{"id":"https://openalex.org/W2961679963","doi":"https://doi.org/10.1016/j.tibs.2019.06.006","title":"Engineering Metalloprotein Functions in Designed and Native Scaffolds","display_name":"Engineering Metalloprotein Functions in Designed and Native Scaffolds","publication_year":2019,"publication_date":"2019-07-13","ids":{"openalex":"https://openalex.org/W2961679963","doi":"https://doi.org/10.1016/j.tibs.2019.06.006","mag":"2961679963","pmid":"https://pubmed.ncbi.nlm.nih.gov/31307903"},"language":"en","primary_location":{"id":"doi:10.1016/j.tibs.2019.06.006","doi":"https://doi.org/10.1016/j.tibs.2019.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2019.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090517829","display_name":"Flavia Nastri","orcid":"https://orcid.org/0000-0002-3390-9822","observed_orcids":["https://orcid.org/0000-0002-3390-9822"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia Nastri","raw_affiliation_strings":["Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003176222","display_name":"Daniele D\u2019Alonzo","orcid":"https://orcid.org/0000-0002-2857-8600","observed_orcids":["https://orcid.org/0000-0002-2857-8600"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele D\u2019Alonzo","raw_affiliation_strings":["Department of Chemical Sciences, University of Napoli \u2018Federico II\u2019, Via Cintia, I-80126 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli \u2018Federico II\u2019, Via Cintia, I-80126 Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054919317","display_name":"Linda Leone","orcid":"https://orcid.org/0000-0001-7293-1814","observed_orcids":["https://orcid.org/0000-0001-7293-1814"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Linda Leone","raw_affiliation_strings":["Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059170387","display_name":"Gerardo Zambrano","orcid":"https://orcid.org/0000-0002-4284-2172","observed_orcids":["https://orcid.org/0000-0002-4284-2172"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gerardo Zambrano","raw_affiliation_strings":["Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035394769","display_name":"Vincenzo Pavone","orcid":"https://orcid.org/0000-0001-6432-0802","observed_orcids":["https://orcid.org/0000-0001-6432-0802"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Pavone","raw_affiliation_strings":["Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066156912","display_name":"Angela Lombardi","orcid":"https://orcid.org/0000-0002-2013-3009","observed_orcids":["https://orcid.org/0000-0002-2013-3009"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Angela Lombardi","raw_affiliation_strings":["Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy. Electronic address: alombard@unina.it","Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy. Electronic address: alombard@unina.it","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Department of Chemical Sciences, University of Napoli 'Federico II', Via Cintia, I-80126 Napoli, Italy","institution_ids":["https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066156912"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":1.4087,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.8236367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"44","issue":"12","first_page":"1022","last_page":"1040"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.08129999786615372,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metalloproteins","display_name":"metalloproteins","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metalloprotein-mimics","display_name":"metalloprotein mimics","score":0.8420000076293945},{"id":"https://openalex.org/keywords/protein-design","display_name":"protein design","score":0.6439999938011169},{"id":"https://openalex.org/keywords/metal-coordination","display_name":"metal coordination","score":0.675000011920929},{"id":"https://openalex.org/keywords/artificial-metalloproteins","display_name":"artificial metalloproteins","score":0.8479999899864197},{"id":"https://openalex.org/keywords/coordination-chemistry","display_name":"coordination chemistry","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C17165728","wikidata":"https://www.wikidata.org/wiki/Q423350","display_name":"Metalloprotein","level":3,"score":0.9571802616119385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5002784729003906},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.44086605310440063},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.42891770601272583},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.30432650446891785},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25913992524147034},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008667","descriptor_name":"Metalloproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tibs.2019.06.006","doi":"https://doi.org/10.1016/j.tibs.2019.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tibs.2019.