{"id":"https://openalex.org/W2963319945","doi":"https://doi.org/10.1080/15384101.2019.1643658","title":"Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells","display_name":"Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells","publication_year":2019,"publication_date":"2019-07-18","ids":{"openalex":"https://openalex.org/W2963319945","doi":"https://doi.org/10.1080/15384101.2019.1643658","mag":"2963319945","pmid":"https://pubmed.ncbi.nlm.nih.gov/31318643","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6738527"},"language":"en","primary_location":{"id":"doi:10.1080/15384101.2019.1643658","doi":"https://doi.org/10.1080/15384101.2019.1643658","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384101.2019.1643658","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2019.1643658?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2019.1643658?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Muhammad Furqan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Furqan","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005432037","display_name":"Zille Huma","orcid":"https://orcid.org/0000-0002-2681-1771","observed_orcids":["https://orcid.org/0000-0002-2681-1771"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zille Huma","raw_affiliation_strings":["Department of Chemistry & Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040346004","display_name":"Zainab Ashfaq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zainab Ashfaq","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018024948","display_name":"Apsra Nasir","orcid":"https://orcid.org/0000-0003-3644-911X","observed_orcids":["https://orcid.org/0000-0003-3644-911X"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Apsra Nasir","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022236752","display_name":"Rahim Ullah","orcid":"https://orcid.org/0000-0003-0739-2003","observed_orcids":["https://orcid.org/0000-0003-0739-2003"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rahim Ullah","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083461575","display_name":"Aishah Bilal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Aishah Bilal","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083585968","display_name":"Maheen Iqbal","orcid":"https://orcid.org/0000-0001-9449-5216","observed_orcids":["https://orcid.org/0000-0001-9449-5216"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Maheen Iqbal","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112456642","display_name":"Muhammad Hashaam Khalid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Hashaam Khalid","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033915531","display_name":"Irshad Hussa\u0131n","orcid":"https://orcid.org/0000-0001-5498-1236","observed_orcids":["https://orcid.org/0000-0001-5498-1236"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Irshad Hussain","raw_affiliation_strings":["Department of Chemistry & Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0001-5498-1236","affiliations":[{"raw_affiliation_string":"Department of Chemistry & Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087031667","display_name":"Amir Faisal","orcid":"https://orcid.org/0000-0002-7376-8286","observed_orcids":["https://orcid.org/0000-0002-7376-8286"]},"institutions":[{"id":"https://openalex.org/I207789805","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35","country_code":"PK","type":"education","lineage":["https://openalex.org/I207789805"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Amir Faisal","raw_affiliation_strings":["Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-7376-8286","affiliations":[{"raw_affiliation_string":"Department of Biology, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore, Pakistan","institution_ids":["https://openalex.org/I207789805"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087031667"],"corresponding_institution_ids":["https://openalex.org/I207789805"],"apc_list":null,"apc_paid":null,"fwci":0.5252,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58607503,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"18","first_page":"2281","last_page":"2292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurora-kinase-inhibitors","display_name":"Aurora kinase inhibitors","score":0.7990000247955322},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6309999823570251},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pictilisib","display_name":"pictilisib","score":0.9800000190734863},{"id":"https://openalex.org/keywords/egfr-inhibition","display_name":"EGFR inhibition","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pi3k-inhibition","display_name":"PI3K inhibition","score":0.9459999799728394},{"id":"https://openalex.org/keywords/3d-spheroid-culture","display_name":"3D spheroid culture","score":0.921999990940094},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/mitotic-spindle-formation","display_name":"mitotic spindle formation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/polyploidy","display_name":"polyploidy","score":0.8700000047683716},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C20552341","wikidata":"https://www.wikidata.org/wiki/Q4822632","display_name":"Aurora inhibitor","level":4,"score":0.6944317817687988},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.6748865246772766},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6231309771537781},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.618973433971405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.570773184299469},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.545821487903595},{"id":"https://openalex.org/C2780808130","wikidata":"https://www.wikidata.org/wiki/Q24745285","display_name":"Aurora kinase","level":4,"score":0.5223404169082642},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5205931663513184},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4316263198852539},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42417436838150024},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.418615460395813},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4099276661872864},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2981141209602356},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.2352912425994873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1400536596775055},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0712088942527771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0685628354549408}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064096","descriptor_name":"Aurora Kinase A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D064107","descriptor_name":"Aurora Kinase B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/15384101.2019.1643658","doi":"https://doi.org/10.1080/15384101.2019.1643658","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384101.2019.1643658","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2019.1643658?