{"id":"https://openalex.org/W2961663205","doi":"https://doi.org/10.1080/01902148.2019.1638466","title":"The novel inhibitor PRI-724 for Wnt/\u03b2-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice","display_name":"The novel inhibitor PRI-724 for Wnt/\u03b2-catenin/CBP signaling ameliorates bleomycin-induced pulmonary fibrosis in mice","publication_year":2019,"publication_date":"2019-07-12","ids":{"openalex":"https://openalex.org/W2961663205","doi":"https://doi.org/10.1080/01902148.2019.1638466","mag":"2961663205","pmid":"https://pubmed.ncbi.nlm.nih.gov/31298961"},"language":"en","primary_location":{"id":"doi:10.1080/01902148.2019.1638466","doi":"https://doi.org/10.1080/01902148.2019.1638466","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01902148.2019.1638466","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://tokushima-u.repo.nii.ac.jp/records/2006973","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051928709","display_name":"Hiroyasu Okazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyasu Okazaki","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090485378","display_name":"Seidai Sato","orcid":"https://orcid.org/0000-0001-7052-764X","observed_orcids":["https://orcid.org/0000-0001-7052-764X"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seidai Sato","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101594784","display_name":"Kazuya Koyama","orcid":"https://orcid.org/0000-0001-6946-9462","observed_orcids":["https://orcid.org/0000-0001-6946-9462"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Koyama","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006634744","display_name":"Shun Morizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun Morizumi","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065417690","display_name":"Shuichi Abe","orcid":"https://orcid.org/0000-0001-8138-5077","observed_orcids":["https://orcid.org/0000-0001-8138-5077","https://orcid.org/0000-0003-2743-176X"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Abe","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090116921","display_name":"Momoyo Azuma","orcid":"https://orcid.org/0000-0003-0118-4158","observed_orcids":["https://orcid.org/0000-0003-0118-4158"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Momoyo Azuma","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038443359","display_name":"Yajuan Chen","orcid":"https://orcid.org/0000-0002-5781-4959","observed_orcids":["https://orcid.org/0000-0002-5781-4959"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yajuan Chen","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050563751","display_name":"Hisatsugu Goto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisatsugu Goto","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076599890","display_name":"Yoshinori Aono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158693","display_name":"Tokushima Hospital","ror":"https://ror.org/05s5g6369","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210158693"]},{"id":"https://openalex.org/I4405283572","display_name":"National Hospital Organization Tokushima Medical Center East Hospital","ror":"https://ror.org/01x6ave17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4405283572"]},{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinori Aono","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","National Hospital Organization Higashi Tokushima Medical Center, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]},{"raw_affiliation_string":"National Hospital Organization Higashi Tokushima Medical Center, Tokushima, Japan;","institution_ids":["https://openalex.org/I4210158693","https://openalex.org/I4405283572"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020768590","display_name":"Hirohisa Ogawa","orcid":"https://orcid.org/0000-0002-6750-5439","observed_orcids":["https://orcid.org/0000-0002-6750-5439"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirohisa Ogawa","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Tokushima University Graduate School, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tokushima University Graduate School, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112455462","display_name":"Kozo Kagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kozo Kagawa","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108723429","display_name":"Haruka Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Nishimura","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101415023","display_name":"Hiroshi Kawano","orcid":"https://orcid.org/0000-0001-9812-4615","observed_orcids":["https://orcid.org/0000-0001-9812-4615"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kawano","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021747264","display_name":"Yuko Toyoda","orcid":"https://orcid.org/0000-0002-9124-7978","observed_orcids":["https://orcid.org/0000-0002-9124-7978"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Toyoda","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045972519","display_name":"Hisanori