732923150062561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7135207056999207},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6197389960289001},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5365502834320068},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.530605137348175},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4791771173477173},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4781937599182129},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.4728406071662903},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4547847509384155},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4502533972263336},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4446895718574524},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4334448575973511},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4199652671813965},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12850788235664368}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jhepr.2019.07.002","doi":"https://doi.org/10.1016/j.jhepr.2019.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhepr.2019.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210202621","display_name":"JHEP Reports","issn_l":"2589-5559","issn":["2589-5559"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JHEP Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7001557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7001557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JHEP Rep","raw_type":"Text"},{"id":"pmid:32039382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32039382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JHEP reports : innovation in hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f278787750f04787ae8a83416852ef3f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f278787750f04787ae8a83416852ef3f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JHEP Reports, Vol 1, Iss 4, Pp 312-328 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jhepr.2019.07.002","doi":"https://doi.org/10.1016/j.jhepr.2019.07.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jhepr.2019.07.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210202621","display_name":"JHEP Reports","issn_l":"2589-5559","issn":["2589-5559"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JHEP Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":231,"referenced_works":["https://openalex.org/W40400977","https://openalex.org/W184209557","https://openalex.org/W1196553794","https://openalex.org/W1511593276","https://openalex.org/W1539916041","https://openalex.org/W1542217491","https://openalex.org/W1609508996","https://openalex.org/W1622799587","https://openalex.org/W1695628563","https://openalex.org/W1758829516","https://openalex.org/W1862785272","https://openalex.org/W1891939305","https://openalex.org/W1942040918","https://openalex.org/W1957007052","https://openalex.org/W1965141016","https://openalex.org/W1966650637","https://openalex.org/W1969489686","https://openalex.org/W1969734540","https://openalex.org/W1973102191","https://openalex.org/W1974811153","https://openalex.org/W1974863952","https://openalex.org/W1975388439","https://openalex.org/W1977670439","https://openalex.org/W1978334327","https://openalex.org/W1979288606","https://openalex.org/W1981581852","https://openalex.org/W1985139805","https://openalex.org/W1985236262","https://openalex.org/W1985592156","https://openalex.org/W1986673931","https://openalex.org/W1987319592","https://openalex.org/W1988287975","https://openalex.org/W1988320060","https://openalex.org/W1988777910","https://openalex.org/W1992116679","https://openalex.org/W1992182388","https://openalex.org/W1992305923","https://openalex.org/W1995201952","https://openalex.org/W1996067821","https://openalex.org/W1997416444","https://openalex.org/W1999374351","https://openalex.org/W2000050828","https://openalex.org/W2000537121","https://openalex.org/W2008884182","https://openalex.org/W2010139869","https://openalex.org/W2013907512","https://openalex.org/W2015279471","https://openalex.org/W2016253107","https://openalex.org/W2022271042","https://openalex.org/W2025635942","https://openalex.org/W2026049223","https://openalex.org/W2029772633","https://openalex.org/W2030379010","https://openalex.org/W2030921297","https://openalex.org/W2031122764","https://openalex.org/W2032965816","https://openalex.org/W2038831349","https