{"id":"https://openalex.org/W2962331597","doi":"https://doi.org/10.2174/1381612825666190709204107","title":"Novelty in Inflammation and Immunomodulation in Migraine","display_name":"Novelty in Inflammation and Immunomodulation in Migraine","publication_year":2019,"publication_date":"2019-10-09","ids":{"openalex":"https://openalex.org/W2962331597","doi":"https://doi.org/10.2174/1381612825666190709204107","mag":"2962331597","pmid":"https://pubmed.ncbi.nlm.nih.gov/31686633"},"language":"en","primary_location":{"id":"doi:10.2174/1381612825666190709204107","doi":"https://doi.org/10.2174/1381612825666190709204107","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612825666190709204107","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007748007","display_name":"Cinzia Cavestro","orcid":"https://orcid.org/0000-0003-1172-1009","observed_orcids":["https://orcid.org/0000-0003-1172-1009"]},"institutions":[{"id":"https://openalex.org/I4210141322","display_name":"Azienda Sanitaria Locale CN2","ror":"https://ror.org/036g5z675","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141322"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cinzia Cavestro","raw_affiliation_strings":["Department of Neurology, Headache Centre, ASL CN2, Alba, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Headache Centre, ASL CN2, Alba, Italy","institution_ids":["https://openalex.org/I4210141322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021795864","display_name":"Marcella Ferrero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141322","display_name":"Azienda Sanitaria Locale CN2","ror":"https://ror.org/036g5z675","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141322"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marcella Ferrero","raw_affiliation_strings":["Department of Neurology, Headache Centre, ASL CN2, Alba, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Headache Centre, ASL CN2, Alba, Italy","institution_ids":["https://openalex.org/I4210141322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025602590","display_name":"Silvia Mandrino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141322","display_name":"Azienda Sanitaria Locale CN2","ror":"https://ror.org/036g5z675","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141322"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvia Mandrino","raw_affiliation_strings":["Department of Neurology, Headache Centre, ASL CN2, Alba, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Headache Centre, ASL CN2, Alba, Italy","institution_ids":["https://openalex.org/I4210141322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075220205","display_name":"Marco Di Tavi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141322","display_name":"Azienda Sanitaria Locale CN2","ror":"https://ror.org/036g5z675","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141322"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Di Tavi","raw_affiliation_strings":["Department of Neurology, Headache Centre, ASL CN2, Alba, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Headache Centre, ASL CN2, Alba, Italy","institution_ids":["https://openalex.org/I4210141322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083780673","display_name":"Eugenia Rota","orcid":"https://orcid.org/0000-0003-3154-7634","observed_orcids":["https://orcid.org/0000-0003-3154-7634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugenia Rota","raw_affiliation_strings":["Neurology Unit, San Giacomo Hospital, Novi Ligure, ASL AL, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Unit, San Giacomo Hospital, Novi Ligure, ASL AL, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007748007"],"corresponding_institution_ids":["https://openalex.org/I4210141322"],"apc_list":null,"apc_paid":null,"fwci":1.0219,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.70752798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"27","first_page":"2919","last_page":"2936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/migraine-pathogenesis","display_name":"migraine pathogenesis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/vascular-theory","display_name":"vascular theory","score":0.6349999904632568},{"id":"https://openalex.org/keywords/trigeminovascular-system","display_name":"trigeminovascular system","score":0.996999979019165},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pituitary-adenylate-cyclase-activating-peptide","display_name":"pituitary adenylate cyclase-activating peptide","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cortical-spreading-depression","display_name":"cortical spreading depression","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glymphatic-system","display_name":"glymphatic system","score":0.9950000047683716},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.843999981880188},{"id":"https://openalex.org/keywords/cgrp-receptor-antagonists","display_name":"CGRP receptor antagonists","score":0.9079999923706055},{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9359999895095825},{"id":"https://openalex.org/keywords/chronic-migraine","display_name":"chronic migraine","score":0.9039999842643738},{"id":"https://openalex.org/keywords/c-fibers","display_name":"C-fibers","score":0.8420000076293945},{"id":"https://openalex.org/keywords/a-delta-fibers","display_name":"A-delta