{"id":"https://openalex.org/W2963444387","doi":"https://doi.org/10.1016/j.jacc.2019.05.045","title":"Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD","display_name":"Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2963444387","doi":"https://doi.org/10.1016/j.jacc.2019.05.045","mag":"2963444387","pmid":"https://pubmed.ncbi.nlm.nih.gov/31345433","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6662618"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacc.2019.05.045","doi":"https://doi.org/10.1016/j.jacc.2019.05.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2019.05.045","pdf_url":"https://www.sciencedirect.com/science/article/pii/S073510971935380X/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S073510971935380X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005889696","display_name":"Sumeet A. Khetarpal","orcid":"https://orcid.org/0009-0000-8269-6889","observed_orcids":["https://orcid.org/0009-0000-8269-6889"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumeet A. Khetarpal","raw_affiliation_strings":["Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts","Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","Department of Medicine, Harvard Medical School, Boston, Massachusetts","Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013162997","display_name":"Arman Qamar","orcid":"https://orcid.org/0000-0003-0607-1240","observed_orcids":["https://orcid.org/0000-0003-0607-1240"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210159766","display_name":"Thrombolysis in Myocardial Infarction Study Group","ror":"https://ror.org/05vp7ha71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210159766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arman Qamar","raw_affiliation_strings":["TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I4210159766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012759454","display_name":"Alexander G. Bick","orcid":"https://orcid.org/0000-0001-5824-9595","observed_orcids":["https://orcid.org/0000-0001-5824-9595"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander G. Bick","raw_affiliation_strings":["Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts","Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","Department of Medicine, Harvard Medical School, Boston, Massachusetts","Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089775220","display_name":"Jos\u00e9 J. Fuster","orcid":"https://orcid.org/0000-0002-5970-629X","observed_orcids":["https://orcid.org/0000-0002-5970-629X"]},"institutions":[{"id":"https://openalex.org/I2809107791","display_name":"Spanish National Centre for Cardiovascular Research","ror":"https://ror.org/02qs1a797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I2809107791","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 J. Fuster","raw_affiliation_strings":["Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain","institution_ids":["https://openalex.org/I2809107791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043655881","display_name":"Sekar Kathiresan","orcid":"https://orcid.org/0000-0002-6724-032X","observed_orcids":["https://orcid.org/0000-0002-6724-032X","https://orcid.org/0000-0002-3711-7101","https://orcid.org/0000-0002-6201-5334"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210120586","display_name":"Verve Therapeutics (United States)","ror":"https://ror.org/02f7f9m65","country_code":"US","type":"company","lineage":["https://openalex.org/I4210120586"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sekar Kathiresan","raw_affiliation_strings":["Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Verve Therapeutics, Cambridge, Massachusetts","Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","Department of Medicine, Harvard Medical School, Boston, Massachusetts","Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts","Verve Therapeutics, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Verve Therapeutics, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210120586","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Verve Therapeutics, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I4210120586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077911256","display_name":"Siddhartha Jaiswal","orcid":"https://orcid.org/0000-0002-9597-0477","observed_orcids":["https://orcid.org/0000-0002-9597-0477"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siddhartha Jaiswal","raw_affiliation_strings":["Department of Pathology, Stanford University School of Medicine, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University School of Medicine, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047884631","display_name":"Pradeep Natarajan","orcid":"https://orcid.org/0000-0001-8402-7435","observed_orcids":["https://orcid.org/0000-0001-8402-7435"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pradeep Natarajan","raw_affiliation_strings":["Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts. Electronic address: pnatarajan@mgh.harvard.edu","Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","Department of Medicine, Harvard Medical School, Boston, Massachusetts","Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts. Electronic address: pnatarajan@mgh.harvard.edu","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5047884631"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I63966007"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.8452,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.85798817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"74","issue":"4","first_page":"578","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis-of-indeterminate-potential","display_name":"clonal hematopoiesis of indeterminate potential","score":1.0},{"id":"https://openalex.org/keywords/atherosclerotic-cardiovascular-disease","display_name":"atherosclerotic cardiovascular disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.921999990940094},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7419999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-disease","display_name":"vascular disease","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7260000109672546},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7357682585716248},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6864492893218994},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5982195734977722},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.48522189259529114},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.42281392216682434},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3956207036972046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3049313426017761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2699412703514099},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2511160969734192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2033456563949585},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.16766536235809326}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jacc.2019.05.045","doi":"https://doi.org/10.1016/j.jacc.2019.05.