://openalex.org/W2039678693","https://openalex.org/W2040507318","https://openalex.org/W2041384370","https://openalex.org/W2041468536","https://openalex.org/W2054677013","https://openalex.org/W2059613020","https://openalex.org/W2062583781","https://openalex.org/W2062812115","https://openalex.org/W2064617441","https://openalex.org/W2068053039","https://openalex.org/W2069412892","https://openalex.org/W2071867050","https://openalex.org/W2073584727","https://openalex.org/W2074203821","https://openalex.org/W2075349184","https://openalex.org/W2079392925","https://openalex.org/W2083588619","https://openalex.org/W2086177834","https://openalex.org/W2087484038","https://openalex.org/W2088929386","https://openalex.org/W2096629131","https://openalex.org/W2099110406","https://openalex.org/W2102849202","https://openalex.org/W2103156933","https://openalex.org/W2107314043","https://openalex.org/W2108282017","https://openalex.org/W2108462699","https://openalex.org/W2108698393","https://openalex.org/W2108816189","https://openalex.org/W2109167239","https://openalex.org/W2109310039","https://openalex.org/W2109673125","https://openalex.org/W2109728760","https://openalex.org/W2111184067","https://openalex.org/W2111244421","https://openalex.org/W2112560527","https://openalex.org/W2113064802","https://openalex.org/W2113544353","https://openalex.org/W2113983413","https://openalex.org/W2115366040","https://openalex.org/W2115433418","https://openalex.org/W2121879147","https://openalex.org/W2122077393","https://openalex.org/W2125239733","https://openalex.org/W2125769789","https://openalex.org/W2130920597","https://openalex.org/W2136226749","https://openalex.org/W2136906985","https://openalex.org/W2138748324","https://openalex.org/W2139351004","https://openalex.org/W2143801678","https://openalex.org/W2146877877","https://openalex.org/W2148020672","https://openalex.org/W2151490108","https://openalex.org/W2151504182","https://openalex.org/W2153747727","https://openalex.org/W2155605350","https://openalex.org/W2159896083","https://openalex.org/W2159969745","https://openalex.org/W2161494184","https://openalex.org/W2161883681","https://openalex.org/W2162051951","https://openalex.org/W2162078466","https://openalex.org/W2162940414","https://openalex.org/W2162996506","https://openalex.org/W2163904781","https://openalex.org/W2164364203","https://openalex.org/W2164375919","https://openalex.org/W2167245776","https://openalex.org/W2168245033","https://openalex.org/W2168763055","https://openalex.org/W2170154233","https://openalex.org/W2170932033","https://openalex.org/W2176459589","https://openalex.org/W2190193027","https://openalex.org/W2204688218","https://openalex.org/W2215535790","https://openalex.org/W2217664544","https://openalex.org/W2223223169","https://openalex.org/W2223377380","https://openalex.org/W2239579612","https://openalex.org/W2274836352","https://openalex.org/W2275659322","https://openalex.org/W2285169196","https://openalex.org/W2290798357","https://openalex.org/W2316193238","https://openalex.org/W2327628147","https://openalex.org/W2341165197","https://openalex.org/W2341236811","https://openalex.org/W2397510559","https://openalex.org/W2397785404","https://openalex.org/W2401868452","https://openalex.org/W2405985041","https://openalex.org/W2470709274","https://openalex.org/W2501628945","https://openalex.org/W2512913340","https://openalex.org/W2515629008","https://openalex.org/W2519479884","https://openalex.org/W2520975418","https://openalex.org/W2529114944","https://openalex.org/W2530347223","https://openalex.org/W2531213507","https://openalex.org/W2551499720","https://openalex.org/W2552584881","https://openalex.org/W2555083717","https://openalex.org/W2558199233","https://openalex.org/W2558996269","https://openalex.org/W2559667044","https://openalex.org/W2560143854","https://openalex.org/W2560275357","https://openalex.org/W2561077285","https://openalex.org/W2562394161","https://openalex.org/W2564221522","https://openalex.org/W2566542468","https://openalex.org/W2569813586","https://openalex.org/W2571158149","https://openalex.org/W2586902684","https://openalex.org/W2590242508","https://openalex.org/W2598765141","https://openalex.org/W2606658420","https://openalex.org/W2607779679","https://openalex.org/W2624674854","https://openalex.org/W2626282634","https://openalex.org/W2726939337","https://openalex.org/W2728177312","https://openalex