{"id":"https://openalex.org/W2962809117","doi":"https://doi.org/10.32707/ercivet.595655","title":"The Dose-Duration-Effect Profile of Agmatine on Rat Primary Neuron Cell Culture","display_name":"The Dose-Duration-Effect Profile of Agmatine on Rat Primary Neuron Cell Culture","publication_year":2019,"publication_date":"2019-07-23","ids":{"openalex":"https://openalex.org/W2962809117","doi":"https://doi.org/10.32707/ercivet.595655","mag":"2962809117"},"language":"en","primary_location":{"id":"doi:10.32707/ercivet.595655","doi":"https://doi.org/10.32707/ercivet.595655","is_oa":true,"landing_page_url":"https://doi.org/10.32707/ercivet.595655","pdf_url":"https://dergipark.org.tr/en/download/article-file/773706","source":{"id":"https://openalex.org/S4306509665","display_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","issn_l":"1304-7280","issn":["1304-7280","2667-5498"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/download/article-file/773706","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067926135","display_name":"Damla Binneto\u011flu","orcid":"https://orcid.org/0000-0002-7041-7253","observed_orcids":["https://orcid.org/0000-0002-7041-7253"]},"institutions":[{"id":"https://openalex.org/I135987583","display_name":"Kafkas University","ror":"https://ror.org/04v302n28","country_code":"TR","type":"education","lineage":["https://openalex.org/I135987583"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Damla B\u0130NNETO\u011eLU","raw_affiliation_strings":["Kafkas University , Faculty of Medicine , Department of Medical Pharmacology , Kars","Kafkas University, Faculty of Medicine, Department of Medical Pharmacology, Kars-TURKEY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kafkas University , Faculty of Medicine , Department of Medical Pharmacology , Kars","institution_ids":["https://openalex.org/I135987583"]},{"raw_affiliation_string":"Kafkas University, Faculty of Medicine, Department of Medical Pharmacology, Kars-TURKEY","institution_ids":["https://openalex.org/I135987583"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067926135"],"corresponding_institution_ids":["https://openalex.org/I135987583"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"2","first_page":"86","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.37380000948905945,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.37380000948905945,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.21240000426769257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.13369999825954437,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agmatine","display_name":"agmatine","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9449999928474426},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/primary-neuronal-cultures","display_name":"primary neuronal cultures","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neuronal-proliferation","display_name":"neuronal proliferation","score":0.5690000057220459},{"id":"https://openalex.org/keywords/neuronal-viability","display_name":"neuronal viability","score":0.7490000128746033},{"id":"https://openalex.org/keywords/exposure-time","display_name":"exposure time","score":0.5149999856948853},{"id":"https://openalex.org/keywords/neurotransmitters","display_name":"neurotransmitters","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2781448169","wikidata":"https://www.wikidata.org/wiki/Q394317","display_name":"Agmatine","level":4,"score":0.9254878759384155},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7877006530761719},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5467811822891235},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.529653012752533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4603132903575897},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.4521121084690094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3569453954696655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20261019468307495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1948658525943756},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06164810061454773},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.32707/ercivet.595655","doi":"https://doi.org/10.32707/ercivet.595655","is_oa":true,"landing_page_url":"https://doi.org/10.32707/ercivet.595655","pdf_url":"https://dergipark.org.tr/en/download/article-file/773706","source":{"id":"https://openalex.org/S4306509665","display_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","issn_l":"1304-7280","issn":["1304-7280","2667-5498"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","raw_type":"journal-article"},{"id":"pmh:oai:dergipark.org.tr:article/595655","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/tr/pub/ercivet/issue/47802/595655","pdf_url":null,"source":{"id":"https://openalex.org/S4306509665","display_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","issn_l":"1304-7280","issn":["1304-7280","2667-5498"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.32707/ercivet.595655","doi":"https://doi.org/10.32707/ercivet.595655","is_oa":true,"landing_page_url":"https://doi.org/10.32707/ercivet.595655","pdf_url":"https://dergipark.org.tr/en/download/article-file/773706","source":{"id":"https://openalex.org/S4306509665","display_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","issn_l":"1304-7280","issn":["1304-7280","2667-5498"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Erciyes \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G683447294","display_name":"Primer N\u00f6ron K\u00fclt\u00fcr\u00fcnde Paklitaksel ve Sisplatin ile \u0130nd\u00fcklenen N\u00f6rotoksisitede Agmatinin N\u00f6roprotektif Etkilerinin Ara\u015ft\u0131r\u0131lmas\u0131","funder_award_id":"216S356","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2962809117.pdf","grobid_xml":"https://content.openalex.org/works/W2962809117.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1240888426","https://openalex.org/W1965258293","https://openalex.org/W1967186063","https://openalex.org/W1970597832","https://openalex.org/W1974876724","https://openalex.org/W1982525105","https://openalex.org/W1989927249","https://openalex.org/W2045972996","https://openalex.org/W2102660424","https://openalex.org/W2113700357","https://openalex.org/W2130080387","https://openalex.org/W2172243158","https://openalex.org/W2736776220","https://openalex.org/W2789967920","https://openalex.org/W2853229984","https://openalex.org/W2912009414","https://openalex.org/W3028668450","https://openalex.org/W3167063947","https://openalex.org/W4313031491"],"related_works":["https://openalex.org/W2912009414","https://openalex.org/W2376879189","https://openalex.org/W2060192065","https://openalex.org/W4289083534","https://openalex.org/W2944732962","https://openalex.org/W2368990231","https://openalex.org/W4382060961","https://openalex.org/W2078264415","https://openalex.org/W1513989058","https://openalex.org/W2367302736"],"abstract_inverted_index":{"Agmatine":[0],"is":[1,39],"a":[2,139,168],"newly":[3],"found":[4],"neurotransmitter":[5],"and":[6,33,63,114,148,156,202],"its":[7],"role":[8],"in":[9,83,146,153,181,191],"important":[10],"modulations":[11],"of":[12,20,24,36,66,109,135,170],"central":[13],"nervous":[14],"systems":[15],"how":[16],"the":[17,30,60,84,118,133,136,192,199,203],"pharmacological":[18],"importance":[19],"agmatine.":[21],"The":[22],"aim":[23],"this":[25,52],"study":[26],"was":[27,123,144,164,184],"to":[28,41,58,132],"investigate":[29],"possible":[31,61],"toxic":[32,62,182],"proliferative":[34],"effects":[35,65],"agmatine,":[37],"which":[38],"known":[40],"have":[42],"endogenous":[43],"neuroprotective":[44,142,189],"effect,":[45],"on":[46],"primary":[47,193],"rat":[48,194],"neuron":[49,195],"culture.":[50],"In":[51,161],"context,":[53],"it":[54],"has":[55],"been":[56],"tried":[57],"determine":[59],"protective":[64],"agmatine":[67,90,187],"at":[68,73,91,167,198],"8":[69,102],"different":[70,75],"exposure":[71,159],"times":[72],"5":[74],"doses.":[76],"Neuron":[77],"cultures":[78],"obtained":[79],"from":[80],"brain":[81],"cortex":[82],"neonatal":[85],"rats":[86],"are":[87],"treated":[88],"with":[89,125],"15":[92],"min,":[93,95],"30":[94],"1":[96,154],"h,":[97],"2":[98],"hours,":[99,101,103,105,107],"4":[100],"12":[104],"24":[106,157,174],"doses":[108],"10-2,":[110],"10-3,":[111],"10-4,":[112],"10-5":[113,147],"10-6":[115,149],"M.":[116],"Then,":[117],"dose":[119,201],"duration":[120],"effect":[121,143,183,190],"relationship":[122],"determined":[124],"MTT":[126],"(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[127],"bromide)":[128],"proliferation":[129,163],"kit.":[130],"According":[131],"results":[134],"viability":[137],"assay,":[138],"statistically":[140,178],"significant":[141,179],"observed":[145,165],"M":[150,172],"doses,":[151],"especially":[152,197],"hour":[155],"hours":[158],"periods.":[160],"addition,":[162],"only":[166],"concentration":[169],"10-4":[171],"for":[173],"hours.":[175],"However,":[176],"no":[177],"difference":[180],"observed.":[185],"Consequently":[186],"showed":[188],"culture,":[196],"lowest":[200],"longest":[204],"exposure.":[205]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2019-07-30T00:00:00"}