{"id":"https://openalex.org/W2963313031","doi":"https://doi.org/10.1002/jor.24427","title":"RE: Talks BJ, Fernquest S, Palmer A, et al. 2019. No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement","display_name":"RE: Talks BJ, Fernquest S, Palmer A, et al. 2019. No Evidence of Systemic Inflammation in Symptomatic Patients With Femoroacetabular Impingement","publication_year":2019,"publication_date":"2019-07-25","ids":{"openalex":"https://openalex.org/W2963313031","doi":"https://doi.org/10.1002/jor.24427","mag":"2963313031","pmid":"https://pubmed.ncbi.nlm.nih.gov/31343771"},"language":"en","primary_location":{"id":"doi:10.1002/jor.24427","doi":"https://doi.org/10.1002/jor.24427","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.24427","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24427","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027580707","display_name":"Christopher L. Mendias","orcid":"https://orcid.org/0000-0002-2384-0171","observed_orcids":["https://orcid.org/0000-0002-2384-0171"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher L. Mendias","raw_affiliation_strings":["Hospital for Special Surgery, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-2384-0171","affiliations":[{"raw_affiliation_string":"Hospital for Special Surgery, New York, New York","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053612238","display_name":"Asheesh Bedi","orcid":"https://orcid.org/0000-0001-8926-7139","observed_orcids":["https://orcid.org/0000-0001-8926-7139"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asheesh Bedi","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"12","first_page":"2621","last_page":"2622"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11018","display_name":"Lower Extremity Biomechanics and Pathologies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/femoroacetabular-impingement","display_name":"femoroacetabular impingement","score":0.9919999837875366},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.996999979019165},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hip-osteoarthritis","display_name":"hip osteoarthritis","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2779961238","wikidata":"https://www.wikidata.org/wiki/Q1910771","display_name":"Femoroacetabular impingement","level":2,"score":0.8999985456466675},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8345593214035034},{"id":"https://openalex.org/C2781054738","wikidata":"https://www.wikidata.org/wiki/Q4813730","display_name":"Athletes","level":2,"score":0.6149187088012695},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5890412330627441},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5473445057868958},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5386322736740112},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.501631498336792},{"id":"https://openalex.org/C2780904754","wikidata":"https://www.wikidata.org/wiki/Q25104748","display_name":"Conservative management","level":2,"score":0.49820423126220703},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4342229962348938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4180571138858795},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37266308069229126},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3647778034210205},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077","descriptor_name":"Acetabulum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006621","descriptor_name":"Hip Joint","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057925","descriptor_name":"Femoracetabular Impingement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jor.24427","doi":"https://doi.org/10.1002/jor.24427","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.24427","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24427","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:31343771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31343771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Letter"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/152571","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/152571","pdf_url":"https://hdl.handle.net/2027.42/152571","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/jor.24427","doi":"https://doi.org/10.1002/jor.24427","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jor.24427","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24427","source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2963313031.pdf","grobid_xml":"https://content.openalex.org/works/W2963313031.