{"id":"https://openalex.org/W2963119028","doi":null,"title":"Regulation of low-density lipoprotein receptor expression by AKT signaling","display_name":"Regulation of low-density lipoprotein receptor expression by AKT signaling","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2963119028","mag":"2963119028"},"language":"en","primary_location":{"id":"pmh:oai:www.duo.uio.no:10852/67505","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/67505","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10852/67505","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049180227","display_name":"Katrine Bjune","orcid":"https://orcid.org/0000-0002-2303-0216","observed_orcids":["https://orcid.org/0000-0002-2303-0216"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Katrine Bjune","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2303-0216","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049180227"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ldl-cholesterol-uptake","display_name":"LDL cholesterol uptake","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.6489999890327454},{"id":"https://openalex.org/keywords/mrna-degradation","display_name":"mRNA degradation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5362752079963684},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48004305362701416},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.4582495093345642},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4500208795070648},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4168587923049927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3718527555465698},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3554285168647766},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3458833694458008},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2261252999305725},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.21697598695755005},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21328961849212646},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.10444283485412598},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.duo.uio.no:10852/67505","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/67505","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2963119028","doi":null,"is_oa":false,"landing_page_url":"https://www.duo.uio.no/bitstream/10852/67505/1/PhD-Bjune-2019.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/67505","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/67505","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2848423184","https://openalex.org/W2010747759","https://openalex.org/W2156116824","https://openalex.org/W2116710893","https://openalex.org/W2401607566","https://openalex.org/W2004056956","https://openalex.org/W2743653840","https://openalex.org/W4409317628","https://openalex.org/W2898478418","https://openalex.org/W2414855032"],"abstract_inverted_index":{"The":[0],"presence":[1],"of":[2,16,27,48,55,65,77,95],"high":[3],"blood":[4],"cholesterol":[5,49,85],"levels,":[6],"hypercholesterolemia,":[7],"is":[8,23,57],"a":[9,20,42,59],"significant":[10],"contributing":[11],"factor":[12],"to":[13],"the":[14,24,46,51,63,70,96,101],"development":[15],"coronary":[17],"heart":[18],"disease,":[19],"condition":[21],"that":[22],"leading":[25],"cause":[26],"death":[28],"for":[29,62],"both":[30,92],"women":[31],"and":[32,53,74,83,99],"men":[33],"in":[34,45],"industrialized":[35],"countries.":[36],"Low-density":[37],"lipoprotein":[38],"receptor":[39],"(LDLR)":[40],"plays":[41],"crucial":[43],"role":[44],"uptake":[47,86],"from":[50],"blood,":[52],"up-regulation":[54],"LDLR":[56,80,97,102],"therefore":[58],"useful":[60],"strategy":[61],"treatment":[64],"hypercholesterolemia.":[66],"We":[67],"have":[68],"investigated":[69],"AKT":[71,78],"signal":[72],"pathway,":[73],"how":[75],"inhibition":[76],"increases":[79],"protein":[81],"levels":[82],"LDL":[84],"by":[87,91],"two":[88],"different":[89],"mechanisms,":[90],"increasing":[93],"transcription":[94],"gene":[98],"decreasing":[100],"mRNA":[103],"decay":[104],"rate.":[105]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2019-07-30T00:00:00"}