{"id":"https://openalex.org/W2962913366","doi":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","title":"Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation","display_name":"Serum electrolytes can promote hydroxyl radical-initiated biomolecular damage from inflammation","publication_year":2019,"publication_date":"2019-07-23","ids":{"openalex":"https://openalex.org/W2962913366","doi":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","mag":"2962913366","pmid":"https://pubmed.ncbi.nlm.nih.gov/31349038"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2019.07.023","doi":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022473753","display_name":"Yukako Komaki","orcid":"https://orcid.org/0000-0003-3339-2939","observed_orcids":["https://orcid.org/0000-0003-3339-2939"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukako Komaki","raw_affiliation_strings":["Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, 422-8526, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010407265","display_name":"Adam M.-A. Simpson","orcid":"https://orcid.org/0000-0002-4850-4828","observed_orcids":["https://orcid.org/0000-0002-4850-4828"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam M-A. Simpson","raw_affiliation_strings":["Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jong Kwon Choe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]},{"id":"https://openalex.org/I4405269456","display_name":"Institute of Construction and Environmental Engineering","ror":"https://ror.org/047v5p666","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4405269456"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Kwon Choe","raw_affiliation_strings":["Department of Civil and Environmental Engineering and Institute of Construction and Environmental Engineering, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul, 08826, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering and Institute of Construction and Environmental Engineering, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul, 08826, Republic of Korea","institution_ids":["https://openalex.org/I139264467","https://openalex.org/I4405269456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058680023","display_name":"Margaux M. Pinney","orcid":"https://orcid.org/0000-0002-7735-5032","observed_orcids":["https://orcid.org/0000-0002-7735-5032"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaux M. Pinney","raw_affiliation_strings":["Department of Biochemistry, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076625801","display_name":"Daniel Herschlag","orcid":"https://orcid.org/0000-0002-4685-1973","observed_orcids":["https://orcid.org/0000-0002-4685-1973"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Herschlag","raw_affiliation_strings":["Department of Biochemistry, Stanford University, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Stanford University, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062265192","display_name":"Yi-Hsueh Brad Chuang","orcid":"https://orcid.org/0000-0002-9128-8200","observed_orcids":["https://orcid.org/0000-0002-9128-8200"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Hsueh Chuang","raw_affiliation_strings":["Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045123804","display_name":"William A. Mitch","orcid":"https://orcid.org/0000-0002-4917-0938","observed_orcids":["https://orcid.org/0000-0002-4917-0938"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William A. Mitch","raw_affiliation_strings":["Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA. Electronic address: wamitch@stanford.edu","Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA"],"raw_orcid":"https://orcid.org/0000-0002-4917-0938","affiliations":[{"raw_affiliation_string":"Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA. Electronic address: wamitch@stanford.edu","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, CA, 94305, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5045123804"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":null,"fwci":0.3307,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52252231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"141","issue":null,"first_page":"475","last_page":"482"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13013","display_name":"Free Radicals and Antioxidants","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-electrolytes","display_name":"serum electrolytes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.8690000176429749},{"id":"https://openalex.org/keywords/carbonate-radical","display_name":"carbonate radical","score":0.7549999952316284},{"id":"https://openalex.org/keywords/halogen-radicals","display_name":"halogen radicals","score":0.9559999704360962},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.578000009059906},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.734000027179718},{"id":"https://openalex.org/keywords/carbonic-anhydrase","display_name":"carbonic anhydrase","score":0.906000018119812},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ketosteroid-isomerase","display_name":"ketosteroid isomerase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tyrosine-oxidation","display_name":"tyrosine oxidation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tryptophan-oxidation","display_name":"tryptophan oxidation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/methionine-oxidation","display_name":"methionine oxidation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/histidine-oxidation","display_name":"histidine oxidation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5569999814033508},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/chemical-kinetic-model","display_name":"chemical kinetic modeling","score":0.7689999938011169},{"id":"https://openalex.org/keywords/gamma-radiolysis","display_name":"gamma radiolysis","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8998528718948364},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.7240046262741089},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6965012550354004},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.5807082653045654},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.5335408449172974},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.4761795401573181},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.47403502464294434},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.4326792061328888},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.4193588197231293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3871903717517853},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3841709494590759}],"mesh":[{"descriptor_ui":"D002254","descriptor_name":"Carbonates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004573","descriptor_name":"Electrolytes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006219","descriptor_name":"Halogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2019.07.023","doi":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:31349038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31349038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.freeradbiomed.2019.07.023","doi":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2019.07.023","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G526698867","display_name":"Collaborative Research: Systematic Investigation of the Structure, Dynamics, and Energetics of Hydrogen Bonds and the Protein Interior Using Ketosteroid Isomerase and Model Systems","funder_award_id":"1714723","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321292","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542"},{"id":"https://openalex.org/F4320333014","display_name":"Stanford Graduate School of Education","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W885119655","https://openalex.org/W1487680459","https://openalex.org/W1567811966","https://openalex.org/W1575458145","https://openalex.org/W1654460714","https://openalex.org/W1768247331","https://openalex.org/W1795244965","https://openalex.org/W1926950498","https://openalex.org/W1971745230","https://openalex.org/W1976616659","https://openalex.org/W1983634320","https://openalex.org/W1985177004","https://openalex.org/W1993250284","https://openalex.org/W1998785678","https://openalex.org/W2018653067","https://openalex.org/W2025892368","https://openalex.org/W2032227357","https://openalex.org/W2062658304","https://openalex.org/W2070505577","https://openalex.org/W2084141237","https://openalex.org/W2086848975","https://openalex.org/W2092434707","https://openalex.org/W2140095307","https://openalex.org/W2148399219","https://openalex.org/W2321178107","https://openalex.org/W2349182623","https://openalex.org/W2519681033","https://openalex.org/W2903516001","https://openalex.org/W2939111230"],"related_works":["https://openalex.org/W2055544017","https://openalex.org/W1654460714","https://openalex.org/W2104519512","https://openalex.org/W1600112653","https://openalex.org/W1623206089","https://openalex.org/W2189696737","https://openalex.org/W2060413256","https://openalex.org/W2646847499","https://openalex.org/W1557671402","https://openalex.org/W1956914327"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-30T00:00:00"}