{"id":"https://openalex.org/W2963423381","doi":null,"title":"IL-6 increases SDCBP expression, cell proliferation, and cell invasion by activating JAK2/STAT3 in human glioma cells.","display_name":"IL-6 increases SDCBP expression, cell proliferation, and cell invasion by activating JAK2/STAT3 in human glioma cells.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2963423381","mag":"2963423381","pmid":"https://pubmed.ncbi.nlm.nih.gov/29118922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5666069"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5666069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5666069","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5666069","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100719399","display_name":"Fang Cao","orcid":"https://orcid.org/0000-0002-4900-8957","observed_orcids":["https://orcid.org/0000-0002-4900-8957"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Cao","raw_affiliation_strings":["Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Zhang","raw_affiliation_strings":["Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102809004","display_name":"Chong Han","orcid":"https://orcid.org/0000-0002-8520-6029","observed_orcids":["https://orcid.org/0000-0002-8520-6029"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chong Han","raw_affiliation_strings":["Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065361831","display_name":"Yang He","orcid":"https://orcid.org/0000-0001-6153-4354","observed_orcids":["https://orcid.org/0000-0001-6153-4354"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang He","raw_affiliation_strings":["Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051524231","display_name":"Qishan Ran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qishan Ran","raw_affiliation_strings":["Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","Department of Stroke Unit and Neurosurgery, The First People's Hospital of ZunyiNo. 98, Fenghuang North Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cerebrovascular Disease, The First Affiliated Hospital of Zunyi Medical CollegeNo. 139, Dalian Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I182386381"]},{"raw_affiliation_string":"Department of Stroke Unit and Neurosurgery, The First People's Hospital of ZunyiNo. 98, Fenghuang North Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I4210117574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043130347","display_name":"Shengtao Yao","orcid":"https://orcid.org/0000-0002-6564-2261","observed_orcids":["https://orcid.org/0000-0002-6564-2261"]},"institutions":[{"id":"https://openalex.org/I4210117574","display_name":"First People\u2019s Hospital of Zunyi","ror":"https://ror.org/02f8z2f57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117574"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengtao Yao","raw_affiliation_strings":["Department of Stroke Unit and Neurosurgery, The First People's Hospital of ZunyiNo. 98, Fenghuang North Avenue, Huichuan District, Zunyi 563000, Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stroke Unit and Neurosurgery, The First People's Hospital of ZunyiNo. 98, Fenghuang North Avenue, Huichuan District, Zunyi 563000, Guizhou, China","institution_ids":["https://openalex.org/I4210117574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0691,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74614533,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"10","first_page":"4617","last_page":"4626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.996999979019165},{"id":"https://openalex.org/keywords/sdcbp","display_name":"SDCBP","score":0.8579999804496765},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/jak2-stat3-signaling-pathway","display_name":"JAK2/STAT3 signaling","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.847000002861023},{"id":"https://openalex.org/keywords/ag490","display_name":"AG490","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.34700000286102295},{"id":"https://openalex.org/keywords/t98g-cells","display_name":"T98G cells","score":0.7680000066757202},{"id":"https://openalex.org/keywords/u87-cells","display_name":"U87 cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7828171849250793},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.74830162525177},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.6764005422592163},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6559404134750366},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6320319771766663},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.6115156412124634},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6073793768882751},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5449598431587219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46591997146606445},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.4627532958984375},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4346466660499573},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43362191319465637},{"id":"https://openalex.org/C32465701","wikidata":"https://www.wikidata.org/wiki/Q14914514","display_name":"Janus