fibers","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8212791681289673},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.7588032484054565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6569892764091492},{"id":"https://openalex.org/C2776089194","wikidata":"https://www.wikidata.org/wiki/Q7002244","display_name":"Neurogenic inflammation","level":5,"score":0.6201229691505432},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.606337308883667},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5290243625640869},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4713427722454071},{"id":"https://openalex.org/C122356138","wikidata":"https://www.wikidata.org/wiki/Q461576","display_name":"Cortical spreading depression","level":3,"score":0.47029396891593933},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.44985756278038025},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.4208261966705322},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39496690034866333},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.37594741582870483},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3452303111553192},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3379586935043335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1753765046596527},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.16912773251533508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1298730969429016},{"id":"https://openalex.org/C2776533618","wikidata":"https://www.wikidata.org/wiki/Q411041","display_name":"Substance P","level":4,"score":0.07579255104064941}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019274","descriptor_name":"Botulinum Toxins, Type A","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051219","descriptor_name":"Pituitary Adenylate Cyclase-Activating Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612825666190709204107","doi":"https://doi.org/10.2174/1381612825666190709204107","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612825666190709204107","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:31686633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31686633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W46438429","https://openalex.org/W56719936","https://openalex.org/W58203946","https://openalex.org/W75200699","https://openalex.org/W199026230","https://openalex.org/W211905087","https://openalex.org/W1722148928","https://openalex.org/W1771060587","https://openalex.org/W1891579824","https://openalex.org/W1957395289","https://openalex.org/W1969330409","https://openalex.org/W1970846628","https://openalex.org/W1973662774","https://openalex.org/W1976505981","https://openalex.org/W1977286827","https://openalex.org/W1979051987","https://openalex.org/W1979882313","https://openalex.org/W1981423842","https://openalex.org/W1982394915","https://openalex.org/W1984626572","https://openalex.org/W1985575316","https://openalex.org/W1987697087","https://openalex.org/W1989871310","https://openalex.org/W1990130323","https://openalex.org/W1992100309","https://openalex.org/W1993819599","https://openalex.org/W1994481205","https://openalex.org/W1995819853","https://openalex.org/W2000761493","https://openalex.org/W2000797422","https://openalex.org/W2002063367","https://openalex.org/W2004442352","https://openalex.org/W2008256912","https://openalex.org/W2011214932","https://openalex.org/W2013033676","https://openalex.org/W2013756203","https://openalex.org/W2018174825","https://openalex.org/W2018299323","https://openalex.org/W2025085922","https://openalex.org/W2026322513","https://openalex.org/W2027475058","https://openalex.org/W2032443632","https://openalex.org/W2033066280","https://openalex.org/W2033650768","https://openalex.org/W2046085057","https://openalex.org/W2046182002","https://openalex.org/W2052442132","https://openalex.org/W2053277833","https://openalex.org/W2056435956","https://openalex.org/W2058466766","https://openalex.org/W2059350861","https://openalex.org/W2061827338","https://openalex.org/W2064485672","https://openalex.org/W2065223010","https://openalex.org/W2065720775","https://openalex.org/W2066888686","https://openalex.org/W2071070452","https://openalex.org/W2072570136","https://openalex.org/W2075130358","https://openalex.org/W2082358684","https://openalex.org/W2087798692","https://openalex.org/W2087985521","https://openalex.org/W2090215105","https://openalex.org/W2093439232","https://openalex.org/W2096457914","https://openalex.org/W2111605706","https://openalex.org/W2113588456","https://openalex.org/W2116944060","https://openalex.org/W2117743525","https://openalex.org/W2121166314","https://openalex.org/W2124636171","https://openalex.org/W2132968602","https://openalex.org/W2134150167","https://openalex.org/W2135235221","https://openalex.org/W2137762446","https://openalex.org/W2137787323","https://openalex.org/W2140255676","https://openalex.org/W2144693103","https://openalex.org/W2148445312","https://openalex.org/W2151181921","https://openalex.org/W2152833268","https://openalex.org/W2156047574","https://openalex.org/W2156933229","https://openalex.org/W2157549170","https://openalex.org/W2157733244","https://openalex.org/W2157866875","https://openalex.org/W2158846562","https://