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S136233269","display_name":"Trends in Biochemical Sciences","issn_l":"0968-0004","issn":["0968-0004","1362-4326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biochemical Sciences","raw_type":"journal-article"},{"id":"pmid:31307903","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31307903","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biochemical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322218","display_name":"Regione Campania","ror":"https://ror.org/02kg21794"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":153,"referenced_works":["https://openalex.org/W20911422","https://openalex.org/W79004830","https://openalex.org/W381446563","https://openalex.org/W586166713","https://openalex.org/W605885627","https://openalex.org/W1528532547","https://openalex.org/W1667811244","https://openalex.org/W1769489414","https://openalex.org/W1787348572","https://openalex.org/W1870141438","https://openalex.org/W1873234105","https://openalex.org/W1893060939","https://openalex.org/W1916034164","https://openalex.org/W1965705572","https://openalex.org/W1966935274","https://openalex.org/W1969660397","https://openalex.org/W1970982745","https://openalex.org/W1974312616","https://openalex.org/W1978964903","https://openalex.org/W1980433289","https://openalex.org/W1984854950","https://openalex.org/W1985042139","https://openalex.org/W1988637509","https://openalex.org/W1999718832","https://openalex.org/W2007606609","https://openalex.org/W2008279485","https://openalex.org/W2009121238","https://openalex.org/W2012073519","https://openalex.org/W2012837790","https://openalex.org/W2013547144","https://openalex.org/W2014011029","https://openalex.org/W2015078708","https://openalex.org/W2018347648","https://openalex.org/W2019137326","https://openalex.org/W2031286484","https://openalex.org/W2038201483","https://openalex.org/W2040293024","https://openalex.org/W2041230004","https://openalex.org/W2041860237","https://openalex.org/W2054687056","https://openalex.org/W2056699351","https://openalex.org/W2061678146","https://openalex.org/W2063755536","https://openalex.org/W2064576403","https://openalex.org/W2064866160","https://openalex.org/W2066222983","https://openalex.org/W2067424042","https://openalex.org/W2067598960","https://openalex.org/W2073237479","https://openalex.org/W2073798474","https://openalex.org/W2074013821","https://openalex.org/W2082334266","https://openalex.org/W2090265120","https://openalex.org/W2091777189","https://openalex.org/W2093448565","https://openalex.org/W2097234267","https://openalex.org/W2102028493","https://openalex.org/W2104460080","https://openalex.org/W2108623728","https://openalex.org/W2119414767","https://openalex.org/W2139094273","https://openalex.org/W2144292836","https://openalex.org/W2148819519","https://openalex.org/W2153089815","https://openalex.org/W2163928997","https://openalex.org/W2170434288","https://openalex.org/W2176126080","https://openalex.org/W2195840322","https://openalex.org/W2202671840","https://openalex.org/W2210464517","https://openalex.org/W2221513807","https://openalex.org/W2282106008","https://openalex.org/W2296423762","https://openalex.org/W2312455466","https://openalex.org/W2315816411","https://openalex.org/W2321149738","https://openalex.org/W2328143741","https://openalex.org/W2331937820","https://openalex.org/W2333550456","https://openalex.org/W2335507105","https://openalex.org/W2344463784","https://openalex.org/W2409713090","https://openalex.org/W2415341105","https://openalex.org/W2433650340","https://openalex.org/W2436169471","https://openalex.org/W2465674018","https://openalex.org/W2467802767","https://openalex.org/W2486539866","https://openalex.org/W2499540264","https://openalex.org/W2504464209","https://openalex.org/W2507192932","https://openalex.org/W2509305261","https://openalex.org/W2509806303","https://openalex.org/W2510208169","https://openalex.org/W2518065908","https://openalex.org/W2528052836","https://openalex.org/W2534014350","https://openalex.org/W2569641753","https://openalex.org/W2605231189","https://openalex.org/W2608503545","https://openalex.org/W2611254423","https://openalex.org/W2623250387","https://openalex.org/W2735839143","https://openalex.org/W2737865963","https://openalex.org/W2737968374","https://openalex.org/W2740081701","https://openalex.org/W2743281804","https://openalex.org/W2747381152","https://openalex.org/W2751562218","https://openalex.org/W2751743037","https://openalex.org/W2761455804","https://openalex.org/W2763303552","https://openalex.org/W2763919471","https://openalex.org/W2765583288","https://openalex.org/W2766348889","https://openalex.org/W2767044445","https://openalex.org/W2767581071","https://openalex.org/W2767622540","https://openalex.org/W2772103638","https://openalex.org/W2778365038","https://openalex.org/W2782337314","https://openalex.org/W2783223544","https://openalex.org/W2784128645","https://openalex.org/W2784164549","https://openalex.org/W2793258669","https://openalex.org/W2795624245","https://openalex.org/W2799738030","https://openalex.org/W2804973580","https://openalex.org/W2808113866","https://openalex.org/W2818311398","https://openalex.org/W2883803427","https://openalex.org/W2886286651","https://openalex.org/W2886575540","https://openalex.org/W2891571079","https://openalex.org/W2891766517","https://openalex.org/W2891779187","https://openalex.org/W2891999158","https://openalex.org/W2892068522","https://openalex.org/W2892150663","https://openalex.org/W2892705846","https://openalex.org/W2898459031","https://openalex.org/W2903339471","https://openalex.org/W2905286816","https://openalex.org/W2911874229","https://openalex.org/W2912340138","https://openalex.org/W2930575615","https://openalex.org/W2935887612","https://openalex.org/W3021991233","https://openalex.org/W4211159207","https://openalex.org/W4230063253","https://openalex.org/W4231059664","https://openalex.org/W4253721833","https://openalex.org/W6688871713"],"related_works":["https://openalex.org/W2020646508","https://openalex.org/W3020848912","https://openalex.org/W3129853719","https://openalex.org/W4396776126","https://openalex.org/W2034971743","https://openalex.org/W2076311895","https://openalex.org/W2049661339","https://openalex.org/W2613937290","https://openalex.org/W2002495053","https://openalex.org/W1966935274"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2019-07-23T00:00:00"}
