{"id":"https://openalex.org/W2962844841","doi":"https://doi.org/10.1074/mcp.tir119.001659","title":"Delta-S-Cys-Albumin: A Lab Test that Quantifies Cumulative Exposure of Archived Human Blood Plasma and Serum Samples to Thawed Conditions*[S]","display_name":"Delta-S-Cys-Albumin: A Lab Test that Quantifies Cumulative Exposure of Archived Human Blood Plasma and Serum Samples to Thawed Conditions*[S]","publication_year":2019,"publication_date":"2019-07-19","ids":{"openalex":"https://openalex.org/W2962844841","doi":"https://doi.org/10.1074/mcp.tir119.001659","mag":"2962844841","pmid":"https://pubmed.ncbi.nlm.nih.gov/31324658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6773563"},"language":"en","primary_location":{"id":"doi:10.1074/mcp.tir119.001659","doi":"https://doi.org/10.1074/mcp.tir119.001659","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.tir119.001659","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/mcp.tir119.001659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007327803","display_name":"Joshua W. Jeffs","orcid":"https://orcid.org/0000-0002-1623-9732","observed_orcids":["https://orcid.org/0000-0002-1623-9732"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua W. Jeffs","raw_affiliation_strings":["School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287"],"raw_orcid":"https://orcid.org/0000-0002-1623-9732","affiliations":[{"raw_affiliation_string":"School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063428145","display_name":"Nilojan Jehanathan","orcid":"https://orcid.org/0000-0002-2869-0520","observed_orcids":["https://orcid.org/0000-0002-2869-0520"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilojan Jehanathan","raw_affiliation_strings":["School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287"],"raw_orcid":"https://orcid.org/0000-0002-2869-0520","affiliations":[{"raw_affiliation_string":"School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036827861","display_name":"Stephanie M.F. Thibert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie M.F. Thibert","raw_affiliation_strings":["School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053248639","display_name":"Shadi Ferdosi","orcid":"https://orcid.org/0000-0003-2933-8809","observed_orcids":["https://orcid.org/0000-0003-2933-8809"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shadi Ferdosi","raw_affiliation_strings":["School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062759790","display_name":"Linda Pham","orcid":"https://orcid.org/0000-0001-8704-6252","observed_orcids":["https://orcid.org/0000-0001-8704-6252"]},"institutions":[{"id":"https://openalex.org/I4210152461","display_name":"Valleywise Health","ror":"https://ror.org/05tbp9v13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Pham","raw_affiliation_strings":["Maricopa Integrated Health System, Phoenix, AZ 85008"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maricopa Integrated Health System, Phoenix, AZ 85008","institution_ids":["https://openalex.org/I4210152461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091784842","display_name":"Zachary T. Wilson","orcid":"https://orcid.org/0000-0003-4206-8954","observed_orcids":["https://orcid.org/0000-0003-4206-8954"]},"institutions":[{"id":"https://openalex.org/I4210152461","display_name":"Valleywise Health","ror":"https://ror.org/05tbp9v13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152461"]},{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary T. Wilson","raw_affiliation_strings":["Maricopa Integrated Health System, Phoenix, AZ 85008; University of Arizona College of Medicine, Phoenix, AZ 85004","Maricopa Integrated Health System, Phoenix, AZ 85008","University of Arizona College of Medicine, Phoenix, AZ 85004"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maricopa Integrated Health System, Phoenix, AZ 85008; University of Arizona College of Medicine, Phoenix, AZ 85004","institution_ids":["https://openalex.org/I4210152461","https://openalex.org/I4405259572"]},{"raw_affiliation_string":"Maricopa Integrated Health System, Phoenix, AZ 85008","institution_ids":["https://openalex.org/I4210152461"]},{"raw_affiliation_string":"University of Arizona College of Medicine, Phoenix, AZ 85004","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088234530","display_name":"Christian S. Breburda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152461","display_name":"Valleywise Health","ror":"https://ror.org/05tbp9v13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210152461"]},{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Breburda","raw_affiliation_strings":["Maricopa Integrated Health System, Phoenix, AZ 85008; University of Arizona College of Medicine, Phoenix, AZ 85004","Maricopa Integrated Health System, Phoenix, AZ 85008","University of Arizona College of Medicine, Phoenix, AZ 85004"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maricopa