{"id":"https://openalex.org/W2962499345","doi":null,"title":"Keratin Microparticles for Drug and Cell Delivery","display_name":"Keratin Microparticles for Drug and Cell Delivery","publication_year":2019,"publication_date":"2019-05-02","ids":{"openalex":"https://openalex.org/W2962499345","mag":"2962499345"},"language":"en","primary_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/89345","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/89345","pdf_url":"http://hdl.handle.net/10919/89345","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10919/89345","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015849915","display_name":"Marc A Thompson","orcid":"https://orcid.org/0000-0001-6688-6770","observed_orcids":["https://orcid.org/0000-0001-6688-6770","https://orcid.org/0009-0008-4104-5666"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marc A Thompson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6688-6770","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015849915"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.014000000432133675,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratosis","display_name":"keratosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/water-in-oil-emulsions","display_name":"water-in-oil emulsions","score":0.9539999961853027},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cell-delivery","display_name":"cell delivery","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antibiotic-delivery","display_name":"antibiotic delivery","score":0.5189999938011169},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9470000267028809},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9120000004768372},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.9079999923706055},{"id":"https://openalex.org/keywords/l6-myoblasts","display_name":"L6 myoblasts","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hydrogel-microparticles","display_name":"hydrogel microparticles","score":0.7369999885559082},{"id":"https://openalex.org/keywords/drug-release-kinetics","display_name":"drug release kinetics","score":0.8159999847412109},{"id":"https://openalex.org/keywords/freeze-thaw-stability","display_name":"freeze-thaw stability","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.5812192559242249},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5520702004432678},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49755337834358215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36941593885421753},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3392395079135895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31245994567871094},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2666149139404297},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2065500020980835},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1658189594745636}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/89345","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/89345","pdf_url":"http://hdl.handle.net/10919/89345","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"mag:2962499345","doi":null,"is_oa":false,"landing_page_url":"https://vtechworks.lib.vt.edu/handle/10919/89345","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/89345","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/89345","pdf_url":"http://hdl.handle.net/10919/89345","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2962499345.pdf","grobid_xml":"https://content.openalex.org/works/W2962499345.