{"id":"https://openalex.org/W2960994232","doi":"https://doi.org/10.1212/wnl.0000000000007967","title":"Cognitive heterogeneity in probable Alzheimer disease: Clinical and neuropathologic features","display_name":"Cognitive heterogeneity in probable Alzheimer disease: Clinical and neuropathologic features","publication_year":2019,"publication_date":"2019-07-18","ids":{"openalex":"https://openalex.org/W2960994232","doi":"https://doi.org/10.1212/wnl.0000000000007967","mag":"2960994232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31320469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6711663"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000007967","doi":"https://doi.org/10.1212/wnl.0000000000007967","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000007967","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6711663/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025915958","display_name":"Yuqi Qiu","orcid":"https://orcid.org/0009-0006-9559-0104","observed_orcids":["https://orcid.org/0009-0006-9559-0104"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuqi Qiu","raw_affiliation_strings":["From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051746525","display_name":"Diane M. Jacobs","orcid":"https://orcid.org/0000-0003-0886-6784","observed_orcids":["https://orcid.org/0000-0003-0886-6784"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane M. Jacobs","raw_affiliation_strings":["From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla"],"raw_orcid":"https://orcid.org/0000-0003-0886-6784","affiliations":[{"raw_affiliation_string":"From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072839298","display_name":"Karen S. Messer","orcid":"https://orcid.org/0000-0002-9298-2413","observed_orcids":["https://orcid.org/0000-0002-9298-2413"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Messer","raw_affiliation_strings":["From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081258864","display_name":"David P. Salmon","orcid":"https://orcid.org/0000-0003-4533-4090","observed_orcids":["https://orcid.org/0000-0003-4533-4090"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Salmon","raw_affiliation_strings":["From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040711752","display_name":"Howard Feldman","orcid":"https://orcid.org/0000-0002-9258-4538","observed_orcids":["https://orcid.org/0000-0002-9258-4538"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard H. Feldman","raw_affiliation_strings":["From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla"],"raw_orcid":"https://orcid.org/0000-0002-9258-4538","affiliations":[{"raw_affiliation_string":"From the Department of Family Medicine and Public Health (Y.Q., K.M.), Department of Neurosciences (D.M.J., D.P.S., H.H.F.), and Shiley-Marcos Alzheimer's Disease Research Center (D.M.J., D.P.S., H.H.F.), University of California, San Diego, La Jolla","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":2.8896,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.89982408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"93","issue":"8","first_page":"e778","last_page":"e790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cognitive-profile","display_name":"cognitive profile","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cognitive-heterogeneity","display_name":"cognitive heterogeneity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/episodic-memory-impairment","display_name":"episodic memory impairment","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.5450000166893005},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7919999957084656},{"id":"https://openalex.org/keywords/braak-stages","display_name":"Braak stages","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tau-pathology","display_name":"tau pathology","score":0.7329999804496765},{"id":"https://openalex.org/keywords/neuropathology","display_name":"neuropathology","score":0.6629999876022339},{"id":"https://openalex.org/keywords/clinical-trial-eligibility-criteria","display_name":"inclusion and exclusion criteria","score":0.5529999732971191},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7547342777252197},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6043676733970642},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5699381828308105},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5393457412719727},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.5357481837272644},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.45509880781173706},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.4321101903915405},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.42397406697273254},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4221295714378357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40572166442871094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33436018228530884},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3284478187561035},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2691359221935272}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1212/wnl.0000000000007967","doi":"https://doi.org/10.1212/wnl.0000000000007967","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000007967","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:31320469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31320469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6711663","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6711663/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt41h1h4n3","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/41h1h4n3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurology, vol 