Integrated Health System, Phoenix, AZ 85008; University of Arizona College of Medicine, Phoenix, AZ 85004","institution_ids":["https://openalex.org/I4210152461","https://openalex.org/I4405259572"]},{"raw_affiliation_string":"Maricopa Integrated Health System, Phoenix, AZ 85008","institution_ids":["https://openalex.org/I4210152461"]},{"raw_affiliation_string":"University of Arizona College of Medicine, Phoenix, AZ 85004","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060743715","display_name":"Chad R. Borges","orcid":"https://orcid.org/0000-0002-8122-3438","observed_orcids":["https://orcid.org/0000-0002-8122-3438"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chad R. Borges","raw_affiliation_strings":["School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287. Electronic address: chad.borges@asu.edu","School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287"],"raw_orcid":"https://orcid.org/0000-0002-8122-3438","affiliations":[{"raw_affiliation_string":"School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287. Electronic address: chad.borges@asu.edu","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"School of Molecular Sciences and The Biodesign Institute at Arizona State University, Tempe, AZ 85287","institution_ids":["https://openalex.org/I55732556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060743715"],"corresponding_institution_ids":["https://openalex.org/I55732556"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.0172,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.9030773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"10","first_page":"2121","last_page":"2137"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.4603999853134155,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.4603999853134155,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3959999978542328,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry-assay","display_name":"mass spectrometry assay","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.8883095979690552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6651300191879272},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.6253029108047485},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.5453405380249023},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5018846988677979},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.4582497477531433},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.42264193296432495},{"id":"https://openalex.org/C86807702","wikidata":"https://www.wikidata.org/wiki/Q2620381","display_name":"Bovine serum albumin","level":2,"score":0.42099565267562866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2845759987831116}],"mesh":[{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005615","descriptor_name":"Freezing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D044967","descriptor_name":"Serum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1074/mcp.tir119.001659","doi":"https://doi.org/10.1074/mcp.tir119.001659","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.tir119.001659","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6773563","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6773563","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Proteomics","raw_type":"Text"},{"id":"pmid:31324658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31324658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & cellular proteomics : MCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/mcp.tir119.001659","doi":"https://doi.org/10.1074/mcp.tir119.001659","is_oa":true,"landing_page_url":"https://doi.org/10.1074/mcp.tir119.001659","pdf_url":null,"source":{"id":"https://openalex.org/S104550190","display_name":"Molecular & Cellular Proteomics","issn_l":"1535-9476","issn":["1535-9476","1535-9484"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular & Cellular Proteomics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2948208037","display_name":"Validation and Advanced Development of Albumin Oxidizability as a Marker of Plasma/Serum Integrity","funder_award_id":"R33CA217702","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309835","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W39663337","https://openalex.org/W206316135","https://openalex.org/W944697290","https://openalex.org/W1585799942","https://openalex.org/W1836945052","https://openalex.org/W1898605379","https://openalex.org/W1968161611","https://openalex.org/W1971507960","https://openalex.org/W1972162204","https://openalex.org/W1974008725","https://openalex.org/W1981568843","https://openalex.org/W1983487843","https://openalex.org/W1994429566","https://openalex.org/W2005298728","https://openalex.org/W2013599309","https://openalex.org/W2015221408","https://openalex.org/W2025370313","https://openalex.org/W2028451971","https://openalex.org/W2031985670","https://openalex