{"id":"https://openalex.org/W2960880420","doi":"https://doi.org/10.3892/or.2019.7240","title":"Growth inhibition and transcriptional effects of ribavirin in lymphoma","display_name":"Growth inhibition and transcriptional effects of ribavirin in lymphoma","publication_year":2019,"publication_date":"2019-07-17","ids":{"openalex":"https://openalex.org/W2960880420","doi":"https://doi.org/10.3892/or.2019.7240","mag":"2960880420","pmid":"https://pubmed.ncbi.nlm.nih.gov/31322273"},"language":"en","primary_location":{"id":"doi:10.3892/or.2019.7240","doi":"https://doi.org/10.3892/or.2019.7240","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2019.7240","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2019.7240/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/or.2019.7240/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053340050","display_name":"Guadalupe Dom\u00ednguez-G\u00f3mez","orcid":"https://orcid.org/0000-0003-3906-4493","observed_orcids":["https://orcid.org/0000-0003-3906-4493"]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Guadalupe Dominguez\u2011Gomez","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031550477","display_name":"Dominique Cortez\u2010Pedroza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Dominique Cortez\u2011Pedroza","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077188074","display_name":"Alma Delia Ch\u00e1vez-Blanco","orcid":"https://orcid.org/0000-0002-4201-5935","observed_orcids":["https://orcid.org/0000-0002-4201-5935"]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alma Chavez\u2011Blanco","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022488513","display_name":"Luc\u00eda Taja\u2010Chayeb","orcid":"https://orcid.org/0000-0002-9592-8527","observed_orcids":["https://orcid.org/0000-0002-9592-8527"]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Lucia Taja\u2011Chayeb","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004575782","display_name":"Alfredo Hidalgo\u2010Miranda","orcid":"https://orcid.org/0000-0003-2315-3977","observed_orcids":["https://orcid.org/0000-0003-2315-3977"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alfredo Hidalgo\u2011Miranda","raw_affiliation_strings":["Cancer Genomics Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077176151","display_name":"Alberto Cedro\u2010Tanda","orcid":"https://orcid.org/0000-0001-8708-462X","observed_orcids":["https://orcid.org/0000-0001-8708-462X"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alberto Cedro\u2011Tanda","raw_affiliation_strings":["Cancer Genomics Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043665171","display_name":"Fredy Omar Beltr\u00e1n\u2010Anaya","orcid":"https://orcid.org/0000-0001-6862-7879","observed_orcids":["https://orcid.org/0000-0001-6862-7879"]},"institutions":[{"id":"https://openalex.org/I4210110970","display_name":"National Institute of Genomic Medicine","ror":"https://ror.org/01qjckx08","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210110970"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fredy Beltran\u2011Anaya","raw_affiliation_strings":["Cancer Genomics Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 14610, Mexico","institution_ids":["https://openalex.org/I4210110970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060564308","display_name":"Jos\u00e9 D\u00edaz\u2010Ch\u00e1vez","orcid":"https://orcid.org/0000-0001-9583-3790","observed_orcids":["https://orcid.org/0000-0001-9583-3790"]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Jose Diaz\u2011Chavez","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086713265","display_name":"Alejandro Schcolnik\u2010Cabrera","orcid":"https://orcid.org/0000-0001-7734-3253","observed_orcids":["https://orcid.org/0000-0001-7734-3253"]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alejandro Schcolnik\u2011Cabrera","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048475618","display_name":"Aurora Gonz\u00e1lez\u2010Fierro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Aurora Gonzalez\u2011Fierro","raw_affiliation_strings":["Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Research, National Cancer Institute (INCAN), Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5097072923","display_name":"Alfonso Due\ufffdas\u2010Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153971","display_name":"Instituto