{"id":"https://openalex.org/W296331451","doi":null,"title":"Uncovering Allostery in a Uniquely Folded Metalloprotein","display_name":"Uncovering Allostery in a Uniquely Folded Metalloprotein","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W296331451","mag":"296331451"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6zh805w9","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6zh805w9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079579970","display_name":"Elizabeth Leigh Baxter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"E.L. Baxter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079579970"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitoneet","display_name":"mitoNEET","score":0.9800000190734863},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.8479999899864197},{"id":"https://openalex.org/keywords/2fe-2s-cluster","display_name":"[2Fe-2S] cluster","score":0.8330000042915344},{"id":"https://openalex.org/keywords/iron-sulfur-clusters","display_name":"iron-sulfur clusters","score":0.9110000133514404},{"id":"https://openalex.org/keywords/homodimer","display_name":"homodimer","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cluster-transfer","display_name":"cluster transfer","score":0.5210000276565552},{"id":"https://openalex.org/keywords/cluster-decay","display_name":"cluster decay","score":0.8619999885559082},{"id":"https://openalex.org/keywords/redox-potential","display_name":"redox potential","score":0.996999979019165},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/metalloproteins","display_name":"metalloproteins","score":0.5989999771118164},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6169646978378296},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.600014865398407},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5406385064125061},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5160448551177979},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.46984782814979553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4329233765602112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.370606392621994},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3480703830718994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29319339990615845},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24798831343650818},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt6zh805w9","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6zh805w9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt6zh805w9","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/6zh805w9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Baxter, Elizabeth Leigh. (2013). Uncovering Allostery in a Uniquely Folded Metalloprotein. UC San Diego: Chemistry and biochemistry. Retrieved from: http://www.escholarship.org/uc/item/6zh805w9","raw_type":"dissertation"},{"id":"mag:296331451","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6zh805w9/qt6zh805w9.pdf?t=msyhwa","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W1966078827","https://openalex.org/W1969554454","https://openalex.org/W1971077204","https://openalex.org/W1973341464","https://openalex.org/W1976906930","https://openalex.org/W1978380407","https://openalex.org/W1980076938","https://openalex.org/W1980237498","https://openalex.org/W1980956149","https://openalex.org/W1985037445","https://openalex.org/W1985806842","https://openalex.org/W1991194470","https://openalex.org/W1992456676","https://openalex.org/W1992931339","https://openalex.org/W1995698798","https://openalex.org/W1998367993","https://openalex.org/W2004861205","https://openalex.org/W2005692769","https://openalex.org/W2006436629","https://openalex.org/W2012462004","https://openalex.org/W2014425795","https://openalex.org/W2018346950","https://openalex.org/W2019100824","https://openalex.org/W2022448511","https://openalex.org/W2025442958","https://openalex.org/W2029377901","https://openalex.org/W2032069813","https://openalex.org/W2033000502","https://openalex.org/W2034282653","https://openalex.org/W2034971743","https://openalex.org/W2035262877","https://openalex.org/W2035407708","https://openalex.org/W2038225128","https://openalex.org/W2039542696","https://openalex.org/W2042553652","https://openalex.org/W2043141532","https://openalex.org/W2044626483","https://openalex.org/W2044882887","https://openalex.org/W2045302409","https://openalex.org/W2046408940","https://openalex.org/W2046469792","https://openalex.org/W2047591801","https://openalex.org/W2048063313","https://openalex.org/W2049808069","https://openalex.org/W2050915787","https://openalex.org/W2053623357","https://openalex.org/W2053960740","https://openalex.org/W2054277796","https://openalex.org/W2055163566","https://openalex.org/W2056245019","https://openalex.org/W2057582542","https://openalex.org/W2060060473","https://openalex.org/W2063254536","https://openalex.org/W2064270413","https://openalex.org/W2064446384","https://openalex.org/W2065864578","https://openalex.org/W2075220720","https://openalex.org/W2076651753","https://openalex.org/W2078176020","https://openalex.org/W2078632235","https://openalex.org/W2082432305","https://openalex.org/W2084098035","https://openalex.org/W2084648182","https://openalex.org/W2087217881","https://openalex.org/W2087729059","https://openalex.org/W2089162704","https://openalex.org/W2092224500","