openalex.org/W2160084385","https://openalex.org/W2160527711","https://openalex.org/W2160914028","https://openalex.org/W2212117330","https://openalex.org/W2268603990","https://openalex.org/W2292619439","https://openalex.org/W2309413820","https://openalex.org/W2322800034","https://openalex.org/W2332116348","https://openalex.org/W2339022261","https://openalex.org/W2569188662","https://openalex.org/W2581247880","https://openalex.org/W2587108302","https://openalex.org/W2587835995","https://openalex.org/W2598060151","https://openalex.org/W2608751463","https://openalex.org/W2613018513","https://openalex.org/W2613063114","https://openalex.org/W2676947678","https://openalex.org/W2726359260","https://openalex.org/W2737197277","https://openalex.org/W2767360633","https://openalex.org/W2768357559","https://openalex.org/W2769013445","https://openalex.org/W2770965214","https://openalex.org/W2771927282","https://openalex.org/W2792154608","https://openalex.org/W2792811290","https://openalex.org/W2799966795","https://openalex.org/W2800794691","https://openalex.org/W2803715733","https://openalex.org/W2805181790","https://openalex.org/W2805937849","https://openalex.org/W2806839281","https://openalex.org/W2808643415","https://openalex.org/W2880621648","https://openalex.org/W2884213127","https://openalex.org/W2885895791","https://openalex.org/W2890050797","https://openalex.org/W2901687990","https://openalex.org/W2910809224","https://openalex.org/W2917297726","https://openalex.org/W2922174162","https://openalex.org/W2925153609","https://openalex.org/W2931739625","https://openalex.org/W2936004119","https://openalex.org/W2936690200","https://openalex.org/W2938743773","https://openalex.org/W2939449854","https://openalex.org/W2939928161","https://openalex.org/W2943600993","https://openalex.org/W2955580540","https://openalex.org/W4211090737"],"related_works":["https://openalex.org/W2735637650","https://openalex.org/W7171682916","https://openalex.org/W2183390942","https://openalex.org/W4323929201","https://openalex.org/W3131964533","https://openalex.org/W3195735894","https://openalex.org/W2390524195","https://openalex.org/W4221049956","https://openalex.org/W4321374289","https://openalex.org/W4411170783"],"abstract_inverted_index":{"BACKGROUND:":[0],"Migraine":[1,72],"is":[2,10],"a":[3,78,91],"diffuse":[4],"and":[5,12,16,40,46,113,132,186,226,231],"disabling":[6],"disease.":[7],"Its":[8],"pathophysiology":[9],"complex":[11],"involves":[13],"both":[14],"central":[15],"peripheral":[17],"dysfunctions.":[18],"OBJECTIVE:":[19],"This":[20],"review":[21,69],"will":[22],"discuss":[23],"the":[24,29,32,36,41,65,83,100,103,110,117,128,141,152,159,165,184,189,196,201,207,211,214,221,227,234,244],"pathogenesis":[25],"of":[26,31,67,102,161,164,188,195,203,224,229,236,238,246],"migraine":[27,166,179],"from":[28,64],"origin":[30],"neuro-inflammatory":[33],"theory,":[34],"to":[35,49,75,82,121,149],"modern":[37],"pathophysiological":[38],"model":[39],"latest":[42],"therapies.":[43],"METHODS:":[44],"PUBMED":[45],"EMBASE":[47],"(up":[48],"May":[50],"2019)":[51],"were":[52],"searched":[53],"for:":[54],"migraine,":[55],"inflammation,":[56],"immunomodulation.":[57],"An":[58],"additional":[59],"search":[60],"was":[61,73,97,138,180],"carried":[62],"out":[63],"bibliography":[66],"previous":[68],"articles.":[70],"RESULTS:":[71],"thought":[74],"be":[76],"mainly":[77],"vascular":[79],"disorder,":[80],"according":[81],"so-called":[84],"\"vascular":[85],"theory\".":[86],"Based":[87],"on":[88],"animal":[89],"models,":[90],"new":[92,204,218],"hypothesis":[93],"called":[94],"\"the":[95],"neuro-inflammatory\"":[96],"conceived":[98],"at":[99],"end":[101],"20th":[104],"century.":[105],"The":[106,192],"growing":[107],"knowledge":[108],"about":[109],"trigeminovascular":[111],"system":[112,143,198],"its":[114],"role":[115],"in":[116,158,178,243],"inflammatory-pain":[118,142],"pathway,":[119],"allowed":[120,200],"identify":[122],"other":[123],"specific":[124],"neurotransmitters,":[125],"such":[126],"as":[127],"Calcitonin":[129],"Gene-Related":[130],"Peptide":[131],"Pituitary":[133],"Adenylate":[134],"Cyclase-Activating":[135],"Peptide.":[136],"Evidence":[137],"provided":[139],"that":[140],"could":[144,154],"become":[145],"sensitised":[146],"and,":[147],"due":[148],"this":[150],"sensitisation,":[151],"pain":[153],"also":[155],"perpetuate,":[156],"even":[157],"absence":[160],"any":[162],"triggers":[163],"attack.":[167],"At":[168],"last,":[169],"brain":[170],"immune":[171,197],"cells":[172],"modification":[173],"during":[174],"cortical":[175],"spreading":[176],"depression":[177],"demonstrated,":[181],"along":[182],"with":[183],"existence":[185],"function":[187,228],"glymphatic":[190],"system.":[191],"better":[193],"comprehension":[194],"abnormalities":[199],"development":[202],"immunomodulating":[205],"drugs:":[206],"monoclonal":[208],"antibodies":[209],"against":[210],"CGRP":[212,215],"or":[213],"receptor.":[216],"Moreover,":[217],"insights":[219],"into":[220],"molecular":[222],"mechanism":[223,235],"CGRP,":[225],"C-fibres":[230],"A\u03b4-fibres,":[232],"highlighted":[233],"action":[237],"Botulinum":[239],"Toxin":[240],"type":[241],"A":[242],"treatment":[245],"chronic":[247],"migraine.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-23T00:00:00"}