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2019.05.045","pdf_url":"https://www.sciencedirect.com/science/article/pii/S073510971935380X/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},{"id":"pmid:31345433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31345433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6662618","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6662618","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Am Coll Cardiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.jacc.2019.05.045","doi":"https://doi.org/10.1016/j.jacc.2019.05.045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2019.05.045","pdf_url":"https://www.sciencedirect.com/science/article/pii/S073510971935380X/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1299449749","display_name":null,"funder_award_id":"TNE-18CVD04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1595975505","display_name":null,"funder_award_id":"SEV-2015-0505","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G3741318032","display_name":null,"funder_award_id":"TNE-18CVD04","funder_id":"https://openalex.org/F4320310567","funder_display_name":"Boston Scientific Corporation"},{"id":"https://openalex.org/G4169769675","display_name":null,"funder_award_id":"SEV-2015-0505","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G4463822314","display_name":null,"funder_award_id":"18SFRN3390085","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4681065090","display_name":"Risk Prediction and Personalizing Therapy to Prevent Critical Limb ischemia in Patients with PAD and Diabetes","funder_award_id":"18SFRN33960262","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G5240891896","display_name":null,"funder_award_id":"TNE-18CVD04","funder_id":"https://openalex.org/F4320307105","funder_display_name":"Amgen"},{"id":"https://openalex.org/G5453574157","display_name":"Understanding modifiers of mendelian mutation penetrance using familial hypercholesterolemia as a model","funder_award_id":"K08HL140203","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5454720240","display_name":null,"funder_award_id":"SEV\u20102015\u20100505","funder_id":"https://openalex.org/F4320323479","funder_display_name":"Centro Nacional de Investigaciones Cardiovasculares"},{"id":"https://openalex.org/G6019571271","display_name":"Somatic TET2 mutation-driven clonal hematopoiesis in atherosclerosis","funder_award_id":"R01HL141123","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G603018768","display_name":null,"funder_award_id":"TNE\u201018CVD04","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G6355960561","display_name":null,"funder_award_id":"T32 HL007604","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8251085824","display_name":null,"funder_award_id":"RYC-2016-20026","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G8792955249","display_name":null,"funder_award_id":"SEV-2015-0505","funder_id":"https://openalex.org/F4320310567","funder_display_name":"Boston Scientific Corporation"},{"id":"https://openalex.org/G9000552312","display_name":"Clonal hematopoiesis and atherosclerosis","funder_award_id":"18CVD04","funder_id":"https://openalex.org/F4320320890","funder_display_name":"Fondation Leducq"},{"id":"https://openalex.org/G9000867580","display_name":"Whole genome sequences in ethnically diverse individuals to comprehensively characterize the genetic mechanisms of dyslipidemias","funder_award_id":"R01HL142711","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000919599","display_name":"Training Grant in Cardiovascular Research","funder_award_id":"T32HL007604","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320310567","display_name":"Boston Scientific Corporation","ror":"https://ror.org/0385es521"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"},{"id":"https://openalex.org/F4320323479","display_name":"Centro Nacional de Investigaciones Cardiovasculares","ror":"https://ror.org/02qs1a797"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963444387.pdf","grobid_xml":"https://content.openalex.org/works/W2963444387.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W269456550","https://openalex.org/W1600722282","https://openalex.org/W1971651222","https://openalex.org/W1980465014","https://openalex.org/W1985823023","https://openalex.org/W1992826811","https://openalex.org/W1997453048","https://openalex.org/W1998367819","https://openalex.org/W2005458309","https://openalex.org/W2006634243","https://openalex.org/W2012753533","https://openalex.org/W2028078153","https://openalex.org/W2029154060","https://openalex.org/W2038449573","https://openalex.org/W2045819100","https://openalex.org/W2049145190","https://openalex.org/W2054744711","https://openalex.org/W2055521874","https://openalex.org/W2066575137","https://openalex.org/W2072367160","https://openalex.org/W2076031927","https://openalex.org/W2076423853","https://openalex.org/W2098000380","https://openalex.org/W2100748836","https://openalex.org/W2114278094","https://openalex.org/W2115551519","https://openalex.org/W2116205277","https://openalex.org/W2126816979","https://openalex.org/W2127296141","https://openalex.org/W2134061682","https://openalex.org/W2134471396","https://openalex.org/W2149858388","https://openalex.org/W2466048836","https://openalex.org/W2466475522","https://openalex.org/W2469730812","https://openalex.org/W2511116391","https://openalex.org/W2578808037","https://openalex.org/W2589366040","https://openalex.org/W2612571615","https://openalex.org/W2628145035","https://openalex.org/W2746373891","https://openalex.org/W2746871805","https://openalex.org/W2748400555","https://openalex.org/W2751498819","https://openalex.org/W2753051611","https://openalex.org/W2770273110","https://openalex.org/W2786854070","https://openalex.org/W2787334626","https://openalex.org/W2791529560","https://openalex.org/W2796704538","https://openalex.org/W2800927741","https://openalex.org/W2803360616","https://openalex.org/W2884701867","https://openalex.org/W2891919070","https://openalex.org/W2900002398","https://openalex.org/W2902919316","https://openalex.org/W2904739194","https://openalex.org/W2917205492","https://openalex.org/W2979122061","https://openalex.org/W4213010269","https://openalex.org/W4242239767","https://openalex.org/W6760260224","https://openalex.org/W6809290245"],"related_works":["https://openalex.org/W3042095806","https://openalex.org/W2967463001","https://openalex.org/W4376604758","https://openalex.org/W4327684303","https://openalex.org/W3198438480","https://openalex.org/W2998000661","https://openalex.org/W7116876105","https://openalex.org/W4313453400","https://openalex.org/W7136357928","https://openalex.org/W7153270364"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}