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6738527","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6738527","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"Text"},{"id":"pmid:31318643","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31318643","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1080/15384101.2019.1643658","doi":"https://doi.org/10.1080/15384101.2019.1643658","is_oa":true,"landing_page_url":"https://doi.org/10.1080/15384101.2019.1643658","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/15384101.2019.1643658?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3487407434","display_name":null,"funder_award_id":"NRPU 5909","funder_id":"https://openalex.org/F4320322799","funder_display_name":"Higher Education Commission, Pakistan"}],"funders":[{"id":"https://openalex.org/F4320311820","display_name":"Lahore University of Management Sciences","ror":"https://ror.org/05b5x4a35"},{"id":"https://openalex.org/F4320322799","display_name":"Higher Education Commission, Pakistan","ror":"https://ror.org/038y3sz68"},{"id":"https://openalex.org/F4320326275","display_name":"Higher Education Commision, Pakistan","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963319945.pdf","grobid_xml":"https://content.openalex.org/works/W2963319945.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1485263743","https://openalex.org/W1757407923","https://openalex.org/W1963701435","https://openalex.org/W1970638831","https://openalex.org/W1976424674","https://openalex.org/W1985338536","https://openalex.org/W1986241711","https://openalex.org/W1990956554","https://openalex.org/W1996506613","https://openalex.org/W1999736153","https://openalex.org/W2007826300","https://openalex.org/W2011853681","https://openalex.org/W2016462887","https://openalex.org/W2024048484","https://openalex.org/W2044210828","https://openalex.org/W2046553897","https://openalex.org/W2047073473","https://openalex.org/W2050978400","https://openalex.org/W2054016620","https://openalex.org/W2076797886","https://openalex.org/W2094305477","https://openalex.org/W2097024101","https://openalex.org/W2105913640","https://openalex.org/W2109776577","https://openalex.org/W2113929218","https://openalex.org/W2125294721","https://openalex.org/W2127621535","https://openalex.org/W2138429565","https://openalex.org/W2150548655","https://openalex.org/W2155391932","https://openalex.org/W2168127523","https://openalex.org/W2171149675","https://openalex.org/W2222507697","https://openalex.org/W2231983423","https://openalex.org/W2236643502","https://openalex.org/W2285408387","https://openalex.org/W2329718760","https://openalex.org/W2585352231","https://openalex.org/W2734611855","https://openalex.org/W2741112897","https://openalex.org/W2788368615","https://openalex.org/W2883399820","https://openalex.org/W2887268276","https://openalex.org/W2901591386","https://openalex.org/W2916623513","https://openalex.org/W2965774769"],"related_works":["https://openalex.org/W2956126581","https://openalex.org/W6948506795","https://openalex.org/W4292581655","https://openalex.org/W1963701435","https://openalex.org/W4225421442","https://openalex.org/W3149063519","https://openalex.org/W7095487459","https://openalex.org/W2105913640","https://openalex.org/W2332324011","https://openalex.org/W2099585680"],"abstract_inverted_index":{"Oral":[0],"cancer":[1,110,179,202,232],"is":[2,213],"the":[3,19,40,63,86,89,123,174,177,198,224],"most":[4],"prevalent":[5],"subtype":[6],"of":[7,18,42,45,55,62,66,88,135,163,176,191,200,228],"head":[8],"and":[9,12,53,76,94,100,114,126,149,166,209,241],"neck":[10],"cancers":[11],"arises":[13],"mainly":[14],"from":[15,33],"squamous":[16],"cells":[17,137],"oral":[20,46,80,109,178,201,231],"cavity.":[21],"Patients":[22],"with":[23,74,97,138,170,193,239],"advanced":[24],"metastatic":[25],"disease":[26],"have":[27,84,222],"poor":[28,77],"overall":[29],"survival":[30],"resulting":[31],"primarily":[32],"limited":[34],"treatment":[35,134],"options.":[36],"Recent":[37],"advances":[38],"in":[39,79,95,108,121,141,205,225,230],"understanding":[41],"molecular":[43],"basis":[44],"tumorigenesis":[47],"provide":[48],"an":[49],"opportunity":[50],"for":[51,69,248],"identification":[52],"validation":[54],"new":[56],"drug":[57,217,237,246],"targets.":[58],"The":[59],"deregulated":[60],"expression":[61],"Aurora":[64,119],"family":[65],"mitotic":[67,143],"kinases,":[68],"example,":[70],"has":[71],"been":[72],"associated":[73],"pathogenesis":[75],"prognosis":[78],"cancer.":[81],"Here,":[82],"we":[83,183,221],"evaluated":[85],"efficacy":[87,227],"pan-Aurora":[90],"inhibitor":[91],"(CCT137690)":[92],"alone":[93],"combination":[96],"different":[98],"chemotherapeutic":[99],"targeted":[101],"drugs":[102],"to":[103,154,172,215],"identify":[104],"its":[105],"synergistic":[106],"partners":[107],"cell":[111,124,156,180,203,233],"lines":[112,125,204],"(ORL-48":[113],"ORL-115).":[115],"CCT137690":[116,139,171,192,229,240],"effectively":[117],"inhibits":[118],"kinases":[120],"both":[122],"displays":[127],"potent":[128],"antiproliferative":[129],"activity":[130],"towards":[131],"them.":[132],"Prolonged":[133],"these":[136,245],"results":[140],"abrogated":[142],"spindle":[144],"formation,":[145],"misaligned":[146],"chromosome":[147],"attachment":[148],"polyploidy":[150],"that":[151,161,185,212],"ultimately":[152],"leads":[153],"apoptotic":[155],"death.":[157],"We":[158],"further":[159],"identified":[160,235],"inhibitors":[162],"EGFR":[164],"(gefitinib)":[165],"PI3-kinase":[167],"(pictilisib)":[168],"synergize":[169],"inhibit":[173,197],"proliferation":[175],"lines.":[181],"Moreover,":[182],"demonstrate":[184],"polyethylene":[186],"glycol-based":[187],"nanocapsules":[188,243],"harboring":[189],"combinations":[190,238,247],"gefitinib":[194],"or":[195],"pictilisib":[196],"growth":[199],"3D":[206],"spheroid":[207],"cultures":[208],"induce":[210],"apoptosis":[211],"comparable":[214],"free":[216],"combinations.":[218],"In":[219],"conclusion,":[220],"demonstrated":[223],"vitro":[226],"lines,":[234],"novel":[236],"synthesized":[242],"containing":[244],"co-administration.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}