93, iss 8","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:6711663","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6711663/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1291425518","display_name":"Michigan Alzheimer's Disease Core Center","funder_award_id":"P30AG053760","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1345365365","display_name":"UC Davis Alzheimer's Disease Core Center","funder_award_id":"P30AG010129","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G135197880","display_name":"Indiana Alzheimer Disease Center","funder_award_id":"P30AG010133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1853056203","display_name":"Wake Forest Alzheimer's Disease Core Center","funder_award_id":"P30AG049638","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2420708263","display_name":"University of Kentucky Alzheimer's Disease Core Center","funder_award_id":"P30AG028383","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2594061558","display_name":"Neurobiology of Alzheimer's Disease and Aging","funder_award_id":"P30AG012300","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2890637872","display_name":"Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial Findings","funder_award_id":"R01AG049810","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3080460668","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005133","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G330169411","display_name":"National Alzheimer's Coordinating Center","funder_award_id":"U01AG016976","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3317175073","display_name":"UCSD Alzheimer's Disease Research Center P50","funder_award_id":"P50AG005131","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3550458066","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005138","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4300107000","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG010124","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4358608740","display_name":"The Alzheimer's Disease Research Center at the University of California, Irvine","funder_award_id":"P50AG016573","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4558411988","display_name":"Stanford Alzheimer's Disease Research Center","funder_award_id":"P50AG047366","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4891425352","display_name":"Oregon Alzheimer's Disease Center","funder_award_id":"P30AG008017","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5029820101","display_name":"Rush Alzheimer's Disease Core Center","funder_award_id":"P30AG010161","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5935928581","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG008051","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6169896762","display_name":"Alzheimer's Disease Research Center - Overall","funder_award_id":"P50AG008702","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6460407080","display_name":"Wisconsin Alzheimer's Disease Research Center","funder_award_id":"P50AG033514","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6541807297","display_name":"University of Kansas Alzheimer's Disease Core Centers","funder_award_id":"P30AG035982","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6914157503","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005681","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6972635252","display_name":"Alzheimer Disease Research Center","funder_award_id":"P50AG005142","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7033301289","display_name":"Yale Alzheimer Disease Research Center","funder_award_id":"P50AG047270","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G704822541","display_name":"Arizona Alzheimer's Disease Core Center","funder_award_id":"P30AG019610","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7103205595","display_name":"Johns Hopkins Alzheimer's Disease Research Center","funder_award_id":"P50AG005146","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7618461031","display_name":"Boston University Alzheimer's Disease Center","funder_award_id":"P30AG013846","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7629573093","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005136","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7637191593","display_name":"Massachusetts Alzheimer's Disease Research Center","funder_award_id":"P50AG005134","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7840397398","display_name":"Alzheimer's Disease Core Center","funder_award_id":"P30AG013854","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7867016969","display_name":"Alzheimer's Disease Cooperative Study","funder_award_id":"U19AG010483","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8060809061","display_name":"Emory Alzheimer's Disease Center","funder_award_id":"P50AG025688","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8141716085","display_name":"University