Uehara","orcid":"https://orcid.org/0000-0003-1709-1386","observed_orcids":["https://orcid.org/0000-0003-1709-1386"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisanori Uehara","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Tokushima University Graduate School, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Tokushima University Graduate School, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059170589","display_name":"Hiroyuki Kouji","orcid":"https://orcid.org/0000-0003-1908-8578","observed_orcids":["https://orcid.org/0000-0003-1908-8578"]},"institutions":[{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]},{"id":"https://openalex.org/I4210130656","display_name":"Prism Biolab Corporation (Japan)","ror":"https://ror.org/03veb6e23","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210130656"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kouji","raw_affiliation_strings":["Faculty of Medicine, Oita University, Yufu-city, Oita, Japan","PRISM BioLab Co., Ltd., Midori-ku, Yokohama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Oita University, Yufu-city, Oita, Japan","institution_ids":["https://openalex.org/I188815454"]},{"raw_affiliation_string":"PRISM BioLab Co., Ltd., Midori-ku, Yokohama, Japan;","institution_ids":["https://openalex.org/I4210130656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102863674","display_name":"Yasuhiko Nishioka","orcid":"https://orcid.org/0000-0002-1084-0009","observed_orcids":["https://orcid.org/0000-0002-1084-0009","https://orcid.org/0000-0001-6311-1654"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuhiko Nishioka","raw_affiliation_strings":["Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;","institution_ids":["https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102863674"],"corresponding_institution_ids":["https://openalex.org/I922474255"],"apc_list":null,"apc_paid":null,"fwci":3.1805,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.92247361,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"45","issue":"7","first_page":"188","last_page":"199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pri-724","display_name":"PRI-724","score":0.9950000047683716},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cbp","display_name":"CBP","score":0.7590000033378601},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bleomycin-induced-lung-injury","display_name":"bleomycin-induced lung injury","score":0.8230000138282776},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8539999723434448},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9819999933242798},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.8379999995231628},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.9377371072769165},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8120231628417969},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.800140380859375},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.6434224843978882},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.5549818873405457},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5192403793334961},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5008697509765625},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.4814862012863159},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.477005273103714},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.45483890175819397},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.4189237058162689},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.40698879957199097},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4044647216796875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39489853382110596},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3798343241214752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2586643695831299},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24800202250480652},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2038494348526001},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07952451705932617}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011658","descriptor_name":"Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011744","descriptor_name":"Pyrimidinones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/01902148.2019.1638466","doi":"https://doi.org/10.1080/01902148.2019.1638466","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01902148.2019.1638466","pdf_url":null,"source":{"id":"https://openalex.org/S97217451","display_name":"Experimental Lung Research","issn_l":"0190-2148","issn":["0190-2148","1521-0499"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Lung Research","raw_type":"journal-article"},{"id":"pmid:31298961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31298961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental lung