.org/W2032022698","https://openalex.org/W2044774901","https://openalex.org/W2055275025","https://openalex.org/W2062103009","https://openalex.org/W2067305246","https://openalex.org/W2071267404","https://openalex.org/W2072218937","https://openalex.org/W2075801595","https://openalex.org/W2081368266","https://openalex.org/W2084257049","https://openalex.org/W2088518810","https://openalex.org/W2114635119","https://openalex.org/W2122283136","https://openalex.org/W2122954515","https://openalex.org/W2123585085","https://openalex.org/W2138780647","https://openalex.org/W2146890885","https://openalex.org/W2147464891","https://openalex.org/W2166172865","https://openalex.org/W2198995631","https://openalex.org/W2325787580","https://openalex.org/W2397281401","https://openalex.org/W2417478683","https://openalex.org/W2605942909","https://openalex.org/W2611435501","https://openalex.org/W2624732901","https://openalex.org/W2735121832","https://openalex.org/W2753797509","https://openalex.org/W2767650726","https://openalex.org/W2784361956","https://openalex.org/W2791851600","https://openalex.org/W2883297117","https://openalex.org/W2883769491","https://openalex.org/W3140292599","https://openalex.org/W3190713319"],"related_works":["https://openalex.org/W7037874890","https://openalex.org/W3040249154","https://openalex.org/W4297499099","https://openalex.org/W2043031160","https://openalex.org/W7167151582","https://openalex.org/W4395048773","https://openalex.org/W2138780647","https://openalex.org/W7116718231","https://openalex.org/W2019892098","https://openalex.org/W4409333402"],"abstract_inverted_index":{"Exposure":[0],"of":[1,18,57,66,76,106,186,188,199,222,229,250,261,279],"blood":[2],"plasma/serum":[3],"(P/S)":[4],"to":[5,70,85,95,121,182,210,232,275],"thawed":[6,71],"conditions":[7],"(>":[8],"\u221230":[9,98],"\u00b0C)":[10],"can":[11,219],"produce":[12],"biomolecular":[13],"changes":[14],"that":[15,62,117,172,196,217,270],"skew":[16],"measurements":[17],"biomarkers":[19],"within":[20],"archived":[21,67,280],"patient":[22,148],"samples,":[23],"potentially":[24],"rendering":[25],"them":[26],"unfit":[27],"for":[28,40,143,155,162,235,240,246,253],"molecular":[29,42],"analysis.":[30],"Because":[31],"freeze-thaw":[32],"histories":[33],"are":[34,46,93],"often":[35],"poorly":[36],"documented,":[37],"objective":[38],"methods":[39],"assessing":[41],"fitness":[43],"before":[44,110],"analysis":[45],"needed.":[47],"We":[48],"report":[49],"a":[50,86],"10-\u03bcl,":[51],"dilute-and-shoot,":[52],"intact-protein":[53],"mass":[54],"spectrometric":[55],"assay":[56],"albumin":[58,79,108],"proteoforms":[59],"called":[60],"\"\u0394S-Cys-Albumin\"":[61],"quantifies":[63],"cumulative":[64],"exposure":[65,221,249],"P/S":[68,81,149,177,205,230,281],"samples":[69,92,133,231,265],"conditions.":[72],"The":[73,100,136,168],"relative":[74,104],"abundance":[75,105],"S-cysteinylated":[77,107],"(oxidized)":[78],"in":[80,102,130,145,176,190],"increases":[82],"inexorably":[83],"but":[84],"maximum":[87,123],"value":[88],"under":[89,267],"100%":[90],"when":[91],"exposed":[94,209],"temperatures":[96],">":[97],"\u00b0C.":[99],"difference":[101],"the":[103,184,200],"(S-Cys-Alb)":[109],"and":[111,161,180,192],"after":[112],"an":[113],"intentional":[114],"incubation":[115],"period":[116],"drives":[118],"this":[119],"proteoform":[120],"its":[122],"level":[124],"is":[125,134,273],"denoted":[126],"as":[127],"\u0394S-Cys-Albumin.":[128],"\u0394S-Cys-Albumin":[129,144,218],"fully":[131],"expired":[132],"zero.":[135],"range":[137],"(mean":[138],"\u00b1":[139,159,166],"95%":[140],"CI)":[141],"observed":[142],"fresh":[146],"cardiac":[147],"(":[150,224],"n":[151,225],"=":[152,226],"97)":[153],"was,":[154],"plasma":[156,191],"12\u201329%":[157],"(20.9":[158],"0.75%)":[160],"serum":[163,193,264],"10\u201324%":[164],"(15.5":[165],"0.64%).":[167],"multireaction":[169],"rate":[170,185],"law":[171],"governs":[173],"S-Cys-Alb":[174,189],"formation":[175,187],"was":[178],"determined":[179],"shown":[181],"predict":[183],"samples\u2014a":[194],"step":[195],"enables":[197],"back-calculation":[198],"time":[201],"at":[202],"which":[203],"unknown":[204],"specimens":[206,252],"have":[207],"been":[208],"room":[211],"temperature.":[212],"A":[213],"blind":[214],"challenge":[215],"demonstrated":[216,269],"detect":[220],"groups":[223],"6":[227],"each)":[228],"23":[233],"\u00b0C":[234,239,245],"2":[236],"h,":[237,242],"4":[238],"16":[241],"or":[243],"\u221220":[244],"24":[247],"h\u2014and":[248],"individual":[251],"modestly":[254],"increased":[255],"times.":[256],"An":[257],"unplanned":[258],"case":[259],"study":[260],"nominally":[262],"pristine":[263],"collected":[266],"NIH-sponsorship":[268],"empirical":[271],"evidence":[272],"required":[274],"ensure":[276],"accurate":[277],"knowledge":[278],"biospecimen":[282],"storage":[283],"history.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-30T00:00:00"}