of Florida - Mt. Sinai Medical Center AD Research Center","funder_award_id":"P50AG047266","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000865327","display_name":"UCSD Shiley-Marcos Alzheimer's Disease Research Center P30","funder_award_id":"P30AG062429","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000911053","display_name":"National Alzheimer's Coordinating Center","funder_award_id":"U24AG072122","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G912028991","display_name":"New Approaches to Dementia Heterogeneity","funder_award_id":"P50AG023501","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G95754455","display_name":"Mayo Alzheimer's Disease Research Center","funder_award_id":"P50AG016574","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1687656967","https://openalex.org/W1818813987","https://openalex.org/W1965616054","https://openalex.org/W1971351343","https://openalex.org/W1974300727","https://openalex.org/W1976133119","https://openalex.org/W1991952617","https://openalex.org/W1999021902","https://openalex.org/W2011832962","https://openalex.org/W2031552319","https://openalex.org/W2052742260","https://openalex.org/W2085870059","https://openalex.org/W2097325576","https://openalex.org/W2102170993","https://openalex.org/W2104199131","https://openalex.org/W2106931873","https://openalex.org/W2112519660","https://openalex.org/W2115017507","https://openalex.org/W2115098571","https://openalex.org/W2116709840","https://openalex.org/W2121584008","https://openalex.org/W2133187296","https://openalex.org/W2146729934","https://openalex.org/W2146855196","https://openalex.org/W2156220037","https://openalex.org/W2172263413","https://openalex.org/W2188679450","https://openalex.org/W2318889296","https://openalex.org/W2582743722","https://openalex.org/W2606029312","https://openalex.org/W2608655868","https://openalex.org/W2626772746","https://openalex.org/W2774400961","https://openalex.org/W4210965305"],"related_works":["https://openalex.org/W2808810893","https://openalex.org/W3198774797","https://openalex.org/W4387362236","https://openalex.org/W4406024129","https://openalex.org/W4401499622","https://openalex.org/W7117328426","https://openalex.org/W2606029312","https://openalex.org/W4380887883","https://openalex.org/W2133187296","https://openalex.org/W3127400033"],"abstract_inverted_index":{"Objective":[0],"To":[1],"identify":[2,95,224],"heterogeneity":[3],"in":[4,80,98,111,177,254],"cognitive":[5,36,96,126,151,160,171,218,226],"profiles":[6,37,97,227],"of":[7,48,101,132,145,155,201,245],"patients":[8,56,102,146,229],"with":[9,57,103,120,136,194,230,238,242],"probable":[10,61,233],"Alzheimer":[11],"disease":[12],"(AD)":[13],"who":[14],"have":[15,249],"mild":[16,58],"to":[17,33,41,59,94],"moderate":[18,60],"dementia":[19],"and":[20,23,32,45,75,89,109,116,130,162,184,216,241],"satisfy":[21],"inclusion":[22],"exclusion":[24,76],"criteria":[25,77],"for":[26,251],"a":[27,99,148],"typical":[28,149],"AD":[29,62,81,105,150,234],"clinical":[30,43,82,128,252],"trial,":[31],"determine":[34],"whether":[35],"are":[38,236],"systematically":[39],"related":[40],"the":[42,49,69,112,141,178],"course":[44],"neuropathologic":[46],"features":[47],"disease.":[50],"Methods":[51],"Neuropsychological":[52],"test":[53,122],"data":[54],"from":[55,68],"(n":[63,106],"=":[64,107],"4,711)":[65],"were":[66,84,92,134,175],"obtained":[67,176],"National":[70],"Alzheimer9s":[71],"Coordinating":[72],"Center.":[73],"Inclusion":[74],"usually":[78],"used":[79,93],"trials":[83,253],"applied.":[85],"Principal":[86],"component":[87],"analysis":[88],"model-based":[90],"clustering":[91],"subset":[100],"autopsy-verified":[104],"800)":[108],"validated":[110],"overall":[113,179],"(nonautopsy)":[114],"sample":[115],"an":[117,165],"independent":[118],"cohort":[119],"similar":[121],"data.":[123],"Relationships":[124],"between":[125],"profile,":[127],"characteristics,":[129],"rate":[131],"decline":[133],"examined":[135],"mixed-effects":[137],"models.":[138],"Results":[139],"In":[140],"autopsy-confirmed":[142],"sample,":[143],"79.6%":[144],"had":[147,164],"profile":[152,167],"(greater":[153],"impairment":[154,169],"episodic":[156],"memory":[157],"than":[158],"other":[159],"functions),":[161],"20.4%":[163],"atypical":[166,182,188],"(comparable":[168],"across":[170],"domains).":[172],"Similar":[173],"results":[174],"(typical":[180,186],"79.8%,":[181],"20.2%)":[183],"validation":[185],"71.8%,":[187],"28.2%)":[189],"samples.":[190],"Atypicality":[191],"was":[192],"associated":[193,237],"younger":[195],"age,":[196],"male":[197],"sex,":[198],"lower":[199,211],"probability":[200],"APOE":[202],"\u03b54,":[203],"less":[204],"severe":[205],"global":[206],"dementia,":[207],"higher":[208],"depression":[209],"scores,":[210],"Braak":[212],"stage":[213],"at":[214],"autopsy,":[215],"slower":[217],"decline.":[219,246],"Conclusion":[220],"We":[221],"can":[222],"reliably":[223],"distinct":[225],"among":[228],"clinically":[231],"diagnosed":[232],"that":[235],"tangle":[239],"pathology":[240],"different":[243],"rates":[244],"This":[247],"may":[248],"implications":[250],"AD,":[255],"especially":[256],"therapies":[257],"targeting":[258],"tau.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2019-07-23T00:00:00"}