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W195107035","https://openalex.org/W264322610","https://openalex.org/W1122291744","https://openalex.org/W1151608245","https://openalex.org/W1158695349","https://openalex.org/W1483430311","https://openalex.org/W1547433582","https://openalex.org/W1566636169","https://openalex.org/W1592815171","https://openalex.org/W1812221069","https://openalex.org/W1844882096","https://openalex.org/W1851857875","https://openalex.org/W1893389145","https://openalex.org/W1914608652","https://openalex.org/W1965350188","https://openalex.org/W1966103500","https://openalex.org/W1966459377","https://openalex.org/W1967293561","https://openalex.org/W1968475097","https://openalex.org/W1968564635","https://openalex.org/W1972287513","https://openalex.org/W1972835811","https://openalex.org/W1973282714","https://openalex.org/W1973606753","https://openalex.org/W1975207418","https://openalex.org/W1977250363","https://openalex.org/W1978862190","https://openalex.org/W1982498935","https://openalex.org/W1982780398","https://openalex.org/W1985235829","https://openalex.org/W1986715280","https://openalex.org/W1990839876","https://openalex.org/W1997777049","https://openalex.org/W1998092723","https://openalex.org/W1998539000","https://openalex.org/W2002354061","https://openalex.org/W2009523551","https://openalex.org/W2016711291","https://openalex.org/W2017075649","https://openalex.org/W2019408568","https://openalex.org/W2021685892","https://openalex.org/W2024743274","https://openalex.org/W2025154544","https://openalex.org/W2028253963","https://openalex.org/W2028289491","https://openalex.org/W2032740145","https://openalex.org/W2037349387","https://openalex.org/W2038498238","https://openalex.org/W2040929841","https://openalex.org/W2041887914","https://openalex.org/W2044217991","https://openalex.org/W2044226511","https://openalex.org/W2048281100","https://openalex.org/W2050261148","https://openalex.org/W2051013988","https://openalex.org/W2051887207","https://openalex.org/W2054364332","https://openalex.org/W2054992092","https://openalex.org/W2056109563","https://openalex.org/W2058719622","https://openalex.org/W2065217821","https://openalex.org/W2068443239","https://openalex.org/W2068720223","https://openalex.org/W2070733566","https://openalex.org/W2071257785","https://openalex.org/W2072371150","https://openalex.org/W2072959645","https://openalex.org/W2073049453","https://openalex.org/W2074640863","https://openalex.org/W2074712576","https://openalex.org/W2077952390","https://openalex.org/W2078120593","https://openalex.org/W2079178433","https://openalex.org/W2079812792","https://openalex.org/W2080035178","https://openalex.org/W2082987954","https://openalex.org/W2085269784","https://openalex.org/W2086859574","https://openalex.org/W2086902602","https://openalex.org/W2088183084","https://openalex.org/W2088991414","https://openalex.org/W2093130113","https://openalex.org/W2095490913","https://openalex.org/W2099018000","https://openalex.org/W2099540110","https://openalex.org/W2103287170","https://openalex.org/W2110957605","https://openalex.org/W2114407371","https://openalex.org/W2118622207","https://openalex.org/W2120208607","https://openalex.org/W2120460012","https://openalex.org/W2121601962","https://openalex.org/W2121695733","https://openalex.org/W2142725722","https://openalex.org/W2145295359","https://openalex.org/W2149970873","https://openalex.org/W2152228042","https://openalex.org/W2159999899","https://openalex.org/W2171093380","https://openalex.org/W2180771258","https://openalex.org/W2219931720","https://openalex.org/W2230902569","https://openalex.org/W2238333901","https://openalex.org/W2276801987","https://openalex.org/W2298706874","https://openalex.org/W2328741275","https://openalex.org/W2332061822","https://openalex.org/W2409910082","https://openalex.org/W2412178706","https://openalex.org/W2431575019","https://openalex.org/W2587398364","https://openalex.org/W2600682079","https://openalex.org/W2765655883","https://openalex.org/W2799662184","https://openalex.org/W2889248714","https://openalex.org/W2890989642","https://openalex.org/W4211070775"],"related_works":["https://openalex.org/W3081080087","https://openalex.org/W1914608652","https://openalex.org/W3043929663","https://openalex.org/W2945786227","https://openalex.org/W1812221069","https://openalex.org/W2735906754","https://openalex.org/W4385984618","https://openalex.org/W3082097274","https://openalex.org/W1971504646","https://openalex.org/W2324183021"],"abstract_inverted_index":{"Keratins":[0],"are":[1,54],"a":[2,16,137,213,258,283,311],"family":[3],"of":[4,19,27,51,85,109,126,189,241,261,321,337,344],"proteins":[5],"found":[6],"within":[7],"human":[8],"hair,":[9],"skin":[10],