{"id":"https://openalex.org/W2961908246","doi":"https://doi.org/10.1002/jhet.3628","title":"Synthesis, antimicrobial activity, and molecular docking study of formylnaphthalenyloxymethyl\u2010triazolyl\u2010N\u2010phenylacetamides","display_name":"Synthesis, antimicrobial activity, and molecular docking study of formylnaphthalenyloxymethyl\u2010triazolyl\u2010N\u2010phenylacetamides","publication_year":2019,"publication_date":"2019-07-17","ids":{"openalex":"https://openalex.org/W2961908246","doi":"https://doi.org/10.1002/jhet.3628","mag":"2961908246"},"language":"en","primary_location":{"id":"doi:10.1002/jhet.3628","doi":"https://doi.org/10.1002/jhet.3628","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.3628","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075724503","display_name":"Mahesh B. Muluk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahesh B. Muluk","raw_affiliation_strings":["Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub-Campus Osmanabad 413501 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub-Campus Osmanabad 413501 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053524904","display_name":"Sambhaji T. Dhumal","orcid":"https://orcid.org/0000-0003-3018-6179","observed_orcids":["https://orcid.org/0000-0003-3018-6179"]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sambhaji T. Dhumal","raw_affiliation_strings":["Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089405233","display_name":"Pramod S. Phatak","orcid":"https://orcid.org/0000-0002-2916-5648","observed_orcids":["https://orcid.org/0000-0002-2916-5648"]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pramod S. Phatak","raw_affiliation_strings":["Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub-Campus Osmanabad 413501 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub-Campus Osmanabad 413501 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056379407","display_name":"Naziya N. M. A. Rehman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naziya N. M. A. Rehman","raw_affiliation_strings":["Department of Microbiology Dr. Babasaheb Ambedkar Marathwada University, Sub-Campus Osmanabad 413501 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology Dr. Babasaheb Ambedkar Marathwada University, Sub-Campus Osmanabad 413501 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059709087","display_name":"Prashant P. Dixit","orcid":"https://orcid.org/0000-0001-9682-2786","observed_orcids":["https://orcid.org/0000-0001-9682-2786"]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prashant P. Dixit","raw_affiliation_strings":["Department of Microbiology Dr. Babasaheb Ambedkar Marathwada University, Sub-Campus Osmanabad 413501 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology Dr. Babasaheb Ambedkar Marathwada University, Sub-Campus Osmanabad 413501 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038717039","display_name":"Prafulla Balkrishna Choudhari","orcid":"https://orcid.org/0000-0002-9137-3982","observed_orcids":["https://orcid.org/0000-0002-9137-3982","https://orcid.org/0000-0003-3833-1916"]},"institutions":[{"id":"https://openalex.org/I4405265460","display_name":"Bharati Vidyapeeth College of Pharmacy, Kolhapur","ror":"https://ror.org/04w5v0h22","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405265460","https://openalex.org/I887998513"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prafulla B. Choudhari","raw_affiliation_strings":["Department of Pharmaceutical Chemistry Bharati Vidhyapeeth College of Pharmacy Kolhapur 416013 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry Bharati Vidhyapeeth College of Pharmacy Kolhapur 416013 Maharashtra India","institution_ids":["https://openalex.org/I4405265460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037699607","display_name":"Ramrao A. Mane","orcid":"https://orcid.org/0000-0002-3562-7845","observed_orcids":["https://orcid.org/0000-0002-3562-7845"]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ramrao A. Mane","raw_affiliation_strings":["Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 Maharashtra India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072493772","display_name":"Kishan Prabhu Haval","orcid":"https://orcid.org/0000-0002-2526-8738","observed_orcids":["https://orcid.org/0000-0002-2526-8738"]},"institutions":[{"id":"https://openalex.org/I165259314","display_name":"Dr. Babasaheb Ambedkar Marathwada University","ror":"https://ror.org/033pfj584","country_code":"IN","type":"education","lineage":["https://openalex.org/I165259314"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Kishan P. Haval","raw_affiliation_strings":["Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub-Campus Osmanabad 413501 Maharashtra India"],"raw_orcid":"https://orcid.org/0000-0002-2526-8738","affiliations":[{"raw_affiliation_string":"Department of Chemistry Dr. Babasaheb Ambedkar Marathwada University Sub-Campus Osmanabad 413501 Maharashtra India","institution_ids":["https://openalex.org/I165259314"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072493772"],"corresponding_institution_ids":["https://openalex.org/I165259314"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":0.8382,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.61857429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"56","issue":"9","first_page":"2411","last_page":"2418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.5439000129699707,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.06889999657869339,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triazole-hybrids","display_name":"triazole hybrids","score":0.6579999923706055},{"id":"https://openalex.org/keywords/acetanilide","display_name":"acetanilide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.8849999904632568},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.8830000162124634},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":1.0},{"id":"https://openalex.org/keywords/dna-gyrase","display_name":"DNA