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1940768227","https://openalex.org/W2107173726","https://openalex.org/W2121169747","https://openalex.org/W2132081815","https://openalex.org/W2140874825","https://openalex.org/W2292142461","https://openalex.org/W2945221064"],"related_works":["https://openalex.org/W7160728485","https://openalex.org/W2945221064","https://openalex.org/W6979076361","https://openalex.org/W3113297211","https://openalex.org/W4385442931","https://openalex.org/W4385442547","https://openalex.org/W6941268705","https://openalex.org/W2334432802","https://openalex.org/W2541899381","https://openalex.org/W2906518425"],"abstract_inverted_index":{"Dear":[0],"Professor":[1],"Sandell,":[2],"We":[3,162,194,241],"are":[4,464,471,488,645],"writing":[5],"in":[6,19,41,66,106,119,139,142,158,174,205,216,223,226,261,282,297,315,330,354,366,369,380,387,397,406,418,427,431,459,474,496,507,517,550,565,575,598,610,629,670,678,720],"regards":[7],"to":[8,32,144,165,237,268,523,622,695,715],"an":[9,221,234,460,593,673],"article":[10,63],"by":[11,48,448,466],"Talks":[12,449,664],"et":[13,450,555,665],"al.1":[14],"that":[15,92,100,152,202,219,491,520,643,710],"was":[16,31,36,109,123,156,360,584],"recently":[17],"published":[18],"the":[20,29,101,117,120,133,149,167,197,238,248,355,381,388,392,433,439,446,475,483,518,551,558,587,590,606,630,658,687,697,704,721,733,737],"Journal":[21],"of":[22,28,38,59,88,104,135,199,286,301,312,328,339,351,364,394,425,457,479,510,560,589,592,605,632,648,651,668,675,689,699,723],"Orthopaedic":[23],"Research.":[24],"The":[25,62,81,97,179,214,423],"stated":[26],"aim":[27],"study":[30,98,173,257],"\u201cdetermine":[33],"whether":[34,54],"there":[35,359,487,539,639],"evidence":[37,393,642,707],"systemic":[39,154,404,534,656],"inflammation":[40,155,252,329,353,396,405,413,426,458,649,669,712],"patients":[42,68,73,108,159,176,232,316,342,407,566,599,724],"with":[43,57,69,71,160,177,190,263,276,317,408,421,567,600,636,686,725],"femoroacetabular":[44],"impingement":[45],"(FAI),":[46],"defined":[47],"serum-free":[49],"light":[50],"chains":[51],"(sFLCs),":[52],"and":[53,77,114,127,184,253,270,292,320,332,372,383,399,401,435,470,477,513,532,569,602,614,728,731,735],"this":[55,217],"correlated":[56],"markers":[58],"disease":[60,525,552,653],"severity.\u201d":[61],"measured":[64],"sFLCs":[65,105,463,492,506,522,644,679],"115":[67,175],"FAI,":[70,274,601],"57":[72],"undergoing":[74,343],"surgical":[75,121,145,210,227,681],"intervention":[76,122,682],"58":[78],"receiving":[79],"physiotherapy.":[80],"authors":[82,150,168,249,484],"did":[83],"not":[84,94,229,444,618,662,684],"include":[85],"a":[86,171,279,293,310,326,361,416,453,541,546,579,626,676,717],"cohort":[87],"demographically":[89],"matched":[90],"athletes":[91,262,272,635],"do":[93,411,443],"have":[95,244,347,504],"FAI.":[96,161,178,254,422,637,671,726],"found":[99],"baseline":[102,690],"levels":[103,118,141,285,300,368],"all":[107],"30.36":[110],"\u00b1":[111,125,129],"9.23":[112],"mg/l,":[113],"at":[115,625],"follow-up,":[116],"29.48":[124],"7.85":[126],"31.68":[128],"9.61":[130],"mg/l.":[131],"On":[132,586],"basis":[134,588],"no":[136,153,502,572,641],"observed":[137,570],"change":[138],"sFLC":[140],"response":[143,549,583],"or":[146,654],"conservative":[147,212,230],"interventions,":[148],"concluded":[151],"present":[157],"would":[163,617],"like":[164],"acknowledge":[166],"on":[169,528,703],"performing":[170],"biomarkers":[172,647],"sample":[180],"size":[181],"is":[182,233,429,540,640,683],"impressive,":[183],"we":[185,373,410,442,616,693,708],"need":[186],"more":[187],"well-powered":[188],"studies":[189,402,503,516],"diverse":[191],"patient":[192],"populations.":[193],"also":[195],"appreciate":[196],"importance":[198],"identifying":[200],"factors":[201],"can":[203,493],"help":[204],"predicting":[206],"appropriate":[207],"candidates":[208],"for":[209,438,545],"versus":[211],"treatment.":[213],"data":[215,660],"paper":[218,447],"showed":[220],"improvement":[222],"patient-reported":[224],"outcomes":[225],"but":[228,441,501],"treated":[231],"important":[235,430],"contribution":[236],"FAI":[239,264,277,344,389,398,428,568],"literature.":[240],"do,":[242],"however,":[243],"concerns":[245],"about":[246],"conclusions":[247],"made":[250],"regarding":[251],"A":[255],"previous":[256],"from":[258,341],"our":[259,370],"lab":[260],"demonstrated":[265],"that,":[266],"compared":[267],"age-":[269],"activity-matched":[271],"without":[273],"those":[275],"had":[278,375],"24%":[280],"increase":[281],"mean":[283,298],"circulating":[284,299],"cartilage":[287,313],"oligomeric":[288],"matrix":[289],"protein":[290,303],"(COMP)":[291],"nearly":[294],"threefold":[295],"elevation":[296],"C-reactive":[302],"(CRP).2":[304],"COMP":[305],"has":[306,322],"been":[307,323],"used":[308,324,473],"as":[309,325],"marker":[311,327,456],"turnover":[314],"osteoarthritis":[318],"(OA),":[319],"CRP":[321,367],"OA":[331],"many":[333],"other":[334,515,530,611],"chronic":[335],"conditions.3":[336],"Additionally,":[337],"biopsies":[338],"tissue":[340],"corrective":[345],"surgery":[346],"shown":[348],"clear":[349,542],"signs":[350],"local":[352,395],"hip":[356,700],"joint.4-6":[357],"While":[358],"fair":[362],"amount":[363],"variability":[365],"study,":[371],"only":[374],"N":[376,384],"=":[377,385],"19":[378],"subjects":[379],"control":[382],"10":[386],"cohort,":[390],"given":[391],"OA,":[400,409],"demonstrating":[403],"think":[412,445],"likely":[414],"plays":[415],"role":[417,544],"symptoms":[419],"associated":[420],"topic":[424],"understanding":[432],"etiology":[434],"treatment":[436,722],"options":[437],"condition,":[440],"al.":[451,666],"measure":[452],"clinically":[454],"meaningful":[455],"athletic":[461],"population.":[462],"produced":[465],"activated":[467,624],"plasma":[468,547,620],"cells,":[469],"commonly":[472],"diagnosis":[476],"monitoring":[478,497],"multiple":[480,511],"myeloma.7":[481],"As":[482],"point":[485],"out,":[486],"some":[489],"indications":[490],"be":[494,623,716],"useful":[495,646],"rheumatoid":[498],"arthritis":[499],"(RA),":[500],"evaluated":[505,557],"OA.":[508],"Outside":[509],"myeloma":[512],"RA,":[514],"literature":[519],"use":[521],"monitor":[524],"progression":[526],"focus":[527],"various":[529,561],"cancers":[531],"severe":[533,655],"diseases.":[535],"For":[536],"these":[537],"conditions,":[538],"suspected":[543],"cell":[548,563,596],"pathology.":[553],"Elias-Jones":[554],"al.6":[556],"presence":[559,597],"immune":[562,582,595,608],"populations":[564],"virtually":[571],"CD3+":[573],"T-lymphocytes":[574],"labral":[576],"biopsies,":[577],"although":[578],"robust":[580],"innate":[581],"present.":[585],"lack":[591],"adaptive":[594,607],"general":[603],"observations":[604],"system":[609],"musculoskeletal":[612],"injuries":[613],"diseases,":[615,657],"anticipate":[619],"cells":[621],"substantial":[627],"level":[628],"case":[631],"otherwise":[633],"healthy":[634],"Since":[638],"outside":[650],"autoimmune":[652],"available":[659,706],"does":[661],"support":[663],"rejection":[667],"Furthermore,":[672],"absence":[674,688],"reduction":[677],"after":[680],"synonymous":[685],"inflammation.":[691],"Although":[692],"continue":[694,714],"understand":[696],"pathophysiology":[698],"impingement,":[701],"based":[702],"best":[705],"hold":[709],"reducing":[711],"should":[713],"clinical":[718],"objective":[719],"C.L.M.":[727],"A.B.":[729],"wrote":[730],"edited":[732],"letter,":[734],"approved":[736],"final":[738],"version.":[739]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-30T00:00:00"}