.org/W2732773839","https://openalex.org/W2733324404","https://openalex.org/W2734724639","https://openalex.org/W2737083386","https://openalex.org/W2741150613","https://openalex.org/W2741982109","https://openalex.org/W2742155329","https://openalex.org/W2743468233","https://openalex.org/W2746874591","https://openalex.org/W2748255442","https://openalex.org/W2748954699","https://openalex.org/W2754229266","https://openalex.org/W2755062963","https://openalex.org/W2766835642","https://openalex.org/W2775026689","https://openalex.org/W2787255324","https://openalex.org/W2791409258","https://openalex.org/W2791728731","https://openalex.org/W2793303845","https://openalex.org/W2802642636","https://openalex.org/W2805588616","https://openalex.org/W2807637161","https://openalex.org/W2808615577","https://openalex.org/W2883001358","https://openalex.org/W2883963712","https://openalex.org/W2884466498","https://openalex.org/W2885541768","https://openalex.org/W2885588864","https://openalex.org/W2885653810","https://openalex.org/W2887038895","https://openalex.org/W2887583392","https://openalex.org/W2888722616","https://openalex.org/W2894746763","https://openalex.org/W2894993577","https://openalex.org/W2896061464","https://openalex.org/W2901946789","https://openalex.org/W2902649075","https://openalex.org/W2902717147","https://openalex.org/W2905282109","https://openalex.org/W2937671907","https://openalex.org/W2946574770","https://openalex.org/W3041087683","https://openalex.org/W3143409077","https://openalex.org/W4213182273","https://openalex.org/W4240800883","https://openalex.org/W4254965081","https://openalex.org/W6656611441","https://openalex.org/W6704247751","https://openalex.org/W6728662870"],"related_works":["https://openalex.org/W3160407865","https://openalex.org/W1826389973","https://openalex.org/W2765105402","https://openalex.org/W3196055218","https://openalex.org/W4385760023","https://openalex.org/W3170394737","https://openalex.org/W2002046476","https://openalex.org/W2341165197","https://openalex.org/W4313515564","https://openalex.org/W3036393486"],"abstract_inverted_index":{"The":[0],"worldwide":[1],"prevalence":[2,105],"of":[3,42,77,92,106,142,158,177],"non-alcoholic":[4],"fatty":[5],"liver":[6,57,108,112],"disease":[7,58],"(NAFLD)":[8],"is":[9,20,33,151],"estimated":[10],"to":[11,38,125,166],"have":[12,102],"reached":[13],"25%":[14],"or":[15],"more":[16,55],"in":[17,22,52,144],"adults.":[18],"NAFLD":[19,32,145],"prevalent":[21],"obese":[23],"individuals,":[24],"but":[25,73],"may":[26,49],"also":[27,74],"affect":[28],"non-obese":[29],"insulin-resistant":[30],"individuals.":[31],"associated":[34],"with":[35,54,71,100],"a":[36,103,127],"2-":[37],"3-fold":[39],"increased":[40],"risk":[41,91],"developing":[43,93],"type":[44],"2":[45],"diabetes":[46,101],"(T2D),":[47],"which":[48],"be":[50,172],"higher":[51,104],"patients":[53,99],"severe":[56],"-":[59],"fibrosis":[60,109],"increases":[61],"this":[62,130],"risk.":[63],"In":[64,129],"NAFLD,":[65],"not":[66],"only":[67],"the":[68,75,90,134,140,156,175],"close":[69],"association":[70],"obesity,":[72],"impairment":[76],"many":[78],"metabolic":[79],"pathways,":[80],"including":[81],"decreased":[82],"hepatic":[83],"insulin":[84,87],"sensitivity":[85],"and":[86,95,110,115,122,146],"secretion,":[88],"increase":[89],"T2D":[94,143,168],"related":[96],"comorbidities.":[97],"Conversely,":[98],"steatohepatitis,":[107],"end-stage":[111],"disease.":[113],"Genetics":[114],"mechanisms":[116,137],"involving":[117],"dysfunctional":[118],"adipose":[119],"tissue,":[120],"lipotoxicity":[121],"glucotoxicity":[123],"appear":[124],"play":[126],"role.":[128],"review,":[131],"we":[132,160],"discuss":[133,161],"altered":[135],"pathophysiological":[136],"that":[138,169],"underlie":[139],"development":[141],"vice":[147],"versa.":[148],"Although":[149],"there":[150],"no":[152],"approved":[153],"therapy":[154],"for":[155,174],"treatment":[157],"NASH,":[159],"pharmacological":[162],"agents":[163],"currently":[164],"available":[165],"treat":[167],"could":[170],"potentially":[171],"useful":[173],"management":[176],"NASH.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":54},{"year":2025,"cited_by_count":72},{"year":2024,"cited_by_count":89},{"year":2023,"cited_by_count":74},{"year":2022,"cited_by_count":63},{"year":2021,"cited_by_count":78},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-30T00:00:00"}