gyrase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8659999966621399},{"id":"https://openalex.org/keywords/heterocyclic-hybrids","display_name":"hybrid heterocyclic compounds","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9004443883895874},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8521854877471924},{"id":"https://openalex.org/C167125095","wikidata":"https://www.wikidata.org/wiki/Q70551687","display_name":"DNA gyrase","level":4,"score":0.7885392904281616},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.6856582760810852},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6632505059242249},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.6489138007164001},{"id":"https://openalex.org/C2777907353","wikidata":"https://www.wikidata.org/wiki/Q903341","display_name":"Triazole","level":2,"score":0.5798479318618774},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5635241270065308},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.5304459929466248},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5238533020019531},{"id":"https://openalex.org/C69610077","wikidata":"https://www.wikidata.org/wiki/Q912270","display_name":"Click chemistry","level":2,"score":0.5077189207077026},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.44012731313705444},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.27361589670181274},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2727821171283722},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23321875929832458},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16960352659225464},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1666668951511383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jhet.3628","doi":"https://doi.org/10.1002/jhet.3628","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jhet.3628","pdf_url":null,"source":{"id":"https://openalex.org/S46134040","display_name":"Journal of Heterocyclic Chemistry","issn_l":"0022-152X","issn":["0022-152X","1943-5193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Heterocyclic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1763205388","https://openalex.org/W1992587080","https://openalex.org/W2014916026","https://openalex.org/W2017227682","https://openalex.org/W2041647645","https://openalex.org/W2045007367","https://openalex.org/W2047289171","https://openalex.org/W2073556554","https://openalex.org/W2085663480","https://openalex.org/W2137577190","https://openalex.org/W2138291798","https://openalex.org/W2142652497","https://openalex.org/W2148075008","https://openalex.org/W2164460325","https://openalex.org/W2191975899","https://openalex.org/W2253088107","https://openalex.org/W2257421664","https://openalex.org/W2259013233","https://openalex.org/W2296758087","https://openalex.org/W2345719294","https://openalex.org/W2396930286","https://openalex.org/W2471503074","https://openalex.org/W2517279251","https://openalex.org/W2521716553","https://openalex.org/W2522573946","https://openalex.org/W2522930283","https://openalex.org/W2532996946","https://openalex.org/W2550229585","https://openalex.org/W2558046765","https://openalex.org/W2565974143","https://openalex.org/W2577017727","https://openalex.org/W2593436234","https://openalex.org/W2594025818","https://openalex.org/W2596837506","https://openalex.org/W2605567181","https://openalex.org/W2689095060","https://openalex.org/W2737563149","https://openalex.org/W2751994003","https://openalex.org/W2767162333","https://openalex.org/W2767814354","https://openalex.org/W2769731110","https://openalex.org/W2770614828","https://openalex.org/W2774970835","https://openalex.org/W2775274728","https://openalex.org/W2779227090","https://openalex.org/W2780374966","https://openalex.org/W2783927504","https://openalex.org/W2805393009","https://openalex.org/W2923149229","https://openalex.org/W2945504815","https://openalex.org/W2949334046","https://openalex.org/W2952963458","https://openalex.org/W2953289435"],"related_works":["https://openalex.org/W2946873152","https://openalex.org/W4404872416","https://openalex.org/W4411929153","https://openalex.org/W4310377338","https://openalex.org/W3017334672","https://openalex.org/W4407407642","https://openalex.org/W3086097771","https://openalex.org/W4392703370","https://openalex.org/W7218596044","https://openalex.org/W2955780214"],"abstract_inverted_index":{"In":[0],"the":[1,28,45,80,88,95,100],"present":[2],"study,":[3],"substituted":[4],"formylnaphthalenyloxymethyl\u2010triazolyl\u2010N\u2010phenylacetamide":[5],"derivatives":[6],"(6a\u2013k)":[7],"have":[8,53],"been":[9],"designed":[10],"and":[11,17,24,40,51,57,85,103],"synthesized":[12,30],"employing":[13],"click":[14],"chemistry":[15],"approach":[16],"evaluated":[18],"for":[19],"their":[20],"in":[21,81],"vitro":[22,82],"antifungal":[23,56],"antibacterial":[25,58],"activities.":[26,59],"All":[27],"newly":[29],"compounds":[31],"were":[32],"thoroughly":[33],"characterized":[34],"by":[35],"1H":[36],"NMR,":[37,39],"13C":[38],"HRMS":[41],"spectral":[42],"techniques.":[43],"Among":[44],"screened":[46],"compounds,":[47],"6d,":[48],"6e,":[49],"6j,":[50],"6k":[52,61],"shown":[54,63],"good":[55],"Compound":[60],"has":[62],"very":[64],"effective":[65],"antimicrobial":[66,91,108],"activity.":[67,92],"We":[68],"further":[69],"performed":[70],"exploratory":[71],"docking":[72],"studies":[73],"on":[74],"microbial":[75],"DNA":[76],"gyrase":[77],"to":[78,86,98],"rationalize":[79],"biological":[83],"data":[84],"demonstrate":[87,99],"mechanism":[89],"of":[90],"This":[93],"is":[94],"first":[96],"report":[97],"formylnaphthalenyloxymethyl,":[101],"triazole,":[102],"N\u2010phenylacetamide":[104],"hybrids":[105],"as":[106],"potential":[107],"agents.":[109]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2019-07-23T00:00:00"}