{"id":"https://openalex.org/W2961369815","doi":"https://doi.org/10.3389/fimmu.2019.01560","title":"Exosomes Derived From Septic Mouse Serum Modulate Immune Responses via Exosome-Associated Cytokines","display_name":"Exosomes Derived From Septic Mouse Serum Modulate Immune Responses via Exosome-Associated Cytokines","publication_year":2019,"publication_date":"2019-07-12","ids":{"openalex":"https://openalex.org/W2961369815","doi":"https://doi.org/10.3389/fimmu.2019.01560","mag":"2961369815","pmid":"https://pubmed.ncbi.nlm.nih.gov/31354717","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6640201"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2019.01560","doi":"https://doi.org/10.3389/fimmu.2019.01560","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.01560","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01560/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01560/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kun Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Gao","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007642882","display_name":"Jingmiao Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingmiao Jin","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101889964","display_name":"Chenyang Huang","orcid":"https://orcid.org/0000-0002-8721-9413","observed_orcids":["https://orcid.org/0000-0002-8721-9413","https://orcid.org/0009-0005-7596-9849"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyang Huang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianhang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhang Li","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023464633","display_name":"Haihua Luo","orcid":"https://orcid.org/0000-0003-4607-9917","observed_orcids":["https://orcid.org/0000-0003-4607-9917"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haihua Luo","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024715983","display_name":"Lei Li","orcid":"https://orcid.org/0000-0001-8489-3368","observed_orcids":["https://orcid.org/0000-0001-8489-3368"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101781843","display_name":"Yukai Huang","orcid":"https://orcid.org/0000-0001-9403-6722","observed_orcids":["https://orcid.org/0000-0001-9403-6722"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yukai Huang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016655840","display_name":"Yong Jiang","orcid":"https://orcid.org/0000-0002-8087-5717","observed_orcids":["https://orcid.org/0000-0002-8087-5717","https://orcid.org/0009-0007-7837-1193"]},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Jiang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failure Research, Department of Pathophysiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016655840"],"corresponding_institution_ids":["https://openalex.org/I58200834"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":3.3695,"has_fulltext":true,"cited_by_count":115,"citation_normalized_percentile":{"value":0.94178325,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"10","issue":null,"first_page":"1560","last_page":"1560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/serum-exosomes","display_name":"serum exosomes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8740000128746033},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.9150000214576721},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9369999766349792},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":1.0},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.7929999828338623},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9760000109672546},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.6539999842643738},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.8928359746932983},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.8253153562545776},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.695869505405426},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6886927485466003},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.6837400197982788},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5875167846679688},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.48199692368507385},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42274340987205505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.384826123714447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3846223056316376},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.09152141213417053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2019.01560","doi":"https://doi.org/10.3389/fimmu.2019.01560","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.01560","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01560/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:31354717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31354717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6640201","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6640201/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:089c567f4aa3404dbbea77917a1b8f9a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/089c567f4aa3404dbbea77917a1b8f9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 10 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2019.01560","doi":"https://doi.org/10.3389/fimmu.2019.01560","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2019.01560","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2019.01560/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3990826543","display_name":null,"funder_award_id":"81671965","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5883221692","display_name":null,"funder_award_id":"U1601225","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2961369815.pdf","grobid_xml":"https://content.openalex.org/works/W2961369815.