https://openalex.org/W2092357419","https://openalex.org/W2096064309","https://openalex.org/W2096773810","https://openalex.org/W2098354564","https://openalex.org/W2098594736","https://openalex.org/W2110035145","https://openalex.org/W2114323152","https://openalex.org/W2115273980","https://openalex.org/W2116048591","https://openalex.org/W2121861881","https://openalex.org/W2122010291","https://openalex.org/W2124880104","https://openalex.org/W2132938122","https://openalex.org/W2138791027","https://openalex.org/W2139543085","https://openalex.org/W2144081223","https://openalex.org/W2144377119","https://openalex.org/W2144729032","https://openalex.org/W2145792347","https://openalex.org/W2147431408","https://openalex.org/W2147949826","https://openalex.org/W2150261148","https://openalex.org/W2151550848","https://openalex.org/W2151715745","https://openalex.org/W2151950872","https://openalex.org/W2153876071","https://openalex.org/W2159407190","https://openalex.org/W2159675211","https://openalex.org/W2163341755","https://openalex.org/W2165768701","https://openalex.org/W2166280318","https://openalex.org/W2171610577","https://openalex.org/W2171755502","https://openalex.org/W2180229411","https://openalex.org/W3089276913","https://openalex.org/W4243378697"],"related_works":["https://openalex.org/W2032069813","https://openalex.org/W2064270413","https://openalex.org/W1995819898","https://openalex.org/W2529886280","https://openalex.org/W2045302409","https://openalex.org/W2789500469","https://openalex.org/W3172852668","https://openalex.org/W2057582542","https://openalex.org/W3211538165","https://openalex.org/W791122623"],"abstract_inverted_index":{"Proteins":[0],"are":[1,59,134,189,313],"linear":[2],"chains":[3],"of":[4,66,96,103,191,228,248,269,295,310,323,350],"amino":[5,324],"acids":[6,325],"that":[7,49,106,118,133,232,253,260,287],"self-":[8],"assemble,":[9],"or":[10],"\"fold\",":[11],"into":[12,30],"3-dimensional":[13],"structures":[14],"which":[15,25,43,80,150,244,326],"perform":[16,52],"tasks":[17],"in":[18,61,153],"organisms.":[19],"Nature":[20],"has":[21],"selected":[22,85],"for":[23,38,86,114,215,347],"sequences":[24],"fold":[26,44],"quickly":[27],"and":[28,63,69,130,157,179,194,230,259,300,335],"efficiently":[29],"their":[31,53],"functional":[32],"structure.":[33],"While":[34],"it":[35,46,88,163,338],"is":[36,47,151,174,213,306],"important":[37],"organisms":[39],"to":[40,108,120,128,136,145,201,224,262,279,289,316,342],"have":[41],"proteins":[42,50,138,351],"efficiently,":[45],"essential":[48],"also":[51],"function.":[54,115,139],"These":[55,186],"two":[56,183],"evolutionary":[57],"pressures":[58],"sometimes":[60],"conflict,":[62],"perfect":[64],"optimization":[65],"both":[67],"folding":[68,82,110,122,227,247],"function":[70,268],"may":[71,83,111,123,198],"not":[72],"always":[73],"be":[74,84,112,124,199,317],"possible.":[75],"For":[76],"example,":[77],"a":[78,100,104,137,148,175,233,242],"mutation":[79],"slows":[81,245],"if":[87],"enhances":[89],"protein":[90,105,149,173,208],"function,":[91],"therefore":[92],"increasing":[93],"the":[94,97,166,195,226,238,246,249,267,270,293,301,320,340],"fitness":[95],"organism.":[98],"As":[99],"result,":[101],"regions":[102,117],"contribute":[107,119],"slow":[109,121],"critical":[113,135,214],"Identifying":[116],"an":[125],"effective":[126],"way":[127],"predict":[129],"identify":[131],"sites":[132],"This":[140,304],"dissertation":[141],"uses":[142],"this":[143,207,254,263,274,283,290,333,348],"approach":[144],"characterize":[146],"mitoNEET,":[147,229],"implicated":[152],"diabetes,":[154],"aging,":[155],"cancer,":[156],"obesity.":[158],"MitoNEET":[159],"was":[160,256],"discovered":[161],"because":[162,308],"unexpectedly":[164],"binds":[165],"commonly":[167],"prescribed":[168],"diabetes":[169],"drug":[170,217,345],"Pioglitazone.":[171],"The":[172],"uniquely":[176],"folded":[177],"homodimer,":[178],"each":[180],"protomer":[181],"coordinates":[182],"[2Fe-2S]":[184],"clusters.":[185],"iron-sulfur":[187],"clusters":[188],"capable":[190],"electron":[192],"transfer,":[193,297],"cluster":[196,296,298],"itself":[197],"transferred":[200],"acceptor":[202],"partner":[203],"proteins.":[204],"Understanding":[205],"how":[206],"regulates":[209],"its":[210],"metal":[211,239,311],"centers":[212,312],"better":[216],"design.":[218],"We":[219,251,285],"used":[220,277],"structure-":[221],"based":[222],"models":[223],"simulate":[225],"observed":[231,286],"loop":[234,291],"far":[235],"removed":[236],"from":[237],"center":[240],"creates":[241],"constraint":[243],"protein.":[250,271],"predicted":[252],"region":[255],"evolutionarily":[257],"conserved,":[258],"mutations":[261],"site":[264],"would":[265],"disrupt":[266],"To":[272],"test":[273],"theory,":[275],"we":[276,336],"mutagenesis":[278],"introduce":[280],"perturbations":[281],"at":[282],"site.":[284],"changes":[288],"alter":[292],"rate":[294],"decay,":[299],"redox":[302],"potential.":[303],"result":[305],"striking":[307],"properties":[309],"traditionally":[314],"thought":[315],"controlled":[318],"by":[319],"small":[321],"fraction":[322],"directly":[327],"surround":[328],"them.":[329],"Our":[330],"work":[331],"challenges":[332],"paradigm,":[334],"feel":[337],"opens":[339],"door":[341],"more":[343],"intelligent":[344],"design":[346],"class":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
