{"id":"https://openalex.org/W2963468136","doi":"https://doi.org/10.1038/s41586-019-1429-3","title":"Flower isoforms promote competitive growth in cancer","display_name":"Flower isoforms promote competitive growth in cancer","publication_year":2019,"publication_date":"2019-07-24","ids":{"openalex":"https://openalex.org/W2963468136","doi":"https://doi.org/10.1038/s41586-019-1429-3","mag":"2963468136","pmid":"https://pubmed.ncbi.nlm.nih.gov/31341286"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-019-1429-3","doi":"https://doi.org/10.1038/s41586-019-1429-3","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-019-1429-3","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044929306","display_name":"Esha Madan","orcid":"https://orcid.org/0000-0002-4941-0612","observed_orcids":["https://orcid.org/0000-0002-4941-0612"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Esha Madan","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007467595","display_name":"Christopher James Pelham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182380053","display_name":"University of Health Sciences and Pharmacy","ror":"https://ror.org/01btzz102","country_code":"US","type":"education","lineage":["https://openalex.org/I182380053"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Pelham","raw_affiliation_strings":["Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, MO, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, MO, USA","institution_ids":["https://openalex.org/I182380053","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Center for Clinical Pharmacology, Washington University School of Medicine and St. Louis College of Pharmacy, St. Louis, USA","institution_ids":["https://openalex.org/I182380053","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067828788","display_name":"Masaki Nagane","orcid":"https://orcid.org/0000-0002-3408-7656","observed_orcids":["https://orcid.org/0000-0002-3408-7656"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaki Nagane","raw_affiliation_strings":["Department of Biochemistry, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Veterinary Medicine, Azabu University, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066981663","display_name":"Taylor M. Parker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor M. Parker","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4390039234","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I4390039234","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101424350","display_name":"Rita Canas\u2010Marques","orcid":"https://orcid.org/0000-0002-7184-4230","observed_orcids":["https://orcid.org/0000-0002-7184-4230"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rita Canas-Marques","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065981817","display_name":"Kimberly Fazio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly Fazio","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University, Omaha, NE, USA","Department of Biomedical Sciences, Creighton University, Omaha, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052497489","display_name":"Kranti Shaik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kranti Shaik","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University, Omaha, NE, USA","Department of Biomedical Sciences, Creighton University, Omaha, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065413217","display_name":"Youzhong Yuan","orcid":"https://orcid.org/0000-0002-7681-2756","observed_orcids":["https://orcid.org/0000-0002-7681-2756","https://orcid.org/0000-0003-4087-3466"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youzhong Yuan","raw_affiliation_strings":["Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035475478","display_name":"Vanessa Henriques","orcid":"https://orcid.org/0000-0002-2154-0853","observed_orcids":["https://orcid.org/0000-0002-2154-0853"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Vanessa Henriques","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086665128","display_name":"Ant\u00f3nio Galzerano","orcid":"https://orcid.org/0000-0002-4297-7907","observed_orcids":["https://orcid.org/0000-0002-4297-7907"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Antonio Galzerano","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076516879","display_name":"Tadashi Yamashita","orcid":"https://orcid.org/0000-0001-8022-0158","observed_orcids":["https://orcid.org/0000-0001-8022-0158"]},"institutions":[{"id":"https://openalex.org/I57361664","display_name":"Azabu University","ror":"https://ror.org/00wzjq897","country_code":"JP","type":"education","lineage":["https://openalex.org/I57361664"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Yamashita","raw_affiliation_strings":["Department of Biochemistry, School of Veterinary Medicine, Azabu University, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, School of Veterinary Medicine, Azabu University, Kanagawa, Japan","institution_ids":["https://openalex.org/I57361664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066572286","display_name":"Miguel Alexandre Ferreira Pinto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel Alexandre Ferreira Pinto","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071982848","display_name":"Ant\u00f3nio M. Palma","orcid":"https://orcid.org/0000-0001-5229-4985","observed_orcids":["https://orcid.org/0000-0001-5229-4985"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Antonio M. Palma","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031548270","display_name":"Denise Camacho","orcid":"https://orcid.org/0000-0002-9218-8447","observed_orcids":["https://orcid.org/0000-0002-9218-8447"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Denise