"and":[11,29,35,45,61,79,87,113,124,139,172,180,222,277,309,332],"nails,":[12],"as":[13,15],"well":[14],"broad":[17],"variety":[18],"animal":[20],"tissue.":[21],"Prior":[22],"research":[23],"suggests":[24],"hydrogel":[25,220],"constructs":[26],"keratin":[28,30,99,104],"derivatives":[31],"exhibit":[32],"several":[33],"mechanical":[34],"biological":[36],"properties":[37,221],"that":[38,314,329],"support":[39,334],"their":[40],"use":[41,127],"for":[42,59,64,204,282],"tissue":[43,65,207],"engineering":[44,66],"regenerative":[46],"medicine":[47],"applications.":[48,151,293],"Microparticle":[49],"formulations":[50],"these":[52],"hydrogels":[53],"an":[55,102,142,267],"intriguing":[56],"delivery":[57,82,256],"vehicle":[58],"drugs":[60],"cellular":[62],"payloads":[63],"purposes":[67],"due":[68],"to":[69,72,97,148,158,169,199,247,269,287],"the":[70,92,167,185,193,274,280,319,348],"ability":[71,268],"exploit":[73],"size,":[74,111],"surface":[75],"area,":[76],"loading":[77,120],"potential":[78,281],"importantly,":[80],"non-invasive":[81],"(i.e.":[83],"injection)":[84],"cells":[86,164],"biologics.":[88],"Here":[89],"we":[90,183],"examine":[91],"water-in-oil":[93],"emulsion":[94],"synthesis":[95,230],"procedure":[96],"produce":[98],"microparticles":[100,131,191],"using":[101,136],"oxidized":[103],"derivative,":[105],"keratose":[106],"(KOS).":[107],"Analyses":[108],"particle":[110],"microstructure,":[112],"other":[114,254],"characterization":[115],"techniques":[116],"were":[117,217,297],"performed.":[118],"Drug":[119],"characteristics,":[121],"release":[122,252],"kinetics,":[123],"feasibility":[125],"in":[128,177,186,249,273,290,325],"two":[129],"different":[130],"was":[132,156],"subsequently":[133],"investigated,":[134],"first":[135],"model-drug":[138],"later":[140],"testing":[141,166],"antibiotic":[143],"payload":[144,255],"on":[145,192],"bacterial":[146,271],"cultures":[147],"validate":[149],"antibacterial":[150],"A":[152],"suspension":[153],"culture":[154],"technique":[155],"developed":[157],"load":[159],"bone":[160],"marrow-derived":[161],"mesenchymyal":[162],"stromal":[163],"(BM-MSCs),":[165],"capacity":[168],"maintain":[170],"viability":[171],"express":[173],"key":[174],"protein-based":[175],"factors":[176],"cell":[178,197,295,303,316],"growth":[179,272,350],"development.":[181],"Finally,":[182,324],"tested":[184],"vitro":[187,326],"effects":[188],"cell-loaded":[190,345],"L6":[194],"skeletal":[195,205,338],"muscle":[196,206,339],"line":[198],"determine":[200],"potentially":[201],"beneficial":[202],"outcomes":[203],"regeneration.":[208],"Largely":[209],"spherical":[210],"particles":[211,243,346],"with":[212,226,341],"porous":[214],"internal":[215],"structure":[216],"obtained,":[218],"displaying":[219],"forming":[223],"viscoelastic":[224],"gels":[225],"small":[227],"differences":[228],"between":[229],"components":[231],"(solvents,":[232],"crosslinkers),":[233],"generating":[234],"tailorable":[235],"properties.":[236],"The":[237],"uniquely":[238],"fibrous":[239],"microstructure":[240],"KOS":[242,331],"may":[244],"lend":[245],"them":[246],"applications":[248],"rapid":[250],"drug":[251],"or":[253],"wherein":[257],"high":[259],"level":[260],"biocompatibility":[262],"is":[263],"desired.":[264],"Data":[265],"showed":[266],"inhibit":[270],"emulsion-generated":[275],"system,":[276],"thereby":[278],"demonstrated":[279],"keratin-based":[284],"microparticle":[285],"construct":[286],"be":[288],"used":[289],"wound":[291],"healing":[292],"Dense":[294],"populations":[296],"loaded":[298],"onto":[299],"particles.":[300],"Particles":[301],"maintained":[302],"viability,":[304],"even":[305],"after":[306],"freeze-thaw":[307],"cycling,":[308],"provided":[310],"material":[312],"substrate":[313],"supported":[315],"attachment":[317],"through":[318],"formation":[320],"focal":[322],"adhesions.":[323],"studies":[327],"show":[328],"both":[330],"BM-MSCs":[333],"varying":[335],"aspects":[336],"development,":[340],"combinatorial":[342],"treatments":[343],"conferring":[347],"greatest":[349],"responses.":[351]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-23T00:00:00"}
