{"id":"https://openalex.org/W2963354076","doi":"https://doi.org/10.1016/j.bmcl.2019.07.039","title":"Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity","display_name":"Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity","publication_year":2019,"publication_date":"2019-07-24","ids":{"openalex":"https://openalex.org/W2963354076","doi":"https://doi.org/10.1016/j.bmcl.2019.07.039","mag":"2963354076","pmid":"https://pubmed.ncbi.nlm.nih.gov/31375290"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2019.07.039","doi":"https://doi.org/10.1016/j.bmcl.2019.07.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2019.07.039","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101795920","display_name":"Tsuyoshi Saitoh","orcid":"https://orcid.org/0000-0001-6105-6292","observed_orcids":["https://orcid.org/0000-0001-6105-6292"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Saitoh","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6105-6292","affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazunori Seki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazunori Seki","raw_affiliation_strings":["Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112405281","display_name":"Ryo Nakajima","orcid":"https://orcid.org/0009-0004-2568-416X","observed_orcids":["https://orcid.org/0009-0004-2568-416X"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryo Nakajima","raw_affiliation_strings":["Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016666460","display_name":"Naoshi Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoshi Yamamoto","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015846745","display_name":"Noriki Kutsumura","orcid":"https://orcid.org/0000-0002-1494-2133","observed_orcids":["https://orcid.org/0000-0002-1494-2133"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriki Kutsumura","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1494-2133","affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108931801","display_name":"Yasuyuki Nagumo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuyuki Nagumo","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012854197","display_name":"Yoko Irukayama\u2010Tomobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Irukayama-Tomobe","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103129528","display_name":"Yasuhiro Ogawa","orcid":"https://orcid.org/0000-0003-1270-4542","observed_orcids":["https://orcid.org/0000-0003-1270-4542"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Ogawa","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057761124","display_name":"Yukiko Ishikawa","orcid":"https://orcid.org/0000-0003-2688-0782","observed_orcids":["https://orcid.org/0000-0003-2688-0782"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Ishikawa","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009330048","display_name":"Ryuji Tanimura","orcid":"https://orcid.org/0000-0002-7865-5686","observed_orcids":["https://orcid.org/0000-0002-7865-5686"]},"institutions":[{"id":"https://openalex.org/I4210115317","display_name":"Toray Industries, Inc. (Japan)","ror":"https://ror.org/029xh1r47","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210115317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuji Tanimura","raw_affiliation_strings":["Pharmaceutical Research Laboratories, Toray Industries Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Laboratories, Toray Industries Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan","institution_ids":["https://openalex.org/I4210115317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006145523","display_name":"Masashi Yanagisawa","orcid":"https://orcid.org/0000-0002-7358-4022","observed_orcids":["https://orcid.org/0000-0002-7358-4022"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Masashi Yanagisawa","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304","https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]},{"raw_affiliation_string":"R&D Center for Frontiers of Mirai in Policy and Technology (F-MIRAI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029754237","display_name":"Hiroshi Nagase","orcid":"https://orcid.org/0000-0003-0428-3979","observed_orcids":["https://orcid.org/0000-0003-0428-3979"]},"institutions":[{"id":"https://openalex.org/I146399215","display_name":"University of Tsukuba","ror":"https://ror.org/02956yf07","country_code":"JP","type":"education","lineage":["https://openalex.org/I146399215"]},{"id":"https://openalex.org/I4405286304","display_name":"International Institute for Integrative Sleep Medicine, University of Tsukuba","ror":"https://ror.org/01s1qrh29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi Nagase","raw_affiliation_strings":["International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. Electronic address: nagase.hiroshi.gt@u.tsukuba.ac.jp","Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan. Electronic address: nagase.hiroshi.gt@u.tsukuba.ac.jp","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]},{"raw_affiliation_string":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan","institution_ids":["https://openalex.org/I146399215"]},{"raw_affiliation_string":"International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan","institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029754237"],"corresponding_institution_ids":["https://openalex.org/I146399215","https://openalex.org/I4405286304"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.6963,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.62778223,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"29","issue":"18","first_page":"2655","last_page":"2658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.22360000014305115,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.22200000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orexin-1-receptor","display_name":"orexin-1 receptor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/morphinan-derivatives","display_name":"morphinan derivatives","score":0.828000009059906},{"id":"https://openalex.org/keywords/d-ring","display_name":"D-ring","score":0.9599999785423279},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8169999718666077},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.7839999794960022},{"id":"https://openalex.org/keywords/amide-side-chains","display_name":"amide side chains","score":0.921999990940094},{"id":"https://openalex.org/keywords/ligand-design","display_name":"ligand design","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.8274407386779785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7953773140907288},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6280590295791626},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5676880478858948},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.519925057888031},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.4667971730232239},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.455265074968338},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4442673623561859},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.43232643604278564},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23385244607925415},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11235576868057251},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.09265479445457458},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000068796","descriptor_name":"Orexin Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009019","descriptor_name":"Morphinans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064446","descriptor_name":"Orexin Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2019.07.039","doi":"https://doi.org/10.1016/j.bmcl.2019.07.039","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2019.07.039","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:31375290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31375290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2911929704","display_name":"Elucidation of molecular mechanism of cognitive dysfunction associated with sepsis and approach to new therapeutic agents","funder_award_id":"19K07314","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4009859260","display_name":"Development of novel photochemical tools to regulate wakefulness","funder_award_id":"18K14352","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320310723","display_name":"Japan Foundation for Applied Enzymology","ror":"https://ror.org/0293d8d10"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1239436365","https://openalex.org/W1970448589","https://openalex.org/W1977320288","https://openalex.org/W1978239891","https://openalex.org/W1980363663","https://openalex.org/W2001272039","https://openalex.org/W2003317794","https://openalex.org/W2024674930","https://openalex.org/W2027740042","https://openalex.org/W2150294078","https://openalex.org/W2152211310","https://openalex.org/W2532930666","https://openalex.org/W2568178450","https://openalex.org/W2731627675","https://openalex.org/W2740032481","https://openalex.org/W2780974634","https://openalex.org/W2918739196"],"related_works":["https://openalex.org/W2731627675","https://openalex.org/W2995396055","https://openalex.org/W2918739196","https://openalex.org/W2780974634","https://openalex.org/W3164222883","https://openalex.org/W4205213523","https://openalex.org/W6996446410","https://openalex.org/W7071399587","https://openalex.org/W870632595","https://openalex.org/W7056149971"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-30T00:00:00"}