Camacho","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084947734","display_name":"Ana I. S. Vieira","orcid":"https://orcid.org/0000-0002-4045-3691","observed_orcids":["https://orcid.org/0000-0002-4045-3691"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Vieira","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Soldini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David Soldini","raw_affiliation_strings":["Institute for Surgical Pathology, University Hospital and University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Surgical Pathology, University Hospital and University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077837457","display_name":"Harikrishna Nakshatri","orcid":"https://orcid.org/0000-0001-8876-0052","observed_orcids":["https://orcid.org/0000-0001-8876-0052"]},"institutions":[{"id":"https://openalex.org/I4390039234","display_name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center","ror":"https://ror.org/00g1d7b60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039234","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harikrishna Nakshatri","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA","Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4390039234","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, USA","institution_ids":["https://openalex.org/I4390039234","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026164472","display_name":"Steven R. Post","orcid":"https://orcid.org/0000-0002-4711-1723","observed_orcids":["https://orcid.org/0000-0002-4711-1723"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Post","raw_affiliation_strings":["Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010497283","display_name":"Christa Rhiner","orcid":"https://orcid.org/0000-0001-7577-8042","observed_orcids":["https://orcid.org/0000-0001-7577-8042"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Christa Rhiner","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009237974","display_name":"Hiroko Yamashita","orcid":"https://orcid.org/0000-0003-4281-8727","observed_orcids":["https://orcid.org/0000-0003-4281-8727"]},"institutions":[{"id":"https://openalex.org/I4210141669","display_name":"Hokkaido University Hospital","ror":"https://ror.org/0419drx70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210141669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroko Yamashita","raw_affiliation_strings":["Department of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, Hokkaido University Hospital, Sapporo, Japan","institution_ids":["https://openalex.org/I4210141669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090118255","display_name":"Davide Accardi","orcid":"https://orcid.org/0000-0002-2158-8048","observed_orcids":["https://orcid.org/0000-0002-2158-8048"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Davide Accardi","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090125940","display_name":"Laura A. Hansen","orcid":"https://orcid.org/0000-0003-3436-8412","observed_orcids":["https://orcid.org/0000-0003-3436-8412"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A. Hansen","raw_affiliation_strings":["Department of Biomedical Sciences, Creighton University, Omaha, NE, USA","Department of Biomedical Sciences, Creighton University, Omaha, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Department of Biomedical Sciences, Creighton University, Omaha, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015800782","display_name":"Carlos Torres Carvalho","orcid":"https://orcid.org/0000-0003-4944-3075","observed_orcids":["https://orcid.org/0000-0003-4944-3075"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carlos Carvalho","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035937813","display_name":"Antonio Lopez-beltran B","orcid":"https://orcid.org/0000-0003-3161-8164","observed_orcids":["https://orcid.org/0000-0003-3161-8164","https://orcid.org/0000-0002-0724-1267"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Antonio L. Beltran","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000616950","display_name":"Periannan Kuppusamy","orcid":"https://orcid.org/0000-0002-3214-0660","observed_orcids":["https://orcid.org/0000-0002-3214-0660"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I4390039367","display_name":"Dartmouth Cancer Center","ror":"https://ror.org/044b05b34","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039367"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Periannan Kuppusamy","raw_affiliation_strings":["Department of Radiology and Medicine, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA","Department of Radiology and Medicine, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Medicine, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]},{"raw_affiliation_string":"Department of Radiology and Medicine, Norris Cotton Cancer Center, Geisel School of Medicine, Dartmouth College, Lebanon, USA","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I4390039367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004603008","display_name":"Rajan Gogna","orcid":"https://orcid.org/0000-0001-7304-7692","observed_orcids":["https://orcid.org/0000-0001-7304-7692","https://orcid.org/0009-0000-0214-6853"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]},{"id":"https://openalex.org/I4405252512","display_name":"Centro Champalimaud","ror":"https://ror.org/007rd1x46","country_code":"PT","type":"other","lineage":["https://openalex.org/I113358080","https://openalex.org/I4405252512"]},{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["PT","US"],"is_corresponding":true,"raw_author_name":"Rajan Gogna","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal. rajan.gogna@research.fchampalimaud.org","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. rajan.gogna@research.fchampalimaud.org","Champalimaud