Nacional de Cancerolog\u00eda","ror":"https://ror.org/04z3afh10","country_code":"MX","type":"government","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210153971"]},{"id":"https://openalex.org/I4405269066","display_name":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/02zz52s52","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4405269066"]},{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alfonso Due\ufffdas\u2011Gonzalez","raw_affiliation_strings":["Unit of Biomedical Research, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)/INCAN, Mexico City 14080, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Biomedical Research, Institute of Biomedical Research, National Autonomous University of Mexico (UNAM)/INCAN, Mexico City 14080, Mexico","institution_ids":["https://openalex.org/I4210153971","https://openalex.org/I4405269066","https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3638,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.49574975,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"42","issue":"3","first_page":"1248","last_page":"1256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.4458000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.2904999852180481,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.8740000128746033},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/hut-78-cells","display_name":"HUT-78 cells","score":0.7900000214576721},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase","display_name":"stearoyl-CoA desaturase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8370000123977661},{"id":"https://openalex.org/keywords/immune-pathways","display_name":"immune pathways","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.6039999723434448},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.5759999752044678},{"id":"https://openalex.org/keywords/epigenetic-therapy","display_name":"epigenetic therapy","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.7444194555282593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6256493926048279},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6024654507637024},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33145418763160706},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2776106595993042},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1823716163635254},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.08435899019241333}],"mesh":[{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071221","descriptor_name":"Enhancer of Zeste Homolog 2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012254","descriptor_name":"Ribavirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2019.7240","doi":"https://doi.org/10.3892/or.2019.7240","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2019.7240","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2019.7240/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:31322273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31322273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2019.7240","doi":"https://doi.org/10.3892/or.2019.7240","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2019.7240","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2019.7240/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2960880420.pdf","grobid_xml":"https://content.openalex.org/works/W2960880420.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1698996065","https://openalex.org/W1968622004","https://openalex.org/W1981461598","https://openalex.org/W1992226313","https://openalex.org/W2010711123","https://openalex.org/W2011034370","https://openalex.org/W2015474565","https://openalex.org/W2017449430","https://openalex.org/W2033489247","https://openalex.org/W2041503985","https://openalex.org/W2047346696","https://openalex.org/W2052313621","https://openalex.org/W2058320288","https://openalex.org/W2060597720","https://openalex.org/W2068356917","https://openalex.org/W2088174971","https://openalex.org/W2112519486","https://openalex.org/W2137623566","https://openalex.org/W2145234555","https://openalex.org/W2169508419","https://openalex.org/W2338878406","https://openalex.org/W2461456620","https://openalex.org/W2491165786","https://openalex.org/W2509400140","https://openalex.org/W2562383504","https://openalex.org/W2620607283","https://openalex.org/W2781832221","https://openalex.org/W2811225034"],"related_works":["https://openalex.org/W2047346696","https://openalex.org/W2743322456","https://openalex.org/W2620607283","https://openalex.org/W2004380688","https://openalex.org/W2487236518","https://openalex.org/W2073144681","https://openalex.org/W1916468062","https://openalex.org/W2006454829","https://openalex.org/W1968622004","https://openalex.org/W1973997212"],"abstract_inverted_index":{"Ribavirin":[0,161],"exhibits":[1],"inhibitory":[2,260,277],"effects":[3,46,56,106,261,278,295],"on":[4,59,109,279],"the":[5,25,34,44,60,65,118,144,151,165,180,187,190,199,231,255,264,303,311,322,339],"epigenetic":[6],"enzyme":[7],"enhancer":[8],"of":[9,28,36,47,57,64,85,90,107,132,137,143,155,167,182,189,222,237,242,245,254,305,325,341],"zeste":[10],"homolog":[11],"2":[12],"(EZH2),":[13],"which":[14,247],"participates":[15],"in":[16,51,100,157,301,330],"lymphomagenesis.":[17],"Additionally,":[18],"preclinical":[19,331],"and":[20,62,75,87,117,130,135,153,208,212,216,233,240,315,332],"clinical":[21,333],"studies":[22,334],"have":[23],"demonstrated":[24,147],"anti\u2011lymphoma":[26,323],"activity":[27,172],"this":[29],"drug.":[30],"To":[31],"further":[32,328],"investigate":[33],"potential":[35,324],"ribavirin":[37,48,58,108,149,195,271,342],"as":[38,173,250,267,343],"an":[39],"anticancer":[40],"treatment":[41],"for":[42,347],"lymphoma,":[43],"tumor\u2011suppressive":[45],"were":[49,82,112,120,196,226],"analyzed":[50,113],"lymphoma":[52,67,78,280,289],"cell":[53,68,80,281,290],"lines.":[54],"The":[55,104,141,220],"viability":[61],"clonogenicity":[63,154],"B\u2011cell":[66],"line":[69,81],"Pfeiffer":[70],"(EZH2\u2011mutant),":[71],"Toledo":[72],"(EZH2":[73],"wild\u2011type)":[74],"cutaneous":[76,287],"T\u2011cell":[77,288],"Hut78":[79,110,284],"assessed.":[83],"Expression":[84],"EZH2":[86,168],"trimethylation":[88,177],"status":[89],"histone":[91],"3,":[92],"lysine":[93],"27":[94],"trimethylated":[95],"(H3K27m3)":[96],"was":[97,248,272],"also":[98],"determined":[99],"response":[101],"to":[102,263,274,337],"ribavirin.":[103,268],"transcriptional":[105],"cells":[111,156],"by":[114,122,175,194,228,310],"microarray":[115],"expression":[116,166,224],"results":[119,142,181,221,318],"validated":[121],"reverse":[123],"transcription\u2011quantitative":[124],"polymerase":[125],"chain":[126],"reaction,":[127],"western":[128],"blotting":[129],"knockout":[131],"signal":[133],"transducer":[134],"activator":[136],"transcription":[138],"1":[139],"(STAT1).":[140],"present":[145],"study":[146],"that":[148,186],"suppressed":[150],"growth":[152,259,276],"a":[158,251,286,344],"dose\u2011dependent":[159],"manner.":[160],"did":[162],"not":[163],"affect":[164],"nor":[169],"altered":[170],"its":[171],"evaluated":[174],"H3K27":[176],"status.":[178],"Furthermore,":[179],"transcriptome":[183],"analysis":[184,225],"indicated":[185],"majority":[188],"canonical":[191,306],"pathways":[192,308],"affected":[193],"associated":[197],"with":[198],"immune":[200,210,307],"system,":[201],"including":[202],"'antigen":[203],"presentation',":[204],"'communication":[205],"between":[206,214],"innate":[207],"adaptive":[209],"cells'":[211],"'cross\u2011talk":[213],"dendritic":[215],"natural":[217],"killer":[218],"cells'.":[219],"gene":[223],"confirmed,":[227],"demonstrating":[229],"at":[230,299],"RNA":[232],"protein":[234],"levels,":[235],"downregulation":[236],"stearoyl\u2011CoA":[238],"desaturase":[239],"upregulation":[241],"STAT1.":[243],"Depletion":[244],"STAT1,":[246],"proposed":[249,273],"key":[252,312],"regulator":[253],"aforementioned":[256],"pathways,":[257],"exerted":[258],"almost":[262],"same":[265],"extent":[266],"In":[269],"conclusion,":[270],"exert":[275],"lines,":[282],"particularly":[283],"cells,":[285],"line.":[291],"Of":[292],"note,":[293],"these":[294],"may":[296],"depend":[297],"on,":[298],"least":[300],"part,":[302],"activation":[304],"regulated":[309],"factors":[313],"STAT1":[314],"interferon\u2011\u03b3.":[316],"Our":[317],"provide":[319],"insight":[320],"into":[321],"ribavirin;":[326],"however,":[327],"investigations":[329],"are":[335],"required":[336],"determine":[338],"effectiveness":[340],"therapeutic":[345],"agent":[346],"treating":[348],"lymphoma.":[349]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2019-07-23T00:00:00"}