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1533291299","https://openalex.org/W1538522759","https://openalex.org/W1545718209","https://openalex.org/W1578530056","https://openalex.org/W1718722862","https://openalex.org/W1762620449","https://openalex.org/W1942668068","https://openalex.org/W1953168141","https://openalex.org/W1967086605","https://openalex.org/W1977692564","https://openalex.org/W1980402776","https://openalex.org/W1995518311","https://openalex.org/W1996649087","https://openalex.org/W1997843836","https://openalex.org/W2004388967","https://openalex.org/W2009644403","https://openalex.org/W2010883684","https://openalex.org/W2019169633","https://openalex.org/W2019589994","https://openalex.org/W2020992406","https://openalex.org/W2023945291","https://openalex.org/W2035355922","https://openalex.org/W2041461587","https://openalex.org/W2047632277","https://openalex.org/W2049100226","https://openalex.org/W2049345643","https://openalex.org/W2053549862","https://openalex.org/W2057713753","https://openalex.org/W2065334512","https://openalex.org/W2076266324","https://openalex.org/W2089238809","https://openalex.org/W2091868933","https://openalex.org/W2101495492","https://openalex.org/W2105725258","https://openalex.org/W2122635106","https://openalex.org/W2126080824","https://openalex.org/W2130781494","https://openalex.org/W2148050305","https://openalex.org/W2149806687","https://openalex.org/W2159114297","https://openalex.org/W2161983082","https://openalex.org/W2167012568","https://openalex.org/W2269341591","https://openalex.org/W2320154784","https://openalex.org/W2345720476","https://openalex.org/W2620241325","https://openalex.org/W2725598653","https://openalex.org/W2766071400","https://openalex.org/W2790861736","https://openalex.org/W2805608765","https://openalex.org/W2884895413","https://openalex.org/W2885490845","https://openalex.org/W4408963027","https://openalex.org/W6699990453"],"related_works":["https://openalex.org/W4415220192","https://openalex.org/W4378673760","https://openalex.org/W3214059785","https://openalex.org/W4296774161","https://openalex.org/W7140287701","https://openalex.org/W3213495432","https://openalex.org/W3157405457","https://openalex.org/W2939847896","https://openalex.org/W2972054198","https://openalex.org/W4391145680"],"abstract_inverted_index":{"Sepsis":[0],"is":[1],"a":[2,214],"life-threatening":[3],"condition":[4],"caused":[5],"by":[6,11,142,166],"an":[7],"immune":[8,49],"response":[9,47],"triggered":[10],"infection,":[12],"and":[13,48,55,79,103,147,157,175,179,186,206,212,220],"highly":[14],"elevated":[15],"cytokine/chemokine":[16],"levels":[17],"in":[18,24,40,73,98,104,114,121,201],"the":[19,25,52,68,74,81,100,105,109,112,122,134,155,170,181,209,233],"blood":[20,123],"play":[21,198],"crucial":[22],"roles":[23,39,200],"progression":[26],"of":[27,70,76,83,111,124,136,159,164,183,232,235],"sepsis.":[28],"Serum":[29],"exosomes":[30,75,90,152,165,194,238],"are":[31],"nanovesicles":[32],"that":[33,193],"have":[34,213],"multiple":[35],"biological":[36,53],"functions,":[37],"playing":[38],"antigen":[41],"presentation,":[42],"intercellular":[43],"signal":[44],"communication,":[45],"inflammatory":[46,171],"surveillance.":[50],"However,":[51],"functions":[54],"related":[56],"molecular":[57],"bases":[58],"remain":[59],"to":[60],"be":[61],"elucidated.":[62],"In":[63,149],"this":[64],"study,":[65],"we":[66],"investigated":[67],"profiles":[69,110],"cytokines/chemokines":[71,96,113,197],"harbored":[72],"septic":[77,93,131],"mice":[78,125,132],"explored":[80],"mechanisms":[82],"immunomodulation":[84],"on":[85,217],"T":[86,160,202],"cells":[87],"treated":[88],"with":[89,127,196],"harvested":[91],"from":[92,130],"mice.":[94,189,223],"Blood":[95],"existed":[97],"both":[99],"soluble":[101],"form":[102],"insoluble":[106],"exosomal":[107],"form;":[108],"these":[115,151,225],"two":[116],"forms":[117],"displayed":[118],"different":[119],"dynamics":[120],"challenged":[126],"LPS.":[128],"Exosomes":[129],"induced":[133],"differentiation":[135],"Th1/Th2":[137],"cells,":[138],"which":[139],"was":[140],"blocked":[141],"specific":[143],"antibodies":[144],"targeting":[145],"IL-12":[146],"IL-4.":[148],"addition,":[150],"significantly":[153],"augmented":[154],"proliferation":[156,205],"migration":[158],"lymphocytes.":[161],"Furthermore,":[162],"preadministration":[163],"intravenous":[167],"injection":[168],"restrained":[169],"response,":[172],"attenuated":[173],"lung":[174],"liver":[176],"tissue":[177],"damage,":[178],"prolonged":[180],"survival":[182],"cecal":[184,218],"ligation":[185,219],"puncture":[187,221],"(CLP)":[188,222],"Our":[190],"results":[191],"indicate":[192],"enriched":[195],"critical":[199],"cell":[203],"differentiation,":[204],"chemotaxis":[207],"during":[208],"sepsis":[210,236],"process":[211],"protective":[215],"effect":[216],"Thus,":[224],"findings":[226],"not":[227],"only":[228],"strengthen":[229],"our":[230],"understanding":[231],"role":[234],"via":[237],"but":[239],"also":[240],"provide":[241],"potential":[242],"targets":[243],"for":[244],"therapeutic":[245],"applications.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2019-07-23T00:00:00"}