research","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006778912","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2006973","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental Lung Research","raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00906:0006778912","doi":null,"is_oa":true,"landing_page_url":"https://tokushima-u.repo.nii.ac.jp/records/2006973","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental Lung Research","raw_type":"doctoral thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1918709511","https://openalex.org/W1938547050","https://openalex.org/W1978270439","https://openalex.org/W1987104810","https://openalex.org/W1993600822","https://openalex.org/W1994304210","https://openalex.org/W1994386798","https://openalex.org/W2002207031","https://openalex.org/W2029795839","https://openalex.org/W2040108549","https://openalex.org/W2043691868","https://openalex.org/W2055271659","https://openalex.org/W2059114286","https://openalex.org/W2074987637","https://openalex.org/W2103170336","https://openalex.org/W2107458437","https://openalex.org/W2115001053","https://openalex.org/W2115254054","https://openalex.org/W2133996143","https://openalex.org/W2142613844","https://openalex.org/W2153408935","https://openalex.org/W2157101382","https://openalex.org/W2344324270","https://openalex.org/W2346093859","https://openalex.org/W2523891005","https://openalex.org/W2592331564","https://openalex.org/W2595541755","https://openalex.org/W2599075603","https://openalex.org/W2755105312","https://openalex.org/W2774934615","https://openalex.org/W2804815706"],"related_works":["https://openalex.org/W2160410315","https://openalex.org/W2344324270","https://openalex.org/W1993600822","https://openalex.org/W3108377437","https://openalex.org/W4293103194","https://openalex.org/W2019131223","https://openalex.org/W2313594206","https://openalex.org/W4224111003","https://openalex.org/W2890528646","https://openalex.org/W2997581185"],"abstract_inverted_index":{"Purpose/Aim":[0],"of":[1,30,43,52,64,73,82,87,92,110,115,125,162,171,182,201,213,235,243,250,266,291],"the":[2,25,28,49,61,65,71,90,108,128,160,169,180,186,199,248,264,276,289,294],"Study:":[3],"Wnt/\u03b2-catenin":[4,31,53],"signaling":[5,32],"was":[6,15,99,193,209,254],"reported":[7],"to":[8,47,59,157],"be":[9],"activated":[10],"in":[11,55,112,127,133,159,173,196,203,221,252,256,293],"pulmonary":[12,34,56,117,216],"fibrosis,":[13],"and":[14,58,75,78,94,103,122,152,207],"focused":[16],"on":[17,89,101],"as":[18,136,138],"a":[19,226,240,281],"target":[20,50],"for":[21],"antifibrotic":[22,62,283],"therapy.":[23],"However,":[24],"mechanism":[26],"how":[27],"inhibition":[29,54,181],"ameliorate":[33],"fibrosis":[35,57,217],"has":[36],"not":[37,229],"been":[38],"fully":[39],"elucidated.":[40],"The":[41,80,120,211],"purpose":[42],"this":[44],"study":[45],"is":[46,280],"explore":[48],"cells":[51,206],"examine":[60],"effect":[63,81],"novel":[66],"inhibitor":[67,278],"PRI-724":[68,111,214,279],"specifically":[69],"disrupting":[70],"interaction":[72],"\u03b2-catenin":[74,126,158,192,202],"CBP.":[76],"Materials":[77],"Methods:":[79],"C-82,":[83],"an":[84,230],"active":[85],"metabolite":[86],"PRI-724,":[88],"expression":[91,170],"TGF-\u03b21":[93,251,267],"\u03b1-smooth":[95],"muscle":[96],"actin":[97],"(SMA)":[98],"examined":[100,107],"fibroblasts":[102,135,175,208],"macrophages.":[104,245,270],"We":[105],"also":[106,262],"effects":[109],"mouse":[113],"model":[114],"bleomycin-induced":[116],"fibrosis.":[118],"Results:":[119],"activation":[121],"increased":[123,153],"accumulation":[124],"canonical":[129],"pathway":[130],"were":[131],"detected":[132],"lung":[134,163,174],"well":[137],"macrophages":[139,292],"stimulated":[140],"by":[141,190,219,268,287],"Wnt3a":[142],"using":[143],"Western":[144],"blotting.":[145],"Treatment":[146],"with":[147,177,225,259],"C-82":[148,167,261],"reduced":[149],"CBP":[150],"protein":[151,155],"p300":[154],"binding":[156],"nucleus":[161],"fibroblasts.":[164],"In":[165,185,246],"addition,":[166,247],"inhibited":[168,263],"SMA":[172],"treated":[176,258],"TGF-\u03b2,":[178],"indicating":[179],"myofibroblast":[183],"differentiation.":[184],"fibrotic":[187],"lungs":[188],"induced":[189,218],"bleomycin,":[191],"stained":[194],"strongly":[195],"macrophages,":[197],"but":[198,228],"staining":[200],"alveolar":[204,244,269],"epithelial":[205],"weak.":[210],"administration":[212],"ameliorated":[215],"bleomycin":[220],"mice":[222,257],"when":[223],"administered":[224],"late,":[227],"early,":[231],"treatment":[232],"schedule.":[233],"Analysis":[234],"bronchoalveolar":[236],"fluid":[237],"(BALF)":[238],"showed":[239],"decreased":[241,255],"number":[242],"level":[249],"BALF":[253],"PRI-724.":[260],"production":[265],"Conclusions:":[271],"These":[272],"results":[273],"suggest":[274],"that":[275,285],"\u03b2-catenin/CBP":[277],"potent":[282],"agent":[284],"acts":[286],"modulating":[288],"activity":[290],"lungs.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-23T00:00:00"}