kinase 2","level":3,"score":0.43113410472869873},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4114803373813629},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36427807807922363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:5666069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5666069","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:29118922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29118922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"mag:2963423381","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29118922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5666069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5666069","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W48986072","https://openalex.org/W1652153701","https://openalex.org/W1820661762","https://openalex.org/W1968855063","https://openalex.org/W1976594597","https://openalex.org/W1979347549","https://openalex.org/W1981072187","https://openalex.org/W1982735609","https://openalex.org/W2007501395","https://openalex.org/W2020812892","https://openalex.org/W2033827824","https://openalex.org/W2051623108","https://openalex.org/W2052432571","https://openalex.org/W2061391354","https://openalex.org/W2062030284","https://openalex.org/W2073057074","https://openalex.org/W2079281499","https://openalex.org/W2079487111","https://openalex.org/W2084823216","https://openalex.org/W2096629377","https://openalex.org/W2122943299","https://openalex.org/W2123431540","https://openalex.org/W2131014649","https://openalex.org/W2135465849","https://openalex.org/W2148977460","https://openalex.org/W2157912474","https://openalex.org/W2164156560","https://openalex.org/W2165174685","https://openalex.org/W2208641275"],"related_works":["https://openalex.org/W2376662407","https://openalex.org/W2062030284","https://openalex.org/W2124224257","https://openalex.org/W3031270073","https://openalex.org/W1965389466","https://openalex.org/W1966707815","https://openalex.org/W7145125454","https://openalex.org/W2762639940","https://openalex.org/W2380739816","https://openalex.org/W2553843038"],"abstract_inverted_index":{"Syndecan-binding":[0],"protein":[1,111],"(SDCBP),":[2],"which":[3,181],"is":[4,26,137,182],"induced":[5,104],"by":[6,68,177,184],"tumor":[7],"necrosis":[8],"factor-\u03b1":[9],"and":[10,15,38,50,66,76,84,92,102,110,142,175],"interferon-\u03b3,":[11],"controls":[12],"the":[13,34,46,116,124,130],"proliferation":[14,75,174],"invasion":[16,77,158,176],"of":[17,21,132,144],"several":[18],"different":[19],"types":[20],"cancer":[22],"cells.":[23,54],"Interleukin-6":[24],"(IL-6)":[25],"known":[27],"to":[28,44],"play":[29],"an":[30],"important":[31],"role":[32],"in":[33,52,60,96],"glioma":[35,53,62,97,154,172],"cell":[36,63,155,173],"growth":[37,156],"invasion.":[39],"The":[40],"present":[41],"study":[42],"aimed":[43],"investigate":[45],"relationship":[47],"between":[48,90],"IL-6":[49,93,99,133,150,170],"SDCBP":[51,55,82,91,105,126,135,160,179],"expression":[56,94,106,161],"was":[57,86,162],"knocked":[58],"down":[59],"two":[61],"lines":[64],"(T98G":[65],"U87)":[67],"small":[69],"interfering":[70],"RNA":[71],"(siRNA)":[72],"transfection.":[73],"Cell":[74],"were":[78],"significantly":[79],"repressed":[80],"following":[81],"knockdown,":[83],"there":[85],"a":[87],"positive":[88],"correlation":[89],"levels":[95],"tissues.":[98],"stimulation":[100],"dose-":[101],"time-dependently":[103],"at":[107],"both":[108],"mRNA":[109],"levels.":[112],"Furthermore,":[113],"pre-treatment":[114],"with":[115],"Janus":[117],"kinase":[118],"2":[119],"(JAK2)":[120],"inhibitor":[121],"AG490":[122],"abolished":[123],"IL-6-induced":[125],"expression,":[127,180],"suggesting":[128],"that":[129,169],"effect":[131],"on":[134,139],"transcription":[136,145],"dependent":[138],"JAK2/signal":[140],"transducer":[141],"activator":[143],"3":[146],"(STAT3)":[147],"signaling.":[148,186],"Finally,":[149],"did":[151],"not":[152],"stimulate":[153],"or":[157],"when":[159],"suppressed.":[163],"In":[164],"summary,":[165],"our":[166],"results":[167],"suggest":[168],"promotes":[171],"inducing":[178],"mediated":[183],"JAK2/STAT3":[185]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}