{"id":"https://openalex.org/W2961537447","doi":null,"title":"The effects of adenosine antagonists on vigilant attention in sleep restricted rats","display_name":"The effects of adenosine antagonists on vigilant attention in sleep restricted rats","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2961537447","mag":"2961537447"},"language":"en","primary_location":{"id":"pmh:oai:commons.lib.jmu.edu:master201019-1632","doi":null,"is_oa":true,"landing_page_url":"https://commons.lib.jmu.edu/master201019/612","pdf_url":"https://commons.lib.jmu.edu/master201019/612","source":{"id":"https://openalex.org/S4377196576","display_name":"JMU Scholoraly Commons (James Madison University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11883440","host_organization_name":"James Madison University","host_organization_lineage":["https://openalex.org/I11883440"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses, 2010-2019","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://commons.lib.jmu.edu/master201019/612","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066576110","display_name":"Morgan Crewe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Morgan Crewe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066576110"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.07109999656677246,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13219","display_name":"Mind wandering and attention","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-receptor-antagonists","display_name":"adenosine receptor antagonists","score":0.8809999823570251},{"id":"https://openalex.org/keywords/sleep-restriction","display_name":"sleep restriction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/vigilant-attention","display_name":"vigilant attention","score":0.6330000162124634},{"id":"https://openalex.org/keywords/psychomotor-vigilance-task","display_name":"psychomotor vigilance task","score":0.8899999856948853},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9539999961853027},{"id":"https://openalex.org/keywords/adenosine-a1-receptor-antagonist","display_name":"adenosine A1 receptor antagonist","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cpt","display_name":"CPT","score":0.6110000014305115},{"id":"https://openalex.org/keywords/adenosine-accumulation","display_name":"adenosine accumulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/rat-strain-differences","display_name":"rat strain differences","score":0.722000002861023},{"id":"https://openalex.org/keywords/sustained-attention","display_name":"sustained attention","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6058154106140137},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.586093544960022},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4895952343940735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3907807469367981},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.33581507205963135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21362075209617615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16379886865615845},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:commons.lib.jmu.edu:master201019-1632","doi":null,"is_oa":true,"landing_page_url":"https://commons.lib.jmu.edu/master201019/612","pdf_url":"https://commons.lib.jmu.edu/master201019/612","source":{"id":"https://openalex.org/S4377196576","display_name":"JMU Scholoraly Commons (James Madison University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11883440","host_organization_name":"James Madison University","host_organization_lineage":["https://openalex.org/I11883440"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses, 2010-2019","raw_type":"thesis"},{"id":"mag:2961537447","doi":null,"is_oa":false,"landing_page_url":"https://commons.lib.jmu.edu/cgi/viewcontent.cgi?article=1632&context=master201019","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:commons.lib.jmu.edu:master201019-1632","doi":null,"is_oa":true,"landing_page_url":"https://commons.lib.jmu.edu/master201019/612","pdf_url":"https://commons.lib.jmu.edu/master201019/612","source":{"id":"https://openalex.org/S4377196576","display_name":"JMU Scholoraly Commons (James Madison University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11883440","host_organization_name":"James Madison University","host_organization_lineage":["https://openalex.org/I11883440"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters Theses, 2010-2019","raw_type":"thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2961537447.pdf","grobid_xml":"https://content.openalex.org/works/W2961537447.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W208904149","https://openalex.org/W1515108121","https://openalex.org/W1548390378","https://openalex.org/W1755462224","https://openalex.org/W1819938305","https://openalex.org/W1967157241","https://openalex.org/W1972846908","https://openalex.org/W1976044450","https://openalex.org/W1977656859","https://openalex.org/W1986105622","https://openalex.org/W1986609940","https://openalex.org/W1988986188","https://openalex.org/W1991139187","https://openalex.org/W1994284751","https://openalex.org/W1998431562","https://openalex.org/W2000837785","https://openalex.org/W2000883142","https://openalex.org/W2002531463","https://openalex.org/W2008161183","https://openalex.org/W2015508347","https://openalex.org/W2026057138","https://openalex.org/W2031737172","https://openalex.org/W2035786997","https://openalex.org/W2036353017","https://openalex.org/W2042180255","https://openalex.org/W2044879783","https://openalex.org/W2045815714","https://openalex.org/W2048995786","https://openalex.org/W2053129765","https://openalex.org/W2053269045","https://openalex.org/W2054554983","https://openalex.org/W2054847765","https://openalex.org/W2065089075","https://openalex.org/W2066733291","https://openalex.org/W2070842225","https://openalex.org/W2074994595","https://openalex.org/W2075574806","https://openalex.org/W2081945207","https://openalex.org/W2082999191","https://openalex.org/W2083143366","https://openalex.org/W2089012546","https://openalex.org/W2091132903","https://openalex.org/W2094761105","https://openalex.org/W2096253586","https://openalex.org/W2110552089","https://openalex.org/W2120543763","https://openalex.org/W2124354639","https://openalex.org/W2128297482","https://openalex.org/W2146981914","https://openalex.org/W2148800933","https://openalex.org/W2150983706","https://openalex.org/W2153762265","https://openalex.org/W2159662907","https://openalex.org/W2169694427","https://openalex.org/W2172587217","https://openalex.org/W2236052756","https://openalex.org/W2474889045","https://openalex.org/W2646597010","https://openalex.org/W2741266150","https://openalex.org/W2766542192","https://openalex.org/W2780807775","https://openalex.org/W2800137028"],"related_works":["https://openalex.org/W2989866913","https://openalex.org/W2065089075","https://openalex.org/W6979693294","https://openalex.org/W148632811","https://openalex.org/W7034127952","https://openalex.org/W2940368687","https://openalex.org/W1977656859","https://openalex.org/W2042180255","https://openalex.org/W4394978830","https://openalex.org/W2082147162"],"abstract_inverted_index":{"The":[0,104,265],"relation":[1],"between":[2],"chronic":[3,23],"sleep":[4,24,69,96,128,150,154,221,245,257,304,315,330],"restriction":[5,25,70,129,151,155,222,246,258,316],"and":[6,152,175,301,343],"performance":[7,40,132,300,319,337],"on":[8,71,130,189,208,232,262,317],"the":[9,19,43,50,66,79,90,107,125,166,178,190,203,274,293,312,324],"Psychomotor":[10],"Vigilance":[11],"Task":[12],"(PVT)":[13],"have":[14,64,87],"been":[15,54],"well":[16,341],"documented":[17],"in":[18,34,37,78,98,101,133,281,298,332,335],"human":[20,51,80],"literature,":[21],"with":[22,58],"as":[26,28,121],"little":[27],"7":[29],"hours":[30,217],"per":[31,218],"night":[32],"resulting":[33],"significant":[35,212],"impairment":[36],"sustained":[38],"attention":[39],"measured":[41,65,193],"via":[42],"PVT.":[44],"Recently,":[45],"an":[46,161,183,242],"analogous":[47],"version":[48],"of":[49,68,92,106,127,160,165,177,205,220,225,239,250,256,267,314,326],"PVT":[52],"has":[53],"developed":[55],"for":[56,124,145,286,295],"use":[57],"rodent":[59],"models":[60],"(rPVT).":[61],"Recent":[62],"studies":[63,84,272],"effects":[67,126,204,313],"rPVT":[72,102,114,131,191,209,233,263,299,318,336],"performance,":[73],"citing":[74],"similar":[75],"results":[76,266,289],"found":[77],"literature.":[81],"However,":[82],"few":[83],"to":[85,111,116,201,303,310],"date":[86],"directly":[88],"examined":[89],"role":[91,325],"adenosine":[93,119,162,173,184,227,327],"accumulation":[94,328],"during":[95,329],"deprivation":[97,331],"producing":[99,333],"deficits":[100,334],"performance.":[103,210,234,264],"purpose":[105],"current":[108],"study":[109,269,279],"was":[110,192],"extend":[112],"previous":[113,271],"research":[115,307],"include":[117],"two":[118,143],"antagonists":[120],"potential":[122,294],"countermeasures":[123],"Sprague":[134],"Dawley":[135],"rats.":[136],"After":[137],"meeting":[138],"baseline":[139],"criterion,":[140],"animals":[141,167,179,240],"experienced":[142],"conditions":[144],"four":[146],"days":[147],"each:":[148],"6hr/day":[149,153],"followed":[156],"by":[157],"i.p.":[158],"administration":[159,224],"antagonist.":[163,187],"Half":[164],"received":[168,180],"30mg/kg":[169],"caffeine,":[170],"a":[171,236,277],"non-selective":[172],"antagonist,":[174],"half":[176],"3mg/kg":[181],"CPT,":[182],"A1":[185],"receptor":[186],"Performance":[188],"daily":[194],"at":[195],"15:00.":[196],"Mixed":[197],"ANOVAs":[198],"were":[199,214],"conducted":[200,280],"analyze":[202],"each":[206],"condition":[207],"No":[211],"differences":[213,297],"found.":[215],"Six":[216],"day":[219],"or":[223],"either":[226],"antagonist":[228],"had":[229,259],"no":[230,260],"effect":[231,261],"Subsequently,":[235],"small":[237],"group":[238],"underwent":[241],"additional":[243],"18hr/day":[244,255],"condition.":[247],"Visual":[248],"analysis":[249],"this":[251,268],"data":[252],"showed":[253],"that":[254],"contradict":[270],"using":[273],"rPVT,":[275],"including":[276],"pilot":[278],"our":[282],"lab.":[283],"Potential":[284],"explanations":[285],"these":[287],"contradictory":[288],"are":[290],"discussed,":[291],"highlighting":[292],"strain":[296],"response":[302],"restriction.":[305],"Future":[306],"should":[308],"seek":[309],"explore":[311],"across":[320],"rat":[321],"strains.":[322],"Additionally,":[323],"is":[338],"still":[339],"not":[340],"understood,":[342],"requires":[344],"further":[345],"investigation.":[346]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2019-07-23T00:00:00"}