Centre for the Unknown, Lisbon, Portugal","Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal. rajan.gogna@research.fchampalimaud.org","institution_ids":["https://openalex.org/I4405252512"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. rajan.gogna@research.fchampalimaud.org","institution_ids":["https://openalex.org/I79620101"]},{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]},{"raw_affiliation_string":"Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091503465","display_name":"Eduardo Moreno","orcid":"https://orcid.org/0000-0001-5040-452X","observed_orcids":["https://orcid.org/0000-0001-5040-452X"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]},{"id":"https://openalex.org/I4405252512","display_name":"Centro Champalimaud","ror":"https://ror.org/007rd1x46","country_code":"PT","type":"other","lineage":["https://openalex.org/I113358080","https://openalex.org/I4405252512"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Eduardo Moreno","raw_affiliation_strings":["Champalimaud Centre for the Unknown, Lisbon, Portugal. eduardo.moreno@research.fchampalimaud.org","Champalimaud Centre for the Unknown, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal. eduardo.moreno@research.fchampalimaud.org","institution_ids":["https://openalex.org/I4405252512"]},{"raw_affiliation_string":"Champalimaud Centre for the Unknown, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5004603008","https://openalex.org/A5091503465"],"corresponding_institution_ids":["https://openalex.org/I113358080","https://openalex.org/I4405252512","https://openalex.org/I79620101"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":5.2739,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.97247011,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"572","issue":"7768","first_page":"260","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0778999999165535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-competition","display_name":"cell competition","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cell-selection","display_name":"cell selection","score":0.5329999923706055},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6019999980926514},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.878000020980835},{"id":"https://openalex.org/keywords/cell-recognition","display_name":"cell recognition","score":0.37700000405311584}],"concepts":[{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7768010497093201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6361332535743713},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5750481486320496},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5554457902908325},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5516893267631531},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.548010528087616},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5168591141700745},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42919689416885376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.365885853767395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3123440146446228},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25594109296798706},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41586-019-1429-3","doi":"https://doi.org/10.1038/s41586-019-1429-3","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-019-1429-3","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:31341286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31341286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:572:y:2019:i:7768:d:10.1038_s41586-019-1429-3","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41586-019-1429-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1541926685","https://openalex.org/W1866742017","https://openalex.org/W1893602976","https://openalex.org/W1908425558","https://openalex.org/W1968483102","https://openalex.org/W1973260880","https://openalex.org/W1983660137","https://openalex.org/W1993533291","https://openalex.org/W1995140801","https://openalex.org/W2001576307","https://openalex.org/W2002225831","https://openalex.org/W2009916940","https://openalex.org/W2023560061","https://openalex.org/W2027775756","https://openalex.org/W2030982446","https://openalex.org/W2031211461","https://openalex.org/W2031289335","https://openalex.org/W2036659547","https://openalex.org/W2042365294","https://openalex.org/W2048208025","https://openalex.org/W2065394786","https://openalex.org/W2065890382","https://openalex.org/W2086440967","https://openalex.org/W2086702072","https://openalex.org/W2093047582","https://openalex.org/W2106880776","https://openalex.org/W2114570899","https://openalex.org/W2115078173","https://openalex.org/W2126525177","https://openalex.org/W2128282415","https://openalex.org/W2133381977","https://openalex.org/W2133920348","https://openalex.org/W2146313292","https://openalex.org/W2167575664","https://openalex.org/W2259938310","https://openalex.org/W2429842404","https://openalex.org/W2441900188","https://openalex.org/W2465201479","https://openalex.org/W2525290462","https://openalex.org/W2594965158","https://openalex.org/W2734791707","https://openalex.org/W2776685243","https://openalex.org/W2778099515","https://openalex.org/W2792077818","https://openalex.org/W2939132826","https://openalex.org/W6940169317"],"related_works":["https://openalex.org/W2076642156","https://openalex.org/W2093047582","https://openalex.org/W3118250975","https://openalex.org/W2963562652","https://openalex.org/W7098224581","https://openalex.org/W2553188405","https://openalex.org/W7203627524","https://openalex.org/W4403687924","https://openalex.org/W7027047316","https://openalex.org/W4393218404"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-30T00:00:00"}